{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T12:55:35Z","timestamp":1782305735044,"version":"3.54.5"},"reference-count":44,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T00:00:00Z","timestamp":1732838400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science and Higher Education of the Russian Federation","award":["Grant 075-15-2021-1344"],"award-info":[{"award-number":["Grant 075-15-2021-1344"]}]},{"name":"Ministry of Science and Higher Education of the Russian Federation","award":["124012400363-2 (08b-23\/110-03)"],"award-info":[{"award-number":["124012400363-2 (08b-23\/110-03)"]}]},{"name":"Lomonosov MSU","award":["Grant 075-15-2021-1344"],"award-info":[{"award-number":["Grant 075-15-2021-1344"]}]},{"name":"Lomonosov MSU","award":["124012400363-2 (08b-23\/110-03)"],"award-info":[{"award-number":["124012400363-2 (08b-23\/110-03)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The spiny mouse (Acomys species) is capable of scarless wound regeneration through largely yet unknown mechanisms. To investigate whether this capacity is related to peculiarities of the hemostatic system, we studied the blood of Acomys cahirinus in comparison to Mus musculus (Balb\/c) to reveal differences in blood composition and clotting in both males and females. In response to surgical manipulations, blood clots formed in wounds of Acomys comprised a stronger hemostatic seal with reduced surgical bleeding in comparison with Balb\/c. Acomys demonstrated notably shorter tail bleeding times and elevated clottable fibrinogen levels. Histological analysis revealed that clots from Acomys blood had densely packed fibrin-rich clots with pronounced fibrin segregation from erythrocytes. Acomys exhibited superior plasma clot stiffness as revealed with thromboelastography. The latter two characteristics are likely due to hyperfibrinogenemia. Light transmission platelet aggregometry demonstrated that ADP-induced platelet aggregates in Acomys males are stable, unlike the aggregates formed in the plasma of Balb\/c undergoing progressive disaggregation over time. There were no apparent distinctions in platelet contractility and baseline expression of phosphatidylserine. Hematological profiling revealed a reduced erythrocytes count but increased mean corpuscular volume and hemoglobin content in Acomys. These results demonstrate the distinctive hemostatic potential of Acomys cahirinus, which may contribute to their remarkable regenerative capacity.<\/jats:p>","DOI":"10.3390\/ijms252312867","type":"journal-article","created":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T03:50:57Z","timestamp":1733111457000},"page":"12867","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Distinct Hemostasis and Blood Composition in Spiny Mouse Acomys cahirinus"],"prefix":"10.3390","volume":"25","author":[{"given":"Nikita S.","family":"Filatov","sequence":"first","affiliation":[{"name":"Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8597-811X","authenticated-orcid":false,"given":"Rafael R.","family":"Khismatullin","sequence":"additional","affiliation":[{"name":"Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8888-8395","authenticated-orcid":false,"given":"Airat I.","family":"Bilyalov","sequence":"additional","affiliation":[{"name":"Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia"},{"name":"Loginov Moscow Clinical Scientific Center, 111123 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7243-8832","authenticated-orcid":false,"given":"Alina I.","family":"Khabirova","sequence":"additional","affiliation":[{"name":"Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7647-2966","authenticated-orcid":false,"given":"Shakhnoza M.","family":"Salyakhutdinova","sequence":"additional","affiliation":[{"name":"Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman V.","family":"Ursan","sequence":"additional","affiliation":[{"name":"Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roza N.","family":"Kasimova","sequence":"additional","affiliation":[{"name":"City Hospital \u2116 11, 420127 Kazan, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8790-1818","authenticated-orcid":false,"given":"Alina D.","family":"Peshkova","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Insaf I.","family":"Gazizov","sequence":"additional","affiliation":[{"name":"Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2339-261X","authenticated-orcid":false,"given":"Elena I.","family":"Shagimardanova","sequence":"additional","affiliation":[{"name":"Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia"},{"name":"Loginov Moscow Clinical Scientific Center, 111123 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary V.","family":"Woroncow","sequence":"additional","affiliation":[{"name":"Institute for Regenerative Medicine, Lomonosov Moscow State University, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrey P.","family":"Kiyasov","sequence":"additional","affiliation":[{"name":"Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0643-1496","authenticated-orcid":false,"given":"Rustem I.","family":"Litvinov","sequence":"additional","affiliation":[{"name":"Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oleg A.","family":"Gusev","sequence":"additional","affiliation":[{"name":"Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia"},{"name":"LIFT, Life Improvement by Future Technologies Institute, 121205 Moscow, Russia"},{"name":"Intractable Disease Research Center, Graduate School of Medicine, Juntendo University, Tokyo 113-8421, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"dev167718","DOI":"10.1242\/dev.167718","article-title":"Model systems for regeneration: The spiny mouse, Acomys cahirinus","volume":"147","author":"Maden","year":"2020","journal-title":"Development"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Maden, M., Brant, J.O., Rubiano, A., Sandoval, A.G.W., Simmons, C., Mitchell, R., Collin-Hooper, H., Jacobson, J., Omairi, S., and Patel, K. 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