{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T08:12:22Z","timestamp":1790928742683,"version":"4.1.0"},"reference-count":107,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T00:00:00Z","timestamp":1732233600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["23-75-30001"],"award-info":[{"award-number":["23-75-30001"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Amyloid beta (A\u03b2) is a neuronal metabolic product that plays an important role in maintaining brain homeostasis. Normally, intensive brain A\u03b2 formation is accompanied by its effective lymphatic removal. However, the excessive accumulation of brain A\u03b2 is observed with age and during the development of Alzheimer\u2019s disease (AD) leading to cognitive impairment and memory deficits. There is emerging evidence that plasmalogens (Pls), as one of the key brain lipids, may be beneficial for AD and cognitive aging. Here, we studied the effects of Pls on cognitive functions and the lymphatic clearance of A\u03b2 from the brain of AD mice and mice of different ages. The results showed that Pls effectively reduce brain A\u03b2 levels and facilitate learning in aged but not old mice. In AD mice, Pls improve the lymphatic clearance of A\u03b2 that is accompanied by an increase in general motor activity and an improvement of the emotional status and learning ability. Thus, these findings suggest that Pls could be a promising candidate for the alternative or concomitant therapy of AD and age-related brain diseases to enhance the lymphatic clearance of A\u03b2 from the brain and cognitive functions.<\/jats:p>","DOI":"10.3390\/ijms252312552","type":"journal-article","created":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T06:41:48Z","timestamp":1732257708000},"page":"12552","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Plasmalogens Improve Lymphatic Clearance of Amyloid Beta from Mouse Brain and Cognitive Functions"],"prefix":"10.3390","volume":"25","author":[{"given":"Alexander","family":"Shirokov","sequence":"first","affiliation":[{"name":"Institute of Biochemistry and Physiology of Plants and Microorganisms, Russian Academy of Sciences, Prospekt Entuziastov 13, 410049 Saratov, Russia"},{"name":"Department of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daria","family":"Zlatogosrkaya","sequence":"additional","affiliation":[{"name":"Department of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktoria","family":"Adushkina","sequence":"additional","affiliation":[{"name":"Department of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0164-7423","authenticated-orcid":false,"given":"Elena","family":"Vodovozova","sequence":"additional","affiliation":[{"name":"Shemyakin\u2013Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Ul. Miklukho-Maklaya, 16\/10, 117997 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4348-9902","authenticated-orcid":false,"given":"Kristina","family":"Kardashevskaya","sequence":"additional","affiliation":[{"name":"Shemyakin\u2013Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Ul. Miklukho-Maklaya, 16\/10, 117997 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruslan","family":"Sultanov","sequence":"additional","affiliation":[{"name":"A.V. Zhirmunsky National Scientific Center of Marine Biology, Far Eastern Branch, Russian Academy of Sciences, Palchevskogo Str. 17, 690041 Vladivostok, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey","family":"Kasyanov","sequence":"additional","affiliation":[{"name":"A.V. Zhirmunsky National Scientific Center of Marine Biology, Far Eastern Branch, Russian Academy of Sciences, Palchevskogo Str. 17, 690041 Vladivostok, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1517-0857","authenticated-orcid":false,"given":"Inna","family":"Blokhina","sequence":"additional","affiliation":[{"name":"Department of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrey","family":"Terskov","sequence":"additional","affiliation":[{"name":"Department of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4681-6465","authenticated-orcid":false,"given":"Maria","family":"Tzoy","sequence":"additional","affiliation":[{"name":"Physics Department, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arina","family":"Evsyukova","sequence":"additional","affiliation":[{"name":"Department of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Dubrovsky","sequence":"additional","affiliation":[{"name":"Shemyakin\u2013Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Ul. 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