{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:29:55Z","timestamp":1780446595668,"version":"3.54.1"},"reference-count":191,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2024,11,16]],"date-time":"2024-11-16T00:00:00Z","timestamp":1731715200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011033","name":"Spanish Agencia Estatal de Investigaci\u00f3n, AEI","doi-asserted-by":"publisher","award":["PID2021-126426OB-I00"],"award-info":[{"award-number":["PID2021-126426OB-I00"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Spanish Ministry of Universities","award":["PID2021-126426OB-I00"],"award-info":[{"award-number":["PID2021-126426OB-I00"]}]},{"name":"University of Valladolid","award":["PID2021-126426OB-I00"],"award-info":[{"award-number":["PID2021-126426OB-I00"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The classical function of the mineralocorticoid receptor (MR) is to maintain electrolytic homeostasis and control extracellular volume and blood pressure. The MR is expressed in the central nervous system (CNS) and is involved in the regulation of the hypothalamic\u2013pituitary\u2013adrenal (HPA) axis as well as sleep physiology, playing a role in the non-rapid eye movement (NREM) phase of sleep. Some patients with psychiatric disorders have very poor sleep quality, and a relationship between MR dysregulation and this disorder has been found in them. In addition, the MR is involved in the regulation of the renal peripheral clock. One of the most common comorbidities observed in patients with chronic kidney disease (CKD) is poor sleep quality. Patients with CKD experience sleep disturbances, including reduced sleep duration, sleep fragmentation, and insomnia. To date, no studies have specifically investigated the relationship between MR activation and CKD-associated sleep disturbances. However, in this review, we analyzed the environment that occurs in CKD and proposed two MR-related mechanisms that may be responsible for these sleep disturbances: the circadian clock disruption and the high levels of MR agonist observed in CKD.<\/jats:p>","DOI":"10.3390\/ijms252212320","type":"journal-article","created":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T04:07:09Z","timestamp":1731902829000},"page":"12320","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Mineralocorticoid Receptor and Sleep Quality in Chronic Kidney Disease"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0355-0250","authenticated-orcid":false,"given":"Juan","family":"de la Puente-Aldea","sequence":"first","affiliation":[{"name":"Unidad de Excelencia Instituto de Biolog\u00eda y Gen\u00e9tica Molecular (IBGM), Universidad de Valladolid\u2014CSIC, 47003 Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1413-0671","authenticated-orcid":false,"given":"Oscar","family":"Lopez-Llanos","sequence":"additional","affiliation":[{"name":"Unidad de Excelencia Instituto de Biolog\u00eda y Gen\u00e9tica Molecular (IBGM), Universidad de Valladolid\u2014CSIC, 47003 Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Horrillo","sequence":"additional","affiliation":[{"name":"Facultad de ciencias de la Salud, Universidad Rey Juan Carlos, 28922 Alcorcon, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hortensia","family":"Marcos-Sanchez","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico Universitario, 47003 Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Sanz-Ballesteros","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico Universitario, 47003 Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6115-4677","authenticated-orcid":false,"given":"Raquel","family":"Franco","sequence":"additional","affiliation":[{"name":"Facultad de ciencias de la Salud, Universidad Rey Juan Carlos, 28922 Alcorcon, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Jaisser","sequence":"additional","affiliation":[{"name":"INSERM U1166, Team Diabetes, Metabolic Diseases and Comorbidities, Sorbonne Universit\u00e9, 75013 Paris, France"},{"name":"INSERM UMR 1116, Centre d\u2019Investigations Cliniques-Plurith\u00e9matique 1433, Universit\u00e9 de Lorraine, CHRU de Nancy, French-Clinical Research Infrastructure Network (F-CRIN) INI-CRCT, 54500 Nancy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6887-2436","authenticated-orcid":false,"given":"Laura","family":"Senovilla","sequence":"additional","affiliation":[{"name":"Unidad de Excelencia Instituto de Biolog\u00eda y Gen\u00e9tica Molecular (IBGM), Universidad de Valladolid\u2014CSIC, 47003 Valladolid, Spain"},{"name":"INSERM U1138, Centre de Recherche des Cordeliers, Equipe Labellis\u00e9e par la Ligue Contre le Cancer, Sorbonne Universit\u00e9, Institut Universitaire de France, 75006 Paris, France"},{"name":"Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, 94805 Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0867-1277","authenticated-orcid":false,"given":"Roberto","family":"Palacios-Ramirez","sequence":"additional","affiliation":[{"name":"Unidad de Excelencia Instituto de Biolog\u00eda y Gen\u00e9tica Molecular (IBGM), Universidad de Valladolid\u2014CSIC, 47003 Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,16]]},"reference":[{"key":"ref_1","first-page":"E183","article-title":"Gluco- and antimineralocorticoid effects on human sleep: A role of central corticosteroid receptors","volume":"260","author":"Born","year":"1991","journal-title":"Am. 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