{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:37:34Z","timestamp":1760146654219,"version":"build-2065373602"},"reference-count":36,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T00:00:00Z","timestamp":1732665600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Federal University of Par\u00e1 (UFPA)","award":["88887.919930\/2023-00","88887.842950\/2023-00","88887.940110\/2023-00","88887.974329\/2024-00","88887.713868\/2022-00"],"award-info":[{"award-number":["88887.919930\/2023-00","88887.842950\/2023-00","88887.940110\/2023-00","88887.974329\/2024-00","88887.713868\/2022-00"]}]},{"DOI":"10.13039\/501100002322","name":"Coordination for the Improvement of Higher Education Personnel","doi-asserted-by":"publisher","award":["88887.919930\/2023-00","88887.842950\/2023-00","88887.940110\/2023-00","88887.974329\/2024-00","88887.713868\/2022-00"],"award-info":[{"award-number":["88887.919930\/2023-00","88887.842950\/2023-00","88887.940110\/2023-00","88887.974329\/2024-00","88887.713868\/2022-00"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"name":"PROPESP-UFPA","award":["88887.919930\/2023-00","88887.842950\/2023-00","88887.940110\/2023-00","88887.974329\/2024-00","88887.713868\/2022-00"],"award-info":[{"award-number":["88887.919930\/2023-00","88887.842950\/2023-00","88887.940110\/2023-00","88887.974329\/2024-00","88887.713868\/2022-00"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The rs12979860 polymorphism, related to the IFNL4 gene, is suggested as a factor that impacts fibrosis progression in hepatitis C virus (HCV) infection and exhibits a wide distribution pattern across global populations. In this retrospective cross-sectional study, we aimed to investigate the frequency of this variant in an Amazonian population from Brazil, as well as its association with liver fibrosis development and its staging in HCV carriers. Our results show a significant association of the TT genotype in the sample of patients with HCV (OR = 2.291; 95% CI = 1.088\u20134.826; p = 0.033) and the greater frequency of the T allele (62.1%), which is similar to the those of African populational groups. Populational genetics analysis showed significant differences in allele frequencies on global levels. The frequency of the C allele in the study population (37.8%) was like that of the African population (39.7%), and differed from all other populations, which ranged from 62.5% to 92.9%. These findings suggest that rs12979860 plays a role in susceptibility to hepatitis C. Additionally, they allow us to propose that the response to hepatitis C infection in this group may resemble that of the African population.<\/jats:p>","DOI":"10.3390\/ijms252312764","type":"journal-article","created":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T11:26:08Z","timestamp":1732706768000},"page":"12764","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Frequencies of an IFNL4 Variant in an Admixed Population from Amazonia and Its Influence on Hepatitis C Infection"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2195-0366","authenticated-orcid":false,"given":"Carolina Cabral","family":"Angelim","sequence":"first","affiliation":[{"name":"Laboratory of Human and Medical Genetics, Federal University of Par\u00e1, Bel\u00e9m 66073-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2264-0493","authenticated-orcid":false,"given":"\u00c1lesson Adam Fonseca","family":"Andrade","sequence":"additional","affiliation":[{"name":"Laboratory of Human and Medical Genetics, Federal University of Par\u00e1, Bel\u00e9m 66073-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata Santos","family":"de Sousa","sequence":"additional","affiliation":[{"name":"Virology Laboratory, Federal University of Par\u00e1, Bel\u00e9m 66073-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raissa Lima","family":"Correa","sequence":"additional","affiliation":[{"name":"Laboratory of Human and Medical Genetics, Federal University of Par\u00e1, Bel\u00e9m 66073-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5572-0561","authenticated-orcid":false,"given":"Amanda Roberta Vieira","family":"Sacramento","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Virology, Evandro Chagas Institute, Ananindeua 67030-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5479-4059","authenticated-orcid":false,"given":"Let\u00edcia Dias","family":"Martins","sequence":"additional","affiliation":[{"name":"Laboratory of Human and Medical Genetics, Federal University of Par\u00e1, Bel\u00e9m 66073-000, Brazil"},{"name":"Postgraduate Program in Virology, Evandro Chagas Institute, Ananindeua 67030-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0278-4972","authenticated-orcid":false,"given":"Simone Regina Souza da Silva","family":"Conde","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Institute of Health Sciences, Federal University of Par\u00e1, Bel\u00e9m 66055-080, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1135-6507","authenticated-orcid":false,"given":"Antonio Carlos Ros\u00e1rio","family":"Vallinoto","sequence":"additional","affiliation":[{"name":"Virology Laboratory, Federal University of Par\u00e1, Bel\u00e9m 66073-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2044-9350","authenticated-orcid":false,"given":"Rosimar Neris Martins","family":"Feitosa","sequence":"additional","affiliation":[{"name":"Virology Laboratory, Federal University of Par\u00e1, Bel\u00e9m 66073-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8916-0283","authenticated-orcid":false,"given":"Greice de Lemos Cardoso","family":"Costa","sequence":"additional","affiliation":[{"name":"Laboratory of Human and Medical Genetics, Federal University of Par\u00e1, Bel\u00e9m 66073-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/ng.2521","article-title":"A Variant Upstream of IFNL3 (IL28B) Creating a New Interferon Gene IFNL4 Is Associated with Impaired Clearance of Hepatitis C Virus","volume":"45","author":"Muchmore","year":"2013","journal-title":"Nat. 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