{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T19:32:19Z","timestamp":1784835139502,"version":"3.55.0"},"reference-count":63,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T00:00:00Z","timestamp":1732838400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministero dell\u2019Universit\u00e0 e della Ricerca","award":["202292PHR2"],"award-info":[{"award-number":["202292PHR2"]}]},{"name":"Ministero dell\u2019Universit\u00e0 e della Ricerca","award":["MIUR D.M. 737\/2021"],"award-info":[{"award-number":["MIUR D.M. 737\/2021"]}]},{"name":"Ministero dell\u2019Istruzione e del Merito","award":["202292PHR2"],"award-info":[{"award-number":["202292PHR2"]}]},{"name":"Ministero dell\u2019Istruzione e del Merito","award":["MIUR D.M. 737\/2021"],"award-info":[{"award-number":["MIUR D.M. 737\/2021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Bridging the gap between cortical morphometric remodeling and gene expression can help to clarify the effects of the selective brain accumulation of Amyloid-\u03b2 (A\u03b2) and tau proteins occurring in the Alzheimer\u2019s disease (AD). To this aim, we derived morphometric similarity (MS) networks from 126 A\u03b2- and tau-positive (A\u03b2+\/tau+) and 172 A\u03b2\u2212\/tau\u2212 subjects, and we investigated the association between group-wise regional MS differences and transcriptional correlates thanks to an imaging transcriptomics approach grounded in the Allen Human Brain Atlas (AHBA). The expressed gene with the highest correlation with MS alterations was BCHE, a gene related to A\u03b2 homeostasis. In addition, notably, among the most promising results derived from the enrichment analysis, we found the immune response to be a biological process and astrocytes, microglia, and oligodendrocyte precursors for the cell types. In summary, by relating cortical MS and AHBA-derived transcriptomics, we were able to retrieve findings suggesting the biological mechanisms underlying the A\u03b2- and tau- induced cortical MS alterations in the AD continuum.<\/jats:p>","DOI":"10.3390\/ijms252312871","type":"journal-article","created":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T04:01:29Z","timestamp":1733198489000},"page":"12871","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Morphometric Similarity Patterning of Amyloid-\u03b2 and Tau Proteins Correlates with Transcriptomics in the Alzheimer\u2019s Disease Continuum"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5357-5180","authenticated-orcid":false,"given":"Lorenza","family":"Brusini","sequence":"first","affiliation":[{"name":"Department of Engineering for Innovation Medicine, University of Verona, 37134 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7817-7984","authenticated-orcid":false,"given":"Giorgio","family":"Dolci","sequence":"additional","affiliation":[{"name":"Department of Engineering for Innovation Medicine, University of Verona, 37134 Verona, Italy"},{"name":"Department of Computer Science, University of Verona, 37134 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9305-3376","authenticated-orcid":false,"given":"Lorenzo","family":"Pini","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, University of Padova, 35121 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7258-1463","authenticated-orcid":false,"given":"Federica","family":"Cruciani","sequence":"additional","affiliation":[{"name":"Department of Engineering for Innovation Medicine, University of Verona, 37134 Verona, Italy"},{"name":"Istituto Fondazione Oncologia Molecolare Ente del Terzo Settore (IFOM ETS)\u2013The Associazione Italiana per la Ricerca sul Cancro (AIRC) Institute of Molecular Oncology, 20139 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4582-0224","authenticated-orcid":false,"given":"Fabrizio","family":"Pizzagalli","sequence":"additional","affiliation":[{"name":"Department of Neurosciences \u201cRita Levi Montalcini\u201d, University of Turin, 10126 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8664-8630","authenticated-orcid":false,"given":"Paolo","family":"Provero","sequence":"additional","affiliation":[{"name":"Department of Neurosciences \u201cRita Levi Montalcini\u201d, University of Turin, 10126 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6889-3461","authenticated-orcid":false,"given":"Gloria","family":"Menegaz","sequence":"additional","affiliation":[{"name":"Department of Engineering for Innovation Medicine, University of Verona, 37134 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4153-3749","authenticated-orcid":false,"given":"Ilaria","family":"Boscolo Galazzo","sequence":"additional","affiliation":[{"name":"Department of Engineering for Innovation Medicine, University of Verona, 37134 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/s41583-021-00533-w","article-title":"The probabilistic model of Alzheimer disease: The amyloid hypothesis revised","volume":"23","author":"Frisoni","year":"2022","journal-title":"Nat. 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