{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:41:28Z","timestamp":1760146888534,"version":"build-2065373602"},"reference-count":48,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T00:00:00Z","timestamp":1734048000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fondo de Investigaci\u00f3n Sanitaria, Instituto de Salud Carlos III, Madrid, Spain","award":["PI18\/00540","PI21\/01683","IB20134","GR21073"],"award-info":[{"award-number":["PI18\/00540","PI21\/01683","IB20134","GR21073"]}]},{"name":"Junta de Extremadura, M\u00e9rida, Spain","award":["PI18\/00540","PI21\/01683","IB20134","GR21073"],"award-info":[{"award-number":["PI18\/00540","PI21\/01683","IB20134","GR21073"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Many clinical, neuroimaging, neuropathological, epidemiological, and genetic data suggest a relationship between essential tremor (ET) and Parkinson\u2019s disease (PD). Several hypothesis-based gene association studies attempted to find a genetic association between these diseases. Recent case\u2013control association studies in Chinese and Spanish populations showed a marginal association between the CD4 rs1922452 and CD4 rs951818 single nucleotide variants (SNVs) and the risk of PD. The proteins encoded by the CD4 and LAG3 genes have an important role in modulating inflammatory responses, and some recent data associated inflammatory markers to ET. This study investigates a possible association between the most common SNVs in the LAG3\/CD4 genes and the risk of ET in the Spanish Caucasian population. We genotyped 267 patients diagnosed with familial ET and 270 age- and sex-matched controls using specific TaqMan assays for CD4 rs1922452, CD4 rs951818, and LAG3 rs870849 variants. We found a decreased risk for ET in carriers of the LAG3 rs870849 C\/C genotype and the LAG3 rs870849C allelic variant exclusively in men. The mean age of onset of ET was not related to any of the variants studied. These data suggest no association of the gene variants studied with the overall risk for ET, except for a slight decrease in risk in male ET patients carrying the variant LAG3 rs870849C. However, such an association lost significance after correcting for multiple comparisons.<\/jats:p>","DOI":"10.3390\/ijms252413403","type":"journal-article","created":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T04:14:52Z","timestamp":1734322492000},"page":"13403","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Common Variants in the LAG3\/CD4 Genes and Risk for Essential Tremor"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6895-9160","authenticated-orcid":false,"given":"Jos\u00e9 A. G.","family":"Ag\u00fandez","sequence":"first","affiliation":[{"name":"University Institute of Molecular Pathology Biomarkers, Universidad de Extremadura, 10071 C\u00e1ceres, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0594-8557","authenticated-orcid":false,"given":"Yolanda","family":"Mac\u00edas","sequence":"additional","affiliation":[{"name":"University Institute of Molecular Pathology Biomarkers, Universidad de Extremadura, 10071 C\u00e1ceres, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hortensia","family":"Alonso-Navarro","sequence":"additional","affiliation":[{"name":"Section of Neurology, Hospital Universitario del Sureste, 28500 Arganda del Rey, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Garc\u00eda-Mart\u00edn","sequence":"additional","affiliation":[{"name":"University Institute of Molecular Pathology Biomarkers, Universidad de Extremadura, 10071 C\u00e1ceres, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8537-3935","authenticated-orcid":false,"given":"Ignacio","family":"\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3 per la Recer\u00e7a Biom\u00e8dica i Social M\u00fatua de Terrassa, 08221 Terrassa, Spain"},{"name":"Movement Disorders Unit, Department of Neurology, Hospital Universitari Mutua de Terrassa, 08221 Terrassa, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pau","family":"Pastor","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3 per la Recer\u00e7a Biom\u00e8dica i Social M\u00fatua de Terrassa, 08221 Terrassa, Spain"},{"name":"Movement Disorders Unit, Department of Neurology, Hospital Universitari Mutua de Terrassa, 08221 Terrassa, Spain"},{"name":"Hospital Universitari Germans Trias y Pujol, 08916 Badalona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1769-4809","authenticated-orcid":false,"given":"Juli\u00e1n","family":"Benito-Le\u00f3n","sequence":"additional","affiliation":[{"name":"Service of Neurology, Department of Medicine, Hospital Doce de Octubre, Universidad Complutense, 28040 Madrid, Spain"},{"name":"CIBERNED, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, 28222 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom\u00e1s","family":"L\u00f3pez-Alburquerque","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital Universitario de Salamanca, 37007 Salamanca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7558-7323","authenticated-orcid":false,"given":"F\u00e9lix Javier","family":"Jim\u00e9nez-Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Section of Neurology, Hospital Universitario del Sureste, 28500 Arganda del Rey, Spain"},{"name":"Department of Medicine-Neurology, Hospital \u201cPr\u00edncipe de Asturias\u201d, Universidad de Alcal\u00e1, 28801 Alcal\u00e1 de Henares, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1212\/WNL.41.2_Part_1.234","article-title":"Essential Tremor: Clinical Correlates in 350 Patients","volume":"41 Pt 1","author":"Lou","year":"1991","journal-title":"Neurology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S1353-8020(97)00031-X","article-title":"Clinical Features of Essential Tremor Seen in Neurology Practice: A Study of 357 Patients","volume":"3","author":"Gasalla","year":"1997","journal-title":"Park. 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