{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T02:29:13Z","timestamp":1793759353916,"version":"4.6.1"},"reference-count":142,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T00:00:00Z","timestamp":1731542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Endometriosis is an oestrogen-dependent inflammatory disease affecting menstruating women, with varying levels of severity. Oestrogen dysregulation is responsible for chronic inflammation, angiogenesis, endometrial lesion development, progression, and infertility during menarche in afflicted women. The inflammatory mediators associated with this chronic painful disease have been established, with research also indicating the relationship between dysbiosis and disease manifestation. Endometriosis is also present with several painful comorbidities, including endometrial cancer, cardiovascular disease, and autoimmunity. The lack of specific and sensitive non-invasive diagnostic procedures, coupled with poor response to current therapeutic approaches, means that treatment needs remain unmet. Surgical procedures are performed to remove endometriosis ectopic lesions, for which the recurrence rate of disease is up to 50%, with certain patients exhibiting no alleviation of symptoms. This review aims to outline the aetiology of endometriosis, detailing novel diagnostic approaches and potential therapeutic approaches, namely advanced therapeutic medical products (ATMPs), including stem cell therapy and clustered regularly interspaced short palindromic repeats (CRISPR) gene editing. This timely review also provides novel insights into the important recent modalities which may be applied for the diagnosis and therapeutic response of endometriosis, including biomarkers, microfluidic platforms, and organoid systems. Undoubtedly, reliable, reproducible, sensitive, and specific models of endometriosis in humans are urgently needed to investigate and detail the aetiology of this debilitating disease.<\/jats:p>","DOI":"10.3390\/ijms252212242","type":"journal-article","created":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T08:06:32Z","timestamp":1731571592000},"page":"12242","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Endometriosis: Future Biological Perspectives for Diagnosis and Treatment"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1240-5315","authenticated-orcid":false,"given":"Mary","family":"Garvey","sequence":"first","affiliation":[{"name":"Department of Life Science, Atlantic Technological University, Ash Lane, F91 YW50 Sligo, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/nrurol.2017.58","article-title":"Pathophysiology and management of urinary tract endometriosis","volume":"14","author":"Nezhat","year":"2017","journal-title":"Nat. Rev. Urol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Ellis, K., Munro, D., and Clarke, J. (2022). Endometriosis Is Undervalued: A Call to Action. Front. Glob. Womens Health, 3.","DOI":"10.3389\/fgwh.2022.902371"},{"key":"ref_3","unstructured":"(2024, September 24). Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/endometriosis#:~:text=Key%20facts,age%20women%20and%20girls%20globally."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Smolarz, B., Szy\u0142\u0142o, K., and Romanowicz, H. (2021). Endometriosis: Epidemiology, Classification, Pathogenesis, Treatment and Genetics (Review of Literature). Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms221910554"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"446","DOI":"10.4103\/ijmr.IJMR_817_18","article-title":"A systematic review on the prevalence of endometriosis in women","volume":"154","author":"Moradi","year":"2021","journal-title":"Indian J. Med. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s13224-014-0578-4","article-title":"Deciding the route for hysterectomy: Indian triage system","volume":"65","author":"Ray","year":"2015","journal-title":"J. Obset. Gynaecol. India"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Chen, P., and Zhang, C.Y. (2022). Association Between Endometriosis and Prognosis of Ovarian Cancer: An Updated Meta-Analysis. Front. Oncol., 12.","DOI":"10.3389\/fonc.2022.732322"},{"key":"ref_8","first-page":"283","article-title":"Endometriosis and related pelvic pain: Association with stress, anxiety and depressive symptoms","volume":"73","author":"Casalechi","year":"2021","journal-title":"Minerva Obset. Gynecol."},{"key":"ref_9","unstructured":"Tsamantioti, E.S., and Mahdy, H. (2024, September 23). Endometriosis, StatPearls [Internet], Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK567777\/."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1111\/1471-0528.13920","article-title":"Pregnancy outcomes in women with endometriosis: A national record linkage study","volume":"124","author":"Saraswat","year":"2017","journal-title":"BJOG"},{"key":"ref_11","first-page":"88","article-title":"Management challenges of deep infiltrating endometriosis","volume":"15","author":"Raslan","year":"2021","journal-title":"Int. J. Fertil. Steril."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"454","DOI":"10.37349\/ei.2022.00062","article-title":"Endometriosis through an immunological lens: A pathophysiology based in immune dysregulation","volume":"2","author":"McCallion","year":"2022","journal-title":"Explor. Immunol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Garvey, M. (2023). The Association between Dysbiosis and Neurological Conditions Often Manifesting with Chronic Pain. Biomedicines, 11.","DOI":"10.3390\/biomedicines11030748"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Donnez, J., and Cacciottola, L. (2022). Endometriosis: An Inflammatory Disease That Requires New Therapeutic Options. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23031518"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Garvey, M. (2024). Intestinal Dysbiosis: Microbial Imbalance Impacts on Colorectal Cancer Initiation, Progression and Disease Mitigation. Biomedicines, 12.","DOI":"10.3390\/biomedicines12040740"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Cano-Herrera, G., Salmun Nehmad, S., Ruiz de Ch\u00e1vez Gasc\u00f3n, J., M\u00e9ndez Vionet, A., van Tienhoven, X.A., Osorio Mart\u00ednez, M.F., Muleiro Alvarez, M., Vasco Rivero, M.X., L\u00f3pez Torres, M.F., and Barroso Valverde, M.J. (2024). Endometriosis: A Comprehensive Analysis of the Pathophysiology, Treatment, and Nutritional Aspects, and Its Repercussions on the Quality of Life of Patients. Biomedicines, 12.","DOI":"10.3390\/biomedicines12071476"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"235","DOI":"10.31083\/j.ceog4910235","article-title":"Global Burden of Endometriosis in 204 Countries and Territories from 1990 to 2019","volume":"49","author":"Feng","year":"2022","journal-title":"Clin. Exp. Obstet. Gynecol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1093\/eurpub\/ckad216","article-title":"Prevalence, diagnostic delay and economic burden of endometriosis and its impact on quality of life: Results from an Eastern Mediterranean population","volume":"34","author":"Swift","year":"2024","journal-title":"Eur. J. Public Health"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"10","DOI":"10.12701\/yujm.2020.00444","article-title":"Classification of endometriosis","volume":"38","author":"Lee","year":"2021","journal-title":"Yeungnam Univ. J. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1093\/humupd\/dmz018","article-title":"The endometrial immune environment of women with endometriosis","volume":"25","author":"Houshdaran","year":"2019","journal-title":"Hum. Reprod. Update"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Lamceva, J., Uljanovs, R., and Strumfa, I. (2023). The Main Theories on the Pathogenesis of Endometriosis. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24054254"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1093\/humupd\/8.1.84","article-title":"Endometriosis, retrograde menstruation and peritoneal inflammation in women and in baboons","volume":"8","author":"Debrock","year":"2002","journal-title":"Hum. Reprod. Update"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Lin, Y.H., Chen, Y.H., Chang, H.Y., Au, H.K., Tzeng, C.R., and Huang, Y.H. (2018). Chronic Niche Inflammation in Endometriosis-Associated Infertility: Current Understanding and Future Therapeutic Strategies. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19082385"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"R41","DOI":"10.1530\/REP-19-0106","article-title":"Endometriosis in MRKH cases as a proof for the coelomic metaplasia hypothesis?","volume":"158","author":"Konrad","year":"2019","journal-title":"Reproduction"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Dymanowska-Dyjak, I., Terpi\u0142owska, B., Morawska-Michalska, I., Michalski, A., Polak, G., Terpi\u0142owski, M., Rahnama-Hezavah, M., and Grywalska, E. (2024). Immune Dysregulation in Endometriomas: Implications for Inflammation. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25094802"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2897","DOI":"10.2147\/IJGM.S417430","article-title":"Autoimmune Disease-Related Hub Genes are Potential Biomarkers and Associated with Immune Microenvironment in Endometriosis","volume":"16","author":"Yang","year":"2023","journal-title":"Int. J. Gen. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e13309","DOI":"10.1111\/aji.13309","article-title":"IL6, IL8, and IL10 in the distinction of malignant ovarian neoplasms and endometriomas","volume":"84","author":"Crispim","year":"2020","journal-title":"Am. J. Reprod. Immunol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"103513","DOI":"10.1016\/j.jri.2022.103513","article-title":"Estrogen receptor beta promotes endometriosis progression by upregulating CD47 expression in ectopic endometrial stromal cells","volume":"151","author":"Hu","year":"2022","journal-title":"J. Reprod. Immunol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1093\/humupd\/dmz005","article-title":"Endometriosis and nuclear receptors","volume":"25","author":"Yilmaz","year":"2019","journal-title":"Hum. Reprod. Update"},{"key":"ref_30","first-page":"40","article-title":"GnRH agonists in the treatment of symptomatic endometriosis: A review","volume":"4","author":"Surrey","year":"2022","journal-title":"F S Rep."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Chen, S., Liu, Y., Zhong, Z., Wei, C., Liu, Y., and Zhu, X. (2023). Peritoneal immune microenvironment of endometriosis: Role and therapeutic perspectives. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1134663"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Nirgianakis, K., Ma, L., McKinnon, B., and Mueller, M.D. (2020). Recurrence patterns after surgery in patients with different endometriosis subtypes: A long-term hospital-based cohort study. J. Clin. Med., 9.","DOI":"10.3390\/jcm9020496"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Imperiale, L., Nisolle, M., No\u00ebl, J.C., and Fastrez, M. (2023). Three Types of Endometriosis: Pathogenesis, Diagnosis and Treatment. State of the Art. J. Clin. Med., 12.","DOI":"10.3390\/jcm12030994"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Tang, H.C., Lin, T.C., Wu, M.H., and Tsai, S.J. (2024). Progesterone resistance in endometriosis: A pathophysiological perspective and potential treatment alternatives. Reprod. Med. Biol., 23.","DOI":"10.1002\/rmb2.12588"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Zou, G., Wang, J., and Xu, X. (2021). Cell subtypes and immune dysfunction in peritoneal fluid of endometriosis revealed by single-cell RNA-sequencing. Cell Biosci., 11.","DOI":"10.1186\/s13578-021-00613-5"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Zhang, H., Mo, Y., Wang, L., Zhang, H., Wu, S., Sandai, D., Shuid, A.N., and Chen, X. (2024). Potential shared pathogenic mechanisms between endometriosis and inflammatory bowel disease indicate a strong initial effect of immune factors. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1339647"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Li, T., Li, R.H.W., Ng, E.H.Y., Yeung, W.S.B., Chiu, P.C.N., and Chan, R.W.S. (2024). Interleukin 6 at menstruation promotes the proliferation and self-renewal of endometrial mesenchymal stromal\/stem cells through the WNT\/\u03b2-catenin signalling pathway. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1378863"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1530\/REP-19-0028","article-title":"Elevated heme impairs macrophage phagocytosis in endometriosis","volume":"158","author":"Liu","year":"2019","journal-title":"Reproduction"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Abramiuk, M., Grywalska, E., Ma\u0142kowska, P., Sierawska, O., Hrynkiewicz, R., and Nied\u017awiedzka-Rystwej, P. (2022). The Role of the Immune System in the Development of Endometriosis. Cells, 11.","DOI":"10.3390\/cells11132028"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s11596-018-1906-1","article-title":"Expression of MMIF, HIF-1\u03b1 and VEGF in serum and endometrial tissues of patients with endometriosis","volume":"38","author":"Zhang","year":"2018","journal-title":"Curr. Med. Sci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e14","DOI":"10.4110\/in.2023.23.e14","article-title":"IL-17A and Th17 cells contribute to endometrial cell survival by inhibiting apoptosis and NK cell mediated cytotoxicity of endometrial cells via ERK1\/2 pathway","volume":"23","author":"Kang","year":"2023","journal-title":"Immune Netw."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.4049\/jimmunol.2400018","article-title":"The Dysregulated IL-23\/TH17 Axis in Endometriosis Pathophysiology","volume":"212","author":"Sisnett","year":"2024","journal-title":"J. Immunol."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Kisovar, A., Becker, C.M., Granne, I., and Southcombe, J.H. (2023). The role of CD8+ T cells in endometriosis: A systematic review. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1225639"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s10735-014-9595-y","article-title":"The intricate role of mast cell proteases and the annexin A1-FPR1 system in abdominal wall endometriosis","volume":"46","author":"Paula","year":"2015","journal-title":"J. Mol. Histol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1093\/intimm\/dxaa078","article-title":"IL-6 in inflammation, autoimmunity and cancer","volume":"33","author":"Hirano","year":"2021","journal-title":"Int. Immunol."},{"key":"ref_46","first-page":"151","article-title":"Serum and peritoneal fluid cytokine profiles in infertile women with endometriosis","volume":"16","author":"Tarokh","year":"2019","journal-title":"Iran. J. Immunol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.fertnstert.2006.11.200","article-title":"Peritoneal fluid macrophages in endometriosis: Correlation between the expression of oestrogen receptors and inflammation","volume":"90","author":"Montagna","year":"2008","journal-title":"Fertil. Steril."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1016\/j.fertnstert.2010.06.069","article-title":"Loss of sympathetic nerve fibers in intestinal endometriosis","volume":"94","author":"Ferrero","year":"2010","journal-title":"Fertil. Steril."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Coxon, L., Wiech, K., and Vincent, K. (2021). Is There a Neuropathic-Like Component to Endometriosis-Associated Pain? Results From a Large Cohort Questionnaire Study. Front. Pain Res., 2.","DOI":"10.3389\/fpain.2021.743812"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.1093\/humrep\/deu172","article-title":"An Increased Level of IL-6 Suppresses NK Cell Activity in Peritoneal Fluid of Patients with Endometriosis via Regulation of SHP-2 Expression","volume":"29","author":"Kang","year":"2014","journal-title":"Hum. Reprod."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1016\/j.fertnstert.2012.07.1117","article-title":"Interleukin-17A Is Present in Neutrophils in Endometrioma and Stimulates the Secretion of Growth-Regulated Oncogene-\u03b1 (Gro-\u03b1) from Endometrioma Stromal Cells","volume":"8","author":"Takamura","year":"2012","journal-title":"Fertil. Steril."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1124\/mol.107.042176","article-title":"Tumor necrosis factor-alpha regulates inflammatory and mesenchymal responses via mitogen-activated protein kinase kinase, p38, and nuclear factor kappaB in human endometriotic epithelial cells","volume":"73","author":"Grund","year":"2008","journal-title":"Mol. Pharmacol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.rbmo.2021.04.012","article-title":"Functional changes of immune cells: Signal of immune tolerance of the ectopic lesions in endometriosis?","volume":"43","author":"Velho","year":"2021","journal-title":"Reprod. Biomed. Online"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Guo, C., and Zhang, C. (2024). Role of the gut microbiota in the pathogenesis of endometriosis: A review. Front. Microbiol., 15.","DOI":"10.3389\/fmicb.2024.1363455"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1093\/humrep\/deae103","article-title":"The role of regulatory T-cells in the development of endometriosis","volume":"39","author":"Knez","year":"2024","journal-title":"Hum. Reprod."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Reis, J.L., Rosa, N.N., Martins, C., \u00c2ngelo-Dias, M., Borrego, L.M., and Lima, J. (2024). The Role of NK and T Cells in Endometriosis. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms251810141"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"25859","DOI":"10.1073\/pnas.1920037117","article-title":"Extracellular vesicle-associated VEGF-C promotes lymphangiogenesis and immune cells infiltration in endometriosis","volume":"117","author":"Li","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1210\/jcem.87.3.8286","article-title":"Serum Leptin Concentrations in Endometriosis","volume":"87","author":"Somigliana","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/j.1600-0897.2009.00779.x","article-title":"Leptin on peritoneal macrophages of patients with endometriosis","volume":"63","author":"Wu","year":"2010","journal-title":"Am. J. Reprod. Immunol."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Maulitz, L., Stickeler, E., Stickel, S., Habel, U., Tchaikovski, S.N., and Chechko, N. (2022). Endometriosis, psychiatric comorbidities and neuroimaging: Estimating the odds of an endometriosis brain. Front. Neuroendocrinol., 65.","DOI":"10.1016\/j.yfrne.2022.100988"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"100045","DOI":"10.1016\/j.jeud.2023.100045","article-title":"Intestinal Permeability and Endometriosis: A pilot investigation","volume":"3","author":"Mohling","year":"2023","journal-title":"J. Endometr. Uterine Disord."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.maturitas.2017.06.025","article-title":"Estrogen-gut microbiome axis: Physiological and clinical implications","volume":"103","author":"Baker","year":"2017","journal-title":"Maturitas"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Uzuner, C., Mak, J., El-Assaad, F., and Condous, G. (2023). The bidirectional relationship between endometriosis and microbiome. Front. Endocrinol., 14.","DOI":"10.3389\/fendo.2023.1110824"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"18586","DOI":"10.1074\/jbc.RA119.010950","article-title":"Gut microbial \u03b2-GlucuronidasesReactivate estrogens as components of the estrobolome that reactivate estrogens","volume":"294","author":"Ervin","year":"2019","journal-title":"J. Biol. Chem."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1007\/s12282-016-0734-z","article-title":"Gastrointestinal microbiome and breast cancer: Correlations, mechanisms and potential clinical implications","volume":"24","author":"Yang","year":"2017","journal-title":"Breast Cancer"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.fertnstert.2023.03.032","article-title":"Gut dysbiosis-derived beta-glucuronidase promotes the development of endometriosis","volume":"120","author":"Wei","year":"2023","journal-title":"Fertil. Steril."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1038\/s41467-017-00901-0","article-title":"The Microbiota Continuum Along the Female Reproductive Tract and Its Relation to Uterine-Related Diseases","volume":"8","author":"Chen","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1007\/s43032-021-00506-5","article-title":"Associations Between Endometriosis and Gut Microbiota","volume":"28","author":"Svensson","year":"2021","journal-title":"Reprod. Sci."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Ata, B., Yildiz, S., Turkgeldi, E., Brocal, V.P., Dinleyici, E.C., and Moya, A. (2019). The endobiota study: Comparison of vaginal, cervical and gut microbiota between women with stage 3\/4 endometriosis and healthy controls. Sci. Rep., 9.","DOI":"10.1038\/s41598-019-39700-6"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Wei, W., Zhang, X., Tang, H., Zeng, L., and Wu, R. (2020). Microbiota composition and distribution along the female reproductive tract of women with endometriosis. Ann. Clin. Microbiol. Antimicrob., 19.","DOI":"10.1186\/s12941-020-00356-0"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Huang, L., Liu, B., Liu, Z., Feng, W., Liu, M., Wang, Y., Peng, D., Fu, X., Zhu, H., and Cui, Z. (2021). Gut Microbiota Exceeds Cervical Microbiota for Early Diagnosis of Endometriosis. Front. Cell. Infect. Microbiol., 11.","DOI":"10.3389\/fcimb.2021.788836"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"e271","DOI":"10.1016\/j.fertnstert.2016.07.781","article-title":"Lipopolysaccharide promotes the development of murine endometriosis-like lesions via nuclear factor-kappa B pathway","volume":"106","author":"Taniguchi","year":"2016","journal-title":"Fertil. Steril."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/rmb2.12083","article-title":"Bacterial contamination hypothesis: A new concept in endometriosis","volume":"17","author":"Khan","year":"2018","journal-title":"Reprod. Med. Biol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1007\/s00404-021-06057-z","article-title":"Gut microbiota imbalance and its correlations with hormone and inflammatory factors in patients with stage 3\/4 endometriosis","volume":"304","author":"Shan","year":"2021","journal-title":"Arch. Gynecol. Obset."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1002\/ijgo.15718","article-title":"Endometrial microbial dysbiosis and metabolic alteration promote the development of endometrial cancer","volume":"167","author":"Han","year":"2024","journal-title":"Int. J. Gynaecol. Obstet."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Sabbadin, C., Saccardi, C., Andrisani, A., Vitagliano, A., Marin, L., Ragazzi, E., Bordin, L., Ambrosini, G., and Armanini, D. (2022). Role of Renin-Angiotensin-Aldosterone System and Cortisol in Endometriosis: A Preliminary Report. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24010310"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"100104","DOI":"10.1016\/j.jtauto.2021.100104","article-title":"Distinct roles of interleukin-17 and T helper 17 cells among autoimmune diseases","volume":"4","author":"Akiyama","year":"2021","journal-title":"J. Transl. Autoimmun."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"e10","DOI":"10.4110\/in.2024.24.e10","article-title":"Cytokines, Vascular Endothelial Growth Factors, and PlGF in Autoimmunity: Insights From Rheumatoid Arthritis to Multiple Sclerosis","volume":"24","author":"Lee","year":"2024","journal-title":"Immune Netw."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1159\/000530896","article-title":"High Frequency of Deep Infiltrating Endometriosis in Patients with Inflammatory Bowel Disease: A Nested Case-Control Study","volume":"41","author":"Neri","year":"2023","journal-title":"Dig. Dis."},{"key":"ref_80","first-page":"A120","article-title":"P127 Endometriosis presenting as ulcerative colitis\u2014A case report","volume":"72","author":"Nitchingham","year":"2023","journal-title":"Gut"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"e78","DOI":"10.1016\/j.fertnstert.2023.08.236","article-title":"Association of endometriosis and inflammatory bowel disease (ibd), findings from epidemiological evidence to genetic links","volume":"120","author":"Gan","year":"2023","journal-title":"Fertil. Steril."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1093\/humupd\/dmz014","article-title":"The association between endometriosis and autoimmune diseases: A systematic review and meta-analysis","volume":"25","author":"Shigesi","year":"2019","journal-title":"Hum. Reprod. Update"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Bin Huraib, G., Al Harthi, F., and Arfin, M. (2020). The Protein Tyrosine Phosphatase Non-Receptor Type 22 (PTPN22) Gene Polymorphism and Susceptibility to Autoimmune Diseases. The Recent Topics in Genetic Polymorphisms, IntechOpen.","DOI":"10.5772\/intechopen.90836"},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Vanni, V.S., Villanacci, R., and Salmeri, N. (2021). Concomitant autoimmunity may be a predictor of more severe stages of endometriosis. Sci. Rep., 11.","DOI":"10.1038\/s41598-021-94877-z"},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Oal\u0103, I.E., Mitranovici, M.I., Chiorean, D.M., Irimia, T., Cri\u0219an, A.I., Melinte, I.M., Cotru\u0219, T., Tudorache, V., Moraru, L., and Moraru, R. (2024). Endometriosis and the Role of Pro-Inflammatory and Anti-Inflammatory Cytokines in Pathophysiology: A Narrative Review of the Literature. Diagnostics, 14.","DOI":"10.3390\/diagnostics14030312"},{"key":"ref_86","unstructured":"Kvaskoff, M. (2024). The Continuous Textbook of Women\u2019s Medicine Series\u2014Gynecology Module Endometriosis. Glob. Libr. Women\u2019s Med., 3. ISSN: 1756-2228."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Reske, J.J., Wilson, M.R., Holladay, J., Siwicki, R.A., Skalski, H., Harkins, S., Adams, M., Risinger, J.I., Hostetter, G., and Lin, K. (2021). Co-existing TP53 and ARID1A mutations promote aggressive endometrial tumorigenesis. PLoS Genet., 17.","DOI":"10.1371\/journal.pgen.1009986"},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Rzewuska, A.M., \u017bybowska, M., Sajkiewicz, I., Spiechowicz, I., \u017bak, K., Abramiuk, M., Ku\u0142ak, K., and Tarkowski, R. (2023). Gonadotropin-Releasing Hormone Antagonists\u2014A New Hope in Endometriosis Treatment?. J. Clin. Med., 12.","DOI":"10.3390\/jcm12031008"},{"key":"ref_89","first-page":"e17048","article-title":"Gross Ascites Secondary to Endometriosis: A Rare Presentation in Pre-Menopausal Women","volume":"13","author":"Bahall","year":"2021","journal-title":"Cureus"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1093\/biolre\/ioaa124","article-title":"Endometrial Organoids: A New Model for the Research of Endometrial-Related Diseases","volume":"103","author":"Gu","year":"2020","journal-title":"Biol. Reprod."},{"key":"ref_91","first-page":"2385048","article-title":"Elevated CA 125 in a case of leaking endometrioma","volume":"2018","author":"Rao","year":"2018","journal-title":"Case Rep. Obstet. Gynecol."},{"key":"ref_92","first-page":"713","article-title":"Correlation of CA-125 serum level and clinico-pathological characteristic of patients with endometriosis","volume":"14","author":"Sekhavat","year":"2016","journal-title":"Int. J. Reprod. Biomed."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"3801","DOI":"10.12659\/MSM.905226","article-title":"Role of Interleukin-6 and Its Receptor in Endometriosis","volume":"23","author":"Li","year":"2017","journal-title":"Med. Sci. Monit."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Anastasiu, C.V., Moga, M.A., Elena Neculau, A., B\u0103lan, A., Sc\u00e2rneciu, I., Dragomir, R.M., Dull, A.-M., and Chicea, L.-M. (2020). Biomarkers for the Noninvasive Diagnosis of Endometriosis: State of the Art and Future Perspectives. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21051750"},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Sheta, M., Taha, E.A., Lu, Y., and Eguchi, T. (2023). Extracellular Vesicles: New Classification and Tumor Immunosuppression. Biology, 12.","DOI":"10.3390\/biology12010110"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s41392-024-01735-1","article-title":"Extracellular vesicles as tools and targets in therapy for diseases","volume":"9","author":"Kumar","year":"2024","journal-title":"Sig. Transduct. Target. Ther."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Chu, X., Hou, M., Li, Y., Zhang, Q., Wang, S., and Ma, J. (2024). Extracellular vesicles in endometriosis: Role and potential. Front. Endocrinol., 15.","DOI":"10.3389\/fendo.2024.1365327"},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Abudula, M., Fan, X., Zhang, J., Li, J., Zhou, X., and Chen, Y. (2022). Ectopic endometrial cell-derived exosomal moesin induces eutopic endometrial cell migration, enhances angiogenesis and cytosolic inflammation in lesions contributes to endometriosis progression. Front. Cell Dev. Biol., 10.","DOI":"10.3389\/fcell.2022.824075"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"2456340","DOI":"10.1155\/2020\/2456340","article-title":"Serum exosomal microRNAs as potential circulating biomarkers for endometriosis","volume":"2020","author":"Zhang","year":"2020","journal-title":"Dis. Markers"},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"P\u00e9rez-Prieto, I., Vargas, E., and Salas-Espejo, E. (2024). Gut microbiome in endometriosis: A cohort study on 1000 individuals. BMC Med., 22.","DOI":"10.1186\/s12916-024-03692-6"},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Chang, C.Y., Chiang, A.J., Lai, M.T., Yan, M.J., Tseng, C.C., Lo, L.C., Wan, L., Li, C.J., Tsui, K.H., and Chen, C.M. (2022). A more diverse cervical microbiome associates with better clinical outcomes in patients with endometriosis: A pilot study. Biomedicines, 10.","DOI":"10.3390\/biomedicines10010174"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/s41420-023-01309-0","article-title":"Gut microbiota and microbiota-derived metabolites promotes endometriosis","volume":"9","author":"Chadchan","year":"2023","journal-title":"Cell Death Discov."},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Garvey, M. (2024). Neonatal Infectious Disease: A Major Contributor to Infant Mortality Requiring Advances in Point-of-Care Diagnosis. Antibiotics, 13.","DOI":"10.3390\/antibiotics13090877"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1800112","DOI":"10.1002\/gch2.201800112","article-title":"Placenta-on-a-Chip: In vitro study of caffeine transport across placental barrier using liquid chromatography mass spectrometry","volume":"3","author":"Pemathilaka","year":"2019","journal-title":"Glob. Chall."},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Deng, Z.M., Dai, F.F., and Wang, R.Q. (2024). Organ-on-a-chip: Future of female reproductive pathophysiological models. J. Nanobiotechnol., 22.","DOI":"10.1186\/s12951-024-02651-w"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"14584","DOI":"10.1038\/ncomms14584","article-title":"A microfluidic culture model of the human reproductive tract and 28-day menstrual cycle","volume":"8","author":"Xiao","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1039\/c2ib00172a","article-title":"Co-cultured endometrial stromal cells and peritoneal mesothelial cells for an in vitro model of endometriosis","volume":"4","author":"Chen","year":"2012","journal-title":"Integr. Biol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"e22551","DOI":"10.1096\/fj.202200872R","article-title":"Modeling ascending Ureaplasma parvum infection through the female reproductive tract using vagina-cervix-decidua-organ-on-a-chip and feto-maternal interface-organ-on-a-chip","volume":"36","author":"Tantengco","year":"2022","journal-title":"FASEB J."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"2720","DOI":"10.1093\/humrep\/deab186","article-title":"Three-dimensional microengineered vascularised endometrium-on-a-chip","volume":"36","author":"Ahn","year":"2021","journal-title":"Hum. Reprod."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1038\/s41556-019-0360-z","article-title":"Patient-derived organoids from endometrial disease capture clinical heterogeneity and are amenable to drug screening","volume":"21","author":"Boretto","year":"2019","journal-title":"Nat. Cell Biol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.fertnstert.2020.08.1398","article-title":"Insight into epigenetics of human endometriosis organoids: DNA methylation analysis of HOX genes and their cofactors","volume":"115","author":"Esfandiari","year":"2021","journal-title":"Fertil. Steril."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.medj.2023.07.004","article-title":"Organoid co-culture model of the human endometrium in a fully synthetic extracellular matrix enables the study of epithelial-stromal crosstalk","volume":"4","author":"Gnecco","year":"2023","journal-title":"Med"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"23132","DOI":"10.1073\/pnas.1915389116","article-title":"Self-renewing endometrial epithelial organoids of the human uterus","volume":"116","author":"Fitzgerald","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_114","unstructured":"(2024, October 23). Available online: https:\/\/www.ema.europa.eu\/en\/human-regulatory-overview\/advanced-therapy-medicinal-products-overview."},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Meade, E., Rowan, N., and Garvey, M. (2023). Bioprocessing and the Production of Antiviral Biologics in the Prevention and Treatment of Viral Infectious Disease. Vaccines, 11.","DOI":"10.3390\/vaccines11050992"},{"key":"ref_116","first-page":"5","article-title":"The Regulatory Landscape for ATMPs in the EU and US: A Comparison","volume":"15","author":"Warreth","year":"2020","journal-title":"Level 3"},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Garc\u00eda-Izquierdo, L., Mar\u00edn-S\u00e1nchez, P., Garc\u00eda-Pe\u00f1arrubia, P., and Mart\u00ednez-Esparza, M. (2024). New Potential Pharmacological Options for Endometriosis Associated Pain. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25137068"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.12688\/f1000research.141510.1","article-title":"Case Report: Implication of antiangiogenic therapy (bevacizumab) along with dichloroacetate therapy on endometriosis patient seeking infertility treatment [version 1; peer review: 1 approved with reservations]","volume":"12","author":"Mehakar","year":"2023","journal-title":"F1000Research"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"521","DOI":"10.3892\/ijmm.2020.4609","article-title":"Advance genome editing technologies in the treatment of human diseases: CRISPR therapy (Review)","volume":"46","author":"Alagoz","year":"2020","journal-title":"Int. J. Mol. Med."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"830","DOI":"10.3892\/mmr.2021.12470","article-title":"CMBs carrying PTX and CRISPR\/Cas9 targeting C-erbB-2 plasmids interfere with endometrial cancer cells","volume":"24","author":"Peng","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0015-0282(01)02984-3","article-title":"PROGINS receptor gene polymorphism is associated with endometriosis","volume":"77","author":"Wieser","year":"2002","journal-title":"Fertil. Steril."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.3727\/096504019X15561873320465","article-title":"CRISPR\/Cas9-Mediated Gene Knockout of ARID1A Promotes Primary Progesterone Resistance by Downregulating Progesterone Receptor B in Endometrial Cancer Cells","volume":"27","author":"Wang","year":"2019","journal-title":"Oncol. Res."},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Balasubramanian, V., Saravanan, R., Balamurugan, S.S.S., Rajendran, S., Joseph, L.D., Dev, B., Srinivasan, B., Balunathan, N., Shanmugasundaram, G., and Gopisetty, G. (2024). Genetic alteration of mRNA editing enzyme APOBEC3B in the pathogenesis of ovarian endometriosis. Reprod. BioMed. Online, 49, ISSN 1472-6483.","DOI":"10.1016\/j.rbmo.2024.104111"},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Chiorean, D.M., Mitranovici, M.-I., Toru, H.S., Cotoi, T.C., Tomu\u021b, A.N., Turdean, S.G., and Cotoi, O.S. (2023). New Insights into Genetics of Endometriosis\u2014A Comprehensive Literature Review. Diagnostics, 13.","DOI":"10.3390\/diagnostics13132265"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1186\/s13287-020-01855-9","article-title":"Mesenchymal stromal cell therapies: Immunomodulatory properties and clinical progress","volume":"11","author":"Wu","year":"2020","journal-title":"Stem Cell Res. Ther."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1038\/cdd.2009.187","article-title":"Mesenchymal stem cells improve small intestinal integrity through regulation of endogenous epithelial cell homeostasis","volume":"17","author":"Mouiseddine","year":"2010","journal-title":"Cell Death Differ."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1001\/jamaoncol.2023.5757","article-title":"Mesenchymal Stem Cells for Prophylaxis of Chronic Graft-vs-Host Disease After Haploidentical Hematopoietic Stem Cell Transplant: An Open-Label Randomized Clinical Trial","volume":"10","author":"Huang","year":"2024","journal-title":"JAMA Oncol."},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Abomaray, F., Wagner, A.K., Chrobok, M., Ekblad-Nordberg, \u00c5., Gidl\u00f6f, S., Alici, E., and G\u00f6therstr\u00f6m, C. (2021). The Effect of Mesenchymal Stromal Cells Derived From Endometriotic Lesions on Natural Killer Cell Function. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.612714"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1016\/j.stem.2021.09.006","article-title":"Mesenchymal stromal cells: Putative microenvironmental modulators become cell therapy","volume":"28","author":"Krampera","year":"2021","journal-title":"Cell Stem Cell"},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Mohamed Rasheed, Z.B., Nordin, F., Wan Kamarul Zaman, W.S., Tan, Y.-F., and Abd Aziz, N.H. (2023). Autologous Human Mesenchymal Stem Cell-Based Therapy in Infertility: New Strategies and Future Perspectives. Biology, 12.","DOI":"10.3390\/biology12010108"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1016\/j.fertnstert.2010.09.064","article-title":"Comparative study of human eutopic and ectopic endometrial mesenchymal stem cells and the development of an in vivo endometriotic invasion model","volume":"95","author":"Kao","year":"2011","journal-title":"Fertil. Steril."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1016\/j.fertnstert.2012.08.003","article-title":"Sorafenib inhibits growth, migration, and angiogenic potential of ectopic endometrial mesenchymal stem cells derived from patients with endometriosis","volume":"98","author":"Moggio","year":"2012","journal-title":"Fertil. Steril."},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Chatzianagnosti, S., Dermitzakis, I., Theotokis, P., Kousta, E., Mastorakos, G., and Manthou, M.E. (2024). Application of Mesenchymal Stem Cells in Female Infertility Treatment: Protocols and Preliminary Results. Life, 14.","DOI":"10.3390\/life14091161"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1186\/s13287-021-02526-z","article-title":"Endometrial stem\/progenitor cells and their roles in immunity, clinical application, and endometriosis","volume":"12","author":"Kong","year":"2021","journal-title":"Stem Cell Res. Ther."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.yexcr.2016.11.020","article-title":"Spatial and Temporal Characterization of Endometrial Mesenchymal Stem-like Cells Activity during the Menstrual Cycle","volume":"350","author":"Xu","year":"2017","journal-title":"Exp. Cell Res."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/s10517-008-0136-0","article-title":"Endometrial mesenchymal stem cells isolated from the menstrual blood","volume":"145","author":"Musina","year":"2008","journal-title":"Bull. Exp. Biol. Med."},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Zhao, Y., Chen, X., Wu, Y., Wang, Y., Li, Y., and Xiang, C. (2018). Transplantation of human menstrual blood-derived mesenchymal stem cells alleviates Alzheimer\u2019s disease-like pathology in APP\/PS1 transgenic mice. Front. Mol. Neurosci., 11.","DOI":"10.3389\/fnmol.2018.00140"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1007\/s11626-011-9399-2","article-title":"Production of functional dendritic cells from menstrual blood: A new dendritic cell source for immune therapy","volume":"47","author":"Phuc","year":"2011","journal-title":"Vitro Cell Dev. Biol. Anim."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"100408","DOI":"10.1016\/j.envadv.2023.100408","article-title":"MSC beneficial effects and limitations, and MSC-derived extracellular vesicles as a new cell-free therapy for tissue regeneration in irradiated condition","volume":"13","author":"Flamant","year":"2023","journal-title":"Environ. Adv."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1016\/j.surg.2021.10.057","article-title":"Autologous versus allogeneic mesenchymal stem cell therapy: The pros and cons","volume":"171","author":"Durand","year":"2022","journal-title":"Surgery"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"e36340","DOI":"10.1016\/j.heliyon.2024.e36340","article-title":"M1 macrophages as promising agents for cell therapy of endometriosis","volume":"10","author":"Artemova","year":"2024","journal-title":"Heliyon"},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Bendifallah, S., Suisse, S., Puchar, A., Delbos, L., Poilblanc, M., Descamps, P., Golfier, F., Jornea, L., Bouteiller, D., and Touboul, C. (2022). Salivary MicroRNA Signature for Diagnosis of Endometriosis. J. Clin. Med., 11.","DOI":"10.3390\/jcm11030612"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/22\/12242\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:32:26Z","timestamp":1760113946000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/22\/12242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,14]]},"references-count":142,"journal-issue":{"issue":"22","published-online":{"date-parts":[[2024,11]]}},"alternative-id":["ijms252212242"],"URL":"https:\/\/doi.org\/10.3390\/ijms252212242","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,14]]}}}