{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T04:28:07Z","timestamp":1781756887575,"version":"3.54.5"},"reference-count":31,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T00:00:00Z","timestamp":1733961600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"MACBIOPEST","award":["MAC2\/1.1a\/289"],"award-info":[{"award-number":["MAC2\/1.1a\/289"]}]},{"name":"MACBIOPEST","award":["PID2022-136549OB-100"],"award-info":[{"award-number":["PID2022-136549OB-100"]}]},{"name":"European Regional Development Fund (FEDER)","award":["MAC2\/1.1a\/289"],"award-info":[{"award-number":["MAC2\/1.1a\/289"]}]},{"name":"European Regional Development Fund (FEDER)","award":["PID2022-136549OB-100"],"award-info":[{"award-number":["PID2022-136549OB-100"]}]},{"name":"MCIN\/AEI\/10.13039\/501100011033\/FEDER, UE","award":["MAC2\/1.1a\/289"],"award-info":[{"award-number":["MAC2\/1.1a\/289"]}]},{"name":"MCIN\/AEI\/10.13039\/501100011033\/FEDER, UE","award":["PID2022-136549OB-100"],"award-info":[{"award-number":["PID2022-136549OB-100"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Considering the detrimental impacts of the current pesticides on the biotic components of the biosphere, the development of novel pesticides is vital. Plant-derived biopesticides have emerged as popular alternatives to create a safer and more sustainable agriculture model. This study aims to validate the previous bioguided fractionation of endemic Canary Islands sage, Salvia canariensis, as a potential source of botanical pesticides using a cultivation process. Accordingly, the bioassay-guided fractionation of the ethanolic extract of the leaves of cultivated S. canariensis on the phytopathogenic fungal mycelia of Botrytis cinerea, Fusarium oxysporum, and Alternaria alternata yielded six known terpenoids. Their abietane diterpenoid-type (1\u20135) and sesquiterpenoid (6) structures were established based on spectroscopic and spectrometric analysis. This strategy identified one abietane diterpenoid, salviol (5), as a potential candidate for the future development of biofungicides with similar potency towards the assayed phytopathogenic fungi to commercial fungicides. Salviol worked in a concentration-dependent manner. Overall, this study reinforces the potential of abietane-type diterpenoids as promising agrochemical lead compounds against infectious diseases caused by phytopathogenic fungi and validates the cultivation of S. canariensis as a potential source of plant-derived biopesticides.<\/jats:p>","DOI":"10.3390\/ijms252413323","type":"journal-article","created":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T03:52:49Z","timestamp":1733975569000},"page":"13323","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Bioassay-Guided Fractionation Networking for Discovery of Biofungicides from Cultivated Salvia canariensis"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4306-2696","authenticated-orcid":false,"given":"Eduardo","family":"Hern\u00e1ndez-\u00c1lvarez","sequence":"first","affiliation":[{"name":"Instituto Universitario de Bio-Org\u00e1nica Antonio Gonz\u00e1lez, Departamento de Qu\u00edmica Org\u00e1nica, Universidad de La Laguna, Avenida Astrof\u00edsico Francisco S\u00e1nchez 2, 38206 La Laguna, Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Rodr\u00edguez-Sabina","sequence":"additional","affiliation":[{"name":"Departamento de Bot\u00e1nica, Ecolog\u00eda y Fisiolog\u00eda Vegetal, Universidad de La Laguna, Avenida Astrof\u00edsico Francisco S\u00e1nchez, 38206 La Laguna, Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guacimara","family":"Gonz\u00e1lez-Delgado","sequence":"additional","affiliation":[{"name":"\u00c1rea de Gesti\u00f3n del Medio Natural y Seguridad, Cabildo Insular de Tenerife, C\/ Las Macetas s\/n, Pabell\u00f3n Insular Santiago Mart\u00edn, 38108 La Laguna, Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2117-8794","authenticated-orcid":false,"given":"Carolina P.","family":"Reyes","sequence":"additional","affiliation":[{"name":"Instituto Universitario de Bio-Org\u00e1nica Antonio Gonz\u00e1lez, Departamento de Bioqu\u00edmica, Microbiolog\u00eda, Biolog\u00eda Celular y Gen\u00e9tica, Universidad de La Laguna, Avenida Astrof\u00edsico Francisco S\u00e1nchez 2, 38206 La Laguna, Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7353-6971","authenticated-orcid":false,"given":"Cristina","family":"Gim\u00e9nez","sequence":"additional","affiliation":[{"name":"Departamento de Bot\u00e1nica, Ecolog\u00eda y Fisiolog\u00eda Vegetal, Universidad de La Laguna, Avenida Astrof\u00edsico Francisco S\u00e1nchez, 38206 La Laguna, Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda \u00c1ngeles","family":"Llar\u00eda-L\u00f3pez","sequence":"additional","affiliation":[{"name":"\u00c1rea de Gesti\u00f3n del Medio Natural y Seguridad, Cabildo Insular de Tenerife, C\/ Las Macetas s\/n, Pabell\u00f3n Insular Santiago Mart\u00edn, 38108 La Laguna, Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9512-7754","authenticated-orcid":false,"given":"Raimundo","family":"Cabrera","sequence":"additional","affiliation":[{"name":"Departamento de Bot\u00e1nica, Ecolog\u00eda y Fisiolog\u00eda Vegetal, Universidad de La Laguna, Avenida Astrof\u00edsico Francisco S\u00e1nchez, 38206 La Laguna, Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel L.","family":"Bazzocchi","sequence":"additional","affiliation":[{"name":"Instituto Universitario de Bio-Org\u00e1nica Antonio Gonz\u00e1lez, Departamento de Qu\u00edmica Org\u00e1nica, Universidad de La Laguna, Avenida Astrof\u00edsico Francisco S\u00e1nchez 2, 38206 La Laguna, Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0641-607X","authenticated-orcid":false,"given":"Ignacio A.","family":"Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Instituto Universitario de Bio-Org\u00e1nica Antonio Gonz\u00e1lez, Departamento de Qu\u00edmica Org\u00e1nica, Universidad de La Laguna, Avenida Astrof\u00edsico Francisco S\u00e1nchez 2, 38206 La Laguna, Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,12]]},"reference":[{"key":"ref_1","unstructured":"Food and Agriculture Organization of the United Nations (FAO) (2021). 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