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These protein states may be the most toxic agents in the pathogenesis of Alzheimer\u2019s and Parkinson\u2019s disease. It was shown that oligomers are important players in the aggregation cascade of these proteins. The structural information about these structural states has been provided by methods such as solution and solid-state NMR, cryo-EM, crosslinking mass spectrometry, AFM, TEM, etc., as well as from hybrid structural biology approaches combining experiments with computational modelling and simulations. The reliable structural models of these protein states may provide valuable information for future drug design and therapies.<\/jats:p>","DOI":"10.3390\/ijms252313049","type":"journal-article","created":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T10:07:10Z","timestamp":1733306830000},"page":"13049","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Structures of Oligomeric States of Tau Protein, Amyloid-\u03b2, \u03b1-Synuclein and Prion Protein Implicated in Alzheimer\u2019s Disease, Parkinson\u2019s Disease and Prionopathies"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1996-6812","authenticated-orcid":false,"given":"Ondrej","family":"Cehlar","sequence":"first","affiliation":[{"name":"Institute of Neuroimmunology, Slovak Academy of Sciences, 84510 Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefana","family":"Njemoga","sequence":"additional","affiliation":[{"name":"Institute of Neuroimmunology, Slovak Academy of Sciences, 84510 Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian","family":"Horvath","sequence":"additional","affiliation":[{"name":"Institute of Neuroimmunology, Slovak Academy of Sciences, 84510 Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Cizmazia","sequence":"additional","affiliation":[{"name":"Institute of Neuroimmunology, Slovak Academy of Sciences, 84510 Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0837-9564","authenticated-orcid":false,"given":"Zuzana","family":"Bednarikova","sequence":"additional","affiliation":[{"name":"Institute of Experimental Physics, Slovak Academy of Sciences, 04001 Kosice, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0388-3078","authenticated-orcid":false,"given":"Exequiel E.","family":"Barrera","sequence":"additional","affiliation":[{"name":"Instituto de Histolog\u00eda y Embriolog\u00eda (IHEM), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), CC56, Universidad Nacional de Cuyo, Mendoza M5502JMA, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"8160","DOI":"10.1523\/JNEUROSCI.4809-05.2006","article-title":"Prefibrillar Amyloid Aggregates Could Be Generic Toxins in Higher Organisms","volume":"26","author":"Baglioni","year":"2006","journal-title":"J. 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