{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T23:59:49Z","timestamp":1784591989365,"version":"3.55.0"},"reference-count":87,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2024,12,14]],"date-time":"2024-12-14T00:00:00Z","timestamp":1734134400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"OMICS compute cluster at the University of L\u00fcbeck","award":["FKZ 01KD2103A"],"award-info":[{"award-number":["FKZ 01KD2103A"]}]},{"name":"OMICS compute cluster at the University of L\u00fcbeck","award":["874719"],"award-info":[{"award-number":["874719"]}]},{"name":"BMBF project OUTLIVE-CRC","award":["FKZ 01KD2103A"],"award-info":[{"award-number":["FKZ 01KD2103A"]}]},{"name":"BMBF project OUTLIVE-CRC","award":["874719"],"award-info":[{"award-number":["874719"]}]},{"name":"Integrated and Standardized NGS Workflows for Personalized Therapy, Instand-NGS4P","award":["FKZ 01KD2103A"],"award-info":[{"award-number":["FKZ 01KD2103A"]}]},{"name":"Integrated and Standardized NGS Workflows for Personalized Therapy, Instand-NGS4P","award":["874719"],"award-info":[{"award-number":["874719"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The complex and heterogeneous genomic landscape of multiple myeloma (MM) and many of its clinical and prognostic implications remains to be understood. In other cancers, such as breast cancer, using whole-exome sequencing (WES) and molecular signatures in clinical practice has revolutionized classification, prognostic prediction, and patient management. However, such integration is still in its early stages in MM. In this study, we analyzed WES data from 35 MM patients to identify potential mutational signatures and driver mutations correlated with clinical and cytogenetic characteristics. Our findings confirm the complex mutational spectrum and its impact on previously described ontogenetic and epigenetic pathways. They show TYW1 as a possible new potential driver gene and find no significant associations of mutational signatures with clinical findings. Further studies are needed to strengthen the role of mutational signatures in the clinical context of patients with MM to improve patient management.<\/jats:p>","DOI":"10.3390\/ijms252413418","type":"journal-article","created":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T04:14:52Z","timestamp":1734322492000},"page":"13418","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Whole-Exome Sequencing, Mutational Signature Analysis, and Outcome in Multiple Myeloma\u2014A Pilot Study"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8960-5040","authenticated-orcid":false,"given":"Lorenz","family":"Oelschl\u00e4ger","sequence":"first","affiliation":[{"name":"Department of Hematology and Oncology, University Medical Center Schleswig-Holstein (UKSH), University Cancer Center Schleswig-Holstein (UCCSH), Campus L\u00fcbeck, 23538 L\u00fcbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"K\u00fcnstner","sequence":"additional","affiliation":[{"name":"Medical Systems Biology Group, L\u00fcbeck Institute of Experimental Dermatology, University of L\u00fcbeck, 23538 L\u00fcbeck, Germany"},{"name":"University Cancer Center Schleswig-Holstein, University Hospital of Schleswig-Holstein, 23538 L\u00fcbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friederike","family":"Frey","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, University Medical Center Schleswig-Holstein (UKSH), University Cancer Center Schleswig-Holstein (UCCSH), Campus L\u00fcbeck, 23538 L\u00fcbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theo","family":"Leitner","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, University Medical Center Schleswig-Holstein (UKSH), University Cancer 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