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The ligands of these receptors, Protein S (PS) and growth arrest specific protein 6 (Gas6), are essential for TAM receptor functions in the amplification and resolution of atherosclerosis. The Axl-Gas6 interaction has various effects on cardiovascular disease. Mer and PS dampen inflammation, thereby protecting against atherosclerosis progression. Tyro3, the least studied TAM receptor in cardiovascular disease, appears to protect against fibrosis in post-myocardial infarction injury. Ultimately, PS, Gas6, and TAM receptors present an exciting avenue of potential therapeutic targets against inflammation associated with atherosclerosis and cardiovascular disease.<\/jats:p>","DOI":"10.3390\/ijms252312736","type":"journal-article","created":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T04:20:12Z","timestamp":1732681212000},"page":"12736","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Functions of TAM Receptors and Ligands Protein S and Gas6 in Atherosclerosis and Cardiovascular Disease"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7419-9241","authenticated-orcid":false,"given":"Teagan","family":"Prouse","sequence":"first","affiliation":[{"name":"Department of Interdisciplinary Oncology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1831-664X","authenticated-orcid":false,"given":"Samarpan","family":"Majumder","sequence":"additional","affiliation":[{"name":"Department of Genetics, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1727-7220","authenticated-orcid":false,"given":"Rinku","family":"Majumder","sequence":"additional","affiliation":[{"name":"Department of Interdisciplinary Oncology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1055\/s-0038-1649503","article-title":"Global Burden of Stroke","volume":"38","author":"Katan","year":"2018","journal-title":"Semin. Neurol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/pin.13202","article-title":"Atherosclerosis: Known and unknown","volume":"72","author":"Fan","year":"2022","journal-title":"Pathol. Int."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/s41586-021-03392-8","article-title":"The changing landscape of atherosclerosis","volume":"592","author":"Libby","year":"2021","journal-title":"Nature"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S1056-8719(00)00125-8","article-title":"The vascular system. An overview of structure and function","volume":"44","author":"Pugsley","year":"2000","journal-title":"J. Pharmacol. Toxicol. Methods"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"H1010","DOI":"10.1152\/ajpheart.00752.2004","article-title":"Control of blood vessel structure: Insights from theoretical models","volume":"288","author":"Pries","year":"2005","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1161\/01.RES.0000255691.76142.4a","article-title":"Phenotypic heterogeneity of the endothelium: I. Structure, function, and mechanisms","volume":"100","author":"Aird","year":"2007","journal-title":"Circ. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/s41569-021-00613-5","article-title":"Apolipoproteins in vascular biology and atherosclerotic disease","volume":"19","author":"Mehta","year":"2022","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"C7","DOI":"10.1016\/j.jacc.2005.09.068","article-title":"Pathogenesis of atherosclerosis","volume":"47","author":"Falk","year":"2006","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s11883-017-0678-6","article-title":"Oxidative Stress in Atherosclerosis","volume":"19","author":"Kattoor","year":"2017","journal-title":"Curr. Atheroscler. Rep."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Hinkley, H., Counts, D.A., VonCanon, E., and Lacy, M. (2023). T Cells in Atherosclerosis: Key Players in the Pathogenesis of Vascular Disease. Cells, 12.","DOI":"10.3390\/cells12172152"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1080\/14728222.2023.2288272","article-title":"Lipid-laden foam cells in the pathology of atherosclerosis: Shedding light on new therapeutic targets","volume":"27","author":"Galindo","year":"2023","journal-title":"Expert. Opin. Ther. Targets"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1126\/science.aaa8064","article-title":"Inflammation. Neutrophil extracellular traps license macrophages for cytokine production in atherosclerosis","volume":"349","author":"Warnatsch","year":"2015","journal-title":"Science"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"297","DOI":"10.3109\/07853890.2014.900272","article-title":"Multiple potential roles for B cells in atherosclerosis","volume":"46","author":"Sage","year":"2014","journal-title":"Ann. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1111\/joim.12296","article-title":"Thrombosis formation on atherosclerotic lesions and plaque rupture","volume":"276","author":"Badimon","year":"2014","journal-title":"J. Intern. Med."},{"key":"ref_15","first-page":"294","article-title":"Atherosclerotic Plaque Healing. Reply","volume":"384","author":"Vergallo","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1161\/ATVBAHA.122.318177","article-title":"Regulated Necrosis in Atherosclerosis","volume":"42","author":"Puylaert","year":"2022","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s11883-020-00891-3","article-title":"Inflammatory Cytokines and Atherosclerotic Plaque Progression. Therapeutic Implications","volume":"22","author":"Sterpetti","year":"2020","journal-title":"Curr. Atheroscler. Rep."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1093\/eurheartj\/ehz962","article-title":"Low-density lipoproteins cause atherosclerotic cardiovascular disease: Pathophysiological, genetic, and therapeutic insights: A consensus statement from the European Atherosclerosis Society Consensus Panel","volume":"41","author":"Boren","year":"2020","journal-title":"Eur. Heart J."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Leong, X.F., Ng, C.Y., and Jaarin, K. (2015). Animal Models in Cardiovascular Research: Hypertension and Atherosclerosis. Biomed. Res. Int., 2015.","DOI":"10.1155\/2015\/528757"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1007\/s11883-016-0632-z","article-title":"The Different Facets of Dyslipidemia and Hypertension in Atherosclerosis","volume":"18","author":"Hurtubise","year":"2016","journal-title":"Curr. Atheroscler. Rep."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Tutusaus, A., Mari, M., Ortiz-Perez, J.T., Nicolaes, G.A.F., Morales, A., and Garcia de Frutos, P. (2020). Role of Vitamin K-Dependent Factors Protein S and GAS6 and TAM Receptors in SARS-CoV-2 Infection and COVID-19-Associated Immunothrombosis. Cells, 9.","DOI":"10.3390\/cells9102186"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/bs.ircmb.2020.09.001","article-title":"TAM receptors and their ligand-mediated activation: Role in atherosclerosis","volume":"357","author":"Cai","year":"2020","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1093\/cvr\/cvz100","article-title":"TAM receptors in cardiovascular disease","volume":"115","author":"McShane","year":"2019","journal-title":"Cardiovasc. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/s41577-019-0167-y","article-title":"How macrophages deal with death","volume":"19","author":"Lemke","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"5635","DOI":"10.4049\/jimmunol.178.9.5635","article-title":"Macrophages and dendritic cells use different Axl\/Mertk\/Tyro3 receptors in clearance of apoptotic cells","volume":"178","author":"Seitz","year":"2007","journal-title":"J. Immunol."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Pu, Y., and Ji, Q. (2022). Tumor-Associated Macrophages Regulate PD-1\/PD-L1 Immunosuppression. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.874589"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/s41571-023-00813-7","article-title":"TAM family kinases as therapeutic targets at the interface of cancer and immunity","volume":"20","author":"Deryckere","year":"2023","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2460","DOI":"10.1182\/blood-2013-09-528752","article-title":"TAM receptors, Gas6, and protein S: Roles in inflammation and hemostasis","volume":"123","year":"2014","journal-title":"Blood"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"eadk5836","DOI":"10.1126\/sciadv.adk5836","article-title":"TFPI\u03b1 anticoagulant function is highly dependent on protein S in vivo","volume":"10","author":"Petri","year":"2024","journal-title":"Sci. Adv."},{"key":"ref_30","first-page":"1","article-title":"Protein S: A Multifunctional Anticoagulant","volume":"2","author":"Dorsey","year":"2017","journal-title":"Biomed. Res. Clin. Pract."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/s12943-019-1022-2","article-title":"Targeting Tyro3, Axl and MerTK (TAM receptors): Implications for macrophages in the tumor microenvironment","volume":"18","author":"Myers","year":"2019","journal-title":"Mol. Cancer"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"153596","DOI":"10.1016\/j.prp.2021.153596","article-title":"A review on the role of GAS6 and GAS6-AS1 in the carcinogenesis","volume":"226","author":"Khoshbakht","year":"2021","journal-title":"Pathol. Res. Pract."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Ni, J., Lin, M., Jin, Y., Li, J., Guo, Y., Zhou, J., Hong, G., Zhao, G., and Lu, Z. (2019). Gas6 Attenuates Sepsis-Induced Tight Junction Injury and Vascular Endothelial Hyperpermeability via the Axl\/NF-kappaB Signaling Pathway. Front. Pharmacol., 10.","DOI":"10.3389\/fphar.2019.00662"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.diabres.2017.03.026","article-title":"Implication of a novel Gla-containing protein, Gas6 in the pathogenesis of insulin resistance, impaired glucose homeostasis, and inflammation: A review","volume":"128","author":"Dihingia","year":"2017","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Zhai, X., Pu, D., Wang, R., Zhang, J., Lin, Y., Wang, Y., Zhai, N., Peng, X., Zhou, Q., and Li, L. (2023). Gas6\/AXL pathway: Immunological landscape and therapeutic potential. Front. Oncol., 13.","DOI":"10.3389\/fonc.2023.1121130"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1002\/path.5368","article-title":"Immunoproteasome subunit \u03b25i regulates diet-induced atherosclerosis through altering MERTK-mediated efferocytosis in knockout mice","volume":"250","author":"Liao","year":"2020","journal-title":"J. Pathol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1161\/CIRCRESAHA.117.311984","article-title":"CANTOS Trial Validates the Inflammatory Pathogenesis of Atherosclerosis: Setting the Stage for a New Chapter in Therapeutic Targeting","volume":"121","author":"Weber","year":"2017","journal-title":"Circ. Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/imr.13267","article-title":"TAM receptors in phagocytosis: Beyond the mere internalization of particles","volume":"319","author":"Fresia","year":"2023","journal-title":"Immunol. Rev."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/bs.ircmb.2020.09.002","article-title":"Post-translational modifications of the ligands: Requirement for TAM receptor activation","volume":"357","author":"Geng","year":"2020","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.bbrc.2004.05.070","article-title":"Vitamin K-dependent Gas6 activates ERK kinase and stimulates growth of cardiac fibroblasts","volume":"319","author":"Stenhoff","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Al Kafri, N., and Hafizi, S. (2019). Tumour-Secreted Protein S (ProS1) Activates a Tyro3-Erk Signalling Axis and Protects Cancer Cells from Apoptosis. Cancers, 11.","DOI":"10.3390\/cancers11121843"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"25750","DOI":"10.1074\/jbc.M114.569020","article-title":"Receptor tyrosine kinases, TYRO3, AXL, and MER, demonstrate distinct patterns and complex regulation of ligand-induced activation","volume":"289","author":"Tsou","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1186\/s12964-019-0461-0","article-title":"TAM receptors, Phosphatidylserine, inflammation, and Cancer","volume":"17","author":"Maimon","year":"2019","journal-title":"Cell Commun. Signal."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/icb.2013.22","article-title":"Breakdown of immune homeostasis in the testis of mice lacking Tyro3, Axl and Mer receptor tyrosine kinases","volume":"91","author":"Zhang","year":"2013","journal-title":"Immunol. Cell Biol."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Yefimova, M.G., Ravel, C., Rolland, A.D., Bourmeyster, N., and Jegou, B. (2021). MERTK-Mediated LC3-Associated Phagocytosis (LAP) of Apoptotic Substrates in Blood-Separated Tissues: Retina, Testis, Ovarian Follicles. Cells, 10.","DOI":"10.3390\/cells10061443"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"316","DOI":"10.2741\/4390","article-title":"The roles of TAM receptor tyrosine kinases in the mammalian testis and immunoprivileged sites","volume":"21","author":"Deng","year":"2016","journal-title":"Front. Biosci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.acvd.2023.07.007","article-title":"Interplay between efferocytosis and atherosclerosis","volume":"116","author":"Rochette","year":"2023","journal-title":"Arch. Cardiovasc. Dis."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/bs.ircmb.2020.09.008","article-title":"Recent advancements in role of TAM receptors on efferocytosis, viral infection, autoimmunity, and tissue repair","volume":"357","author":"Ranta","year":"2020","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1146\/annurev-immunol-042617-053010","article-title":"Apoptosis and Clearance of Apoptotic Cells","volume":"36","author":"Nagata","year":"2018","journal-title":"Annu. Rev. Immunol."},{"key":"ref_50","first-page":"e1261","article-title":"Coordinated expression of tyro3, axl, and mer receptors in macrophage ontogeny","volume":"3","author":"Malawista","year":"2016","journal-title":"Macrophage"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s00262-019-02421-w","article-title":"TAM-ing T cells in the tumor microenvironment: Implications for TAM receptor targeting","volume":"69","author":"Peeters","year":"2020","journal-title":"Cancer Immunol. Immunother."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/j.cell.2007.10.034","article-title":"TAM receptors are pleiotropic inhibitors of the innate immune response","volume":"131","author":"Rothlin","year":"2007","journal-title":"Cell"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1158\/2326-6066.CIR-18-0841","article-title":"MERTK Acts as a Costimulatory Receptor on Human CD8 T Cells","volume":"7","author":"Peeters","year":"2019","journal-title":"Cancer Immunol. Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.immuni.2013.06.010","article-title":"T cell-derived protein S engages TAM receptor signaling in dendritic cells to control the magnitude of the immune response","volume":"39","author":"Chan","year":"2013","journal-title":"Immunity"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/s41573-023-00846-8","article-title":"Therapeutic targeting of the functionally elusive TAM receptor family","volume":"23","author":"Miao","year":"2024","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/bs.ircmb.2020.09.011","article-title":"Immunological role of TAM receptors in the cancer microenvironment","volume":"357","author":"Gadiyar","year":"2020","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"109753","DOI":"10.1016\/j.clim.2023.109753","article-title":"Tyro3 receptor tyrosine kinase contributes to pathogenic phenotypes of fibroblast-like synoviocytes in rheumatoid arthritis and disturbs immune cell balance in experimental arthritis","volume":"255","author":"Wang","year":"2023","journal-title":"Clin. Immunol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1002\/art.41552","article-title":"MicroRNA-34a-5p Promotes Joint Destruction During Osteoarthritis","volume":"73","author":"Endisha","year":"2021","journal-title":"Arthritis Rheumatol."},{"key":"ref_59","first-page":"2503","article-title":"MicroRNA-7 inhibits colorectal cancer cell proliferation, migration and invasion via TYRO3 and phosphoinositide 3-kinase\/protein B kinase\/mammalian target of rapamycin pathway suppression","volume":"42","author":"Qin","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/s41420-023-01497-9","article-title":"Defective efferocytosis by aged macrophages promotes STING signaling mediated inflammatory liver injury","volume":"9","author":"Hu","year":"2023","journal-title":"Cell Death Discov."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Lahey, K.C., Varsanyi, C., Wang, Z., Aquib, A., Gadiyar, V., Rodrigues, A.A., Pulica, R., Desind, S., Davra, V., and Calianese, D.C. (2024). Regulation of Mertk Surface Expression via ADAM17 and gamma-Secretase Proteolytic Processing. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25084404"},{"key":"ref_62","first-page":"e9349","article-title":"Global Epidemiology of Ischemic Heart Disease: Results from the Global Burden of Disease Study","volume":"12","author":"Khan","year":"2020","journal-title":"Cureus"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.diabres.2013.12.057","article-title":"The levels of plasma growth arrest-specific protein 6 is associated with insulin sensitivity and inflammation in women","volume":"103","author":"Kuo","year":"2014","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.bbrc.2016.10.066","article-title":"Protective effects of estrogen against vascular calcification via estrogen receptor a-dependent growth arrest-specific gene 6 transactivation","volume":"480","author":"Son","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.bbrc.2006.12.018","article-title":"GAS6 is an estrogen-inducible gene in mammary epithelial cells","volume":"353","author":"Mo","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"16111","DOI":"10.18632\/aging.103584","article-title":"Testosterone ameliorates vascular aging via the Gas6\/Axl signaling pathway","volume":"12","author":"Chen","year":"2020","journal-title":"Aging"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1530\/ERC-16-0126","article-title":"Role of protein S in castration-resistant prostate cancer-like cells","volume":"23","author":"Ning","year":"2016","journal-title":"Endocr. Relat. Cancer"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"13444","DOI":"10.1074\/jbc.M109.062430","article-title":"Down-regulation of PROS1 gene expression by 17beta-estradiol via estrogen receptor alpha (ERalpha)-Sp1 interaction recruiting receptor-interacting protein 140 and the corepressor-HDAC3 complex","volume":"285","author":"Suzuki","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.critrevonc.2013.07.004","article-title":"Protein S: A multifunctional anticoagulant vitamin K-dependent protein at the crossroads of coagulation, inflammation, angiogenesis, and cancer","volume":"88","author":"Suleiman","year":"2013","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1007\/s12020-014-0234-x","article-title":"Plasma growth arrest-specific protein 6 levels in premenopausal and postmenopausal women: The role of endogenous estrogen","volume":"47","author":"Hung","year":"2014","journal-title":"Endocrine"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1210\/jc.2013-3426","article-title":"Functional consequences of AXL sequence variants in hypogonadotropic hypogonadism","volume":"99","author":"Xu","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1111\/j.1538-7836.2007.02730.x","article-title":"Upregulation of protein S by progestins","volume":"5","author":"Hughes","year":"2007","journal-title":"J. Thromb. Haemost."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"S68","DOI":"10.1016\/S0168-8227(16)31066-X","article-title":"Gender differences in plasma growth arrest-specific protein 6 levels in adult subjects","volume":"120","author":"Hung","year":"2016","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.clinbiochem.2018.11.018","article-title":"Circulating Gas6 is associated with reduced human carotid atherosclerotic plaque burden in high risk cardiac patients","volume":"64","author":"Holden","year":"2019","journal-title":"Clin. Biochem."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"e944462","DOI":"10.12659\/MSM.944462","article-title":"Elevated Plasma Levels of Growth Arrest Specific 6 (Gas6) Protein in Severe Obesity: Implications for Adipose Tissue and Inflammation","volume":"30","author":"Sola","year":"2024","journal-title":"Med. Sci. Monit."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"100655","DOI":"10.1016\/j.cpcardiol.2020.100655","article-title":"Obesity and Coronary Heart Disease: Epidemiology, Pathology, and Coronary Artery Imaging","volume":"46","author":"Katta","year":"2021","journal-title":"Curr. Probl. Cardiol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1038\/s41401-021-00846-7","article-title":"Extracellular vesicles in vascular remodeling","volume":"43","author":"Ye","year":"2022","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/bs.apha.2017.08.002","article-title":"Matrix Metalloproteinases, Vascular Remodeling, and Vascular Disease","volume":"81","author":"Wang","year":"2018","journal-title":"Adv. Pharmacol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1161\/01.RES.83.7.697","article-title":"Increased expression of Axl tyrosine kinase after vascular injury and regulation by G protein-coupled receptor agonists in rats","volume":"83","author":"Melaragno","year":"1998","journal-title":"Circ. Res."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"H917","DOI":"10.1152\/ajpheart.00253.2022","article-title":"Role of Axl in target organ inflammation and damage due to hypertensive aortic remodeling","volume":"323","author":"Chen","year":"2022","journal-title":"Am. J. Physiol.-Heart Circ. Physiol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.biopha.2017.07.091","article-title":"Renin-angiotensin-aldosterone (RAAS): The ubiquitous system for homeostasis and pathologies","volume":"94","author":"Patel","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1161\/HYPERTENSIONAHA.115.06254","article-title":"Growth Arrest-Specific 6 Exacerbates Pressure Overload-Induced Cardiac Hypertrophy","volume":"67","author":"Zhao","year":"2016","journal-title":"Hypertension"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.vph.2010.07.002","article-title":"Pharmacological inhibition of Axl affects smooth muscle cell functions under oxidative stress","volume":"53","author":"Smolock","year":"2010","journal-title":"Vascul. Pharmacol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1016\/j.freeradbiomed.2013.09.011","article-title":"Oxidative stress enhances Axl-mediated cell migration through an Akt1\/Rac1-dependent mechanism","volume":"65","author":"Huang","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"F398","DOI":"10.1152\/ajprenal.00258.2016","article-title":"Cilostazol inhibits uremic toxin-induced vascular smooth muscle cell dysfunction: Role of Axl signaling","volume":"312","author":"Lee","year":"2017","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1038\/s41401-022-01029-8","article-title":"Circulating small extracellular vesicles promote proliferation and migration of vascular smooth muscle cells via AXL and MerTK activation","volume":"44","author":"Lee","year":"2023","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.1038\/s41388-023-02810-7","article-title":"AXL activates YAP through the EGFR-LATS1\/2 axis and confers resistance to EGFR-targeted drugs in head and neck squamous cell carcinoma","volume":"42","author":"Okamoto","year":"2023","journal-title":"Oncogene"},{"key":"ref_88","first-page":"2719","article-title":"The potential role of YAP in Axl-mediated resistance to EGFR tyrosine kinase inhibitors","volume":"9","author":"Saab","year":"2019","journal-title":"Am. J. Cancer Res."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"134786","DOI":"10.1016\/j.jhazmat.2024.134786","article-title":"Gas6-Axl signal promotes indoor VOCs exposure-induced pulmonary fibrosis via pulmonary microvascular endothelial cells-fibroblasts cross-talk","volume":"474","author":"Liu","year":"2024","journal-title":"J. Hazard. Mater."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/s41580-023-00631-w","article-title":"Biology and therapeutic targeting of vascular endothelial growth factor A","volume":"24","author":"Ferrara","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s00726-009-0448-z","article-title":"Taurine restores Axl\/Gas6 expression in vascular smooth muscle cell calcification model","volume":"39","author":"Liao","year":"2010","journal-title":"Amino Acids"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"10586","DOI":"10.1074\/jbc.M115.699058","article-title":"The Gas6-Axl Protein Interaction Mediates Endothelial Uptake of Platelet Microparticles","volume":"291","author":"Happonen","year":"2016","journal-title":"J. Biol. Chem."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1189\/jlb.0909610","article-title":"TNF-\u03b1, IL-6, and IL-1 expression is inhibited by GAS6 in monocytes\/macrophages","volume":"87","author":"Alciato","year":"2010","journal-title":"J. Leukocyte Biol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"e2024596118","DOI":"10.1073\/pnas.2024596118","article-title":"The GAS6-AXL signaling pathway triggers actin remodeling that drives membrane ruffling, macropinocytosis, and cancer-cell invasion","volume":"118","author":"Poswiata","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"11831","DOI":"10.1002\/jcb.28462","article-title":"Overexpression of Axl reverses endothelial cells dysfunction in high glucose and hypoxia","volume":"120","author":"Zuo","year":"2019","journal-title":"J. Cell Biochem."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.tcm.2014.10.021","article-title":"Vascular calcification: Mechanisms of vascular smooth muscle cell calcification","volume":"25","author":"Leopold","year":"2015","journal-title":"Trends Cardiovasc. Med."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Lee, S.J., Lee, I.K., and Jeon, J.H. (2020). Vascular Calcification-New Insights into Its Mechanism. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21082685"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1161\/01.RES.0000074881.56564.46","article-title":"Receptor tyrosine kinase Axl modulates the osteogenic differentiation of pericytes","volume":"92","author":"Collett","year":"2003","journal-title":"Circ. Res."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s11010-017-3023-z","article-title":"Vitamin K2 inhibits rat vascular smooth muscle cell calcification by restoring the Gas6\/Axl\/Akt anti-apoptotic pathway","volume":"433","author":"Qiu","year":"2017","journal-title":"Mol. Cell Biochem."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1161\/ATVBAHA.118.311298","article-title":"miR-34a Promotes Vascular Smooth Muscle Cell Calcification by Downregulating SIRT1 (Sirtuin 1) and Axl (AXL Receptor Tyrosine Kinase)","volume":"38","author":"Badi","year":"2018","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2006.09.070","article-title":"Gas6\/Axl-PI3K\/Akt pathway plays a central role in the effect of statins on inorganic phosphate-induced calcification of vascular smooth muscle cells","volume":"556","author":"Son","year":"2007","journal-title":"Eur. J. Pharmacol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.1016\/j.ajpath.2012.01.036","article-title":"Immune modulation of vascular resident cells by Axl orchestrates carotid intima-media thickening","volume":"180","author":"Gerloff","year":"2012","journal-title":"Am. J. Pathol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1136\/jclinpath-2013-202000","article-title":"Expression of growth arrest-specific protein 6 and Axl molecules in the left internal mammary artery of patients undergoing coronary artery bypass grafting","volume":"67","author":"Lee","year":"2014","journal-title":"J. Clin. Pathol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1097\/MAJ.0000000000000362","article-title":"Elevated serum levels of soluble Axl in acute coronary syndrome","volume":"349","author":"Liu","year":"2015","journal-title":"Am. J. Med. Sci."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/1755-5922.12112","article-title":"Growth arrest-specific 6 and cardiometabolic risk factors in patients with psoriasis","volume":"33","author":"Sunbul","year":"2015","journal-title":"Cardiovasc. Ther."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/imr.13215","article-title":"Lipid metabolism in dendritic cell biology","volume":"317","author":"You","year":"2023","journal-title":"Immunol. Rev."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"H1048","DOI":"10.1152\/ajpheart.00495.2015","article-title":"Axl modulates immune activation of smooth muscle cells in vein graft remodeling","volume":"309","author":"Batchu","year":"2015","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1161\/CIRCRESAHA.121.319643","article-title":"Growth Arrest Specific-6 and Axl Coordinate Inflammation and Hypertension","volume":"129","author":"Barbaro","year":"2021","journal-title":"Circ. Res."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1016\/j.ajpath.2018.04.013","article-title":"Innate Immune Cells Are Regulated by Axl in Hypertensive Kidney","volume":"188","author":"Batchu","year":"2018","journal-title":"Am. J. Pathol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1080\/10641963.2017.1288739","article-title":"Growth arrest-specific protein 6 (Gas6) as a noninvasive biomarker for early detection of diabetic nephropathy","volume":"39","author":"Li","year":"2017","journal-title":"Clin. Exp. Hypertens."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.ijcard.2014.03.016","article-title":"AXL receptor tyrosine kinase is increased in patients with heart failure","volume":"173","author":"Batlle","year":"2014","journal-title":"Int. J. Cardiol."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Cristobal, H., Enjuanes, C., Batlle, M., Tajes, M., Campos, B., Francesch, J., Moliner, P., Farrero, M., Andrea, R., and Ortiz-Perez, J.T. (2023). Prognostic Value of Soluble AXL in Serum from Heart Failure Patients with Preserved and Reduced Left Ventricular Ejection Fraction. J. Pers. Med., 13.","DOI":"10.3390\/jpm13030446"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1177\/2048872617740833","article-title":"Serum levels of Growth Arrest-Specific 6 protein and soluble AXL in patients with ST-segment elevation myocardial infarction","volume":"8","author":"Caldentey","year":"2019","journal-title":"Eur. Heart J. Acute Cardiovasc. Care"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"e139576","DOI":"10.1172\/JCI139576","article-title":"Macrophage AXL receptor tyrosine kinase inflames the heart after reperfused myocardial infarction","volume":"131","author":"DeBerge","year":"2021","journal-title":"J. Clin. Investig."},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Vago, J.P., Valdrighi, N., Blaney-Davidson, E.N., Hornikx, D., Neefjes, M., Barba-Sarasua, M.E., Thielen, N.G.M., van den Bosch, M.H.J., van der Kraan, P.M., and Koenders, M.I. (2023). Gas6\/Axl Axis Activation Dampens the Inflammatory Response in Osteoarthritic Fibroblast-like Synoviocytes and Synovial Explants. Pharmaceuticals, 16.","DOI":"10.3390\/ph16050703"},{"key":"ref_116","first-page":"389","article-title":"Inflammation and its resolution in atherosclerosis: Mediators and therapeutic opportunities","volume":"16","author":"Back","year":"2019","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/nature07201","article-title":"Origin and physiological roles of inflammation","volume":"454","author":"Medzhitov","year":"2008","journal-title":"Nature"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1096\/fj.201902126R","article-title":"Resolvin D1 promotes efferocytosis in aging by limiting senescent cell-induced MerTK cleavage","volume":"34","author":"Rymut","year":"2020","journal-title":"FASEB J."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"2713","DOI":"10.1172\/JCI97950","article-title":"The role of non-resolving inflammation in atherosclerosis","volume":"128","author":"Kasikara","year":"2018","journal-title":"J. Clin. Investig."},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Castilla-Madrigal, R., Gil-Iturbe, E., Lopez de Calle, M., Moreno-Aliaga, M.J., and Lostao, M.P. (2020). DHA and its derived lipid mediators MaR1, RvD1 and RvD2 block TNF-alpha inhibition of intestinal sugar and glutamine uptake in Caco-2 cells. J. Nutr. Biochem., 76.","DOI":"10.1016\/j.jnutbio.2019.108264"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"101597","DOI":"10.1016\/j.smim.2022.101597","article-title":"E-series resolvin metabolome, biosynthesis and critical role of stereochemistry of specialized pro-resolving mediators (SPMs) in inflammation-resolution: Preparing SPMs for long COVID-19, human clinical trials, and targeted precision nutrition","volume":"59","author":"Serhan","year":"2022","journal-title":"Semin. Immunol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1038\/s41569-023-00984-x","article-title":"Specialized pro-resolving mediators in vascular inflammation and atherosclerotic cardiovascular disease","volume":"21","author":"Fredman","year":"2024","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/s41569-024-01037-7","article-title":"Efferocytosis in atherosclerosis","volume":"21","author":"Adkar","year":"2024","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Kotlyarov, S., and Kotlyarova, A. (2022). Molecular Pharmacology of Inflammation Resolution in Atherosclerosis. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23094808"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/s41418-019-0370-1","article-title":"Resolvin D1 promotes the targeting and clearance of necroptotic cells","volume":"27","author":"Gerlach","year":"2020","journal-title":"Cell Death Differ."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"106700","DOI":"10.1016\/j.prostaglandins.2022.106700","article-title":"DHA, RvD1, RvD5, and MaR1 reduce human coronary arteries contractions induced by PGE(2)","volume":"165","author":"Bouhadoun","year":"2023","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1161\/CIRCRESAHA.116.309492","article-title":"Resolving Lipid Mediators Maresin 1 and Resolvin D2 Prevent Atheroprogression in Mice","volume":"119","author":"Viola","year":"2016","journal-title":"Circ. Res."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.pharmthera.2018.02.003","article-title":"Efferocytosis in atherosclerotic lesions: Malfunctioning regulatory pathways and control mechanisms","volume":"188","author":"Tajbakhsh","year":"2018","journal-title":"Pharmacol. Ther."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1172\/JCI90520","article-title":"MerTK receptor cleavage promotes plaque necrosis and defective resolution in atherosclerosis","volume":"127","author":"Cai","year":"2017","journal-title":"J. Clin. Investig."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s12974-020-02041-7","article-title":"Mer regulates microglial\/macrophage M1\/M2 polarization and alleviates neuroinflammation following traumatic brain injury","volume":"18","author":"Wu","year":"2021","journal-title":"J. Neuroinflamm."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.jacbts.2017.12.006","article-title":"CCR2(+) Monocyte-Derived Infiltrating Macrophages Are Required for Adverse Cardiac Remodeling During Pressure Overload","volume":"3","author":"Patel","year":"2018","journal-title":"JACC Basic. Transl. Sci."},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Lundquist, M.R., and Jaffrey, S.R. (2023). Gas6-Axl Signaling Induces SRF\/MRTF-A Gene Transcription via MICAL2. Genes, 14.","DOI":"10.3390\/genes14122231"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"e86269","DOI":"10.7554\/eLife.86269","article-title":"Apoptosis recognition receptors regulate skin tissue repair in mice","volume":"12","author":"Justynski","year":"2023","journal-title":"eLife"},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Qiu, S., Liu, J., Chen, J., Li, Y., Bu, T., Li, Z., Zhang, L., Sun, W., Zhou, T., and Hu, W. (2024). Targeted delivery of MerTK protein via cell membrane engineered nanoparticle enhances efferocytosis and attenuates atherosclerosis in diabetic ApoE(-\/-) Mice. J. Nanobiotechnol., 22.","DOI":"10.1186\/s12951-024-02463-y"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"eaar3721","DOI":"10.1126\/scisignal.aar3721","article-title":"MerTK signaling in macrophages promotes the synthesis of inflammation resolution mediators by suppressing CaMKII activity","volume":"11","author":"Cai","year":"2018","journal-title":"Sci. Signal."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/imr.12376","article-title":"Apoptotic cell recognition receptors and scavenger receptors","volume":"269","author":"Penberthy","year":"2016","journal-title":"Immunol. Rev."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1172\/JCI97943","article-title":"Resolvins in inflammation: Emergence of the pro-resolving superfamily of mediators","volume":"128","author":"Serhan","year":"2018","journal-title":"J. Clin. Investig."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"ra21","DOI":"10.1126\/scisignal.2005864","article-title":"Mer signaling increases the abundance of the transcription factor LXR to promote the resolution of acute sterile inflammation","volume":"8","author":"Choi","year":"2015","journal-title":"Sci. Signal."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"e022352","DOI":"10.1161\/JAHA.122.022352","article-title":"Loss of PI3Kalpha Mediates Protection From Myocardial Ischemia-Reperfusion Injury Linked to Preserved Mitochondrial Function","volume":"12","author":"Zhabyeyev","year":"2023","journal-title":"J. Am. Heart Assoc."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"6526","DOI":"10.1073\/pnas.1524292113","article-title":"MerTK cleavage limits proresolving mediator biosynthesis and exacerbates tissue inflammation","volume":"113","author":"Cai","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"C776","DOI":"10.1152\/ajpcell.00145.2019","article-title":"Angiotensin II deteriorates advanced atherosclerosis by promoting MerTK cleavage and impairing efferocytosis through the ATR\/ROS\/p38 MAPK\/ADAM17 pathway","volume":"317","author":"Zhang","year":"2019","journal-title":"Am. J. Physiol.-Cell Physiol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"4161","DOI":"10.1007\/s00018-021-03779-w","article-title":"Contribution of ADAM17 and related ADAMs in cardiovascular diseases","volume":"78","author":"Kawai","year":"2021","journal-title":"Cell Mol. Life Sci."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"e2303267","DOI":"10.1002\/adhm.202303267","article-title":"Genetically Engineered Macrophages Co-Loaded with CD47 Inhibitors Synergistically Reconstruct Efferocytosis and Improve Cardiac Remodeling Post Myocardial Ischemia Reperfusion Injury","volume":"13","author":"Tan","year":"2024","journal-title":"Adv. Healthc. Mater."},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Sufit, A., Lee-Sherick, A.B., DeRyckere, D., Rupji, M., Dwivedi, B., Varella-Garcia, M., Pierce, A.M., Kowalski, J., Wang, X., and Frye, S.V. (2016). MERTK Inhibition Induces Polyploidy and Promotes Cell Death and Cellular Senescence in Glioblastoma Multiforme. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0165107"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.jaut.2010.08.001","article-title":"Disrupted Mer receptor tyrosine kinase expression leads to enhanced MZ B-cell responses","volume":"35","author":"Shao","year":"2010","journal-title":"J. Autoimmun."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"283","DOI":"10.2353\/ajpath.2009.080807","article-title":"Up-regulation of soluble Axl and Mer receptor tyrosine kinases negatively correlates with Gas6 in established multiple sclerosis lesions","volume":"175","author":"Weinger","year":"2009","journal-title":"Am. J. Pathol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.7150\/thno.93036","article-title":"Disturbed flow impairs MerTK-mediated efferocytosis in aortic endothelial cells during atherosclerosis","volume":"14","author":"Wu","year":"2024","journal-title":"Theranostics"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1182\/blood-2008-05-158048","article-title":"Human protein S inhibits the uptake of AcLDL and expression of SR-A through Mer receptor tyrosine kinase in human macrophages","volume":"113","author":"Liao","year":"2009","journal-title":"Blood"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"5245308","DOI":"10.1155\/2020\/5245308","article-title":"Mechanistic Insights into the Oxidized Low-Density Lipoprotein-Induced Atherosclerosis","volume":"2020","author":"Khatana","year":"2020","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Liao, C.C., Xu, J.W., Huang, W.C., Chang, H.C., and Tung, Y.T. (2022). Plasma Proteomic Changes of Atherosclerosis after Exercise in ApoE Knockout Mice. Biology, 11.","DOI":"10.3390\/biology11020253"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1161\/CIRCRESAHA.117.311327","article-title":"MerTK Cleavage on Resident Cardiac Macrophages Compromises Repair After Myocardial Ischemia Reperfusion Injury","volume":"121","author":"DeBerge","year":"2017","journal-title":"Circ. Res."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1161\/CIRCRESAHA.113.302155","article-title":"A MERry response after myocardial infarction","volume":"113","author":"Arandjelovic","year":"2013","journal-title":"Circ. Res."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"100286","DOI":"10.1016\/j.xpro.2020.100286","article-title":"Isolation of exophers from cardiomyocyte-reporter mouse strains by fluorescence-activated cell sorting","volume":"2","author":"Hidalgo","year":"2021","journal-title":"STAR Protoc."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.cell.2020.08.031","article-title":"A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart","volume":"183","author":"Santiago","year":"2020","journal-title":"Cell"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.yjmcc.2015.08.009","article-title":"Cardiomyocytes induce macrophage receptor shedding to suppress phagocytosis","volume":"87","author":"Zhang","year":"2015","journal-title":"J. Mol. Cell Cardiol."},{"key":"ref_156","first-page":"187","article-title":"Neutrophils orchestrate post-myocardial infarction healing by polarizing macrophages towards a reparative phenotype","volume":"38","author":"Horckmans","year":"2017","journal-title":"Eur. Heart J."},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Wei, Z., Chen, Z., Zhao, Y., Fan, F., Xiong, W., Song, S., Yin, Y., Hu, J., Yang, K., and Yang, L. (2021). Mononuclear phagocyte system blockade using extracellular vesicles modified with CD47 on membrane surface for myocardial infarction reperfusion injury treatment. Biomaterials, 275.","DOI":"10.1016\/j.biomaterials.2021.121000"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/nature18935","article-title":"CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis","volume":"536","author":"Kojima","year":"2016","journal-title":"Nature"},{"key":"ref_159","doi-asserted-by":"crossref","unstructured":"Smart, S.K., Vasileiadi, E., Wang, X.D., DeRyckere, D., and Graham, D.K. (2018). The Emerging Role of TYRO3 as a Therapeutic Target in Cancer. Cancers, 10.","DOI":"10.3390\/cancers10120474"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1160\/TH09-11-0787","article-title":"Association study between polymorphims in GAS6-TAM genes and carotid atherosclerosis","volume":"104","author":"Hurtado","year":"2010","journal-title":"Thromb. Haemost."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1126\/science.aaf1358","article-title":"The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity","volume":"352","author":"Chan","year":"2016","journal-title":"Science"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1161\/CIRCRESAHA.118.311362","article-title":"NLRP3 Inflammasome and the IL-1 Pathway in Atherosclerosis","volume":"122","author":"Grebe","year":"2018","journal-title":"Circ. Res."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/bs.ircmb.2021.02.002","article-title":"Tyro3, Axl, Mertk receptor-mediated efferocytosis and immune regulation in the tumor environment","volume":"361","author":"Zhou","year":"2021","journal-title":"Int. Rev. Cell Mol. Biol."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/23\/12736\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:40:23Z","timestamp":1760114423000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/23\/12736"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,27]]},"references-count":163,"journal-issue":{"issue":"23","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["ijms252312736"],"URL":"https:\/\/doi.org\/10.3390\/ijms252312736","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,27]]}}}