{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:25:28Z","timestamp":1792427128940,"version":"4.5.0"},"reference-count":52,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T00:00:00Z","timestamp":1732752000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Resveratrol is a natural polyphenolic compound that may have multiple influences on human health, including antiaging, anti-inflammatory, anti-neoplastic, antioxidant, insulin-sensitizing, cardioprotective and vasodilating activities. Growing evidence also suggests a potential positive effect of resveratrol on female fertility. The aim of the present study was to collate and appraise the scientific literature on the relationship between resveratrol and female fertility. We systematically searched Medline, PubMed, Web of Science and Embase from the databases\u2019 inception (1951, 1951, 1947 and 1900, respectively) until 9th May 2024. All in vivo or in vitro retrospective or prospective studies reporting the effects of resveratrol interventions on women\u2019s fertility were included. We ultimately incorporated twenty-four studies into a systematic review with a narrative summary of the results; of those studies, nine were performed on women seeking natural or assisted fertility, and fifteen were in vitro studies performed on human cells and tissues in different stages of the reproductive cascade. The current literature, though limited, suggests that resveratrol may play a role in female infertility. Specifically, it may significantly and positively impact reproductive outcomes, owing to its potential therapeutic effects improving ovarian function. Further studies are now needed to better understand resveratrol\u2019s effects and define the optimal dosage and periods of intake to maximize beneficial effects, as well as to prevent adverse outcomes on implantation, subsequent pregnancy and the fetus.<\/jats:p>","DOI":"10.3390\/ijms252312792","type":"journal-article","created":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T03:21:23Z","timestamp":1732764083000},"page":"12792","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Resveratrol and Female Fertility: A Systematic Review"],"prefix":"10.3390","volume":"25","author":[{"given":"Alessandro","family":"Bertoldo","sequence":"first","affiliation":[{"name":"U.O.S.D. of Assisted Reproductive Technologies \u201cG. Beltrame\u201d, Ospedale di Oderzo, ULSS2, 31046 Treviso, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4122-0774","authenticated-orcid":false,"given":"Damiano","family":"Pizzol","sequence":"additional","affiliation":[{"name":"Health Unit, Eni, Maputo 1100, Mozambique"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1628-9948","authenticated-orcid":false,"given":"Dong Keon","family":"Yon","sequence":"additional","affiliation":[{"name":"Center for Digital Health, Medical Science Research Institute, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul 02447, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maura","family":"Callegari","sequence":"additional","affiliation":[{"name":"U.O.S.D. of Assisted Reproductive Technologies \u201cG. Beltrame\u201d, Ospedale di Oderzo, ULSS2, 31046 Treviso, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Gobbo","sequence":"additional","affiliation":[{"name":"U.O.S.D. of Assisted Reproductive Technologies \u201cG. Beltrame\u201d, Ospedale di Oderzo, ULSS2, 31046 Treviso, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierluigi","family":"Cuccurese","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Ospedale di Oderzo, ULSS2, 31046 Treviso, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie","family":"Butler","sequence":"additional","affiliation":[{"name":"Faculty of Science and Engineering, Anglia Ruskin University, Cambridge CB1 1PT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanna","family":"Caminada","sequence":"additional","affiliation":[{"name":"Health Unit, Eni, 00144 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Stebbing","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, Anglia Ruskin University, Cambridge CB1 1PT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Richardson","sequence":"additional","affiliation":[{"name":"The Queen Elizabeth Hospital King\u2019s Lynn NHS Foundation Trust, King\u2019s Lynn PE30 4ET, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Gawronska","sequence":"additional","affiliation":[{"name":"Centre for Health, Performance and Wellbeing, Anglia Ruskin University, Cambridge CB1 1PT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5340-9833","authenticated-orcid":false,"given":"Lee","family":"Smith","sequence":"additional","affiliation":[{"name":"Centre for Health, Performance and Wellbeing, Anglia Ruskin University, Cambridge CB1 1PT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Hasan, M., and Bae, H. 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