{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T15:52:37Z","timestamp":1790610757070,"version":"4.1.0"},"reference-count":249,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T00:00:00Z","timestamp":1733875200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Union\u2014the European Regional Development Fund within the Operational Programme \u201cInnovative economy\u201d"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Numerous compounds involved in the regulation of the cardiovascular system are also engaged in the control of metabolism. This review gives a survey of literature showing that arginine vasopressin (AVP), which is an effective cardiovascular peptide, exerts several direct and indirect metabolic effects and may play the role of the link adjusting blood supply to metabolism of tissues. Secretion of AVP and activation of AVP receptors are regulated by changes in blood pressure and body fluid osmolality, hypoxia, hyperglycemia, oxidative stress, inflammation, and several metabolic hormones; moreover, AVP turnover is regulated by insulin. Acting on V1a receptors in the liver, AVP stimulates glycogenolysis, reduces synthesis of glycogen, and promotes fatty acid synthesis and acetyl CoA carboxylase activity. Stimulating V1b receptors in the pancreatic islands, AVP promotes release of insulin and glucagon-like peptide-1 (GLP-1) and potentiates stimulatory effects of glucose and ACTH on secretion of insulin. Simultaneously, insulin increases AVP secretion by neurons of the paraventricular nucleus and the supraoptic nucleus. There is strong evidence that secretion of AVP and its metabolic effectiveness are significantly altered in metabolic and cardiovascular diseases. Both experimental and clinical data indicate that inappropriate interactions of AVP and insulin play an important role in the development of insulin resistance in obesity and diabetes mellitus.<\/jats:p>","DOI":"10.3390\/ijms252413307","type":"journal-article","created":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T12:58:49Z","timestamp":1733921929000},"page":"13307","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Molecular Interaction Between Vasopressin and Insulin in Regulation of Metabolism: Impact on Cardiovascular and Metabolic Diseases"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3761-508X","authenticated-orcid":false,"given":"Ewa","family":"Szczepanska-Sadowska","sequence":"first","affiliation":[{"name":"Department of Experimental and Clinical Physiology, Centre for Preclinical Research, Medical University of Warsaw, 02-097 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Cudnoch-J\u0119drzejewska","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Physiology, Centre for Preclinical Research, Medical University of Warsaw, 02-097 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3535-715X","authenticated-orcid":false,"given":"Tymoteusz","family":"\u017bera","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Physiology, Centre for Preclinical Research, Medical University of Warsaw, 02-097 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/s41581-020-0278-5","article-title":"Genetics of Diabetes Mellitus and Diabetes Complications","volume":"16","author":"Cole","year":"2020","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"49","DOI":"10.2337\/dc17-0426","article-title":"Five-Year Effectiveness of the Multidisciplinary Risk Assessment and Management Programme-Diabetes Mellitus (RAMP-DM) on Diabetes-Related Complications and Health Service Uses-A Population-Based and Propensity-Matched Cohort Study","volume":"41","author":"Wan","year":"2018","journal-title":"Diabetes Care"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1001\/jama.2015.7008","article-title":"Association of Cardiometabolic Multimorbidity with Mortality","volume":"314","author":"Kaptoge","year":"2015","journal-title":"JAMA"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1016\/j.jacc.2021.02.057","article-title":"Therapeutic Manipulation of Myocardial Metabolism: JACC State-of-the-Art Review","volume":"77","author":"Honka","year":"2021","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"3332","DOI":"10.1210\/JC.2015-2362","article-title":"Copeptin, Insulin Resistance, and Risk of Incident Diabetes in Older Men","volume":"100","author":"Wannamethee","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_6","unstructured":"Pilowsky, P.M. (2023). Chapter 2-The Contribution of Angiotensin Peptides to Cardiovascular Neuroregulation in Health and Disease. Angiotensin, Academic Press. Molecular Mediators in Health and Disease: How Cells Communicate."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1053\/meta.2002.34052","article-title":"Glucose Dependency of Arginine Vasopressin-Induced Insulin and Glucagon Release from the Perfused Rat Pancreas","volume":"51","author":"Hsu","year":"2002","journal-title":"Metabolism"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Mavani, G.P., DeVita, M.V., and Michelis, M.F. (2015). A Review of the Nonpressor and Nonantidiuretic Actions of the Hormone Vasopressin. Front. Med., 2.","DOI":"10.3389\/fmed.2015.00019"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1111\/j.1365-2265.1985.tb00145.x","article-title":"The Effect of Vasopressin Infusion on Glucose Metabolism in Man","volume":"22","author":"Spruce","year":"1985","journal-title":"Clin. Endocrinol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1172\/JCI114626","article-title":"Insulin-Induced Hypoglycemia Stimulates Corticotropin-Releasing Factor and Arginine Vasopressin Secretion into Hypophysial Portal Blood of Conscious, Unrestrained Rams","volume":"85","author":"Caraty","year":"1990","journal-title":"J. Clin. Investig."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1007\/s40618-017-0807-7","article-title":"Copeptin and Insulin Resistance: Effect Modification by Age and 11 \u03b2-HSD2 Activity in a Population-Based Study","volume":"41","author":"Canivell","year":"2018","journal-title":"J. Endocrinol. Investig."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"15724","DOI":"10.1016\/S0021-9258(18)55457-0","article-title":"Mechanisms of the Stimulation of Insulin Release by Arginine-Vasopressin in Normal Mouse Islets","volume":"265","author":"Gao","year":"1990","journal-title":"J. Biol. Chem."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1097\/PSY.0000000000000768","article-title":"Association of Copeptin With Sense of Coherence in Individuals with Varying Degrees of Glucose Intolerance","volume":"82","author":"Madhu","year":"2020","journal-title":"Psychosom. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"54","DOI":"10.2337\/diab.38.1.54","article-title":"Vasopressin in Rats with Genetic and Streptozocin-Induced Diabetes","volume":"38","author":"Brooks","year":"1989","journal-title":"Diabetes"},{"key":"ref_15","first-page":"E538","article-title":"Effect of Insulin on Osmoregulation of Vasopressin","volume":"252","author":"Vokes","year":"1987","journal-title":"Am. J. Physiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"503","DOI":"10.2337\/diab.28.5.503","article-title":"Plasma Vasopressin in Uncontrolled Diabetes Mellitus","volume":"28","author":"Zerbe","year":"1979","journal-title":"Diabetes"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.ejphar.2009.09.017","article-title":"Enhanced Effect of Neuropeptide Y on Food Intake Caused by Blockade of the V(1A) Vasopressin Receptor","volume":"622","author":"Aoyagi","year":"2009","journal-title":"Eur. J. Pharmacol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0031-9384(91)90251-I","article-title":"Mechanisms of Vasopressin\u2019s Anorectic Effect","volume":"49","author":"Langhans","year":"1991","journal-title":"Physiol. Behav."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s12576-021-00802-4","article-title":"Chemogenetic Activation of Endogenous Arginine Vasopressin Exerts Anorexigenic Effects via Central Nesfatin-1\/NucB2 Pathway","volume":"71","author":"Sanada","year":"2021","journal-title":"J. Physiol. Sci."},{"key":"ref_20","first-page":"1277","article-title":"Plasma and Cerebrospinal Fluid Measures of Arginine Vasopressin Secretion in Patients with Bulimia Nervosa and in Healthy Subjects","volume":"74","author":"Demitrack","year":"1992","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1017\/S0007114516002804","article-title":"Oxidative Stress and Nitric Oxide Are Increased in Obese Children and Correlate with Cardiometabolic Risk and Renal Function","volume":"116","author":"Sousa","year":"2016","journal-title":"Br. J. Nutr."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"F1143","DOI":"10.1152\/ajprenal.00664.2013","article-title":"Renal Vasoconstriction by Vasopressin V1a Receptors Is Modulated by Nitric Oxide, Prostanoids, and Superoxide but Not the ADP Ribosyl Cyclase CD38","volume":"306","author":"Moss","year":"2014","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1007\/s001250050962","article-title":"Upregulation of Hypothalamic Nitric Oxide Synthase Gene Expression in Streptozotocin-Induced Diabetic Rats","volume":"41","author":"Serino","year":"1998","journal-title":"Diabetologia"},{"key":"ref_24","first-page":"809","article-title":"Oxidative Stress and Inflammatory Markers in Prediabetes and Diabetes","volume":"70","author":"Luc","year":"2019","journal-title":"J. Physiol. Pharmacol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/0300-9084(88)90185-X","article-title":"Structure, Processing and Evolution of the Neurohypophysial Hormone-Neurophysin Precursors","volume":"70","author":"Acher","year":"1988","journal-title":"Biochimie"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/0006-3002(54)90202-4","article-title":"The structure of bovine vasopressin","volume":"14","author":"Acher","year":"1954","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/s41586-020-03040-7","article-title":"Universal Nomenclature for Oxytocin-Vasotocin Ligand and Receptor Families","volume":"592","author":"Theofanopoulou","year":"2021","journal-title":"Nature"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/bs.vh.2019.08.011","article-title":"Oxytocin\/Vasopressin-like Neuropeptide Signaling in Insects","volume":"113","author":"Monjon","year":"2020","journal-title":"Vitam. Horm."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1113\/expphysiol.2013.072561","article-title":"Physiology of Invertebrate Oxytocin and Vasopressin Neuropeptides","volume":"99","author":"Gruber","year":"2014","journal-title":"Exp. Physiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1111\/j.1365-2826.2011.02236.x","article-title":"Cell-Type Specific Expression of Oxytocin and Vasopressin Genes: An Experimental Odyssey","volume":"24","author":"Gainer","year":"2012","journal-title":"J. Neuroendocrinol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1002\/j.1460-2075.1983.tb01497.x","article-title":"Structural Organization of the Rat Gene for the Arginine Vasopressin-Neurophysin Precursor","volume":"2","author":"Schmale","year":"1983","journal-title":"EMBO J."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1373\/clinchem.2005.060038","article-title":"Assay for the Measurement of Copeptin, a Stable Peptide Derived from the Precursor of Vasopressin","volume":"52","author":"Morgenthaler","year":"2006","journal-title":"Clin. Chem."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0014-5793(86)80320-9","article-title":"Guinea Pig Copeptin. The Glycopeptide Domain of the Vasopressin Precursor","volume":"197","author":"Chauvet","year":"1986","journal-title":"FEBS Lett."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"S37","DOI":"10.1111\/j.1751-7133.2010.00177.x","article-title":"Copeptin: A Biomarker of Cardiovascular and Renal Function","volume":"16","author":"Morgenthaler","year":"2010","journal-title":"Congest. Heart Fail."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Proczka, M., Przybylski, J., Cudnoch-J\u0119drzejewska, A., Szczepa\u0144ska-Sadowska, E., and \u017bera, T. (2021). Vasopressin and Breathing: Review of Evidence for Respiratory Effects of the Antidiuretic Hormone. Front. Physiol., 12.","DOI":"10.3389\/fphys.2021.744177"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s11906-018-0823-9","article-title":"Dysregulation of the Renin-Angiotensin System and the Vasopressinergic System Interactions in Cardiovascular Disorders","volume":"20","author":"Czarzasta","year":"2018","journal-title":"Curr. Hypertens. Rep."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"306","DOI":"10.2174\/1389200218666170119145900","article-title":"Vasopressin and Related Peptides; Potential Value in Diagnosis, Prognosis and Treatment of Clinical Disorders","volume":"18","author":"Zera","year":"2017","journal-title":"Curr. Drug Metab."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s13679-019-00355-z","article-title":"Oxytocin and Vasopressin Systems in Obesity and Metabolic Health: Mechanisms and Perspectives","volume":"8","author":"Ding","year":"2019","journal-title":"Curr. Obes. Rep."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"R982","DOI":"10.1152\/ajpregu.00543.2016","article-title":"Acute Hypoxia Activates Neuroendocrine, but Not Presympathetic, Neurons in the Paraventricular Nucleus of the Hypothalamus: Differential Role of Nitric Oxide","volume":"312","author":"Coldren","year":"2017","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1161\/CIRCULATIONAHA.109.909663","article-title":"Plasma Copeptin and the Risk of Diabetes Mellitus","volume":"121","author":"Wang","year":"2010","journal-title":"Circulation"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/S0301-0082(98)00072-0","article-title":"Physiological Pathways Regulating the Activity of Magnocellular Neurosecretory Cells","volume":"57","author":"Leng","year":"1999","journal-title":"Prog. Neurobiol."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Szczepanska-Sadowska, E., Czarzasta, K., Bogacki-Rychlik, W., and Kowara, M. (2024). The Interaction of Vasopressin with Hormones of the Hypothalamo-Pituitary-Adrenal Axis: The Significance for Therapeutic Strategies in Cardiovascular and Metabolic Diseases. Int. J. Mol. Sci., 25.","DOI":"10.20944\/preprints202406.0449.v1"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"7604","DOI":"10.1523\/JNEUROSCI.5328-03.2004","article-title":"Suprachiasmatic GABAergic Inputs to the Paraventricular Nucleus Control Plasma Glucose Concentrations in the Rat via Sympathetic Innervation of the Liver","volume":"24","author":"Kalsbeek","year":"2004","journal-title":"J. Neurosci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0079-6123(08)64379-4","article-title":"Vasopressin and Oxytocin: Distribution and Putative Functions in the Brain","volume":"60","author":"Buijs","year":"1983","journal-title":"Prog. Brain Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1002\/cne.902050306","article-title":"Immunohistochemical Identification of Neurons in the Paraventricular Nucleus of the Hypothalamus That Project to the Medulla or to the Spinal Cord in the Rat","volume":"205","author":"Sawchenko","year":"1982","journal-title":"J. Comp. Neurol."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Szczepanska-Sadowska, E., Wsol, A., Cudnoch-Jedrzejewska, A., and \u017bera, T. (2021). Complementary Role of Oxytocin and Vasopressin in Cardiovascular Regulation. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222111465"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Szczepanska-Sadowska, E., Wsol, A., Cudnoch-Jedrzejewska, A., Czarzasta, K., and \u017bera, T. (2022). Multiple Aspects of Inappropriate Action of Renin\u2014Angiotensin, Vasopressin, and Oxytocin Systems in Neuropsychiatric and Neurodegenerative Diseases. J. Clin. Med., 11.","DOI":"10.3390\/jcm11040908"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/BF00233648","article-title":"Immuno-Electron Microscopical Demonstration of Vasopressin and Oxytocin Synapses in the Limbic System of the Rat","volume":"204","author":"Buijs","year":"1979","journal-title":"Cell Tissue Res."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Szczepanska-Sadowska, E. (2022). The Heart as a Target of Vasopressin and Other Cardiovascular Peptides in Health and Cardiovascular Diseases. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232214414"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1210\/endo.142.4.8067","article-title":"Immunohistochemical Localization of the Vasopressin V1b Receptor in the Rat Brain and Pituitary Gland: Anatomical Support for Its Involvement in the Central Effects of Vasopressin","volume":"142","author":"Hernando","year":"2001","journal-title":"Endocrinology"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/nature08826","article-title":"An Intrinsic Vasopressin System in the Olfactory Bulb Is Involved in Social Recognition","volume":"464","author":"Tobin","year":"2010","journal-title":"Nature"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1002\/jnr.490180209","article-title":"Carrier-Mediated Transport of Vasopressin across the Blood-Brain Barrier of the Mouse","volume":"18","author":"Banks","year":"1987","journal-title":"J. Neurosci. Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0079-6123(08)62330-4","article-title":"Peptide Receptors of the Blood-Brain Barrier and Substrate Transport into the Brain","volume":"91","author":"Ermisch","year":"1992","journal-title":"Prog. Brain Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/jcbfm.1985.49","article-title":"Blood-Brain Barrier and Peptides","volume":"5","author":"Ermisch","year":"1985","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1016\/0024-3205(83)90352-1","article-title":"Minireview. Peptides and the Blood-Brain Barrier","volume":"32","author":"Meisenberg","year":"1983","journal-title":"Life Sci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1161\/01.RES.84.3.365","article-title":"Evidence for a Vasopressin System in the Rat Heart","volume":"84","author":"Hupf","year":"1999","journal-title":"Circ. Res."},{"key":"ref_57","first-page":"498","article-title":"Identification by RT-PCR and Immunolocalization of Arginine Vasopressin in Rat Pancreas","volume":"25","author":"Macari","year":"1999","journal-title":"Diabetes Metab."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1097\/00000441-198811000-00003","article-title":"Oxytocin and Vasopressin Are Present in Human and Rat Pancreas","volume":"296","author":"Amico","year":"1988","journal-title":"Am. J. Med. Sci."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s12022-017-9492-5","article-title":"Pancreatic Neuroendocrine Tumor Producing Insulin and Vasopressin","volume":"29","author":"Alshaikh","year":"2018","journal-title":"Endocr. Pathol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"e27453","DOI":"10.1097\/MD.0000000000027453","article-title":"Pancreatic Neuroendocrine Tumor Producing Vasopressin: A Case Report","volume":"100","author":"Li","year":"2021","journal-title":"Medicine"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/356523a0","article-title":"Molecular Cloning and Expression of a Rat V1a Arginine Vasopressin Receptor","volume":"356","author":"Morel","year":"1992","journal-title":"Nature"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1006\/geno.1996.0055","article-title":"Structure, Sequence, Expression, and Chromosomal Localization of the Human V1a Vasopressin Receptor Gene","volume":"31","author":"Thibonnier","year":"1996","journal-title":"Genomics"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1046\/j.1365-2826.1999.00332.x","article-title":"Localization of Vasopressin (V1a) Receptor Binding and MRNA in the Rhesus Monkey Brain","volume":"11","author":"Young","year":"1999","journal-title":"J. Neuroendocrinol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"6783","DOI":"10.1073\/pnas.92.15.6783","article-title":"Extrapituitary Expression of the Rat V1b Vasopressin Receptor Gene","volume":"92","author":"Lolait","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1111\/j.1365-2826.2011.02241.x","article-title":"The Hypothalamic-Neurohypophyseal System: From Genome to Physiology","volume":"24","author":"Murphy","year":"2012","journal-title":"J. Neuroendocrinol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1210\/endo.131.1.1535312","article-title":"Distribution of V1a and V2 Vasopressin Receptor Messenger Ribonucleic Acids in Rat Liver, Kidney, Pituitary and Brain","volume":"131","author":"Ostrowski","year":"1992","journal-title":"Endocrinology"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0306-4522(96)00591-X","article-title":"Distribution of Vasopressin and Oxytocin Receptors in the Rat Spinal Cord: Sex-Related Differences and Effect of Castration in Pudendal Motor Nuclei","volume":"78","author":"Tribollet","year":"1997","journal-title":"Neuroscience"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0079-6123(08)61561-7","article-title":"Vasopressin Binding Sites in the Central Nervous System: Distribution and Regulation","volume":"119","author":"Tribollet","year":"1998","journal-title":"Prog. Brain Res."},{"key":"ref_69","first-page":"349","article-title":"Vasopressin V1a, V1b and V2 Receptors MRNA in the Kidney and Heart of the Renin Transgenic TGR(MRen2)27 and Sprague Dawley Rats","volume":"53","author":"Luszczyk","year":"2002","journal-title":"J. Physiol. Pharmacol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.peptides.2018.03.004","article-title":"Vasopressin V1a Receptors Are Present in the Carotid Body and Contribute to the Control of Breathing in Male Sprague-Dawley Rats","volume":"102","author":"Zera","year":"2018","journal-title":"Peptides"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1210\/en.2006-1315","article-title":"Alteration of Glucose Homeostasis in V1a Vasopressin Receptor-Deficient Mice","volume":"148","author":"Aoyagi","year":"2007","journal-title":"Endocrinology"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"F351","DOI":"10.1152\/ajprenal.00049.2006","article-title":"Axial Heterogeneity of Vasopressin-Receptor Subtypes along the Human and Mouse Collecting Duct","volume":"292","author":"Carmosino","year":"2007","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"E566","DOI":"10.1152\/ajpendo.00148.2003","article-title":"Pancreatic Vasopressin V1b Receptors: Characterization in In-R1-G9 Cells and Localization in Human Pancreas","volume":"285","author":"Folny","year":"2003","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/hep.1840170124","article-title":"Vasopressin Gene Expression in Rats with Experimental Cirrhosis","volume":"17","author":"Kim","year":"1993","journal-title":"Hepatology"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1124\/mol.65.3.623","article-title":"Vasopressin Stimulates Insulin Release from Islet Cells through V1b Receptors: A Combined Pharmacological\/Knockout Approach","volume":"65","author":"Oshikawa","year":"2004","journal-title":"Mol. Pharmacol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1159\/000108655","article-title":"Vasopressin Receptor MRNA Expression in the Human Gastrointestinal Tract","volume":"40","author":"Monstein","year":"2008","journal-title":"Eur. Surg. Res."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Rotoli, B.M., Visigalli, R., Ferrari, F., Ranieri, M., Tamma, G., Dall\u2019Asta, V., and Barilli, A. (2022). Desmopressin Stimulates Nitric Oxide Production in Human Lung Microvascular Endothelial Cells. Biomolecules, 12.","DOI":"10.3390\/biom12030389"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"H2262","DOI":"10.1152\/ajpheart.01320.2006","article-title":"Functional Arginine Vasopressin System in Early Heart Maturation","volume":"293","author":"Gutkowska","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/0922-4106(94)90226-7","article-title":"Distribution and Developmental Change of Vasopressin V1A and V2 Receptor MRNA in Rats","volume":"267","author":"Hirasawa","year":"1994","journal-title":"Eur. J. Pharmacol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1006\/bbrc.1994.2864","article-title":"Evidence for the Existence of Vasopressin V2 Receptor MRNA in Rat Hippocampus","volume":"205","author":"Hirasawa","year":"1994","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_81","first-page":"1","article-title":"Evolving Concepts in G Protein-Coupled Receptor Endocytosis: The Role in Receptor Desensitization and Signaling","volume":"53","author":"Ferguson","year":"2001","journal-title":"Pharmacol. Rev."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1152\/physrev.00035.2011","article-title":"Vasopressin V1a and V1b Receptors: From Molecules to Physiological Systems","volume":"92","author":"Koshimizu","year":"2012","journal-title":"Physiol. Rev."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"19S","DOI":"10.1111\/j.1469-445X.2000.tb00004.x","article-title":"Regulation of Vasopressin V1b Receptors in the Anterior Pituitary Gland of the Rat","volume":"85","author":"Aguilera","year":"2000","journal-title":"Exp. Physiol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/0006-8993(91)90280-9","article-title":"Central Vasopressin Receptors Are Upregulated by Deoxycorticosterone Acetate","volume":"559","author":"Swords","year":"1991","journal-title":"Brain Res."},{"key":"ref_85","first-page":"E217","article-title":"Vasopressin V1 and V2 Receptors in Diabetes Mellitus","volume":"266","author":"Trinder","year":"1994","journal-title":"Am. J. Physiol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1053\/meta.2003.50047","article-title":"Angiotensin II Upregulates the Expression of Vasopressin V2 MRNA in the Inner Medullary Collecting Duct of the Rat","volume":"52","author":"Wong","year":"2003","journal-title":"Metabolism"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"R1815","DOI":"10.1152\/ajpregu.2001.280.6.R1815","article-title":"NO Inhibits Supraoptic Oxytocin and Vasopressin Neurons via Activation of GABAergic Synaptic Inputs","volume":"280","author":"Stern","year":"2001","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1111\/j.1440-1681.2012.05693.x","article-title":"Downregulation of Vasopressin V1A Receptors and Activation of Mitogen-Activated Protein Kinase in Rat Mesangial Cells Cultured under High-Glucose Conditions","volume":"39","author":"Tahara","year":"2012","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1002\/jnr.23537","article-title":"The Prelimbic Cortex Muscarinic M\u2083 Receptor-Nitric Oxide-Guanylyl Cyclase Pathway Modulates Cardiovascular Responses in Rats","volume":"93","author":"Fassini","year":"2015","journal-title":"J. Neurosci. Res."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1113\/JP270297","article-title":"From Synaptically Localized to Volume Transmission by Nitric Oxide","volume":"594","author":"Garthwaite","year":"2016","journal-title":"J. Physiol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1016\/j.jacc.2003.06.002","article-title":"Inflammation-Induced Vasoconstrictor Hyporeactivity Is Caused by Oxidative Stress","volume":"42","author":"Pleiner","year":"2003","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1161\/CIRCRESAHA.121.318063","article-title":"Oxidative Stress and Hypertension","volume":"128","author":"Griendling","year":"2021","journal-title":"Circ. Res."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1097\/01.CCM.0000251127.45385.CD","article-title":"Vasopressin: Mechanisms of Action on the Vasculature in Health and in Septic Shock","volume":"35","author":"Barrett","year":"2007","journal-title":"Crit. Care Med."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"R979","DOI":"10.1152\/ajpregu.00520.2001","article-title":"Cytokine-Mediated Downregulation of Vasopressin V(1A) Receptors during Acute Endotoxemia in Rats","volume":"282","author":"Bucher","year":"2002","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"e12686","DOI":"10.1111\/jne.12686","article-title":"Nitric Oxide Acutely Modulates Hypothalamic and Neurohypophyseal Carbon Monoxide and Hydrogen Sulphide Production to Control Vasopressin, Oxytocin and Atrial Natriuretic Peptide Release in Rats","volume":"31","author":"Coletti","year":"2019","journal-title":"J. Neuroendocrinol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.neulet.2005.02.040","article-title":"Inhibitory Effect of Gaseous Neuromodulators in Vasopressin and Oxytocin Release Induced by Endotoxin in Rats","volume":"381","author":"Elias","year":"2005","journal-title":"Neurosci. Lett."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0169-328X(97)00197-6","article-title":"Activation of Heme Oxygenase and Consequent Carbon Monoxide Formation Inhibits the Release of Arginine Vasopressin from Rat Hypothalamic Explants. Molecular Linkage between Heme Catabolism and Neuroendocrine Function","volume":"50","author":"Mancuso","year":"1997","journal-title":"Mol. Brain Res."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1159\/000097340","article-title":"The Role of Carbon Monoxide in the Regulation of Neuroendocrine Function","volume":"4","author":"Mancuso","year":"1997","journal-title":"Neuroimmunomodulation"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/jne.12245","article-title":"Carbon Monoxide and Nitric Oxide Interactions in Magnocellular Neurosecretory Neurones during Water Deprivation","volume":"27","author":"Reis","year":"2015","journal-title":"J. Neuroendocrinol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1210\/en.2015-1958","article-title":"A Functional Coupling Between Carbon Monoxide and Nitric Oxide Contributes to Increased Vasopressin Neuronal Activity in Heart Failure Rats","volume":"157","author":"Reis","year":"2016","journal-title":"Endocrinology"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1113\/jphysiol.2004.077735","article-title":"Cellular Sources, Targets and Actions of Constitutive Nitric Oxide in the Magnocellular Neurosecretory System of the Rat","volume":"562","author":"Stern","year":"2005","journal-title":"J. Physiol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1113\/expphysiol.2007.037911","article-title":"Central Nitric Oxide Blocks Vasopressin, Oxytocin and Atrial Natriuretic Peptide Release and Antidiuretic and Natriuretic Responses Induced by Central Angiotensin II in Conscious Rats","volume":"92","author":"Reis","year":"2007","journal-title":"Exp. Physiol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"S283","DOI":"10.1097\/01.fjc.0000166275.32421.c6","article-title":"Neuronal Nitric Oxide Synthase Activity in the Paraventricular Nucleus Buffers Central Endothelin-1-Induced Pressor Response and Vasopressin Secretion","volume":"44","author":"Rossi","year":"2004","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.peptides.2009.01.024","article-title":"Nitric Oxide Mediates Feedback Inhibition in Angiotensin II-Induced Upregulation of Vasopressin MRNA","volume":"30","author":"Zhang","year":"2009","journal-title":"Peptides"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.freeradbiomed.2014.03.024","article-title":"Reactive Oxygen Species Are Physiological Mediators of the Noradrenergic Signaling Pathway in the Mouse Supraoptic Nucleus","volume":"71","author":"Parmentier","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1210\/endo.134.3.7509733","article-title":"Up-Regulation of Nitric Oxide Synthase (NOS) Gene Expression Together with NOS Activity in the Rat Hypothalamo-Hypophysial System after Chronic Salt Loading: Evidence of a Neuromodulatory Role of Nitric Oxide in Arginine Vasopressin and Oxytocin Secretio","volume":"134","author":"Kadowaki","year":"1994","journal-title":"Endocrinology"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1152\/physiol.00040.2014","article-title":"Gaseous Modulators in the Control of the Hypothalamic Neurohypophyseal System","volume":"30","author":"Ruginsk","year":"2015","journal-title":"Physiology"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"5330","DOI":"10.1523\/JNEUROSCI.3674-14.2015","article-title":"Neuronal-Derived Nitric Oxide and Somatodendritically Released Vasopressin Regulate Neurovascular Coupling in the Rat Hypothalamic Supraoptic Nucleus","volume":"35","author":"Du","year":"2015","journal-title":"J. Neurosci."},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Busnardo, C., Fassini, A., Rodrigues, B., Antunes-Rodrigues, J., Crestani, C.C., and Corr\u00eaa, F.M.A. (2021). N-Methyl-D-Aspartate Glutamate Receptor Modulates Cardiovascular and Neuroendocrine Responses Evoked by Hemorrhagic Shock in Rats. BioMed Res. Int., 2021.","DOI":"10.1155\/2021\/1156031"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"12103","DOI":"10.1523\/JNEUROSCI.3367-10.2010","article-title":"Chronic Intermittent Hypoxia Induces NMDA Receptor-Dependent Plasticity and Suppresses Nitric Oxide Signaling in the Mouse Hypothalamic Paraventricular Nucleus","volume":"30","author":"Coleman","year":"2010","journal-title":"J. Neurosci."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3109\/10253890109001139","article-title":"The Roles of Carbon Monoxide and Nitric Oxide in the Control of the Neuroendocrine Stress Response: Complementary or Redundant","volume":"4","author":"Navarra","year":"2001","journal-title":"Stress"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1016\/j.peptides.2010.06.031","article-title":"Role of Central NO-CGMP Pathway in Vasopressin and Oxytocin Gene Expression during Sepsis","volume":"31","author":"Aguila","year":"2010","journal-title":"Peptides"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1210\/endo.133.3.7689960","article-title":"Nitric Oxide Modulates the Release of Vasopressin from Rat Hypothalamic Explants","volume":"133","author":"Yasin","year":"1993","journal-title":"Endocrinology"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1620\/tjem.174.59","article-title":"Effects of a Nitric Oxide Synthase Inhibitor on Vasopressin and Atrial Natriuretic Hormone Release, Thermogenesis and Cardiovascular Functions in Response to Interleukin-1 Beta in Rats","volume":"174","author":"Yamamoto","year":"1994","journal-title":"Tohoku J. Exp. Med."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1161\/01.HYP.29.1.58","article-title":"Receptor Subtype for Vasopressin-Induced Release of Nitric Oxide from Rat Kidney","volume":"29","author":"Hirata","year":"1997","journal-title":"Hypertension"},{"key":"ref_116","first-page":"H99","article-title":"L-NAME Antagonizes Vasopressin V2-Induced Vasodilatation in Dogs","volume":"266","author":"Liard","year":"1994","journal-title":"Am. J. Physiol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1161\/01.HYP.30.5.1112","article-title":"Arginine Vasopressin Increases Nitric Oxide Synthesis in Cytokine-Stimulated Rat Cardiac Myocytes","volume":"30","author":"Yamamoto","year":"1997","journal-title":"Hypertension"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.lfs.2007.05.018","article-title":"Arginine Vasopressin Increases INOS-NO System Activity in Cardiac Fibroblasts through NF-KappaB Activation and Its Relation with Myocardial Fibrosis","volume":"81","author":"Fan","year":"2007","journal-title":"Life Sci."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1006\/phrs.2002.0967","article-title":"Cardiac Necrosis Markers Associated with Low Nitric Oxide Levels in the Plasma of Rabbits after Treatment with Vasopressin: Protective Effects of Nitroglycerin Administration","volume":"45","author":"Pinelli","year":"2002","journal-title":"Pharmacol. Res."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1111\/j.1549-8719.2000.tb00139.x","article-title":"TNF-Alpha Modulates Arteriolar Reactivity Secondary to a Change in Intimal Permeability","volume":"7","author":"Matsuki","year":"2000","journal-title":"Microcirculation"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1097\/00005344-199402000-00023","article-title":"Nitric Oxide May Participate in V2 Vasopressin-Receptor-Mediated Renal Vasodilation","volume":"23","author":"Aki","year":"1994","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1161\/hy02t2.102908","article-title":"Vasopressin Increases Intracellular NO Concentration via Ca(2+) Signaling in Inner Medullary Collecting Duct","volume":"39","author":"Mori","year":"2002","journal-title":"Hypertension"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1161\/01.HYP.32.5.896","article-title":"Arginine Vasopressin-Mediated Stimulation of Nitric Oxide within the Rat Renal Medulla","volume":"32","author":"Park","year":"1998","journal-title":"Hypertension"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1291\/hypres.20.29","article-title":"Role of Nitric Oxide in Desmopressin-Induced Vasodilation of Microperfused Rabbit Afferent Arterioles","volume":"20","author":"Kiyomoto","year":"1997","journal-title":"Hypertens. Res."},{"key":"ref_125","first-page":"F433","article-title":"AVP Inhibits LPS- and IL-1beta-Stimulated NO and CGMP via V1 Receptor in Cultured Rat Mesangial Cells","volume":"276","author":"Umino","year":"1999","journal-title":"Am. J. Physiol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/nrendo.2010.229","article-title":"Vaptans for the Treatment of Hyponatremia","volume":"7","author":"Robertson","year":"2011","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1056\/NEJMoa065181","article-title":"Tolvaptan, a Selective Oral Vasopressin V2-Receptor Antagonist, for Hyponatremia","volume":"355","author":"Schrier","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Al Therwani, S., Rosenb\u00e6k, J.B., Mose, F.H., Bech, J.N., and Pedersen, E.B. (2017). Effect of Tolvaptan on Renal Water and Sodium Excretion and Blood Pressure during Nitric Oxide Inhibition: A Dose-Response Study in Healthy Subjects. BMC Nephrol., 18.","DOI":"10.1186\/s12882-017-0501-1"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"R354","DOI":"10.1152\/ajpregu.00065.2002","article-title":"Synergistic Effects of Nitric Oxide and Prostaglandins on Renal Escape from Vasopressin-Induced Antidiuresis","volume":"284","author":"Murase","year":"2003","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1080\/00365520410009528","article-title":"Effects of Vasopressin on Portal-Systemic Collaterals of Cirrhotic Rats","volume":"40","author":"Chan","year":"2005","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.jhep.2003.10.010","article-title":"Chronic Inhibition of Nitric Oxide Increases the Collateral Vascular Responsiveness to Vasopressin in Portal Hypertensive Rats","volume":"40","author":"Huang","year":"2004","journal-title":"J. Hepatol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1042\/cs0990475","article-title":"Splanchnic Hyposensitivity to Glypressin in a Haemorrhage\/Transfused Rat Model of Portal Hypertension: Role of Nitric Oxide and Bradykinin","volume":"99","author":"Chu","year":"2000","journal-title":"Clin. Sci."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"33776","DOI":"10.1074\/jbc.M201904200","article-title":"Inducible Nitric-Oxide Synthase Attenuates Vasopressin-Dependent Ca2+ Signaling in Rat Hepatocytes","volume":"277","author":"Patel","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1042\/bj1720311","article-title":"Rapid Stimulation by Vasopressin, Oxytocin and Angiotensin II of Glycogen Degradation in Hepatocyte Suspensions","volume":"172","author":"Hems","year":"1978","journal-title":"Biochem. J."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1042\/bj1760627","article-title":"Activation of Pyruvate Dehydrogenase in the Perfused Rat Liver by Vasopressin","volume":"176","author":"Hems","year":"1978","journal-title":"Biochem. J."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1042\/bj1940155","article-title":"Phosphatidylinositol Metabolism in Rat Hepatocytes Stimulated by Vasopressin","volume":"194","author":"Kirk","year":"1981","journal-title":"Biochem. J."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1042\/bj1760893","article-title":"Stimulation by Vasopressin, Angiotensin and Oxytocin of Gluconeogenesis in Hepatocyte Suspensions","volume":"176","author":"Whitton","year":"1978","journal-title":"Biochem. J."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1210\/endo-109-3-818","article-title":"Insulin-Induced Hypoglycemia in Conscious Dogs. I. Dose-Related Pituitary and Adrenal Responses","volume":"109","author":"Shinsako","year":"1981","journal-title":"Endocrinology"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"e72919","DOI":"10.7554\/eLife.72919","article-title":"Arginine-Vasopressin Mediates Counter-Regulatory Glucagon Release and Is Diminished in Type 1 Diabetes","volume":"10","author":"Kim","year":"2021","journal-title":"eLife"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1042\/bj2270079","article-title":"Stimulation of Inositol Trisphosphate Formation in Hepatocytes by Vasopressin, Adrenaline and Angiotensin II and Its Relationship to Changes in Cytosolic Free Ca2+","volume":"227","author":"Charest","year":"1985","journal-title":"Biochem. J."},{"key":"ref_141","first-page":"93","article-title":"The Relationships between Receptor Binding Capacity for Norepinephrine, Angiotensin II, and Vasopressin and Release of Inositol Trisphosphate, Ca2+ Mobilization, and Phosphorylase Activation in Rat Liver","volume":"28","author":"Lynch","year":"1985","journal-title":"Mol. Pharmacol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"5574","DOI":"10.1016\/S0021-9258(18)91052-5","article-title":"Relationship between Inositol Polyphosphate Production and the Increase of Cytosolic Free Ca2+ Induced by Vasopressin in Isolated Hepatocytes","volume":"259","author":"Thomas","year":"1984","journal-title":"J. Biol. Chem."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1042\/bj1980485","article-title":"Stimulation of Hepatic Lipogenesis and Acetyl-Coenzyme A Carboxylase by Vasopressin","volume":"198","author":"Denton","year":"1981","journal-title":"Biochem. J."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1042\/bj1600023","article-title":"Resistance to Hepatic Action of Vasopressin in Genetically Obese (Ob\/Ob) Mice","volume":"160","author":"Hems","year":"1976","journal-title":"Biochem. J."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1042\/bj2690795","article-title":"Altered Regulation of Glycogen Metabolism by Vasopressin and Phenylephrine in Hepatocytes from Insulin-Resistant Obese (Fa\/Fa) Rats. Role of Protein Kinase C","volume":"269","author":"Massillon","year":"1990","journal-title":"Biochem. J."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1073\/pnas.87.3.1052","article-title":"Insulin, Oxytocin, and Vasopressin Stimulate Protein Kinase C Activity in Adipocyte Plasma Membranes","volume":"87","author":"Egan","year":"1990","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0378-3782(92)90168-G","article-title":"Immunoreactive Arginine Vasopressin in Human Fetal and Neonatal Skeletal Muscle","volume":"28","author":"Smith","year":"1992","journal-title":"Early Hum. Dev."},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Adamo, S., Pigna, E., Lugar\u00e0, R., Moresi, V., Coletti, D., and Bouch\u00e9, M. (2019). Skeletal Muscle: A Significant Novel Neurohypophyseal Hormone-Secreting Organ. Front. Physiol., 9.","DOI":"10.3389\/fphys.2018.01885"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/0031-9384(89)90098-X","article-title":"The Effects of Adrenalectomy, Corticotropin Releasing Factor and Vasopressin on the Sympathetic Firing Rate of Nerves to Interscapular Brown Adipose Tissue in the Zucker Rat","volume":"45","author":"Holt","year":"1989","journal-title":"Physiol. Behav."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1007\/PL00005201","article-title":"Role of Vasopressin on Excitatory Amino Acids Mediated Pressor Responses in the Periaqueductal Gray Area","volume":"357","author":"Pizzirusso","year":"1998","journal-title":"Naunyn Schmiedeberg\u2019s Arch. Pharmacol."},{"key":"ref_151","first-page":"E108","article-title":"Actions of Neurohypophysial Peptides on Pancreatic Hormone Release","volume":"246","author":"Dunning","year":"1984","journal-title":"Am. J. Physiol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0034-5288(97)90129-6","article-title":"Effects of Oxytocin, Arginine-Vasopressin and Lysine-Vasopressin on Insulin and Glucagon Secretion in Sheep","volume":"62","author":"Mineo","year":"1997","journal-title":"Res. Vet. Sci."},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Yun, Y., Guo, S., and Xie, X. (2024). V1bR Enhances Glucose-Stimulated Insulin Secretion by Paracrine Production of Glucagon Which Activates GLP-1 Receptor. Cell Biosci., 14.","DOI":"10.1186\/s13578-024-01288-4"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1677\/JOE-07-0645","article-title":"Vasopressin Potentiates Corticotropin-Releasing Hormone-Induced Insulin Release from Mouse Pancreatic Beta-Cells","volume":"197","author":"Howell","year":"2008","journal-title":"J. Endocrinol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1111\/j.1365-2826.2007.01560.x","article-title":"Attenuated Stress Response to Acute Lipopolysaccharide Challenge and Ethanol Administration in Vasopressin V1b Receptor Knockout Mice","volume":"19","author":"Lolait","year":"2007","journal-title":"J. Neuroendocrinol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"3595","DOI":"10.1002\/j.1460-2075.1989.tb08532.x","article-title":"Vasopressin Directly Closes ATP-Sensitive Potassium Channels Evoking Membrane Depolarization and an Increase in the Free Intracellular Ca2+ Concentration in Insulin-Secreting Cells","volume":"8","author":"Martin","year":"1989","journal-title":"EMBO J."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1042\/bj2880847","article-title":"Somatostatin Inhibits Vasopressin-Stimulated Phosphoinositide Hydrolysis and Influx of Extracellular Calcium in Clonal Hamster Beta (HIT) Cells","volume":"288","author":"Richardson","year":"1992","journal-title":"Biochem. J."},{"key":"ref_158","first-page":"E56","article-title":"Characterization of Receptors Mediating AVP\u2014And OT-Induced Glucagon Release from the Rat Pancreas","volume":"277","author":"Cheng","year":"1999","journal-title":"Am. J. Physiol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"E127","DOI":"10.1152\/ajpendo.00269.2016","article-title":"Acute and Chronic Hyperglycemic Effects of Vasopressin in Normal Rats: Involvement of V(1A) Receptors","volume":"312","author":"Taveau","year":"2017","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1055\/s-2001-16345","article-title":"Expression of Arginine Vasopressin and Vasopressin V1a Receptor MRNA in Diabetic (Db\/Db) Mice","volume":"109","author":"Morita","year":"2001","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1677\/joe.1.06864","article-title":"Mutual Regulation of Vasopressin- and Oxytocin-Induced Glucagon Secretion in V1b Vasopressin Receptor Knockout Mice","volume":"192","author":"Fujiwara","year":"2007","journal-title":"J. Endocrinol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.ejphar.2009.04.008","article-title":"Both V(1A) and V(1B) Vasopressin Receptors Deficiency Result in Impaired Glucose Tolerance","volume":"613","author":"Nakamura","year":"2009","journal-title":"Eur. J. Pharmacol."},{"key":"ref_163","doi-asserted-by":"crossref","unstructured":"Mohan, S., Lafferty, R., Tanday, N., Flatt, P.R., Moffett, R.C., and Irwin, N. (2021). Beneficial Impact of Ac3IV, an AVP Analogue Acting Specifically at V1a and V1b Receptors, on Diabetes Islet Morphology and Transdifferentiation of Alpha- and Beta-Cells. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0261608"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"170772","DOI":"10.1016\/j.peptides.2022.170772","article-title":"Ac3IV, a V1a and V1b Receptor Selective Vasopressin Analogue, Protects against Hydrocortisone-Induced Changes in Pancreatic Islet Cell Lineage","volume":"152","author":"Mohan","year":"2022","journal-title":"Peptides"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.bbrc.2010.12.126","article-title":"Enhanced Glucose Tolerance in the Brattleboro Rat","volume":"405","author":"Nakamura","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"E1092","DOI":"10.1152\/ajpendo.00440.2007","article-title":"Vasopressin Is a Physiological Substrate for the Insulin-Regulated Aminopeptidase IRAP","volume":"293","author":"Wallis","year":"2007","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"14454","DOI":"10.1074\/jbc.C115.639203","article-title":"Coordinated Regulation of Vasopressin Inactivation and Glucose Uptake by Action of TUG Protein in Muscle","volume":"290","author":"Habtemichael","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/bs.vh.2019.08.017","article-title":"Vasopressin Inactivation: Role of Insulin-Regulated Aminopeptidase","volume":"113","author":"Li","year":"2020","journal-title":"Vitam. Horm."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"101975","DOI":"10.1016\/j.npep.2019.101975","article-title":"The Influence of Post-Infarct Heart Failure and High Fat Diet on the Expression of Apelin APJ and Vasopressin V1a and V1b Receptors","volume":"78","author":"Czarzasta","year":"2019","journal-title":"Neuropeptides"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.mce.2006.04.032","article-title":"Arginine Vasopressin Stimulates 11beta-Hydroxysteroid Dehydrogenase Type 2 Expression in the Mineralocorticosteroid Target Cells","volume":"256","author":"Rubis","year":"2006","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.jtcvs.2012.03.014","article-title":"Endothelin and Vasopressin Influence Splanchnic Blood Flow Distribution during and after Cardiopulmonary Bypass","volume":"145","author":"Bomberg","year":"2013","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1097\/01.anes.0000267599.02140.86","article-title":"Effects of Vasopressin on Microcirculatory Blood Flow in the Gastrointestinal Tract in Anesthetized Pigs in Septic Shock","volume":"106","author":"Hiltebrand","year":"2007","journal-title":"Anesthesiology"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1097\/SHK.0000000000001726","article-title":"A Randomized Porcine Study in Low Cardiac Output of Vasoactive and Inotropic Drug Effects on the Gastrointestinal Tract","volume":"56","author":"Seilitz","year":"2021","journal-title":"Shock"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1186\/s13054-019-2643-y","article-title":"Exogenous Vasopressin Dose-Dependently Modulates Gastric Microcirculatory Oxygenation in Dogs via V1A Receptor","volume":"23","author":"Truse","year":"2019","journal-title":"Crit. Care"},{"key":"ref_175","doi-asserted-by":"crossref","unstructured":"Schulz, J., Bauer, I., Herminghaus, A., Picker, O., Truse, R., and Vollmer, C. (2021). Sub-Therapeutic Vasopressin but Not Therapeutic Vasopressin Improves Gastrointestinal Microcirculation in Septic Rats: A Randomized, Placebo-Controlled, Blinded Trial. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0257034"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.regpep.2013.10.005","article-title":"Arginine Vasopressin, via Activation of Post-Junctional V1 Receptors, Induces Contractile Effects in Mouse Distal Colon","volume":"187","author":"Mastropaolo","year":"2013","journal-title":"Regul. Pept."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"173740","DOI":"10.1016\/j.ejphar.2020.173740","article-title":"Copeptin, a Surrogate Marker of Arginine(8) Vasopressin, Has No Ability to Modulate Human and Mouse Gastric Motility","volume":"892","author":"Makwana","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"G519","DOI":"10.1152\/ajpgi.00390.2011","article-title":"Alteration of Antral and Proximal Colonic Motility Induced by Chronic Psychological Stress Involves Central Urocortin 3 and Vasopressin in Rats","volume":"303","author":"Ataka","year":"2012","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.peptides.2016.11.001","article-title":"Opposite Effects of Central Oxytocin and Arginine Vasopressin on Changes in Gastric Motor Function Induced by Chronic Stress","volume":"87","author":"Sinen","year":"2017","journal-title":"Peptides"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/ijo.2016.202","article-title":"Effects of Small Intestinal Glucose on Glycaemia, Insulinaemia and Incretin Hormone Release Are Load-Dependent in Obese Subjects","volume":"41","author":"Trahair","year":"2017","journal-title":"Int. J. Obes."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"110606","DOI":"10.1016\/j.diabres.2023.110606","article-title":"Determinants of Blood Glucose Concentrations Following a High Carbohydrate Meal in Type 2 Diabetes: A Multiple Linear Regression Analysis","volume":"198","author":"Xie","year":"2023","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.molmet.2019.09.010","article-title":"Glucagon-like Peptide 1 (GLP-1)","volume":"30","author":"Finan","year":"2019","journal-title":"Mol. Metab."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"380","DOI":"10.2337\/diabetes.52.2.380","article-title":"The Influence of GLP-1 on Glucose-Stimulated Insulin Secretion: Effects on Beta-Cell Sensitivity in Type 2 and Nondiabetic Subjects","volume":"52","author":"Kjems","year":"2003","journal-title":"Diabetes"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1161\/CIRCRESAHA.121.319874","article-title":"GLP1R Attenuates Sympathetic Response to High Glucose via Carotid Body Inhibition","volume":"130","author":"Pauza","year":"2022","journal-title":"Circ. Res."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1007\/s00125-023-05906-7","article-title":"The Expanding Incretin Universe: From Basic Biology to Clinical Translation","volume":"66","author":"Drucker","year":"2023","journal-title":"Diabetologia"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1001\/jamacardio.2020.1966","article-title":"Use of Glucagon-Like Peptide-1 Receptor Agonists in Patients with Type 2 Diabetes and Cardiovascular Disease: A Review","volume":"5","author":"Honigberg","year":"2020","journal-title":"JAMA Cardiol."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"4865","DOI":"10.1113\/JP272053","article-title":"Role of Enteroendocrine L-Cells in Arginine Vasopressin-Mediated Inhibition of Colonic Anion Secretion","volume":"594","author":"Pais","year":"2016","journal-title":"J. Physiol."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.peptides.2019.01.001","article-title":"The L Cell Transcriptome Is Unaffected by Vertical Sleeve Gastrectomy but Highly Dependent upon Position within the Gastrointestinal Tract","volume":"113","author":"Rollins","year":"2019","journal-title":"Peptides"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.mce.2012.06.023","article-title":"Action of Glucagon-like Peptide 1 and Glucose Levels on Corticotropin-Releasing Factor and Vasopressin Gene Expression in Rat Hypothalamic 4B Cells","volume":"362","author":"Kageyama","year":"2012","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"4445","DOI":"10.1210\/endo.138.10.5270","article-title":"Central Administration of Glucagon-like Peptide-1 Activates Hypothalamic Neuroendocrine Neurons in the Rat","volume":"138","author":"Larsen","year":"1997","journal-title":"Endocrinology"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1007\/s11102-024-01451-7","article-title":"GLP-1 Receptor Agonists May Enhance the Effects of Desmopressin in Individuals with AVP Deficiency: A Case Series and Proposed Mechanism","volume":"27","author":"Nakhleh","year":"2024","journal-title":"Pituitary"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/S0006-8993(01)02404-0","article-title":"Arginine-Vasopressin in Nucleus of the Tractus Solitarius Induces Hyperglycemia and Brain Glucose Retention","volume":"902","author":"Yarkov","year":"2001","journal-title":"Brain Res."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"E156","DOI":"10.1152\/ajpendo.00642.2020","article-title":"Insulin Action in the Brain Regulates Both Central and Peripheral Functions","volume":"321","author":"Agrawal","year":"2021","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.ejphar.2004.02.040","article-title":"The Source of Cerebral Insulin","volume":"490","author":"Banks","year":"2004","journal-title":"Eur. J. Pharmacol."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.tins.2022.03.001","article-title":"Insulin Action in the Brain: Cell Types, Circuits, and Diseases","volume":"45","author":"Chen","year":"2022","journal-title":"Trends Neurosci."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"8445","DOI":"10.1016\/S0021-9258(17)37214-9","article-title":"Insulin Gene Expression and Insulin Synthesis in Mammalian Neuronal Cells","volume":"269","author":"Devaskar","year":"1994","journal-title":"J. Biol. Chem."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"64","DOI":"10.2337\/db16-0861","article-title":"Insulin Regulates Astrocytic Glucose Handling Through Cooperation With IGF-I","volume":"66","author":"Fernandez","year":"2017","journal-title":"Diabetes"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/jnc.13909","article-title":"The Neuronal Insulin Receptor in Its Environment","volume":"140","author":"Gralle","year":"2017","journal-title":"J. Neurochem."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/S0140-6736(77)90610-9","article-title":"Plasma-Arginine-Vasopressin Response to Insulin-Induced Hypoglycaemia","volume":"2","author":"Baylis","year":"1977","journal-title":"Lancet"},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1677\/joe.0.1530401","article-title":"Effect of Insulin-Induced Hypoglycaemia on Secretion Patterns and Rates of Corticotrophin-Releasing Hormone, Arginine Vasopressin and Adrenocorticotrophin in Horses","volume":"153","author":"Alexander","year":"1997","journal-title":"J. Endocrinol."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1210\/endo-117-1-323","article-title":"Hypophysiotropic Regulation of Adrenocorticotropin Secretion in Response to Insulin-Induced Hypoglycemia","volume":"117","author":"Plotsky","year":"1985","journal-title":"Endocrinology"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/j.1464-5491.1989.tb02106.x","article-title":"Vasopressin Secretion during Insulin-Induced Hypoglycaemia: Exaggerated Responses in People with Type 1 Diabetes","volume":"6","author":"Thompson","year":"1989","journal-title":"Diabet. Med."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/BF00254508","article-title":"Cephalic Phase, Reflex Insulin Secretion. Neuroanatomical and Physiological Characterization","volume":"20","author":"Berthoud","year":"1981","journal-title":"Diabetologia"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/0306-4522(86)90082-5","article-title":"Autoradiographic Localization of Insulin Receptors in Rat Brain: Prominence in Olfactory and Limbic Areas","volume":"17","author":"Hill","year":"1986","journal-title":"Neuroscience"},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0306-4522(89)90036-5","article-title":"Distribution of Insulin Receptor-like Immunoreactivity in the Rat Forebrain","volume":"31","author":"Unger","year":"1989","journal-title":"Neuroscience"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1007\/s11064-007-9519-2","article-title":"Enhanced Expressions of Arginine Vasopressin (Avp) in the Hypothalamic Paraventricular and Supraoptic Nuclei of Type 2 Diabetic Rats","volume":"33","author":"Yi","year":"2008","journal-title":"Neurochem. Res."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"R447","DOI":"10.1152\/ajpregu.00520.2013","article-title":"Supraoptic Oxytocin and Vasopressin Neurons Function as Glucose and Metabolic Sensors","volume":"306","author":"Song","year":"2014","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.molmet.2014.12.001","article-title":"Central Insulin Signaling Modulates Hypothalamus-Pituitary-Adrenal Axis Responsiveness","volume":"4","author":"Chong","year":"2015","journal-title":"Mol. Metab."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"e12841","DOI":"10.1111\/jne.12841","article-title":"Peripheral Insulin Administration Enhances the Electrical Activity of Oxytocin and Vasopressin Neurones in Vivo","volume":"32","author":"Paiva","year":"2020","journal-title":"J. Neuroendocrinol."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1007\/s00125-015-3496-9","article-title":"Vasopressin and Hydration Play a Major Role in the Development of Glucose Intolerance and Hepatic Steatosis in Obese Rats","volume":"58","author":"Taveau","year":"2015","journal-title":"Diabetologia"},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1042\/cs0880671","article-title":"Down-Regulation of Vasopressin V1a Receptor MRNA in Diabetes Mellitus in the Rat","volume":"88","author":"Phillips","year":"1995","journal-title":"Clin. Sci."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.peptides.2019.02.005","article-title":"Association of Copeptin, a Surrogate Marker for Arginine Vasopressin Secretion, with Insulin Resistance: Influence of Adolescence and Psychological Stress","volume":"115","author":"Thomsen","year":"2019","journal-title":"Peptides"},{"key":"ref_213","doi-asserted-by":"crossref","unstructured":"Seelig, E., Bilz, S., Keller, U., Meienberg, F., and Christ-Crain, M. (2013). Concentrations of the Stress Hormone Copeptin Increase upon Hypoglycaemia in Patients with Type 1 Diabetes Dependent of Hypoglycaemia Awareness. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0072876"},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1172\/JCI118709","article-title":"Obesity\/Insulin Resistance Is Associated with Endothelial Dysfunction. Implications for the Syndrome of Insulin Resistance","volume":"97","author":"Steinberg","year":"1996","journal-title":"J. Clin. Investig."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1254\/jphs.91.187","article-title":"Stress and Vascular Responses: Oxidative Stress and Endothelial Dysfunction in the Insulin-Resistant State","volume":"91","author":"Shinozaki","year":"2003","journal-title":"J. Pharmacol. Sci."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.mvr.2010.05.004","article-title":"Oxidative Stress in Response to High Glucose Levels in Endothelial Cells and in Endothelial Progenitor Cells: Evidence for Differential Glutathione Peroxidase-1 Expression","volume":"80","author":"Felice","year":"2010","journal-title":"Microvasc. Res."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jdiacomp.2012.03.011","article-title":"Hyperglycemia and Oxidative Stress in Cultured Endothelial Cells--a Comparison of Primary Endothelial Cells with an Immortalized Endothelial Cell Line","volume":"26","author":"Karbach","year":"2012","journal-title":"J. Diabetes Complicat."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1046\/j.1523-1755.2003.00728.x","article-title":"Effects of Diabetes, Insulin and Antioxidants on NO Synthase Abundance and NO Interaction with Reactive Oxygen Species","volume":"63","author":"Koo","year":"2003","journal-title":"Kidney Int."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1007\/s00424-020-02443-9","article-title":"Nitric Oxide Interacts with Cholinoceptors to Modulate Insulin Secretion by Pancreatic \u03b2 Cells","volume":"472","author":"Mussa","year":"2020","journal-title":"Pflugers Arch."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.brainres.2011.04.015","article-title":"Effects of Nitric Oxide Synthase Blockade on Dorsal Vagal Stimulation-Induced Pancreatic Insulin Secretion","volume":"1394","author":"Mussa","year":"2011","journal-title":"Brain Res."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.freeradbiomed.2015.11.012","article-title":"Reciprocal Interaction among Gasotransmitters in Isolated Pancreatic \u03b2-Cells","volume":"90","author":"Moustafa","year":"2016","journal-title":"Free Radic. Biol. Med."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.niox.2014.11.007","article-title":"Protective Effect of Hydrogen Sulfide on Pancreatic Beta-Cells","volume":"46","author":"Okamoto","year":"2015","journal-title":"Nitric Oxide Biol. Chem."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1172\/JCI115426","article-title":"Insulin Attenuates Vasopressin-Induced Calcium Transients and a Voltage-Dependent Calcium Response in Rat Vascular Smooth Muscle Cells","volume":"88","author":"Standley","year":"1991","journal-title":"J. Clin. Investig."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/j.1365-2265.1987.tb01151.x","article-title":"Effect of Obesity and Weight Loss on the Arginine Vasopressin Response to Insulin-Induced Hypoglycaemia","volume":"27","author":"Coiro","year":"1987","journal-title":"Clin. Endocrinol."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1007\/BF03349617","article-title":"Increase by Naloxone of Arginine Vasopressin and Oxytocin Responses to Insulin-Induced Hypoglycemia in Obese Men","volume":"13","author":"Coiro","year":"1990","journal-title":"J. Endocrinol. Investig."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1210\/jcem-68-3-688","article-title":"Arginine Vasopressin and Oxytocin Responses to Insulin-Induced Hypoglycemia in Type 1 (Insulin-Dependent) Diabetes","volume":"68","author":"Fisher","year":"1989","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1055\/s-2007-1004891","article-title":"Arginine Vasopressin Response to Insulin-Induced Hypoglycemia in Insulin-Dependent Diabetics with Asymptomatic Hypoglycemia","volume":"22","author":"Wolf","year":"1990","journal-title":"Horm. Metab. Res."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1007\/s00125-019-4953-7","article-title":"Loss of Arginine Vasopressin- and Vasoactive Intestinal Polypeptide-Containing Neurons and Glial Cells in the Suprachiasmatic Nucleus of Individuals with Type 2 Diabetes","volume":"62","author":"Hogenboom","year":"2019","journal-title":"Diabetologia"},{"key":"ref_229","first-page":"E317","article-title":"Regulation of Plasma Vasopressin in Insulin-Dependent Diabetes Mellitus","volume":"249","author":"Zerbe","year":"1985","journal-title":"Am. J. Physiol."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1007\/BF00257428","article-title":"Plasma Vasopressin during Insulin Withdrawal in Insulin-Dependent Diabetes","volume":"20","author":"Milles","year":"1981","journal-title":"Diabetologia"},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1046\/j.1365-2826.1996.05124.x","article-title":"Osmoregulation of Plasma Vasopressin in Diabetes Mellitus with Sustained Hyperglycemia","volume":"8","author":"Iwasaki","year":"1996","journal-title":"J. Neuroendocrinol."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1159\/000488124","article-title":"Vasopressin and Diabetic Kidney Disease","volume":"72","year":"2018","journal-title":"Ann. Nutr. Metab."},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"E1100","DOI":"10.1152\/ajpendo.00214.2004","article-title":"Attenuation of Vasopressin-Induced Antidiuresis in Poorly Controlled Type 2 Diabetes","volume":"287","author":"Agha","year":"2004","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_234","doi-asserted-by":"crossref","unstructured":"Berton, A.M., Parasiliti-Caprino, M., Prencipe, N., Bioletto, F., Lopez, C., Bona, C., Caputo, M., Rumbolo, F., Ponzetto, F., and Settanni, F. (2023). Copeptin Adaptive Response to SGLT2 Inhibitors in Patients with Type 2 Diabetes Mellitus: The GliRACo Study. Front. Neurosci., 17.","DOI":"10.3389\/fnins.2023.1098404"},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1620\/tjem.177.49","article-title":"Changes in Plasma Vasopressin Levels and Cardiovascular Function Due to Postural Changes in Diabetic Neuropathy","volume":"177","author":"Sato","year":"1995","journal-title":"Tohoku J. Exp. Med."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1042\/cs0770589","article-title":"Vasopressin Secretion in Diabetic Subjects with and without Autonomic Neuropathy: Responses to Osmotic and Postural Stimulation","volume":"77","author":"Reid","year":"1989","journal-title":"Clin. Sci."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1210\/jc.2010-2499","article-title":"Correlation of Plasma Copeptin and Vasopressin Concentrations in Hypo-, Iso-, and Hyperosmolar States","volume":"96","author":"Balanescu","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.1210\/jc.2008-2278","article-title":"Plasma Carboxy-Terminal Provasopressin (Copeptin): A Novel Marker of Insulin Resistance and Metabolic Syndrome","volume":"94","author":"Saleem","year":"2009","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"E1065","DOI":"10.1210\/jc.2010-2981","article-title":"Plasma Copeptin, a Unifying Factor behind the Metabolic Syndrome","volume":"96","author":"Struck","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1007\/s00125-012-2545-x","article-title":"Sex Differences in the Association between Plasma Copeptin and Incident Type 2 Diabetes: The Prevention of Renal and Vascular Endstage Disease (PREVEND) Study","volume":"55","author":"Abbasi","year":"2012","journal-title":"Diabetologia"},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1210\/jc.2016-1113","article-title":"Plasma Copeptin, AVP Gene Variants, and Incidence of Type 2 Diabetes in a Cohort from the Community","volume":"101","author":"Roussel","year":"2016","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s00592-014-0609-8","article-title":"Plasma Copeptin Is Associated with Type 2 Diabetes in Men but Not in Women in the Population-Based KORA F4 Study","volume":"52","author":"Then","year":"2015","journal-title":"Acta Diabetol."},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.34067\/KID.0002622021","article-title":"Peripheral Insulin Resistance Is Associated with Copeptin in Patients with Chronic Kidney Disease","volume":"2","author":"Arroyo","year":"2021","journal-title":"Kidney360"},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/ki.2009.397","article-title":"Copeptin, a Surrogate Marker of Vasopressin, Is Associated with Microalbuminuria in a Large Population Cohort","volume":"77","author":"Meijer","year":"2010","journal-title":"Kidney Int."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1097\/MNH.0000000000000335","article-title":"Vasopressin and Diabetic Nephropathy","volume":"26","author":"Roussel","year":"2017","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"3639","DOI":"10.2337\/dc13-0683","article-title":"Plasma Copeptin and Renal Outcomes in Patients with Type 2 Diabetes and Albuminuria","volume":"36","author":"Velho","year":"2013","journal-title":"Diabetes Care"},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1007\/s00125-013-2922-0","article-title":"Copeptin, a Surrogate Marker for Arginine Vasopressin, Is Associated with Declining Glomerular Filtration in Patients with Diabetes Mellitus (ZODIAC-33)","volume":"56","author":"Boertien","year":"2013","journal-title":"Diabetologia"},{"key":"ref_248","first-page":"100","article-title":"Copeptin and Renal Function Decline, Cardiovascular Events and Mortality in Type 1 Diabetes","volume":"37","author":"Heinrich","year":"2022","journal-title":"Dial. Transpl. Assoc."},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/s12933-018-0753-5","article-title":"Plasma Copeptin, Kidney Disease, and Risk for Cardiovascular Morbidity and Mortality in Two Cohorts of Type 2 Diabetes","volume":"17","author":"Velho","year":"2018","journal-title":"Cardiovasc. 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