{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:37:18Z","timestamp":1760146638321,"version":"build-2065373602"},"reference-count":22,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T00:00:00Z","timestamp":1732579200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009594","name":"Uni P\u00e9cs","doi-asserted-by":"publisher","award":["015_2024_PTE_RK\/31","CH-10-6\/2024","2024-1.2.5-T\u00c9T-2024-00006","20720230012","TKP2021-EGA-17"],"award-info":[{"award-number":["015_2024_PTE_RK\/31","CH-10-6\/2024","2024-1.2.5-T\u00c9T-2024-00006","20720230012","TKP2021-EGA-17"]}],"id":[{"id":"10.13039\/501100009594","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Chinese-Hungarian Intergovernmental S&amp;T Cooperation Programme","award":["015_2024_PTE_RK\/31","CH-10-6\/2024","2024-1.2.5-T\u00c9T-2024-00006","20720230012","TKP2021-EGA-17"],"award-info":[{"award-number":["015_2024_PTE_RK\/31","CH-10-6\/2024","2024-1.2.5-T\u00c9T-2024-00006","20720230012","TKP2021-EGA-17"]}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities of China","doi-asserted-by":"publisher","award":["015_2024_PTE_RK\/31","CH-10-6\/2024","2024-1.2.5-T\u00c9T-2024-00006","20720230012","TKP2021-EGA-17"],"award-info":[{"award-number":["015_2024_PTE_RK\/31","CH-10-6\/2024","2024-1.2.5-T\u00c9T-2024-00006","20720230012","TKP2021-EGA-17"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"name":"New National Excellence Program of the Ministry for Innovation and Technology of Hungary","award":["015_2024_PTE_RK\/31","CH-10-6\/2024","2024-1.2.5-T\u00c9T-2024-00006","20720230012","TKP2021-EGA-17"],"award-info":[{"award-number":["015_2024_PTE_RK\/31","CH-10-6\/2024","2024-1.2.5-T\u00c9T-2024-00006","20720230012","TKP2021-EGA-17"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The therapeutical applicability of the anticancer drug phototrexate, a photoswitchable derivative of the antimetabolite dihydrofolate reductase inhibitor methotrexate, highly depends on the stability of its bioactive isomer. Considering that only the cis configuration of phototrexate is bioactive, in this work, the effect of the molecular environment on the stability of the cis isomer of this drug has been investigated. UV-vis absorption and fluorescence-based solvent relaxation methods have been used. Protic methanol and non-protic dimethylsulfoxide were used as medium-ranged permittivity solvents. The results showed a decreased rate of cis \u2192 trans conversion and enhanced stabilities of the cis isomer in methanol. Temperature-dependent measurements of the isomerization rate reflect the increased activation energy in methanol.<\/jats:p>","DOI":"10.3390\/ijms252312703","type":"journal-article","created":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T09:10:14Z","timestamp":1732612214000},"page":"12703","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of the Protic vs. Non-Protic Molecular Environment on the cis to trans Conformation Change of Phototrexate Drug"],"prefix":"10.3390","volume":"25","author":[{"given":"Fl\u00f3ri\u00e1n","family":"Bencze","sequence":"first","affiliation":[{"name":"Institute of Organic and Medicinal Chemistry, Faculty of Pharmacy, University of P\u00e9cs, Honv\u00e9d \u00fatja 1, H-7624 P\u00e9cs, Hungary"},{"name":"Department of Physical Chemistry and Materials Science, Faculty of Sciences, University of P\u00e9cs, Ifj\u00fas\u00e1g \u00fatja 6, H-7624 P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e1szl\u00f3","family":"Kiss","sequence":"additional","affiliation":[{"name":"Institute of Organic and Medicinal Chemistry, Faculty of Pharmacy, University of P\u00e9cs, Honv\u00e9d \u00fatja 1, H-7624 P\u00e9cs, Hungary"},{"name":"J\u00e1nos Szent\u00e1gothai Research Center, Ifj\u00fas\u00e1g \u00fatja 20, H-7624 P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heng","family":"Li","sequence":"additional","affiliation":[{"name":"Fujian Provincial Key Laboratory of Semiconductors and Applications, Collaborative Innovation Center for Optoelectronic Semiconductors and Efficient Devices, Department of Physics, Xiamen University, Xiamen 361005, China"},{"name":"Jiujiang Research Institute, Xiamen University, Jiujiang 332000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Yan","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Photoelectric Materials and Devices, School of Materials Science and Engineering, Tianjin University of Technology, Tianjin 300384, China"},{"name":"Key Laboratory of Display Materials and Photoelectric Devices, Tianjin University of Technology, Ministry of Education, Tianjin 300384, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e1szl\u00f3","family":"Koll\u00e1r","sequence":"additional","affiliation":[{"name":"J\u00e1nos Szent\u00e1gothai Research Center, Ifj\u00fas\u00e1g \u00fatja 20, H-7624 P\u00e9cs, Hungary"},{"name":"HUN-REN-PTE Research Group for Selective Chemical Syntheses, Ifj\u00fas\u00e1g u. 6., H-7624 P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1554-4225","authenticated-orcid":false,"given":"S\u00e1ndor","family":"Kuns\u00e1gi-M\u00e1t\u00e9","sequence":"additional","affiliation":[{"name":"Institute of Organic and Medicinal Chemistry, Faculty of Pharmacy, University of P\u00e9cs, Honv\u00e9d \u00fatja 1, H-7624 P\u00e9cs, Hungary"},{"name":"J\u00e1nos Szent\u00e1gothai Research Center, Ifj\u00fas\u00e1g \u00fatja 20, H-7624 P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2174\/1570163812666150602144310","article-title":"Targeted Cancer Therapy: The Next Generation of Cancer Treatment","volume":"12","author":"Baudino","year":"2015","journal-title":"Curr. 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