{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T22:33:31Z","timestamp":1788734011650,"version":"build-2803163510"},"reference-count":90,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T00:00:00Z","timestamp":1733184000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fundaci\u00f3n Universidad de Oviedo","award":["FUO-22-043"],"award-info":[{"award-number":["FUO-22-043"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Ageing leads to a gradual deterioration of the organs, with the brain being particularly susceptible, often leading to neurodegeneration. This process includes well-known changes such as tau hyperphosphorylation and beta-amyloid deposition, which are commonly associated with neurodegenerative diseases but are also present in ageing. These structures are triggered by earlier cellular changes such as energy depletion and impaired protein synthesis, both of which are essential for cell function. These changes may in part be induced by environmental pollution, which has been shown to accelerate these processes. Cold Atmospheric Plasma (CAP) or atmospheric pressure gas discharge plasmas have shown promise in activating the immune system and improving cellular function in vitro, although their effects at the organ level remain poorly understood. Our aim in this work is to investigate the effect of a device that combines CAP treatment with the effective removal of environmental nanoparticles, typical products of pollution, on the activity of aged mouse brains. The results showed an increase in energy capacity, a reduction in reticulum stress and an activation of cellular autophagic clearance, minimising aggresomes in the brain. This leads to a reduction in key markers of neurodegeneration such as tau hyperphosphorylation and beta-amyloid deposition, demonstrating the efficacy of the tested product at the brain level.<\/jats:p>","DOI":"10.3390\/ijms252312986","type":"journal-article","created":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T04:01:29Z","timestamp":1733198489000},"page":"12986","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Combining Cold Atmospheric Plasma and Environmental Nanoparticle Removal Device Reduces Neurodegenerative Markers"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-4796-4965","authenticated-orcid":false,"given":"Nerea","family":"Men\u00e9ndez-Coto","sequence":"first","affiliation":[{"name":"Department of Morphology and Cell Biology, University of Oviedo, 33006 Oviedo, Spain"},{"name":"Research Group Oxidative Stress Knowledge and Advanced Research (OSKAR), Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA), 33011 Oviedo, Spain"},{"name":"Instituto de Neurociencias del Principado de Asturias (INEUROPA), 33006 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8422-230X","authenticated-orcid":false,"given":"Claudia","family":"Garcia-Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Morphology and Cell Biology, University of Oviedo, 33006 Oviedo, Spain"},{"name":"Research Group Oxidative Stress Knowledge and Advanced Research (OSKAR), Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA), 33011 Oviedo, Spain"},{"name":"Instituto de Neurociencias del Principado de Asturias (INEUROPA), 33006 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Javier","family":"Baena-Huerta","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA), 33011 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4432-9652","authenticated-orcid":false,"given":"Rub\u00e9n","family":"Zapata-P\u00e9rez","sequence":"additional","affiliation":[{"name":"UCAM HiTech Sport & Health Innovation Hub, Universidad Cat\u00f3lica de Murcia, Guadalupe de Maciascoque, 30107 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rub\u00e9n","family":"Rabad\u00e1n-Ros","sequence":"additional","affiliation":[{"name":"UCAM HiTech Sport & Health Innovation Hub, Universidad Cat\u00f3lica de Murcia, Guadalupe de Maciascoque, 30107 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0554-2365","authenticated-orcid":false,"given":"Estrella","family":"N\u00fa\u00f1ez-Delicado","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias de la Salud, Universidad Cat\u00f3lica San Antonio de Murcia 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Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6609-6258","authenticated-orcid":false,"given":"Ana","family":"Coto-Montes","sequence":"additional","affiliation":[{"name":"Department of Morphology and Cell Biology, University of Oviedo, 33006 Oviedo, Spain"},{"name":"Research Group Oxidative Stress Knowledge and Advanced Research (OSKAR), Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA), 33011 Oviedo, Spain"},{"name":"Instituto de Neurociencias del Principado de Asturias (INEUROPA), 33006 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1038\/461895a","article-title":"Alzheimer\u2019s Disease","volume":"461","author":"Mucke","year":"2009","journal-title":"Nature"},{"key":"ref_2","first-page":"263","article-title":"An Insight into the Role 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