{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:49:11Z","timestamp":1787028551208,"version":"build-2736575974"},"reference-count":65,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T00:00:00Z","timestamp":1732924800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Multiple sclerosis (MS) is a condition that is characterized by damage to the central nervous system (CNS) that causes patients to experience cognitive and physical difficulties. Although the disease has a complex etiology that involves genetic and environmental factors, little is known about the role of genes and gene loci in its development. Aims: This study aimed to investigate the effects of genes and gene loci on the immune system during the development of MS. We aimed to identify the main genes and gene loci that play roles in MS pathogenesis and the implications for the future development of clinical treatment approaches. A systematic review of articles published over the last decade was conducted. This review focused on studies about the genetic and epigenetic mechanisms underlying MS onset and progression. Genome-wide association studies (GWASs) as well as papers describing the role of the immune system in disease development were prioritized. Key genetic loci and immune system-related genes, such as HLA class II genes, are associated with MS susceptibility. Studies have also shown that epigenetic modifications, such as DNA methylation, influence disease progression via the immune system.<\/jats:p>","DOI":"10.3390\/ijms252312906","type":"journal-article","created":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T05:43:43Z","timestamp":1733118223000},"page":"12906","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Genes, Gene Loci, and Their Impacts on the Immune System in the Development of Multiple Sclerosis: A Systematic Review"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9793-0970","authenticated-orcid":false,"given":"Borros","family":"Arneth","sequence":"first","affiliation":[{"name":"Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, Hospital of the Universities of Giessen and Marburg (UKGM), Justus Liebig University Giessen, Feulgenstr. 12, 35392 Giessen, Germany"},{"name":"Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, Hospital of the Universities of Giessen and Marburg (UKGM), Philipps University Marburg, Baldinger Str., 35043 Marburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"a028944","DOI":"10.1101\/cshperspect.a028944","article-title":"Lifestyle and Environmental Factors in Multiple Sclerosis","volume":"9","author":"Alfredsson","year":"2019","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1177\/1352458511421105","article-title":"The major cause of multiple sclerosis is environmental: Genetics has a minor role\u2014Yes","volume":"17","author":"Taylor","year":"2011","journal-title":"Mult. Scler. J."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/nrneurol.2016.187","article-title":"Interactions between genetic, lifestyle and environmental risk factors for multiple sclerosis","volume":"13","author":"Olsson","year":"2017","journal-title":"Nat. Rev. Neurol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e1018","DOI":"10.1002\/cti2.1018","article-title":"Genome-wide association studies of multiple sclerosis","volume":"7","author":"Cotsapas","year":"2018","journal-title":"Clin. Transl. Immunol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1093\/bfgp\/elr004","article-title":"Genome-wide association studies in multiple sclerosis: Lessons and future prospects","volume":"10","author":"Kemppinen","year":"2011","journal-title":"Briefings Funct. Genom."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1101\/cshperspect.a028951","article-title":"Genetics of multiple sclerosis: An overview and new directions","volume":"8","author":"Patsopoulos","year":"2018","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Yousuf, A., and Qurashi, A. (2021). Noncoding RNAs in the pathogenesis of multiple sclerosis. Front. Genet., 12.","DOI":"10.3389\/fgene.2021.717922"},{"key":"ref_8","unstructured":"International Multiple Sclerosis Genetics Consortium (2019). Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility. Science, 365, eaav7188."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"International Multiple Sclerosis Genetics Consortium, Harroud, A., Stridh, P., McCauley, J.L., Saarela, J., Bosch, A.M.R.v.D., Engelenburg, H.J., Beecham, A.H., Alfredsson, L., and Alikhani, K. (2023). Locus for severity implicates CNS resilience in progression of multiple sclerosis. Nature, 619, 323\u2013331.","DOI":"10.1038\/s41586-023-06250-x"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Chan, V. (2020). Epigenetics in multiple sclerosis. Adv. Exp. Med. Biol., 1253.","DOI":"10.1007\/978-981-15-3449-2_12"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"4049","DOI":"10.1007\/s12035-016-9966-3","article-title":"DNA Methylation: A New Player in Multiple Sclerosis","volume":"54","author":"Li","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.tig.2017.09.004","article-title":"The Genetics of Multiple Sclerosis: From 0 to 200 in 50 Years","volume":"33","author":"Baranzini","year":"2017","journal-title":"Trends Genet."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s12017-014-8298-6","article-title":"Epigenetics of Multiple Sclerosis: An Updated Review","volume":"17","year":"2015","journal-title":"NeuroMolecular Med."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Maglione, A., Zuccal\u00e0, M., Tosi, M., Clerico, M., and Rolla, S. (2021). Host Genetics and Gut Microbiome: Perspectives for Multiple Sclerosis. Genes, 12.","DOI":"10.3390\/genes12081181"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Lu, H., Wu, P.-F., Zhang, W., and Liao, X. (2021). Circulating Interleukins and Risk of Multiple Sclerosis: A Mendelian Randomization Study. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.647588"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Catal\u00e0-Senent, J.F., Andreu, Z., Hidalgo, M.R., Soler-S\u00e1ez, I., Roig, F.J., Yanguas-Cas\u00e1s, N., Neva-Alejo, A., L\u00f3pez-Cerd\u00e1n, A., de la Iglesia-Vay\u00e1, M., and Stranger, B.E. (2023). A deep transcriptome meta-analysis reveals sex differences in multiple sclerosis. Neurobiol. Dis., 181.","DOI":"10.1016\/j.nbd.2023.106113"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1007\/s00439-015-1601-2","article-title":"A review of genome-wide association studies for multiple sclerosis: Classical and hypothesis-driven approaches","volume":"134","author":"Bashinskaya","year":"2015","journal-title":"Hum. Genet."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"21546","DOI":"10.1073\/pnas.2003339117","article-title":"Immune signatures of prodromal multiple sclerosis in monozygotic twins","volume":"117","author":"Gerdes","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/acn3.51244","article-title":"Clinical and transcriptional recovery profiles in pediatric and adult multiple sclerosis patients","volume":"8","author":"Menascu","year":"2020","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e2018457118","DOI":"10.1073\/pnas.2018457118","article-title":"Sunlight exposure exerts immunomodulatory effects to reduce multiple sclerosis severity","volume":"118","author":"Ostkamp","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Faber, H., Kurtoic, D., Krishnamoorthy, G., Weber, P., P\u00fctz, B., M\u00fcller-Myhsok, B., Weber, F., and Andlauer, T.F.M. (2020). Gene Expression in Spontaneous Experimental Autoimmune Encephalomyelitis Is Linked to Human Multiple Sclerosis Risk Genes. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.02165"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Stojkovic, L., Jovanovic, I., Dincic, E., Djordjevic, A., Kuveljic, J., Djuric, T., Stankovic, A., Vojinovic, S., and Zivkovic, M. (2024). Targeted RNAseq Revealed the Gene Expression Signature of Ferroptosis-Related Processes Associated with Disease Severity in Patients with Multiple Sclerosis. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25053016"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Ferr\u00e8, L., Filippi, M., and Esposito, F. (2020). Involvement of Genetic Factors in Multiple Sclerosis. Front. Cell. Neurosci., 14.","DOI":"10.3389\/fncel.2020.612953"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/ana.25263","article-title":"Genome sequencing uncovers phenocopies in primary progressive multiple sclerosis","volume":"84","author":"Jia","year":"2018","journal-title":"Ann. Neurol."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Horjus, J., van Mourik-Banda, T., Heerings, M.A.P., Hakobjan, M., De Witte, W., Heersema, D.J., Jansen, A.J., Strijbis, E.M.M., de Jong, B.A., and Slettenaar, A.E.J. (2022). Whole Exome Sequencing in Multi-Incident Families Identifies Novel Candidate Genes for Multiple Sclerosis. Int. J. Mol. Sci., 23.","DOI":"10.1101\/2022.02.28.22271609"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e2111920118","DOI":"10.1073\/pnas.2111920118","article-title":"Specific hypomethylation programs underpin B cell activation in early multiple sclerosis","volume":"118","author":"Ma","year":"2021","journal-title":"Proc. Natl. Acad. Sci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s12017-016-8422-x","article-title":"Epigenetic Modifications and Therapy in Multiple Sclerosis","volume":"19","author":"Aslani","year":"2017","journal-title":"NeuroMolecular Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.autrev.2019.05.010","article-title":"Aberrant expression of alternative splicing variants in multiple sclerosis\u2014A systematic review","volume":"18","author":"Hecker","year":"2019","journal-title":"Autoimmun. Rev."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1139\/gen-2022-0040","article-title":"miR-181a-5p is a potential candidate epigenetic biomarker in multiple sclerosis","volume":"65","author":"Emre","year":"2022","journal-title":"Genome"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.gpb.2015.09.004","article-title":"Applications of Next-Generation Sequencing in Systemic Autoimmune Diseases","volume":"13","author":"Ma","year":"2015","journal-title":"Genom. Proteom. Bioinform."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Sabaie, H., Salkhordeh, Z., Asadi, M.R., Ghafouri-Fard, S., Amirinejad, N., Behzadi, M.A., Hussen, B.M., Taheri, M., and Rezazadeh, M. (2021). Long Non-Coding RNA- Associated Competing Endogenous RNA Axes in T-Cells in Multiple Sclerosis. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.770679"},{"key":"ref_32","first-page":"1409069","article-title":"The Involvement of HLA Class II Alleles in Multiple Sclerosis: A Systematic Review with Meta-analysis","volume":"2019","author":"Capittini","year":"2019","journal-title":"Dis. Markers"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1093\/ije\/dyv364","article-title":"Meta-analysis of genome-wide association studies reveals genetic overlap between Hodgkin lymphoma and multiple sclerosis","volume":"45","author":"Khankhanian","year":"2016","journal-title":"Int. J. Epidemiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.tig.2021.04.012","article-title":"Multiple sclerosis: Doubling down on MHC","volume":"37","author":"Martin","year":"2021","journal-title":"Trends Genet."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.gene.2014.12.045","article-title":"Variants of CYP27B1 are associated with both multiple sclerosis and neuromyelitis optica patients in Han Chinese population","volume":"557","author":"Zhuang","year":"2015","journal-title":"Gene"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1038\/s41467-018-04732-5","article-title":"DNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in multiple sclerosis","volume":"9","author":"Kular","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/ana.24429","article-title":"A pharmacogenetic study implicates SLC9a9 in multiple sclerosis disease activity","volume":"78","author":"Esposito","year":"2015","journal-title":"Ann. Neurol."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Akkad, D.A., Olischewsky, A., Reiner, F., Hellwig, K., Esser, S., Epplen, J.T., Curk, T., Gold, R., and Haghikia, A. (2015). Combinations of Susceptibility Genes Are Associated with Higher Risk for Multiple Sclerosis and Imply Disease Course Specificity. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0127632"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1111\/ene.13565","article-title":"Global transcriptome profiling of mild relapsing-remitting versus primary progressive multiple sclerosis","volume":"25","author":"Koch","year":"2018","journal-title":"Eur. J. Neurol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1007\/s12031-018-1046-x","article-title":"CpG Island Methylation Patterns in Relapsing-Remitting Multiple Sclerosis","volume":"64","author":"Sokratous","year":"2018","journal-title":"J. Mol. Neurosci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/978-3-030-56153-6_3","article-title":"Targeting nuclear factor-kappa B signaling pathway by curcumin: Implications for the treatment of multiple sclerosis","volume":"1291","author":"Gachpazan","year":"2021","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.gene.2016.04.042","article-title":"Gene expression profiles of autophagy-related genes in multiple sclerosis","volume":"588","author":"Igci","year":"2016","journal-title":"Gene"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Bos, S.D., Page, C.M., Andreassen, B.K., Elboudwarej, E., Gustavsen, M.W., Briggs, F., Quach, H., Leikfoss, I.S., Bj\u00f8lgerud, A., and Berge, T. (2015). Genome-Wide DNA Methylation Profiles Indicate CD8+ T Cell Hypermethylation in Multiple Sclerosis. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0117403"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Creanza, T.M., Liguori, M., Liuni, S., Nuzziello, N., and Ancona, N. (2016). Meta-Analysis of Differential Connectivity in Gene Co-Expression Networks in Multiple Sclerosis. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17060936"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e1075","DOI":"10.1212\/NXI.0000000000001075","article-title":"T-Cell Specificity Influences Disease Heterogeneity in Multiple Sclerosis","volume":"8","author":"Cruciani","year":"2021","journal-title":"Neurol.\u2014Neuroimmunol. Neuroinflamm."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"5056","DOI":"10.1038\/ncomms6056","article-title":"Multiple sclerosis-associated IL2RA polymorphism controls GM-CSF production in human TH cells","volume":"5","author":"Hartmann","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"577650","DOI":"10.1016\/j.jneuroim.2021.577650","article-title":"Different neuroinflammatory gene expression profiles in highly active and benign multiple sclerosis","volume":"358","author":"Ivanova","year":"2021","journal-title":"J. Neuroimmunol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/tpj.2015.85","article-title":"Pharmacogenetic study of long-term response to interferon-\u03b2 treatment in multiple sclerosis","volume":"17","author":"Clarelli","year":"2017","journal-title":"Pharmacogenomics J."},{"key":"ref_49","unstructured":"International Multiple Sclerosis Genetics Consortium (2018). Low-frequency and rare-coding variation contributes to multiple sclerosis risk. Cell, 175, 1679.e7."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Carlberg, C., and Mycko, M.P. (2023). Linking Mechanisms of Vitamin D Signaling with Multiple Sclerosis. Cells, 12.","DOI":"10.3390\/cells12192391"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Burnard, S.M., Lea, R.A., Benton, M., Eccles, D., Kennedy, D.W., Lechner-Scott, J., and Scott, R.J. (2021). Capturing SNP Association across the NK Receptor and HLA Gene Regions in Multiple Sclerosis by Targeted Penalised Regression Models. Genes, 13.","DOI":"10.3390\/genes13010087"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1093\/brain\/awaa421","article-title":"Cell type-specific transcriptomics identifies neddylation as a novel therapeutic target in multiple sclerosis","volume":"144","author":"Kim","year":"2021","journal-title":"Brain"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.biocel.2015.05.010","article-title":"Genomic imprinting: A missing piece of the Multiple Sclerosis puzzle?","volume":"67","author":"Ruhrmann","year":"2015","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1152\/physiolgenomics.00060.2017","article-title":"Epigenetic research in multiple sclerosis: Progress, challenges, and opportunities","volume":"49","author":"Zheleznyakova","year":"2017","journal-title":"Physiol. Genom."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Hecker, M., Boxberger, N., Illner, N., Fitzner, B., Schr\u00f6der, I., Winkelmann, A., Dudesek, A., Meister, S., Koczan, D., and Lorenz, P. (2019). A genetic variant associated with multiple sclerosis inversely affects the expression of CD58 and microRNA-548ac from the same gene. PLOS Genet., 15.","DOI":"10.1371\/journal.pgen.1007961"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Liu, A., Manuel, A.M., Dai, Y., and Zhao, Z. (2022). Prioritization of risk genes in multiple sclerosis by a refined Bayesian framework followed by tissue-specificity and cell type feature assessment. BMC Genom., 23.","DOI":"10.1186\/s12864-022-08580-y"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"103383","DOI":"10.1016\/j.msard.2021.103383","article-title":"Human endogenous retrovirus and multiple sclerosis: A review and transcriptome findings","volume":"57","author":"Nali","year":"2022","journal-title":"Mult. Scler. Relat. Disord."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.jaad.2015.11.004","article-title":"Clustering of autoimmune diseases in patients with rosacea","volume":"74","author":"Egeberg","year":"2016","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1212\/WNL.0000000000001744","article-title":"Mitochondrial DNA sequence variation in multiple sclerosis","volume":"85","author":"Tranah","year":"2015","journal-title":"Neurology"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.jns.2017.02.015","article-title":"SOCS gene family expression profile in the blood of multiple sclerosis patients","volume":"375","author":"Toghi","year":"2017","journal-title":"J. Neurol. Sci."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Castro, K., Ntranos, A., Amatruda, M., Petracca, M., Kosa, P., Chen, E.Y., Morstein, J., Trauner, D., Watson, C.T., and Kiebish, M.A. Body Mass Index in Multiple Sclerosis modulates ceramide-induced DNA methylation and disease course. 2019, 43, 392\u2013410.","DOI":"10.1016\/j.ebiom.2019.03.087"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2928","DOI":"10.1016\/j.celrep.2016.08.036","article-title":"Dynamic Response Genes in CD4+ T Cells Reveal a Network of Interactive Proteins that Classifies Disease Activity in Multiple Sclerosis","volume":"16","author":"Hellberg","year":"2016","journal-title":"Cell Rep."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Davies, J.L., Thompson, S., Kaur-Sandhu, H., Sawcer, S., Coles, A., Ban, M., and Jones, J. (2016). Increased THEMIS First Exon Usage in CD4+ T-Cells Is Associated with a Genotype that Is Protective against Multiple Sclerosis. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0158327"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s40478-019-0705-7","article-title":"Transcriptome analysis of normal-appearing white matter reveals cortisol- and disease-associated gene expression profiles in multiple sclerosis","volume":"7","author":"Melief","year":"2019","journal-title":"Acta Neuropathol. Commun."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Khankhanian, P., Matsushita, T., Madireddy, L., Liz\u00e9e, A., Din, L., Mor\u00e9, J.M., Gourraud, P.-A., Hauser, S.L., Baranzini, S.E., and Oksenberg, J.R. (2015). Genetic contribution to multiple sclerosis risk among Ashkenazi Jews. BMC Med Genet., 16.","DOI":"10.1186\/s12881-015-0201-2"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/23\/12906\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:43:30Z","timestamp":1760114610000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/23\/12906"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,30]]},"references-count":65,"journal-issue":{"issue":"23","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["ijms252312906"],"URL":"https:\/\/doi.org\/10.3390\/ijms252312906","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,30]]}}}