{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T13:02:31Z","timestamp":1788786151040,"version":"build-2803163510"},"reference-count":189,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T00:00:00Z","timestamp":1732060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Science Center","award":["2021\/43\/B\/NZ7\/01903"],"award-info":[{"award-number":["2021\/43\/B\/NZ7\/01903"]}]},{"name":"National Science Center","award":["SUB1\/NN\/22\/001\/2201"],"award-info":[{"award-number":["SUB1\/NN\/22\/001\/2201"]}]},{"name":"National Science Center","award":["B.SUB.23.359"],"award-info":[{"award-number":["B.SUB.23.359"]}]},{"name":"National Science Center","award":["B.SUB.24.305"],"award-info":[{"award-number":["B.SUB.24.305"]}]},{"DOI":"10.13039\/501100005297","name":"Medical University of Bia\u0142ystok","doi-asserted-by":"publisher","award":["2021\/43\/B\/NZ7\/01903"],"award-info":[{"award-number":["2021\/43\/B\/NZ7\/01903"]}],"id":[{"id":"10.13039\/501100005297","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005297","name":"Medical University of Bia\u0142ystok","doi-asserted-by":"publisher","award":["SUB1\/NN\/22\/001\/2201"],"award-info":[{"award-number":["SUB1\/NN\/22\/001\/2201"]}],"id":[{"id":"10.13039\/501100005297","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005297","name":"Medical University of Bia\u0142ystok","doi-asserted-by":"publisher","award":["B.SUB.23.359"],"award-info":[{"award-number":["B.SUB.23.359"]}],"id":[{"id":"10.13039\/501100005297","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005297","name":"Medical University of Bia\u0142ystok","doi-asserted-by":"publisher","award":["B.SUB.24.305"],"award-info":[{"award-number":["B.SUB.24.305"]}],"id":[{"id":"10.13039\/501100005297","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The literature analysis conducted in this review discusses the latest achievements in the identification of cardiovascular damage induced by oxidative stress with secondary platelet mitochondrial dysfunction. Damage to the platelets of mitochondria as a result of their interactions with reactive oxygen species (ROS) and reactive nitrogen species (RNS) can lead to their numerous ischemic events associated with hypoxia or hyperoxia processes in the cell. Disturbances in redox reactions in the platelet mitochondrial membrane lead to the direct oxidation of cellular macromolecules, including nucleic acids (DNA base oxidation), membrane lipids (lipid peroxidation process) and cellular proteins (formation of reducing groups in repair proteins and amino acid peroxides). Oxidative changes in biomolecules inducing tissue damage leads to inflammation, initiating pathogenic processes associated with faster cell aging or their apoptosis. The consequence of damage to platelet mitochondria and their excessive activation is the induction of cardiovascular and neurodegenerative diseases (Parkinson\u2019s and Alzheimer\u2019s), as well as carbohydrate metabolism disorders (diabetes). The oxidation of mitochondrial DNA can lead to modifications in its bases, inducing the formation of exocyclic adducts of the ethano and propano type. As a consequence, it disrupts DNA repair processes and conduces to premature neoplastic transformation in critical genes such as the p53 suppressor gene, which leads to the development of various types of tumors. The topic of new innovative methods and techniques for the analysis of oxidative stress in platelet mitochondria based on methods such as a nicking assay, oxygen consumption assay, Total Thrombus formation Analysis System (T-Tas), and continuous-flow left ventricular assist devices (CF-LVADs) was also discussed. They were put together into one scientific and research platform. This will enable the facilitation of faster diagnostics and the identification of platelet mitochondrial damage by clinicians and scientists in order to implement adequate therapeutic procedures and minimize the risk of the induction of cardiovascular diseases, including ischemic events correlated with them. A quantitative analysis of the processes of thrombus formation in cardiovascular diseases will provide an opportunity to select specific anticoagulant and thrombolytic drugs under conditions of preserved hemostasis.<\/jats:p>","DOI":"10.3390\/ijms252212467","type":"journal-article","created":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T10:37:35Z","timestamp":1732099055000},"page":"12467","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Effect of Oxidative Stress on Mitochondrial Damage and Repair in Heart Disease and Ischemic Events"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4025-3750","authenticated-orcid":false,"given":"Pawe\u0142","family":"Kowalczyk","sequence":"first","affiliation":[{"name":"Department of Animal Nutrition, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Instytucka 3, 05-110 Jab\u0142onna, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8964-5520","authenticated-orcid":false,"given":"Sebastian","family":"Krych","sequence":"additional","affiliation":[{"name":"Student\u2019s Scientific Association, Department of Cardiac, Vascular and Endovascular Surgery and Transplantology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland"},{"name":"Silesian Centre for Heart Diseases in Zabrze, Department of Cardiac, Vascular and Endovascular Surgery and Transplantology, Medical University of Silesia, 40-055 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karol","family":"Kramkowski","sequence":"additional","affiliation":[{"name":"Department of Physical Chemistry, Medical University of Bialystok, Kili\u0144skiego 1, 15-089 Bia\u0142ystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agata","family":"J\u0119czmyk","sequence":"additional","affiliation":[{"name":"Students\u2019 Scientific Association, III Department of Cardiology, School of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8945-7351","authenticated-orcid":false,"given":"Tomasz","family":"Hrapkowicz","sequence":"additional","affiliation":[{"name":"Silesian Centre for Heart Diseases in Zabrze, Department of Cardiac, Vascular and Endovascular Surgery and Transplantology, Medical University of Silesia, 40-055 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,20]]},"reference":[{"key":"ref_1","unstructured":"(2013, May 15). WHO Fact Sheet. Available online: http:\/\/www.who.int\/mediacentre\/factsheets\/fs310\/en\/."},{"key":"ref_2","first-page":"e6","article-title":"Heart Disease and Stroke Statistics\u20132013 Update: A Report From the American Heart Association","volume":"127","author":"Go","year":"2013","journal-title":"Circulation"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e147","DOI":"10.1016\/j.jacc.2013.05.019","article-title":"2013 ACCF\/AHA guideline for the management of heart failure: A report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines","volume":"62","author":"Yancy","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.cnur.2015.07.012","article-title":"Heart Failure: Pathophysiology, Diagnosis, Medical Treatment Guidelines, and Nursing Management","volume":"50","author":"Rogers","year":"2015","journal-title":"Nurs. Clin. N. Am."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1002\/ehf2.12555","article-title":"Highlights in heart failure","volume":"6","author":"Tomasoni","year":"2019","journal-title":"ESC Heart Fail."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"7","DOI":"10.2174\/157340211501190129144451","article-title":"Heart Failure","volume":"15","author":"Chaudhry","year":"2019","journal-title":"Curr. Hypertens. Rev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ccep.2018.11.001","article-title":"The Many Faces of Heart Failure","volume":"11","author":"Snipelisky","year":"2019","journal-title":"Card. Electrophysiol. Clin."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.jacc.2020.05.075","article-title":"Heart Failure With Recovered Left Ventricular Ejection Fraction: JACC Scientific Expert Panel","volume":"76","author":"Wilcox","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/jon.12694","article-title":"Assessing Cerebrovascular Hemodynamics Using Transcranial Doppler in Patients with Mechanical Circulatory Support Devices","volume":"30","author":"Melmed","year":"2020","journal-title":"J. Neuroimaging"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1080\/17434440.2019.1635006","article-title":"Mechanical circulatory support for the right ventricle in combination with a left ventricular assist device","volume":"16","author":"Shimada","year":"2019","journal-title":"Expert. Rev. Med. Devices"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1080\/15265161.2023.2201196","article-title":"ECMO as a Destination Therapy is Not a Bridge to Nowhere","volume":"23","author":"Allen","year":"2023","journal-title":"Am. J. Bioeth."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.cjca.2019.10.033","article-title":"Destination-Therapy Ventricular Assist Device in Children: \u201cThe Future Is Now\u201d","volume":"36","author":"Tunuguntla","year":"2020","journal-title":"Can. J. Cardiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1007\/s11897-019-00438-x","article-title":"Left Ventricular Assist Device as Destination Therapy: A State of the Science and Art of Long-Term Mechanical Circulatory Support","volume":"16","author":"Hanff","year":"2019","journal-title":"Curr. Heart Fail. Rep."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1056\/NEJMoa053063","article-title":"Left ventricular assist device and drug therapy for the reversal of heart failure","volume":"355","author":"Birks","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.ccc.2023.06.004","article-title":"Left Ventricular Assist Device Emergencies: Diagnosis and Management","volume":"40","author":"Sennhauser","year":"2024","journal-title":"Crit. Care Clin."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.hfc.2021.05.007","article-title":"Left Ventricular Assist Device: Indication, Timing, and Management","volume":"17","author":"Frigerio","year":"2021","journal-title":"Heart Fail. Clin."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.ccl.2020.01.007","article-title":"Right Ventricular Failure After Left Ventricular Assist Device","volume":"38","author":"Cogswell","year":"2020","journal-title":"Cardiol. Clin."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"5551","DOI":"10.1002\/ehf2.13565","article-title":"The dominant left ventricular assist device: Lessons from an era","volume":"8","author":"Alam","year":"2021","journal-title":"ESC Heart Fail."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.healun.2012.12.004","article-title":"Fifth INTERMACS annual report: Risk factor analysis from more than 6,000 mechanical circulatory support patients","volume":"32","author":"Kirklin","year":"2013","journal-title":"J. Heart Lung Transplant."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.healun.2010.12.001","article-title":"Third INTER-MACS Annual Report: The evolution of destination therapy in the United States","volume":"30","author":"Kirklin","year":"2011","journal-title":"J. Heart Lung Transplant."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1016\/j.jacc.2010.10.062","article-title":"Results of the post-U.S. Food and Drug Administration-approval study with a continuous flow left ventricular assist de-vice as a bridge to heart transplantation: A prospective study using the INTERMACS (Interagency Registry for Mechanically Assisted Circulatory Support)","volume":"57","author":"Starling","year":"2011","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Klaeske, K., Meyer, A.L., Saeed, D., Eifert, S., Jawad, K., Sieg, F., Haunschild, J., Borger, M.A., and Dieterlen, M.T. (2022). Decreased Platelet Specific Receptor Expression of P-Selectin and GPIIb\/IIIa Predict Future Non-Surgical Bleeding in Patients after Left Ventricular Assist Device Implantation. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms231810252"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1080\/09537104.2021.1881950","article-title":"Platelet activation and aggregation in different centrifugal-flow left ventricular assist devices","volume":"33","author":"Tscharre","year":"2022","journal-title":"Platelets."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.1111\/aor.14319","article-title":"Acquired platelet defects are responsible for nonsurgical bleeding in left ventricular assist device recipients","volume":"46","author":"Arias","year":"2022","journal-title":"Artif. Organs."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1111\/jth.15279","article-title":"Device-induced platelet dysfunction in patients after left ventricular assist device implantation","volume":"19","author":"Klaeske","year":"2021","journal-title":"J. Thromb. Haemost."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1177\/0003319720946977","article-title":"Endothelial Function in Patients with Continuous-Flow Left Ventricular Assist Devices","volume":"72","author":"Poredos","year":"2021","journal-title":"Angiology."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1097\/MAT.0000000000001281","article-title":"Endothelial Dysfunction-related Neurological Bleeds with Continuous Flow-Left Ventricular Assist Devices Measured by Digital Thermal Monitor","volume":"67","author":"Ali","year":"2021","journal-title":"ASAIO J."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s12265-011-9321-z","article-title":"Effects of continuous flow left ventricular assist device support on microvascular endothelial function","volume":"5","author":"Lou","year":"2012","journal-title":"J. Cardiovasc. Transl. Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1111\/j.1540-8191.2010.01050.x","article-title":"Destination therapy: Patient selection and current outcomes","volume":"25","author":"Lietz","year":"2010","journal-title":"J. Card. Surg."},{"key":"ref_30","first-page":"357","article-title":"European results with a continuous flow ventricular assist device for advanced heart failure patients","volume":"37","author":"Lahpor","year":"2010","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.2147\/JMDH.S245620","article-title":"Atypical Hemolytic-Uremic Syndrome: Genetic Basis, Clinical Manifestations, and a Multidisciplinary Approach to Management","volume":"16","author":"Yerigeri","year":"2023","journal-title":"J. Multidiscip. Healthc."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"106777","DOI":"10.1016\/j.phrs.2023.106777","article-title":"Research progress on the interaction between oxidative stress and platelets: Another avenue for cancer?","volume":"191","author":"Zhang","year":"2023","journal-title":"Pharmacol. Res."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Chan, C.H.H., Simmonds, M.J., Fraser, K.H., Igarashi, K., Ki, K.K., Murashige, T., Joseph, M.T., Fraser, J.F., Tansley, G.D., and Watanabe, N. (2022). Discrete responses of erythrocytes, platelets, and von Willebrand factor to shear. J. Biomech., 130.","DOI":"10.1016\/j.jbiomech.2021.110898"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.thromres.2022.09.019","article-title":"Role of thrombin to non-physiological shear stress induced platelet activation and function alternation","volume":"219","author":"Sun","year":"2022","journal-title":"Thromb. Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"C428","DOI":"10.1152\/ajpcell.00148.2016","article-title":"Shear stress induces Galpha(q\/11) activation independently of G protein-coupled receptor activation in endothelial cells","volume":"312","author":"Melchior","year":"2017","journal-title":"Am. J. Physiol.\u2014Cell Physiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.bbrc.2013.04.005","article-title":"Shear stress-induced Ang II AT1 receptor activation: G-protein dependent and independent mechanisms","volume":"434","author":"Barauna","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s11010-015-2515-y","article-title":"Activation and shedding of platelet glycoprotein IIb\/IIIa under non-physiological shear stress","volume":"409","author":"Chen","year":"2015","journal-title":"Mol. Cell. Biochem."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1111\/aor.13783","article-title":"Shear-dependent platelet aggregation size","volume":"44","author":"Chan","year":"2020","journal-title":"Artif. Organs."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Rennier, K., and Ji, J.Y. (2015). Shear stress attenuates apoptosis due to TNFalpha, oxidative stress, and serum depletion via death-associated protein kinase (DAPK) expression. BMC Res. Notes, 8.","DOI":"10.1186\/s13104-015-1037-8"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"e23750","DOI":"10.1002\/jcla.23750","article-title":"Procoagulant platelets: Generation, characteristics, and therapeutic target","volume":"35","author":"Chu","year":"2021","journal-title":"J. Clin. Lab. Anal."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1097\/MOH.0000000000000601","article-title":"Molecular and functional characteristics of megakaryocytes and platelets in aging","volume":"27","author":"Esparza","year":"2020","journal-title":"Curr. Opin. Hematol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10456-018-9651-4","article-title":"Platelets: The holy grail in cancer blood biomarker research?","volume":"22","author":"Sabrkhany","year":"2019","journal-title":"Angiogenesis"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s10555-017-9681-1","article-title":"Platelets, circulating tumor cells, and the circulome","volume":"36","author":"Lam","year":"2017","journal-title":"Cancer Metastasis Rev."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1182\/blood-2017-05-787259","article-title":"Procoagulant platelets: Generation, function, and therapeutic targeting in thrombosis","volume":"130","author":"Agbani","year":"2017","journal-title":"Blood"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.phrs.2017.06.003","article-title":"Distinct characteristics of neonatal platelet reactivity","volume":"123","author":"Tesfamariam","year":"2017","journal-title":"Pharmacol. Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1182\/asheducation-2016.1.256","article-title":"Platelets in infectious disease","volume":"2016","author":"Middleton","year":"2016","journal-title":"Hematology Am. Soc. Hematol. Educ. Program"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.jinf.2022.02.004","article-title":"Early predictive value of platelet function for clinical outcome in sepsis","volume":"84","author":"Cao","year":"2022","journal-title":"J. Infect."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1161\/01.ATV.0000152726.49229.bf","article-title":"Role of mitochondrial permeability transition pore in coated-platelet formation","volume":"25","author":"Remenyi","year":"2005","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Sokolovskaya, A.A., Popov, M.A., Sergeeva, E.A., Metelkin, A.A., Zybin, D.I., Shumakov, D.V., and Kubatiev, A.A. (2023). Investigation of Platelet Apoptosis in Patients after Surgical Myocardial Revascularization. Biomedicines, 11.","DOI":"10.3390\/biomedicines11020251"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1055\/s-2003-40669","article-title":"P2Y12, a new platelet ADP receptor, target of clopidogrel","volume":"3","author":"Herbert","year":"2003","journal-title":"Semin. Vasc. Med."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Koessler, J., Schwarz, M., Weber, K., Etzel, J., Koessler, A., Boeck, M., and Kobsar, A. (2017). The role of adenosine diphosphate mediated platelet responsiveness for the stability of platelet integrity in citrated whole blood under ex vivo conditions. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0188193"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Ahn, Y.H., Lee, J.Y., Park, H.D., Kim, T.H., Park, M.C., Choi, G., and Kim, S. (2016). Identification of a New Morpholine Scaffold as a P2Y12 Receptor Antagonist. Molecules., 21.","DOI":"10.3390\/molecules21091114"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/nature13083","article-title":"Structure of the human P2Y12 receptor in complex with an antithrombotic drug","volume":"509","author":"Zhang","year":"2014","journal-title":"Nature"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1113\/jphysiol.2014.287599","article-title":"Temporal sequence of activation of cells involved in purinergic neurotransmission in the colon","volume":"593","author":"Baker","year":"2015","journal-title":"J. Physiol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"e209","DOI":"10.1016\/j.thromres.2012.02.001","article-title":"Pennogenin tetraglycoside stimulates secretion-dependent activation of rat platelets: Evidence for critical roles of adenosine diphosphate receptor signal pathways","volume":"129","author":"Cong","year":"2012","journal-title":"Thromb. Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1111\/jth.12952","article-title":"P2Y12 receptors: Structure and function","volume":"13","author":"Cattaneo","year":"2015","journal-title":"J. Thromb. Haemost."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1080\/09537100310001612399","article-title":"Agonist concentration-dependent differential responsivity of a human platelet purinergic receptor: Pharmacological and kinetic studies of aggregation, deaggregation and shape change responses mediated by the purinergic P2Y1 receptor in vitro","volume":"14","author":"Maayani","year":"2003","journal-title":"Platelets"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1006\/bbrc.2001.4816","article-title":"P2y(12), a new platelet ADP receptor, target of clopidogrel","volume":"283","author":"Savi","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_59","first-page":"432","article-title":"Molecular cloning of the platelet P2T(AC) ADP receptor: Pharmacological comparison with another ADP receptor, the P2Y(1) receptor","volume":"60","author":"Takasaki","year":"2001","journal-title":"Mol. Pharmacol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1182\/blood-2007-05-092684","article-title":"Critical role for the mitochondrial permeability transition pore and cyclophilin D in platelet activation and thrombosis","volume":"111","author":"Jobe","year":"2008","journal-title":"Blood"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Rawish, E., and Langer, H.F. (2022). Platelets and the Role of P2X Receptors in Nociception, Pain, Neuronal Toxicity and Thromboinflammation. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23126585"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Li, D., Huang, L.T., Zhang, C.P., Li, Q., and Wang, J.H. (2022). Insights Into the Role of Platelet-Derived Growth Factors: Implications for Parkinson\u2019s Disease Pathogenesis and Treatment. Front. Aging Neurosci., 14.","DOI":"10.3389\/fnagi.2022.890509"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1159\/000520102","article-title":"Identification of Novel Biomarkers in Platelets for Diagnosing Parkinson\u2019s Disease","volume":"85","author":"Zhang","year":"2022","journal-title":"Eur. Neurol."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Strijkova, V., Todinova, S., Andreeva, T., Langari, A., Bogdanova, D., Zlatareva, E., Kalaydzhiev, N., Milanov, I., and Taneva, S.G. (2022). Platelets\u2019 Nanomechanics and Morphology in Neurodegenerative Pathologies. Biomedicines, 10.","DOI":"10.3390\/biomedicines10092239"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Bondarenko, O., and Saarma, M. (2021). Neurotrophic Factors in Parkinson\u2019s Disease: Clinical Trials, Open Challenges and Nanoparticle-Mediated Delivery to the Brain. Front. Cell. Neurosci., 15.","DOI":"10.3389\/fncel.2021.682597"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Espinosa-Parrilla, Y., Gonzalez-Billault, C., Fuentes, E., Palomo, I., and Alarc\u00f3n, M. (2019). Decoding the Role of Platelets and Related MicroRNAs in Aging and Neurodegenerative Disorders. Front. Aging Neurosci., 11.","DOI":"10.3389\/fnagi.2019.00151"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"4892","DOI":"10.1111\/jcmm.15194","article-title":"Mitochondrial biogenesis: An update","volume":"24","author":"Popov","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1042\/bse0470069","article-title":"Regulation of mitochondrial biogenesis","volume":"47","author":"Jornayvaz","year":"2010","journal-title":"Essays Biochem."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0968-0004(00)01609-1","article-title":"The internal structure of mitochondria","volume":"25","author":"Frey","year":"2000","journal-title":"Trends Biochem. Sci."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1146\/annurev.cb.04.110188.001445","article-title":"Biogenesis of mitochondria","volume":"4","author":"Attardi","year":"1988","journal-title":"Annu. Rev. Cell Biol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s41021-021-00199-x","article-title":"Etheno adducts: From tRNA modifications to DNA adducts and back to miscoding ribonucleotides","volume":"43","author":"Guengerich","year":"2021","journal-title":"Genes. Environ."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/978-3-319-98788-0_6","article-title":"Chronic Ethanol Consumption and Generation of Etheno-DNA Adducts in Cancer-Prone Tissues","volume":"1032","author":"Peccerella","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.redox.2014.08.009","article-title":"The role of reactive oxygen species (ROS) and cytochrome P-450 2E1 in the generation of carcinogenic etheno-DNA adducts","volume":"3","author":"Linhart","year":"2014","journal-title":"Redox Biol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0027-5107(99)00008-1","article-title":"Etheno DNA-base adducts from endogenous reactive species","volume":"424","author":"Nair","year":"1999","journal-title":"Mutat. Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"145","DOI":"10.18388\/abp.1998_4329","article-title":"Formation of DNA etheno adducts in rodents and humans and their role in carcinogenesis","volume":"45","author":"Barbin","year":"1998","journal-title":"Acta Biochim. Pol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1097\/00008469-199712000-00007","article-title":"Etheno-DNA base adducts as tools in human cancer aetiology and chemoprevention","volume":"6","author":"Bartsch","year":"1997","journal-title":"Eur. J. Cancer Prev."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/j.freeradbiomed.2010.06.027","article-title":"Aberrant repair of etheno\u2013DNA adducts in leukocytes and colon tissue of colon cancer patients","volume":"49","author":"Wilczura","year":"2010","journal-title":"Free. Radic. Biol. Med."},{"key":"ref_78","first-page":"277","article-title":"In-flammation increases oxidative DNA damage repair and stimulates preneoplastic changes in colons of newborn rats","volume":"67","author":"Kowalczyk","year":"2016","journal-title":"J. Physiol. Pharmacol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"6766","DOI":"10.7150\/thno.60143","article-title":"Coronary microvascular injury in myocardial infarction: Perception and knowledge for mitochondrial quality control","volume":"11","author":"Chang","year":"2021","journal-title":"Theranostics"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1093\/eurheartj\/ehx393","article-title":"2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force for the man-agement of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC)","volume":"39","author":"Ibanez","year":"2018","journal-title":"Eur. Heart J."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1161\/CIRCULATIONAHA.114.011201","article-title":"Systematic review of patients presenting with suspected myocardial infarction and non-obstructive coronary arteries","volume":"131","author":"Pasupathy","year":"2015","journal-title":"Circulation"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1093\/eurheartj\/ehu469","article-title":"Acute myocardial infarction with no obstructive coronary atherosclerosis: Mechanisms and management","volume":"36","author":"Niccoli","year":"2015","journal-title":"Eur. Heart J."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1089\/ars.2011.4324","article-title":"Platelet function in health and disease: From molecular mechanisms, redox considerations to novel therapeutic opportunities","volume":"17","author":"Ferroni","year":"2012","journal-title":"Antioxid. Redox Signal"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1111\/j.1538-7836.2007.02505.x","article-title":"Thrombin induces apoptotic events through the generation of reactive oxygen species in human platelets","volume":"5","author":"Lopez","year":"2007","journal-title":"J. Thromb. Haemost."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/0002-8703(79)90003-6","article-title":"Thrombosis of epicardial coronary veins in acute myocardial infarction","volume":"97","author":"Hansen","year":"1979","journal-title":"Am. Heart J."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1253\/circj.CJ-22-0297","article-title":"Impact of Platelet Reactivity on Ischemic and Bleeding Events After Percutaneous Coronary Intervention\u2014A Long-Term Perspective","volume":"86","author":"Numasawa","year":"2022","journal-title":"Circ. J."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.ijcard.2017.10.022","article-title":"Percutaneous coronary intervention of bifurcation lesions and platelet reactivity","volume":"250","author":"Redfors","year":"2018","journal-title":"Int. J. Cardiol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1055\/s-0038-1649484","article-title":"Peri-Procedural Platelet Reactivity in Percutaneous Coronary Intervention","volume":"118","author":"Alexopoulos","year":"2018","journal-title":"Thromb. Haemost."},{"key":"ref_89","first-page":"221","article-title":"Antiplatelet Therapy in Percutaneous Coronary Intervention","volume":"5","author":"Fanaroff","year":"2016","journal-title":"Interv. Cardiol. Clin."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"(2011). Bonello L, Sabatier F, Camoin-Jau L, Paganelli F, Dignat-George F Platelets and endothelium: Two key players in percutaneous coronary intervention. Arch. Cardiovasc. Dis., 104, 601\u2013603.","DOI":"10.1016\/j.acvd.2011.10.003"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1002\/path.1598","article-title":"Molecular and cellular basis of restenosis after percutaneous coronary intervention: The intertwining roles of platelets, leukocytes, and the coagulation-fibrinolysis system","volume":"203","author":"Lee","year":"2004","journal-title":"J. Pathol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"64","DOI":"10.18087\/cardio.2022.4.n2020","article-title":"The role of platelet glycoprotein IIb\/IIIa inhibitors in current treatment of acute coronary syndrome","volume":"62","author":"Sukhinina","year":"2022","journal-title":"Kardiologiia"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.2165\/11594100-000000000-00000","article-title":"Triple antiplatelet therapy in acute coronary syndromes","volume":"71","author":"Valgimigli","year":"2011","journal-title":"Drugs"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/s10354-010-0747-8","article-title":"Antithrombotic therapy in patients with coronary artery disease and with type 2 diabetes mellitus","volume":"160","author":"Farhan","year":"2010","journal-title":"Wien. Med. Wochenschr."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.2337\/diacare.26.7.2181","article-title":"The platelet in diabetes: Focus on prevention of ischemic events","volume":"26","author":"Colwell","year":"2003","journal-title":"Diabetes Care"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0736-4679(02)00680-7","article-title":"Utility of platelet adp receptor antagonism in the emergency department: A review","volume":"24","author":"Pollack","year":"2003","journal-title":"J. Emerg. Med."},{"key":"ref_97","first-page":"166","article-title":"T-TAS() 01 as a new tool for the evaluation of hemostasis in thrombocytopenic patients after platelet transfusion","volume":"22","author":"Samanbar","year":"2024","journal-title":"Blood Transfus."},{"key":"ref_98","first-page":"55","article-title":"Flow-chamber device (T-TAS) to diagnose patients suspected of platelet function defects","volume":"22","author":"Lecchi","year":"2024","journal-title":"Blood Transfus."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1080\/09537104.2021.1882669","article-title":"The Total Thrombus Formation (T-TAS) platelet (PL) assay, a novel test that evaluates whole blood platelet thrombus formation under physiological conditions","volume":"33","author":"Zheng","year":"2022","journal-title":"Platelets"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1055\/s-0039-1693411","article-title":"Total Thrombus-Formation Analysis System (T-TAS): Clinical Application of Quantitative Analysis of Thrombus Formation in Cardiovascular Disease","volume":"119","author":"Kaikita","year":"2019","journal-title":"Thromb. Haemost."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1080\/09537104.2018.1535704","article-title":"Evaluation of the Total Thrombus-Formation System (T-TAS): Application to human and mouse blood analysis","volume":"30","author":"Mori","year":"2019","journal-title":"Platelets"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.carpath.2015.07.004","article-title":"An autopsy report of acute myocardial infarction with hypertrophic obstructive cardiomyopathy-like heart","volume":"24","author":"Ushikoshi","year":"2015","journal-title":"Cardiovasc. Pathol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1097\/HCO.0b013e3283583247","article-title":"Myocardial infarction without obstructive coronary artery disease","volume":"27","author":"Reynolds","year":"2012","journal-title":"Curr. Opin. Cardiol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1093\/ajhp\/58.18.1709","article-title":"Recognition, pathophysiology, and management of acute myocardial infarction","volume":"58","author":"Cheng","year":"2001","journal-title":"Am. J. Health Syst. Pharm."},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Moscatelli, S., Montecucco, F., Carbone, F., Valbusa, A., Massobrio, L., Porto, I., Brunelli, C., and Rosa, G.M. (2019). An Emerging Cardiovascular Disease: Takotsubo Syndrome. BioMed Res. Int., 2019.","DOI":"10.1155\/2019\/6571045"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"168","DOI":"10.3121\/cmr.2009.866","article-title":"Virchow\u2019s contribution to the understanding of thrombosis and cellular biology","volume":"8","author":"Kumar","year":"2010","journal-title":"Clin. Med. Res."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"640S","DOI":"10.1378\/chest.102.6_Supplement.640S","article-title":"Pathogenesis of venous thrombosis","volume":"102","author":"Mammen","year":"1992","journal-title":"Chest"},{"key":"ref_108","first-page":"983","article-title":"Thrombose du sinus coronaire sur sonde stimulation endo-ventriculaire droite","volume":"69","author":"Veyre","year":"1976","journal-title":"Arch. Mal. Coeur"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1378\/chest.101.4.1154","article-title":"Pericardial tamponade and coronary sinus thrombosis associated with central venous catheterization","volume":"101","author":"Figuerola","year":"1992","journal-title":"Chest"},{"key":"ref_110","first-page":"66","article-title":"Coronary sinus thrombosis: A potential complication of right heart catheterization","volume":"30","author":"Guindi","year":"1987","journal-title":"Can. J. Surg."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/S0022-3468(81)80564-7","article-title":"Coronary sinus thrombosis: A central venous catheter complication","volume":"16","author":"Philips","year":"1981","journal-title":"J. Pediatr. Surg."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1136\/hrt.13.3.397","article-title":"A complication following coronary sinus and cardiac vein catherization in man","volume":"13","author":"McMichael","year":"1951","journal-title":"Br. Heart J."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1016\/0022-3468(90)90506-5","article-title":"Coronary sinus thrombosis and myocardial infarction secondary to ventriculoatrial shunt insertion","volume":"25","author":"Wells","year":"1990","journal-title":"J. Pediatr. Surg."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/0002-9149(85)90904-X","article-title":"Aspergillus fumigatus thrombi causing total occlusion of both coronary arterial ostia, all four major epicardial veins and coronary sinus and associated with purulent pericarditis","volume":"56","author":"Ross","year":"1985","journal-title":"Am. J. Cardiol."},{"key":"ref_115","first-page":"231","article-title":"Coronary sinus thrombosis in patients after heart transplantation","volume":"31","author":"Urbanova","year":"1989","journal-title":"CorVasa"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1002\/ccd.1810080410","article-title":"Angiographic demonstration of coronary, sinus thrombosis: A potential consequence of trauma to the coronary sinus","volume":"8","author":"Hazan","year":"1982","journal-title":"Cathet Cardiovasc. Diagn."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1007\/s004280000279","article-title":"Cardiac vein thrombosis and haemorrhagic myo-cardial necrosis; report of a case with review of the literature","volume":"437","author":"Zender","year":"2000","journal-title":"Virchows Arch."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/0002-8703(46)90502-9","article-title":"The presence and pathogenesis of endocardial and subendocardial degeneration, mural thrombi, and thromboses of the thebesian veins in cardiac failure from causes other than myocardial infarction","volume":"31","author":"Flynn","year":"1946","journal-title":"Am. Heart J."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0002-8703(58)90267-9","article-title":"Cardiac vein thrombosis with myocardial hemorrhage","volume":"55","author":"Lake","year":"1958","journal-title":"Am. Heart J."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"W60","DOI":"10.1097\/RTI.0000000000000456","article-title":"Anomalies of the Coronary Sinus and Its Tributaries: Evaluation on Multidetector Computed Tomography Angiography","volume":"35","author":"Sinha","year":"2020","journal-title":"J. Thorac. Imaging"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jmbbm.2011.09.001","article-title":"Comparison of tbiaxial mechanical properties of coronary sinus tissues from porcine, ovine and aged human species","volume":"6","author":"Pham","year":"2012","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.csbj.2019.12.013","article-title":"The genomics of oxidative DNA damage, repair, and resulting mutagenesis","volume":"18","author":"Poetsch","year":"2020","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1096\/fj.02-0752rev","article-title":"Oxidative DNA damage: Mechanisms, mutation, and disease","volume":"17","author":"Cooke","year":"2003","journal-title":"FASEB J."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.mrfmmm.2004.01.007","article-title":"Long- chain adducts of trans-4-hydroxy-2-nonenal to DNA bases cause recombination, base substitutions and frameshift mutations in M13 phage","volume":"550","author":"Kowalczyk","year":"2004","journal-title":"Mutat. Res."},{"key":"ref_125","first-page":"107","article-title":"Aberrant crypt foci","volume":"26","author":"Alrawi","year":"2006","journal-title":"Anticancer Res."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/j.tcb.2023.04.002","article-title":"tRNA modifications: Insights into their role in human cancers","volume":"33","author":"Wang","year":"2023","journal-title":"Trends Cell Biol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1016\/S0040-4039(01)96762-0","article-title":"New reaction of adenine and cytosine derivatives, potentially useful for nucleic acid modifications","volume":"22","author":"Kochetkov","year":"1971","journal-title":"Tetrahedron Lett."},{"key":"ref_128","first-page":"273","article-title":"Etheno-bridged nucleotides in structural diagnosis and carcinogenesis","volume":"3","author":"Leonard","year":"1992","journal-title":"Biochem. Mol. Biol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1093\/carcin\/17.10.2105","article-title":"Lipid peroxidation as a potential endogenous source for the formation of exocyclic DNA adducts","volume":"17","author":"Chung","year":"1996","journal-title":"Carcinogenesis"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1093\/carcin\/17.5.1167","article-title":"Characterization of an N6-oxo-propenyl-2\u2032-deoxyadenosine adduct in malondialdehyde-modified DNA using liquid chromatography electrospray ionization tandem mass spectrometry","volume":"17","author":"Chaudhary","year":"1996","journal-title":"Carcinogenesis"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1039\/C9TB02266J","article-title":"Mitochondria-targeted tetrahedral DNA nanostructures for doxorubicin delivery and enhancement of apoptosis","volume":"8","author":"Yan","year":"2020","journal-title":"J. Mater. Chem. B"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1093\/carcin\/16.8.1847","article-title":"32P-postlabelling determination of DNA adducts of malonaldehyde in humans: Total white blood cells and breast tissue","volume":"16","author":"Vaca","year":"1995","journal-title":"Carcinogenesis"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1093\/carcin\/13.4.727","article-title":"Etheno adducts formed in DNA of vinyl chloride-exposed rats are highly persistent in liver","volume":"13","author":"Swenberg","year":"1992","journal-title":"Carcinogenesis"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/0378-4274(95)03593-1","article-title":"Dose-response relationships for carcinogens","volume":"82\u201383","author":"Swenberg","year":"1995","journal-title":"Toxicol. Lett."},{"key":"ref_135","unstructured":"Swenberg, J.A., Bogdanffy, M.S., Ham, A., Holt, S., Kim, A., Morinello, E.J., Ranasinghe, A., Scheller, N., and Upton, P.B. (1999). Formation and repair of DNA adducts in vinyl chloride- and vinyl fluoride-induced carcinogenesis. Exocyclic DNA Adducts in Mutagenesis and Carcinogenesis, IARC."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1021\/tx000058r","article-title":"Development of a 32P-postlabeling method for the detection of 1,N2-propanodeoxyguanosine adducts of trans-4-hydroxy-2-nonenal in vivo","volume":"13","author":"Wacker","year":"2000","journal-title":"Chem. Res. Toxicol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0009-2797(01)00259-9","article-title":"Detection of 1,N2-propanodeoxyguanosine adducts of trans-4-hydroxy-2-nonenal after gavage of trans-4-hydroxy-2-nonenal or induction of lipid peroxidation with carbon tetrachloride in F344 rats","volume":"137","author":"Wacker","year":"2001","journal-title":"Chem. Biol. Interact."},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Torgasheva, N.A., Diatlova, E.A., Grin, I.R., Endutkin, A.V., Mechetin, G.V., Vokhtantsev, I.P., Yudkina, A.V., and Zharkov, D.O. (2022). Noncatalytic Domains in DNA Glycosylases. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23137286"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1186\/s12936-020-03355-w","article-title":"Molecular characterization of Plasmodium falciparum DNA- 3-methyladenine glycosylase","volume":"19","author":"Pinthong","year":"2020","journal-title":"Malar. J."},{"key":"ref_140","first-page":"4098","article-title":"Mutagenesis induced by a single 1,N6-ethenodeoxyadenosine adduct in human cells","volume":"60","author":"Levine","year":"2000","journal-title":"Cancer Res."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0921-8777(99)00050-6","article-title":"A phylogenomic study of DNA repair genes, proteins, and processes","volume":"435","author":"Eisen","year":"1999","journal-title":"Mutat. Res."},{"key":"ref_142","unstructured":"Friedberg, E.C., Walker, G.C., and Siede, W. (1995). DNA Repair and Mutagenesis, American Society of Microbiology Press."},{"key":"ref_143","unstructured":"Speina, E. (2003). Glycosylases of Exocyclic Adducts to DNA Bases and Products of Their Rearrangement Studied in Model Systems and in Lung Cancer. [Ph.D. Thesis, Institute of Biochemistry and Biophysics of the Polish Academy of Sciences]."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/S0891-5849(02)00878-X","article-title":"Oxidative DNA damage: Assessment of the role in carcinogenesis, artherosclerosis, and acquired immunodeficiency syndrome","volume":"33","author":"Gackowski","year":"2002","journal-title":"Free Radic. Biol. Med."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nature01322","article-title":"Inflammation and cancer","volume":"420","author":"Coussens","year":"2002","journal-title":"Nature"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"12105","DOI":"10.1021\/bi00096a022","article-title":"Substrate specificity of the Escherichia coli endonuclease III: Excision of thymine- and cytosine-derived lesions in DNA produced by radiation-generated free radicals","volume":"32","author":"Dizdaroglu","year":"1993","journal-title":"Biochemistry"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s13567-019-0685-4","article-title":"The potential of acetylsalicylic acid and vitamin E in modulating inflammatory cascades in chickens under lipopolysaccharide-induced inflammation","volume":"50","author":"Konieczka","year":"2019","journal-title":"Vet. Res."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"102406","DOI":"10.1016\/j.rpth.2024.102406","article-title":"Chan Factors that modulate platelet reactivity as measured by 5 assay platforms in 3429 individuals","volume":"8","author":"Melissa","year":"2024","journal-title":"Res. Pract. Thromb. Haemost."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"201","DOI":"10.5551\/jat.ED120","article-title":"Monitoring of Antithrombotic Therapy","volume":"27","author":"Yamazaki","year":"2020","journal-title":"J. Atheroscler. Thromb."},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Melchinger, H., Jain, K., Tyagi, T., and Hwa, J. (2019). Role of platelet mitochondria: Life in a nucleus-free zone. Front. Cardiovasc. Med., 6.","DOI":"10.3389\/fcvm.2019.00153"},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"Kuhlbrandt, W. (2015). Structure and function of mitochondrial membran\u0119 protein complexes. BMC Biol., 13.","DOI":"10.1186\/s12915-015-0201-x"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1146\/annurev-genet-102108-134850","article-title":"The role of mitochondria in apoptosis","volume":"43","author":"Wang","year":"2009","journal-title":"Annu. Rev. Genet."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3389\/fgene.2016.00161","article-title":"Mitochondrial ROS and the effectors of the intrinsic apoptotic pathway in aging cells: The discerning killers!","volume":"7","author":"Hekimi","year":"2016","journal-title":"Front. Genet."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"1539.e6","DOI":"10.1016\/j.cell.2016.08.027","article-title":"Lipid biosynthesis coordinates a mitochondrial-to-cytosolic stress response","volume":"166","author":"Kim","year":"2016","journal-title":"Cell"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1111\/j.1365-3148.2010.01065.x","article-title":"Role of mitochondria in the maintenance of platelet function during in vitro storage","volume":"21","author":"Hayashi","year":"2011","journal-title":"Transfus. Med."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1182\/bloodadvances.2018025155","article-title":"Platelet respiration","volume":"3","author":"Kholmukhamedov","year":"2019","journal-title":"Blood Adv."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s13148-015-0078-0","article-title":"Platelet mitochondrial DNA methylation: A potential new marker of cardiovascular disease","volume":"7","author":"Baccarelli","year":"2015","journal-title":"Clin. Epigenetics"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1055\/s-0031-1285833","article-title":"Platelet mitochondrial dysfunction is evident in type 2 diabetes in association with modifications of mitochondrial antioxidant stress proteins","volume":"120","author":"Avila","year":"2012","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s13054-015-0762-7","article-title":"Platelet mitochondrial dysfunction in critically ill patients: Comparison between sepsis and cardiogenic shock","volume":"19","author":"Protti","year":"2015","journal-title":"Crit. Care"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mrrev.2003.11.001","article-title":"Oxidative DNA damage and disease: Induction, repair and significance","volume":"567","author":"Evans","year":"2004","journal-title":"Mutat. Res."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/362709a0","article-title":"Instability and decay of the primary structure of DNA","volume":"362","author":"Lindahl","year":"1993","journal-title":"Nature"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1093\/nar\/29.2.449","article-title":"Human MTH1 protein hydrolyzes the oxidized ribonucleotide, 2-hydroxy-ATP","volume":"29","author":"Fujikawa","year":"2001","journal-title":"Nucleic Acids Res."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"18201","DOI":"10.1074\/jbc.274.26.18201","article-title":"The oxidized forms of dATP are substrates for the human MutT homologue the hMTH1 protein","volume":"274","author":"Fujikawa","year":"1999","journal-title":"J. Biol. Chem."},{"key":"ref_164","doi-asserted-by":"crossref","unstructured":"Bray, P.F., McKenzie, S.E., Edelstein, L.C., Nagalla, S., Delgrosso, K., Ertel, A., Kupper, J., Jing, Y., Londin, E., and Loher, P. (2013). The complex transcriptional landscape of the anucleate human platelet. BMC Genom., 14.","DOI":"10.1186\/1471-2164-14-1"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1146\/annurev-pathmechdis-012419-032711","article-title":"Mechanisms of Disease Mitochondrial Dynamics and Its Involvement in Disease","volume":"15","author":"Chan","year":"2020","journal-title":"Annu. Rev. Pathol. Mech. Dis."},{"key":"ref_166","doi-asserted-by":"crossref","unstructured":"Burnouf, T., Chou, M.-L., Lundy, D.J., Chuang, E.-Y., Tseng, C.-L., and Goubran, H. (2023). Expanding applications of allogeneic platelets, platelet lysates, and platelet extracellular vesicles in cell therapy, regenerative medicine, and targeted drug delivery. J. Biomed. Sci., 30.","DOI":"10.1186\/s12929-023-00972-w"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1161\/CIRCRESAHA.123.322914","article-title":"Mi-tofusin-2 Regulates Platelet Mitochondria and Function","volume":"134","author":"Jacob","year":"2024","journal-title":"Circ. Res."},{"key":"ref_168","doi-asserted-by":"crossref","unstructured":"Li, Y., Deng, S.L., Lian, Z.X., and Yu, K. (2019). Roles of Toll-Like Receptors in Nitroxidative Stress in Mammals. Cells, 8.","DOI":"10.3390\/cells8060576"},{"key":"ref_169","first-page":"585","article-title":"Antiplatelet treatment in acute coronary syndromes","volume":"12","author":"Witkowski","year":"2005","journal-title":"Folia Cardiol."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"536","DOI":"10.3109\/09537104.2014.948840","article-title":"Intraplatelet reactive oxygen species, mitochondrial damage and platelet apoptosis augment non-surgical bleeding in heart failure patients supported by continuous-flow left ventricular assist device","volume":"26","author":"Mondal","year":"2015","journal-title":"Platelets"},{"key":"ref_171","doi-asserted-by":"crossref","unstructured":"Kowalczyk, P., Kaczy\u0144ska, K., Kleczkowska, P., Bukowska-O\u015bko, I., Kramkowski, K., and Sulejczak, D. (2022). The Lactoferrin Phenome-non-A Miracle Molecule. Molecules, 27.","DOI":"10.3390\/molecules27092941"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"155596","DOI":"10.1016\/j.metabol.2023.155596","article-title":"Energy metabolism in platelets fuels thrombus formation: Halting the thrombosis engine with small-molecule modulators of platelet metabolism","volume":"145","author":"Kulkarni","year":"2023","journal-title":"Metabolism"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1161\/01.CIR.91.5.1314","article-title":"Nitric oxide is responsible for flow-dependent dilatation of human peripheral conduit arteries in vivo","volume":"91","author":"Joannides","year":"1995","journal-title":"Circulation"},{"key":"ref_174","doi-asserted-by":"crossref","unstructured":"Gallo, G., Rubattu, S., and Volpe, M. (2024). Mitochondrial Dysfunction in Heart Failure: From Pathophysiological Mechanisms to Therapeutic Opportunities. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25052667"},{"key":"ref_175","doi-asserted-by":"crossref","unstructured":"Ren, H., Hu, W., Jiang, T., Yao, Q., Qi, Y., and Huang, K. (2024). Mechanical stress induced mitochondrial dysfunction in cardiovascular diseases: Novel mechanisms and therapeutic targets. Biomed. Pharmacother., 174.","DOI":"10.1016\/j.biopha.2024.116545"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.jacbts.2024.01.007","article-title":"Mitochondrial Ca2+ Uniporter-Dependent Energetic Dysfunction Drives Hypertrophy in Heart Failure","volume":"9","author":"Estrada","year":"2024","journal-title":"JACC Basic. Transl. Sci."},{"key":"ref_177","doi-asserted-by":"crossref","unstructured":"Pan, X., Hao, E., Zhang, F., Wei, W., Du, Z., Yan, G., Wang, X., Deng, J., and Hou, X. (2024). Diabetes cardiomyopathy: Targeted regulation of mitochondrial dysfunction and therapeutic potential of plant secondary metabolites. Front. Pharmacol., 15.","DOI":"10.3389\/fphar.2024.1401961"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"373","DOI":"10.3109\/09537104.2013.821604","article-title":"The role of mitochondrial permeability transition pore in regulating the shedding of the platelet GPIbalpha ectodomain","volume":"25","author":"Wang","year":"2014","journal-title":"Platelets."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1055\/s-2006-939550","article-title":"An overview of the structure and function of thrombin","volume":"32","author":"Davie","year":"2006","journal-title":"Semin. Thromb. Hemost."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1182\/blood-2014-05-573543","article-title":"Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A2 to promote inflammation","volume":"124","author":"Boudreau","year":"2014","journal-title":"Blood."},{"key":"ref_181","doi-asserted-by":"crossref","unstructured":"Ramaiah, P., Patra, I., Abbas, A., Fadhil, A.A., Abohassan, M., Al-Qaim, Z.H., Hameed, N.M., Al-Gazally, M.E., Kemil Almotlaq, S.S., and Mustafa, Y.F. (2022). Mitofusin-2 in cancer: Friend or foe?. Arch. Biochem. Biophys., 730.","DOI":"10.1016\/j.abb.2022.109395"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"4829","DOI":"10.1038\/s41467-023-40600-7","article-title":"MTH1 protects platelet mitochondria from oxidative damage and regulates platelet function and thrombosis","volume":"14","author":"Ding","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"113147","DOI":"10.1016\/j.celrep.2023.113147","article-title":"Cancer cells reprogram to metastatic state through the acquisition of platelet mitochon-dria","volume":"42","author":"Zhang","year":"2023","journal-title":"Cell Rep."},{"key":"ref_184","doi-asserted-by":"crossref","unstructured":"Ross, D.M., Liang, H.P.H., Iqra, Z., Whittaker, S., Tan, C.W., Dale, B.J., and Chen, V.M. (2023). Platelets from patients with myeloproliferative neo-plasms have increased numbers of mitochondria that are hypersensitive to depolarization by thrombin. Sci. Rep., 13.","DOI":"10.1038\/s41598-023-36266-2"},{"key":"ref_185","first-page":"75","article-title":"J Gerontol A Supple-menting Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial","volume":"78","author":"Kumar","year":"2023","journal-title":"Biol. Sci. Med. Sci."},{"key":"ref_186","doi-asserted-by":"crossref","unstructured":"Picca, A., Calvani, R., Coelho-Junior, H.J., and Marzetti, E. (2021). Cell Death and Inflammation: The Role of Mitochondria in Health and Disease. Cells, 10.","DOI":"10.3390\/cells10030537"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.lfs.2017.11.019","article-title":"Mitochondrial dysfunction in obesity","volume":"192","author":"Costa","year":"2018","journal-title":"Life Sci."},{"key":"ref_188","doi-asserted-by":"crossref","unstructured":"Kowalczyk, P., Madej, A., Szymczak, M., and Ostaszewski, R. (2020). \u03b1-Amidoamids as New Replacements of Antibiotics-Research on the Chosen K12, R2-R4 E. coli Strains. Materials, 13.","DOI":"10.3390\/ma13225169"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1007\/s00203-016-1249-x","article-title":"The role of Proteus mirabilis cell wall features in biofilm formation","volume":"198","author":"Czerwonka","year":"2016","journal-title":"Arch. Microbiol."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/22\/12467\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:36:09Z","timestamp":1760114169000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/22\/12467"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,20]]},"references-count":189,"journal-issue":{"issue":"22","published-online":{"date-parts":[[2024,11]]}},"alternative-id":["ijms252212467"],"URL":"https:\/\/doi.org\/10.3390\/ijms252212467","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,20]]}}}