{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:47:54Z","timestamp":1790117274152,"version":"4.0.1"},"reference-count":203,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T00:00:00Z","timestamp":1734480000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The receptor for advanced glycation end-products (RAGE), a member of the immunoglobulin superfamily, is expressed in various cell types and mediates cellular responses to a wide range of ligands. The activation of RAGE triggers complex signaling pathways that drive inflammatory, oxidative, and proliferative responses, which are increasingly implicated in the pathogenesis of skin diseases. Despite its well-established roles in conditions such as diabetes, cancer, and chronic inflammation, the contribution of RAGE to skin pathologies remains underexplored. This review synthesizes current findings on RAGE\u2019s involvement in the pathophysiology of skin diseases, including conditions such as psoriasis, atopic dermatitis, and lichen planus, focusing on its roles in inflammatory signaling, tissue remodeling, and skin cancer progression. Additionally, it examines RAGE-modulating treatments investigated in dermatological contexts, highlighting their potential as therapeutic options. Given RAGE\u2019s significance in a variety of skin conditions, further research into its mediated pathways may uncover new opportunities for targeted interventions in skin-specific RAGE signaling.<\/jats:p>","DOI":"10.3390\/ijms252413570","type":"journal-article","created":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T11:17:22Z","timestamp":1734520642000},"page":"13570","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["The RAGE Pathway in Skin Pathology Development: A Comprehensive Review of Its Role and Therapeutic Potential"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9664-3099","authenticated-orcid":false,"given":"Marcin","family":"Radziszewski","sequence":"first","affiliation":[{"name":"Department of Histology and Embryology, Medical University of Warsaw, 02-004 Warsaw, Poland"},{"name":"Department of Thoracic Surgery, National Medical Institute of the Ministry of the Interior and Administration, 02-507 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryszard","family":"Galus","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Medical University of Warsaw, 02-004 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"\u0141uszczy\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Medical University of Warsaw, 02-004 Warsaw, Poland"},{"name":"Laboratory of Molecular Oncology and Innovative Therapies, Military Institute of Medicine National Research Institute, 04-141 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Winiarski","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, National Medical Institute of the Ministry of the Interior and Administration, 02-507 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dariusz","family":"W\u0105sowski","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, National Medical Institute of the Ministry of the Interior and Administration, 02-507 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5371-8476","authenticated-orcid":false,"given":"Jacek","family":"Malejczyk","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Medical University of Warsaw, 02-004 Warsaw, Poland"},{"name":"Institute of Health Sciences, Faculty of Medical and Health Sciences, University of Siedlce, 08-110 Siedlce, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0683-1791","authenticated-orcid":false,"given":"Pawe\u0142","family":"W\u0142odarski","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Medical University of Warsaw, 02-004 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aneta","family":"\u015acie\u017cy\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Medical University of Warsaw, 02-004 Warsaw, Poland"},{"name":"Laboratory of Molecular Oncology and Innovative Therapies, Military Institute of Medicine National Research Institute, 04-141 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1146\/annurev-med-041316-085215","article-title":"Targeting RAGE Signaling in Inflammatory Disease","volume":"69","author":"Hudson","year":"2018","journal-title":"Annu. Rev. Med."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Guarneri, F., Custurone, P., Papaianni, V., and Gangemi, S. (2021). Involvement of RAGE and Oxidative Stress in Inflammatory and Infectious Skin Diseases. Antioxidants, 10.","DOI":"10.3390\/antiox10010082"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Tampa, M., Neagu, M., Caruntu, C., Constantin, C., and Georgescu, S.R. (2022). Skin Inflammation-A Cornerstone in Dermatological Conditions. J. Pers. Med., 12.","DOI":"10.3390\/jpm12091370"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/dmrr.2560","article-title":"AGEs and chronic subclinical inflammation in diabetes: Disorders of immune system","volume":"31","author":"Hu","year":"2015","journal-title":"Diabetes Metab. Res. Rev."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Senatus, L.M., and Schmidt, A.M. (2017). The AGE-RAGE Axis: Implications for Age-Associated Arterial Diseases. Front. Genet., 8.","DOI":"10.3389\/fgene.2017.00187"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"14998","DOI":"10.1016\/S0021-9258(18)42138-2","article-title":"Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins","volume":"267","author":"Neeper","year":"1992","journal-title":"J. Biol. Chem."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"3818196","DOI":"10.1155\/2020\/3818196","article-title":"Advanced Glycation End Products (AGEs): Biochemistry, Signaling, Analytical Methods, and Epigenetic Effects","volume":"2020","author":"Perrone","year":"2020","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1189\/jlb.1012519","article-title":"RAGE regulation and signaling in inflammation and beyond","volume":"94","author":"Kierdorf","year":"2013","journal-title":"J. Leukoc. Biol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1152\/advan.00058.2013","article-title":"Pattern recognition receptors in innate immunity, host defense, and immunopathology","volume":"37","author":"Suresh","year":"2013","journal-title":"Adv. Physiol. Educ."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s10522-019-09808-3","article-title":"The receptor for advanced glycation end-products (RAGE) is an important pattern recognition receptor (PRR) for inflammaging","volume":"20","author":"Teissier","year":"2019","journal-title":"Biogerontology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/j.micinf.2004.08.004","article-title":"RAGE (receptor for advanced glycation end products): A central player in the inflammatory response","volume":"6","author":"Chavakis","year":"2004","journal-title":"Microbes Infect."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Yue, Q., Song, Y., Liu, Z., Zhang, L., Yang, L., and Li, J. (2022). Receptor for Advanced Glycation End Products (RAGE): A Pivotal Hub in Immune Diseases. Molecules, 27.","DOI":"10.3390\/molecules27154922"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/nature00858","article-title":"Release of chromatin protein HMGB1 by necrotic cells triggers inflammation","volume":"418","author":"Scaffidi","year":"2002","journal-title":"Nature"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1007\/s12035-017-0419-4","article-title":"RAGE-TLR Crosstalk Sustains Chronic Inflammation in Neurodegeneration","volume":"55","author":"Brokos","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1080\/14728222.2018.1439924","article-title":"Extracellular HMGB1 as a therapeutic target in inflammatory diseases","volume":"22","author":"Andersson","year":"2018","journal-title":"Expert. Opin. Ther. Targets."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"4046","DOI":"10.1158\/1078-0432.CCR-13-0495","article-title":"HMGB1 in cancer: Good, bad, or both?","volume":"19","author":"Kang","year":"2013","journal-title":"Clin. Cancer Res."},{"key":"ref_17","first-page":"163","article-title":"HMGB1 and its physiological and pathological roles","volume":"113","author":"Naglova","year":"2012","journal-title":"Bratisl. Lek. Listy"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Cer\u00f3n, J.J., Ort\u00edn-Bustillo, A., L\u00f3pez-Mart\u00ednez, M.J., Mart\u00ednez-Subiela, S., Eckersall, P.D., Tecles, F., Tvarijonaviciute, A., and Mu\u00f1oz-Prieto, A. (2023). S-100 Proteins: Basics and Applications as Biomarkers in Animals with Special Focus on Calgranulins (S100A8, A9, and A12). Biology, 12.","DOI":"10.3390\/biology12060881"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Gonzalez, L.L., Garrie, K., and Turner, M.D. (2020). Role of S100 proteins in health and disease. Biochim. Biophys. Acta Mol. Cell Res., 1867.","DOI":"10.1016\/j.bbamcr.2020.118677"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1111\/bjd.13125","article-title":"The antimicrobial protein S100A7\/psoriasin enhances the expression of keratinocyte differentiation markers and strengthens the skin\u2019s tight junction barrier","volume":"171","author":"Hattori","year":"2014","journal-title":"Br. J. Dermatol."},{"key":"ref_21","first-page":"2075","article-title":"Knockdown of S100A4 decreases tumorigenesis and metastasis in osteosarcoma cells by repression of matrix metalloproteinase-9","volume":"12","author":"Zhang","year":"2011","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.1161\/ATVBAHA.114.304306","article-title":"EN-RAGE: A novel inflammatory marker for incident coronary heart disease","volume":"34","author":"Ligthart","year":"2014","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/382685a0","article-title":"RAGE and amyloid-beta peptide neurotoxicity in Alzheimer\u2019s disease","volume":"382","author":"Yan","year":"1996","journal-title":"Nature"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1006\/exnr.2001.7732","article-title":"Involvement of microglial receptor for advanced glycation endproducts (RAGE) in Alzheimer\u2019s disease: Identification of a cellular activation mechanism","volume":"171","author":"Lue","year":"2001","journal-title":"Exp. Neurol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1479-5876-7-17","article-title":"RAGE (Receptor for Advanced Glycation Endproducts), RAGE ligands, and their role in cancer and inflammation","volume":"7","author":"Sparvero","year":"2009","journal-title":"J. Transl. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.bbrc.2014.06.074","article-title":"HMGB1-DNA complex-induced autophagy limits AIM2 inflammasome activation through RAGE","volume":"450","author":"Liu","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.tibs.2011.08.008","article-title":"RAGE: A single receptor fits multiple ligands","volume":"36","author":"Fritz","year":"2011","journal-title":"Trends Biochem. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/978-1-62703-230-8_15","article-title":"RAGE-mediated cell signaling","volume":"963","author":"Rouhiainen","year":"2013","journal-title":"Methods Mol. Biol."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Gutowska, K., Czajkowski, K., and Kury\u0142owicz, A. (2023). Receptor for the Advanced Glycation End Products (RAGE) Pathway in Adipose Tissue Metabolism. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241310982"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vph.2015.06.011","article-title":"Soluble RAGEs\u2014Prospects for treating & tracking metabolic and inflammatory disease","volume":"72","author":"Schmidt","year":"2015","journal-title":"Vascul Pharmacol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"940","DOI":"10.2174\/092986709787581888","article-title":"Soluble forms of RAGE in human diseases: Clinical and therapeutical implications","volume":"16","author":"Santilli","year":"2009","journal-title":"Curr. Med. Chem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s12933-022-01535-3","article-title":"Circulating levels of AGEs and soluble RAGE isoforms are associated with all-cause mortality and development of cardiovascular complications in type 2 diabetes: A retrospective cohort study","volume":"21","author":"Sabbatinelli","year":"2022","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Zhang, D.Q., Wang, R., Li, T., Zhou, J.P., Chang, G.Q., Zhao, N., Yang, L.N., Zhai, H., and Yang, L. (2016). Reduced soluble RAGE is associated with disease severity of axonal Guillain-Barr\u00e9 syndrome. Sci. Rep., 6.","DOI":"10.1038\/srep21890"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1080\/07357900701560521","article-title":"Receptor for advanced glycation end products (RAGE)\u2014Soluble form (sRAGE) and gene polymorphisms in patients with breast cancer","volume":"25","author":"Mestek","year":"2007","journal-title":"Cancer Investig."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1177\/10998004211021496","article-title":"Analysis of RAGE Proteome and Interactome in Lung Adenocarcinoma Using PANTHER and STRING Databases","volume":"23","author":"Downs","year":"2021","journal-title":"Biol. Res. Nurs."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1042\/bj20021371","article-title":"Novel splice variants of the receptor for advanced glycation end-products expressed in human vascular endothelial cells and pericytes, and their putative roles in diabetes-induced vascular injury","volume":"370","author":"Yonekura","year":"2003","journal-title":"Biochem. J."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1002\/jnr.21692","article-title":"Expression of the receptor for advanced glycation end products in oligodendrocytes in response to oxidative stress","volume":"86","author":"Qin","year":"2008","journal-title":"J. Neurosci. Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.diabet.2009.04.009","article-title":"Differential effect of plasma or erythrocyte AGE-ligands of RAGE on expression of transcripts for receptor isoforms","volume":"35","author":"Grossin","year":"2009","journal-title":"Diabetes Metab."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/exd.12899","article-title":"Epidermal expression of receptor for advanced glycation end products (RAGE) is related to inflammation and apoptosis in human skin","volume":"25","author":"Iwamura","year":"2016","journal-title":"Exp. Dermatol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2400","DOI":"10.1038\/jid.2013.185","article-title":"Keratinocyte-specific deletion of the receptor RAGE modulates the kinetics of skin inflammation in vivo","volume":"133","author":"Leibold","year":"2013","journal-title":"J. Investig. Dermatol."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Sultana, R., Parveen, A., Kang, M.C., Hong, S.M., and Kim, S.Y. (2024). Glyoxal-derived advanced glycation end products (GO-AGEs) with UVB critically induce skin inflammaging: In vitro and in silico approaches. Sci. Rep., 14.","DOI":"10.1038\/s41598-024-52037-z"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.4049\/jimmunol.181.2.1499","article-title":"Chemotactic activity of S100A7 (Psoriasin) is mediated by the receptor for advanced glycation end products and potentiates inflammation with highly homologous but functionally distinct S100A15","volume":"181","author":"Wolf","year":"2008","journal-title":"J. Immunol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"14123","DOI":"10.1021\/acsnano.3c04726","article-title":"Echinacoside-Zinc Nanomaterial Inhibits Skin Glycation by Suppressing the Transcriptional Activation of the Receptor for Advanced Glycation End-Products","volume":"17","author":"Han","year":"2023","journal-title":"ACS Nano"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"250","DOI":"10.2174\/138920010791196337","article-title":"HMGB1-directed drug discovery targeting cutaneous inflammatory dysregulation","volume":"11","author":"Lamore","year":"2010","journal-title":"Curr. Drug Metab."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1159\/000534639","article-title":"Advanced Glycation End Products-Induced Activation of Keratinocytes: A Mechanism Underlying Cutaneous Immune Response in Psoriasis","volume":"15","author":"Kang","year":"2023","journal-title":"J. Innate Immun."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"782","DOI":"10.2340\/00015555-2661","article-title":"Advanced Glycation End Products are Increased in the Skin and Blood of Patients with Severe Psoriasis","volume":"97","author":"Papagrigoraki","year":"2017","journal-title":"Acta Derm. Venereol."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Damasiewicz-Bodzek, A., and Nowak, A. (2022). Concentrations of N6-Carboxymethyllysine (CML), N6-Carboxyethyllysine (CEL), and Soluble Receptor for Advanced Glycation End-Products (sRAGE) Are Increased in Psoriatic Patients. Biomolecules, 12.","DOI":"10.3390\/biom12121870"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Karas, A., Holmannova, D., Borsky, P., Fiala, Z., Andrys, C., Hamakova, K., Svadlakova, T., Palicka, V., Krejsek, J., and Rehacek, V. (2022). Significantly Altered Serum Levels of NAD, AGE, RAGE, CRP, and Elastin as Potential Biomarkers of Psoriasis and Aging-A Case-Control Study. Biomedicines, 10.","DOI":"10.3390\/biomedicines10051133"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"7","DOI":"10.2147\/PTT.S190507","article-title":"Increased dermal expression of chromatin-associated protein HMGB1 and concomitant T-cell expression of the DNA RAGE in patients with psoriasis vulgaris","volume":"9","author":"Strohbuecker","year":"2019","journal-title":"Psoriasis"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s00403-002-0301-7","article-title":"Gene polymorphisms (G82S, 1704G\/T, 2184A\/G and 2245G\/A) of the receptor of advanced glycation end products (RAGE) in plaque psoriasis","volume":"294","year":"2002","journal-title":"Arch. Dermatol Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1590\/abd1806-4841.20175038","article-title":"Study of serum levels and skin expression of S100B protein in psoriasis","volume":"92","author":"Salem","year":"2017","journal-title":"An. Bras. Dermatol."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Yoshioka, M., Sawada, Y., Saito-Sasaki, N., Yoshioka, H., Hama, K., Omoto, D., Ohmori, S., Okada, E., and Nakamura, M. (2021). High S100A2 expression in keratinocytes in patients with drug eruption. Sci. Rep., 11.","DOI":"10.1038\/s41598-021-85009-8"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1038\/jid.2009.206","article-title":"Significance of the S100A4 protein in psoriasis","volume":"130","author":"Zibert","year":"2010","journal-title":"J. Investig. Dermatol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"8465083","DOI":"10.1155\/2020\/8465083","article-title":"Alarmins HMGB1, IL-33, S100A7, and S100A12 in Psoriasis Vulgaris","volume":"2020","author":"Borsky","year":"2020","journal-title":"Mediators Inflamm."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1111\/jdv.13269","article-title":"Among the S100 proteins, S100A12 is the most significant marker for psoriasis disease activity","volume":"30","author":"Wagenpfeil","year":"2016","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1096\/fj.03-0148fje","article-title":"Molecular cloning and characterization of alternatively spliced mRNA isoforms from psoriatic skin encoding a novel member of the S100 family","volume":"17","author":"Wolf","year":"2003","journal-title":"FASEB J."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Lei, H., Li, X., Jing, B., Xu, H., and Wu, Y. (2017). Human S100A7 Induces Mature Interleukin1\u03b1 Expression by RAGE-p38 MAPK-Calpain1 Pathway in Psoriasis. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0169788"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1111\/exd.13023","article-title":"S100A7 (psoriasin) inhibits human epidermal differentiation by enhanced IL-6 secretion through I\u03baB\/NF-\u03baB signalling","volume":"25","author":"Son","year":"2016","journal-title":"Exp. Dermatol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/j.1365-2133.2008.08904.x","article-title":"Detection of psoriasin\/S100A7 in the sera of patients with psoriasis","volume":"160","author":"Anderson","year":"2009","journal-title":"Br. J. Dermatol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1111\/exd.14167","article-title":"In vivo quantitative analysis of advanced glycation end products in atopic dermatitis-Possible culprit for the comorbidities?","volume":"29","author":"Hong","year":"2020","journal-title":"Exp. Dermatol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"766","DOI":"10.5114\/ada.2023.133585","article-title":"Serum sRAGE levels in children with atopic dermatitis: A prospective study","volume":"40","author":"Sagiroglu","year":"2023","journal-title":"Postepy Dermatol. Alergol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s00011-016-0914-5","article-title":"Circulating soluble receptor for advanced glycation end products is decreased and inversely associated with acute phase response in chronic spontaneous urticaria","volume":"65","author":"Grzanka","year":"2016","journal-title":"Inflamm. Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1111\/exd.12563","article-title":"DAMP molecules S100A9 and S100A8 activated by IL-17A and house-dust mites are increased in atopic dermatitis","volume":"23","author":"Jin","year":"2014","journal-title":"Exp. Dermatol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.jaci.2013.04.046","article-title":"Intrinsic atopic dermatitis shows similar TH2 and higher TH17 immune activation compared with extrinsic atopic dermatitis","volume":"132","author":"Dhingra","year":"2013","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/jid.2008.268","article-title":"The antimicrobial protein psoriasin (S100A7) is upregulated in atopic dermatitis and after experimental skin barrier disruption","volume":"129","author":"Harder","year":"2009","journal-title":"J. Investig. Dermatol."},{"key":"ref_66","first-page":"53","article-title":"Diagnosis and treatment of lichen planus","volume":"84","author":"Usatine","year":"2011","journal-title":"Am. Fam. Physician"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1111\/j.1365-2133.2004.06257.x","article-title":"Lichen planus and hepatitis C virus: A multicentre study of patients with oral lesions and a systematic review","volume":"151","author":"Lodi","year":"2004","journal-title":"Br. J. Dermatol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1365-2133.2005.06999.x","article-title":"Lichen planus is associated with human herpesvirus type 7 replication and infiltration of plasmacytoid dendritic cells","volume":"154","author":"Teunissen","year":"2006","journal-title":"Br. J. Dermatol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"485","DOI":"10.2340\/00015555-2306","article-title":"Up-regulation of Proinflammatory Genes and Cytokines Induced by S100A8 in CD8+ T Cells in Lichen Planus","volume":"96","author":"Domingues","year":"2016","journal-title":"Acta Derm. Venereol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s00403-018-1837-5","article-title":"Up-regulation of HMGB1 and TLR4 in skin lesions of lichen planus","volume":"310","author":"Hirata","year":"2018","journal-title":"Arch. Dermatol. Res."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/eos.12416","article-title":"Role of the high mobility group box 1 signalling axes via the receptor for advanced glycation end-products and toll-like receptor-4 in the immunopathology of oral lichen planus: A potential drug target?","volume":"126","author":"Salem","year":"2018","journal-title":"Eur J Oral Sci."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"266","DOI":"10.5152\/iao.2017.3411","article-title":"Cholesteatoma Definition and Classification: A Literature Review","volume":"13","author":"Rutkowska","year":"2017","journal-title":"J. Int. Adv. Otol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s00109-014-1217-3","article-title":"Molecular signaling of the HMGB1\/RAGE axis contributes to cholesteatoma pathogenesis","volume":"93","author":"Szczepanski","year":"2015","journal-title":"J. Mol. Med."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"\u0141uczak, M.W., D\u017caman, K., Zar\u0119ba, \u0141., Czerwaty, K., Siewiera, J., G\u0142uszko, A., Olszewska, E., Brzost, J., Kantor, I., and Szczepa\u0144ski, M.J. (2023). HMGB1 Carried by Small Extracellular Vesicles Potentially Plays a Role in Promoting Acquired Middle Ear Cholesteatoma. Diagnostics, 13.","DOI":"10.3390\/diagnostics13223469"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.micinf.2015.06.002","article-title":"The receptor for advanced glycation end products promotes bacterial growth at distant body sites in Staphylococcus aureus skin infection","volume":"17","author":"Achouiti","year":"2015","journal-title":"Microbes Infect."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1093\/infdis\/jiy007","article-title":"Lack of Receptor for Advanced Glycation End Products Leads to Less Severe Staphylococcal Skin Infection but More Skin Abscesses and Prolonged Wound Healing","volume":"218","author":"Na","year":"2018","journal-title":"J. Infect. Dis."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1111\/j.1365-2133.2005.07112.x","article-title":"The expression of RAGE and EN-RAGE in leprosy","volume":"154","author":"Kim","year":"2006","journal-title":"Br. J. Dermatol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"155056","DOI":"10.1016\/j.cyto.2020.155056","article-title":"Profiling inflammatory response in lesions of cutaneous leishmaniasis patients using a non-invasive sampling method combined with a high-throughput protein detection assay","volume":"130","author":"Taslimi","year":"2020","journal-title":"Cytokine"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"4349","DOI":"10.4049\/jimmunol.0801199","article-title":"The receptor for advanced glycation end products impairs host defense in pneumococcal pneumonia","volume":"182","author":"Schouten","year":"2009","journal-title":"J. Immunol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1159\/000348739","article-title":"Limited role of the receptor for advanced glycation end products during Streptococcus pneumoniae bacteremia","volume":"5","author":"Achouiti","year":"2013","journal-title":"J. Innate Immun."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.matbio.2024.01.002","article-title":"S100A4 a classical DAMP as a therapeutic target in fibrosis","volume":"127","year":"2024","journal-title":"Matrix Biol."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Kim, J., Park, J.C., Lee, M.H., Yang, C.E., Lee, J.H., and Lee, W.J. (2017). High-Mobility Group Box 1 Mediates Fibroblast Activity via RAGE-MAPK and NF-\u03baB Signaling in Keloid Scar Formation. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19010076"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"2901","DOI":"10.1002\/art.22042","article-title":"Increase in production of matrix metalloproteinase 13 by human articular chondrocytes due to stimulation with S100A4: Role of the receptor for advanced glycation end products","volume":"54","author":"Yammani","year":"2006","journal-title":"Arthritis Rheum."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1136\/annrheumdis-2013-204516","article-title":"S100A4 amplifies TGF-\u03b2-induced fibroblast activation in systemic sclerosis","volume":"74","author":"Tomcik","year":"2015","journal-title":"Ann. Rheum. Dis."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1093\/rheumatology\/kead295","article-title":"S100A4-neutralizing monoclonal antibody 6B12 counteracts the established experimental skin fibrosis induced by bleomycin","volume":"63","author":"Tran","year":"2024","journal-title":"Rheumatology"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1002\/art.42781","article-title":"Effect of Anti-S100A4 Monoclonal Antibody Treatment on Experimental Skin Fibrosis and Systemic Sclerosis-Specific Transcriptional Signatures in Human Skin","volume":"76","author":"Tomcik","year":"2024","journal-title":"Arthritis Rheumatol."},{"key":"ref_87","first-page":"194","article-title":"S100A9 aggravates bleomycin-induced dermal fibrosis in mice via activation of ERK1\/2 MAPK and NF-\u03baB pathways","volume":"21","author":"Xu","year":"2018","journal-title":"Iran. J. Basic. Med. Sci."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.jid.2016.10.040","article-title":"S100A12 Induced in the Epidermis by Reduced Hydration Activates Dermal Fibroblasts and Causes Dermal Fibrosis","volume":"137","author":"Zhao","year":"2017","journal-title":"J. Investig. Dermatol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s13075-020-02159-2","article-title":"Alternatively activated macrophages are associated with the \u03b12AP production that occurs with the development of dermal fibrosis: The role of alternatively activated macrophages on the development of fibrosis","volume":"22","author":"Kanno","year":"2020","journal-title":"Arthritis Res. Ther."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1007\/s10067-013-2305-4","article-title":"Increased expression of S100A8 and S100A9 in patients with diffuse cutaneous systemic sclerosis. A correlation with organ involvement and immunological abnormalities","volume":"32","author":"Xu","year":"2013","journal-title":"Clin. Rheumatol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/s10875-008-9252-x","article-title":"Clinical significance of serum HMGB-1 and sRAGE levels in systemic sclerosis: Association with disease severity","volume":"29","author":"Yoshizaki","year":"2009","journal-title":"J. Clin. Immunol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1093\/rheumatology\/kel076","article-title":"Circulating levels of Nepsilon-(carboxymethyl)lysine are increased in systemic sclerosis","volume":"46","author":"Kaloudi","year":"2007","journal-title":"Rheumatology"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1093\/rheumatology\/kep151","article-title":"Expression of advanced glycation end products and their receptor in skin from patients with systemic sclerosis with and without calcinosis","volume":"48","author":"Davies","year":"2009","journal-title":"Rheumatology"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"2059513116676828","DOI":"10.1177\/2059513116676828","article-title":"The effects of advanced glycation end products (AGEs) on dermal wound healing and scar formation: A systematic review","volume":"2","author":"Moortgat","year":"2016","journal-title":"Scars Burn. Health"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1600-0625.2011.01408.x","article-title":"Involvement of RAGE, MAPK and NF-\u03baB pathways in AGEs-induced MMP-9 activation in HaCaT keratinocytes","volume":"21","author":"Zhu","year":"2012","journal-title":"Exp. Dermatol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"109831","DOI":"10.1016\/j.diabres.2022.109831","article-title":"AGEs-induced MMP-9 activation mediated by Notch1 signaling is involved in impaired wound healing in diabetic rats","volume":"186","author":"Zhu","year":"2022","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1097\/DAD.0b013e31816a8c5b","article-title":"Effects of extracellular matrix glycosylation on proliferation and apoptosis of human dermal fibroblasts via the receptor for advanced glycosylated end products","volume":"30","author":"Niu","year":"2008","journal-title":"Am. J. Dermatopathol."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Loughlin, D.T., and Artlett, C.M. (2010). Precursor of advanced glycation end products mediates ER-stress-induced caspase-3 activation of human dermal fibroblasts through NAD(P)H oxidase 4. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0011093"},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Serban, A.I., Stanca, L., Geicu, O.I., Munteanu, M.C., and Dinischiotu, A. (2016). RAGE and TGF-\u03b21 Cross-Talk Regulate Extracellular Matrix Turnover and Cytokine Synthesis in AGEs Exposed Fibroblast Cells. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0152376"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s10103-016-1898-7","article-title":"S100a8\/NF-\u03baB signal pathway is involved in the 800-nm diode laser-induced skin collagen remodeling","volume":"31","author":"Ren","year":"2016","journal-title":"Lasers Med. Sci."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/j.clinthera.2016.02.028","article-title":"Key Role of DAMP in Inflammation, Cancer, and Tissue Repair","volume":"38","author":"Pandolfi","year":"2016","journal-title":"Clin. Ther."},{"key":"ref_102","first-page":"330","article-title":"Receptor for advanced glycation end as drug targets in diabetes-induced skin lesion","volume":"9","author":"Chen","year":"2017","journal-title":"Am. J. Transl. Res."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/s41419-020-2432-1","article-title":"RAGE acts as an oncogenic role and promotes the metastasis of human lung cancer","volume":"11","author":"Chen","year":"2020","journal-title":"Cell Death Dis."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1038\/onc.2016.324","article-title":"Targeting of RAGE-ligand signaling impairs breast cancer cell invasion and metastasis","volume":"36","author":"Kwak","year":"2017","journal-title":"Oncogene"},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Applegate, C.C., Nelappana, M.B., Nielsen, E.A., Kalinowski, L., Dobrucki, I.T., and Dobrucki, L.W. (2023). RAGE as a Novel Biomarker for Prostate Cancer: A Systematic Review and Meta-Analysis. Cancers, 15.","DOI":"10.3390\/cancers15194889"},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Wen, Y., Zhu, Y., Zhang, C., Yang, X., Gao, Y., Li, M., Yang, H., Liu, T., and Tang, H. (2022). Chronic inflammation, cancer development and immunotherapy. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.1040163"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1084\/jem.20070679","article-title":"RAGE signaling sustains inflammation and promotes tumor development","volume":"205","author":"Gebhardt","year":"2008","journal-title":"J. Exp. Med."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.jdermsci.2016.12.011","article-title":"HMGB1\/RAGE axis promotes autophagy and protects keratinocytes from ultraviolet radiation-induced cell death","volume":"85","author":"Mou","year":"2017","journal-title":"J. Dermatol. Sci."},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Iotzova-Weiss, G., Dziunycz, P.J., Freiberger, S.N., L\u00e4uchli, S., Hafner, J., Vogl, T., French, L.E., and Hofbauer, G.F. (2015). S100A8\/A9 stimulates keratinocyte proliferation in the development of squamous cell carcinoma of the skin via the receptor for advanced glycation-end products. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0120971"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.21873\/anticanres.11282","article-title":"Clinical Implications of High-mobility Group Box-1 (HMGB1) and the Receptor for Advanced Glycation End-products (RAGE) in Cutaneous Malignancy: A Systematic Review","volume":"37","author":"Nguyen","year":"2017","journal-title":"Anticancer. Res."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Olaoba, O.T., Kadasah, S., Vetter, S.W., and Leclerc, E. (2020). RAGE Signaling in Melanoma Tumors. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21238989"},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Li Pomi, F., Borgia, F., Custurone, P., Vaccaro, M., Pioggia, G., and Gangemi, S. (2022). Role of HMGB1 in Cutaneous Melanoma: State of the Art. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23169327"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1046\/j.0022-202X.2004.22218.x","article-title":"Regulation of human melanoma growth and metastasis by AGE-AGE receptor interactions","volume":"122","author":"Abe","year":"2004","journal-title":"J. Investig. Dermatol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1158\/0008-5472.CAN-11-3843","article-title":"S100A9 is a novel ligand of EMMPRIN that promotes melanoma metastasis","volume":"73","author":"Hibino","year":"2013","journal-title":"Cancer Res."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"e009552","DOI":"10.1136\/jitc-2024-009552","article-title":"S100A9 and HMGB1 orchestrate MDSC-mediated immunosuppression in melanoma through TLR4 signaling","volume":"12","author":"Cicortas","year":"2024","journal-title":"J. Immunother. Cancer."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1007\/s10585-016-9801-2","article-title":"MCAM, as a novel receptor for S100A8\/A9, mediates progression of malignant melanoma through prominent activation of NF-\u03baB and ROS formation upon ligand binding","volume":"33","author":"Ruma","year":"2016","journal-title":"Clin. Exp. Metastasis."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"2909","DOI":"10.1158\/0008-5472.CAN-18-3134","article-title":"Upregulation of PD-L1 via HMGB1-Activated IRF3 and NF-\u03baB Contributes to UV Radiation-Induced Immune Suppression","volume":"79","author":"Wang","year":"2019","journal-title":"Cancer Res."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.jid.2018.05.035","article-title":"HMGB1\/RAGE Mediates UVB-Induced Secretory Inflammatory Response and Resistance to Apoptosis in Human Melanocytes","volume":"139","author":"Zhang","year":"2019","journal-title":"J. Investig. Dermatol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.bbrc.2011.08.132","article-title":"Copper-mediated cross-linking of S100A4, but not of S100A2, results in proinflammatory effects in melanoma cells","volume":"413","author":"Wolf","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1111\/jcmm.12808","article-title":"Interaction of extracellular S100A4 with RAGE prompts prometastatic activation of A375 melanoma cells","volume":"20","author":"Herwig","year":"2016","journal-title":"J. Cell Mol. Med."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.bbrc.2016.07.009","article-title":"Extracellular S100A4 affects endothelial cell integrity and stimulates transmigration of A375 melanoma cells","volume":"477","author":"Herwig","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1111\/1346-8138.12323","article-title":"Upregulation of S100P, receptor for advanced glycation end products and ezrin in malignant melanoma","volume":"40","author":"Zhu","year":"2013","journal-title":"J. Dermatol."},{"key":"ref_123","first-page":"F65","article-title":"RAGE and S100 protein transcription levels are highly variable in human melanoma tumors and cells","volume":"28","author":"Leclerc","year":"2009","journal-title":"Gen. Physiol. Biophys."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.biocel.2014.10.001","article-title":"The receptor for advanced glycation end products influences the expression of its S100 protein ligands in melanoma tumors","volume":"57","author":"Meghnani","year":"2014","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1002\/ijc.29619","article-title":"Diminished levels of the soluble form of RAGE are related to poor survival in malignant melanoma","volume":"137","author":"Wagner","year":"2015","journal-title":"Int. J. Cancer."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"259","DOI":"10.4161\/derm.22028","article-title":"Advanced glycation end products: Key players in skin aging?","volume":"4","author":"Gkogkolou","year":"2012","journal-title":"Dermatoendocrinology"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/sj.jid.5700070","article-title":"The receptor for advanced glycation end products is highly expressed in the skin and upregulated by advanced glycation end products and tumor necrosis factor-alpha","volume":"126","author":"Lohwasser","year":"2006","journal-title":"J. Investig. Dermatol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.mad.2017.02.001","article-title":"Glycation stimulates cutaneous monocyte differentiation in reconstructed skin in vitro","volume":"162","author":"Pageon","year":"2017","journal-title":"Mech. Ageing Dev."},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Hiramoto, K., Imai, M., Tanaka, S., and Ooi, K. (2023). Changes in the AGE\/Macrophage\/TNF-\u03b1 Pathway Affect Skin Dryness during KK-Ay\/Tajcl Mice Aging. Life, 13.","DOI":"10.3390\/life13061339"},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Lee, E.J., Kim, J.Y., and Oh, S.H. (2016). Advanced glycation end products (AGEs) promote melanogenesis through receptor for AGEs. Sci. Rep., 6.","DOI":"10.1038\/srep27848"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1046\/j.1523-1747.2002.01788.x","article-title":"Photosensitized growth inhibition of cultured human skin cells: Mechanism and suppression of oxidative stress from solar irradiation of glycated proteins","volume":"119","author":"Wondrak","year":"2002","journal-title":"J. Investig. Dermatol."},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Yao, A., Zhang, Y., Ouyang, M., Wen, L., and Lai, W. (2024). Expression profiles and functional analysis of transfer RNA-derived small RNAs (tsRNAs) in photoaged human dermal fibroblasts. Photochem. Photobiol.","DOI":"10.1111\/php.14015"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1111\/jocd.14261","article-title":"HMGB1-RAGE-moesin axis may be indicted for acne vulgaris","volume":"21","author":"Salem","year":"2022","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"e38785","DOI":"10.1097\/MD.0000000000038785","article-title":"Investigating the mechanism of PAD in the treatment of acne based on network pharmacology and molecular docking: A review","volume":"103","author":"Yan","year":"2024","journal-title":"Medicine"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/j.1365-2796.2011.02432.x","article-title":"High-mobility group box 1 represents a potential marker of disease activity and novel therapeutic target in systemic lupus erythematosus","volume":"270","author":"Urbonaviciute","year":"2011","journal-title":"J. Intern. Med."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.autrev.2010.05.015","article-title":"HMGB1 in systemic lupus Erythematosus: Its role in cutaneous lesions development","volume":"9","author":"Abdulahad","year":"2010","journal-title":"Autoimmun. Rev."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"432","DOI":"10.4103\/ijdvl.IJDVL_113_16","article-title":"Expression of the receptor for advanced glycation end products in acquired reactive perforating collagenosis","volume":"83","author":"Akoglu","year":"2017","journal-title":"Indian. J. Dermatol. Venereol. Leprol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"313","DOI":"10.5021\/ad.2011.23.3.313","article-title":"Expression of Pro-inflammatory Protein S100A12 (EN-RAGE) in Beh\u00e7et\u2019s Disease and Its Association with Disease Activity: A Pilot Study","volume":"23","author":"Han","year":"2011","journal-title":"Ann. Dermatol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1097\/SAP.0000000000001279","article-title":"Extracorporal Shock Wave Therapy Enhances Receptor for Advanced Glycated End-Product-Dependent Flap Survival and Angiogenesis","volume":"80","author":"Birgin","year":"2018","journal-title":"Ann. Plast. Surg."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"109165","DOI":"10.1016\/j.clim.2022.109165","article-title":"RAGE antagonism with azeliragon improves xenograft rejection by T cells in humanized mice","volume":"245","author":"Joshi","year":"2022","journal-title":"Clin. Immunol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1007\/s11064-015-1814-8","article-title":"Effects of RAGE-Specific Inhibitor FPS-ZM1 on Amyloid-\u03b2 Metabolism and AGEs-Induced Inflammation and Oxidative Stress in Rat Hippocampus","volume":"41","author":"Hong","year":"2016","journal-title":"Neurochem. Res."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1002\/cbf.3623","article-title":"TTP488 ameliorates NLRP3-associated inflammation, viability, apoptosis, and ROS production in an Alzheimer\u2019s disease cell model by mediating the JAK1\/STAT3\/NF\u03baB\/IRF3 pathway","volume":"39","author":"Xue","year":"2021","journal-title":"Cell Biochem. Funct."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"e016696","DOI":"10.1161\/JAHA.120.016696","article-title":"Novel Receptor for Advanced Glycation End Products-Blocking Antibody to Treat Diabetic Peripheral Artery Disease","volume":"10","author":"Johnson","year":"2021","journal-title":"J. Am. Heart Assoc."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1093\/rheumatology\/kem141","article-title":"Synovial fluid expression of autoantibodies specific for RAGE relates to less erosive course of rheumatoid arthritis","volume":"46","author":"Pullerits","year":"2007","journal-title":"Rheumatology"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1007\/s00011-012-0518-7","article-title":"The effect of sRAGE-Fc fusion protein attenuates inflammation and decreases mortality in a murine cecal ligation and puncture model","volume":"61","author":"Jeong","year":"2012","journal-title":"Inflamm. Res."},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Ooi, H., Nasu, R., Furukawa, A., Takeuchi, M., and Koriyama, Y. (2022). Pyridoxamine and Aminoguanidine Attenuate the Abnormal Aggregation of \u03b2-Tubulin and Suppression of Neurite Outgrowth by Glyceraldehyde-Derived Toxic Advanced Glycation End-Products. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.921611"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1007\/s12551-018-0471-y","article-title":"S100 proteins as therapeutic targets","volume":"10","author":"Bresnick","year":"2018","journal-title":"Biophys. Rev."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"306","DOI":"10.3892\/mmr.2014.2207","article-title":"Anti-fibrotic effects of specific-siRNA targeting of the receptor for advanced glycation end products in a rat model of experimental hepatic fibrosis","volume":"10","author":"Cai","year":"2014","journal-title":"Mol. Med. Rep."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jfda.2016.10.017","article-title":"Polyphenols with antiglycation activity and mechanisms of action: A review of recent findings","volume":"25","author":"Yeh","year":"2017","journal-title":"J. Food Drug Anal."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"4847812","DOI":"10.1155\/2016\/4847812","article-title":"Metformin Inhibits Advanced Glycation End Products-Induced Inflammatory Response in Murine Macrophages Partly through AMPK Activation and RAGE\/NF\u03baB Pathway Suppression","volume":"2016","author":"Zhou","year":"2016","journal-title":"J. Diabetes Res."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1002\/1097-4644(20010401)81:1<102::AID-JCB1027>3.0.CO;2-Y","article-title":"Role of receptor for advanced glycation end-product (RAGE) and the JAK\/STAT-signaling pathway in AGE-induced collagen production in NRK-49F cells","volume":"81","author":"Huang","year":"2001","journal-title":"J. Cell Biochem."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.ijcard.2009.01.008","article-title":"C-reactive protein (CRP) up-regulates expression of receptor for advanced glycation end products (RAGE) and its inflammatory ligand EN-RAGE in THP-1 cells: Inhibitory effects of atorvastatin","volume":"142","author":"Mahajan","year":"2010","journal-title":"Int. J. Cardiol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"850","DOI":"10.2174\/092986608785203746","article-title":"Telmisartan inhibits advanced glycation end products (AGEs)-elicited endothelial cell injury by suppressing AGE receptor (RAGE) expression via peroxisome proliferator-activated receptor-gammaactivation","volume":"15","author":"Yamagishi","year":"2008","journal-title":"Protein Pept. Lett."},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"Ramadass, V., Vaiyapuri, T., and Tergaonkar, V. (2020). Small Molecule NF-\u03baB Pathway Inhibitors in Clinic. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21145164"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1097\/WAD.0b013e318204b550","article-title":"PF-04494700, an oral inhibitor of receptor for advanced glycation end products (RAGE), in Alzheimer disease","volume":"25","author":"Sabbagh","year":"2011","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1212\/WNL.0000000000000364","article-title":"Clinical trial of an inhibitor of RAGE-A\u03b2 interactions in Alzheimer disease","volume":"82","author":"Galasko","year":"2014","journal-title":"Neurology"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"112","DOI":"10.59566\/IJBS.2013.9112","article-title":"Pharmacological control of receptor of advanced glycation end-products and its biological effects in psoriasis","volume":"9","author":"Mezentsev","year":"2013","journal-title":"Int. J. Biomed. Sci."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"111033","DOI":"10.1016\/j.intimp.2023.111033","article-title":"Rutin attenuates inflammation by downregulating AGE-RAGE signaling pathway in psoriasis: Network pharmacology analysis and experimental evidence","volume":"125 Pt. A","author":"Wang","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"2805","DOI":"10.2147\/DDDT.S417954","article-title":"Deciphering the Mechanism of Xijiao Dihuang Decoction in Treating Psoriasis by Network Pharmacology and Experimental Validation","volume":"17","author":"Guo","year":"2023","journal-title":"Drug Des. Dev. Ther."},{"key":"ref_160","doi-asserted-by":"crossref","unstructured":"Tang, B., Zheng, X., Luo, Q., Li, X., Yang, Y., Bi, Y., Chen, Y., Han, L., Chen, H., and Lu, C. (2024). Network pharmacology and gut microbiota insights: Unraveling Shenling Baizhu powder\u2019s role in psoriasis treatment. Front. Pharmacol., 15.","DOI":"10.3389\/fphar.2024.1362161"},{"key":"ref_161","doi-asserted-by":"crossref","unstructured":"Liu, X., Wang, X., Duan, X., Poorun, D., Xu, J., Zhang, S., Gan, L., He, M., Zhu, K., and Ming, Z. (2017). Lipoxin A4 and its analog suppress inflammation by modulating HMGB1 translocation and expression in psoriasis. Sci. Rep., 7.","DOI":"10.1038\/s41598-017-07485-1"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.intimp.2014.10.014","article-title":"Resveratrol attenuates HMGB1 signaling and inflammation in house dust mite-induced atopic dermatitis in mice","volume":"23","author":"Karuppagounder","year":"2014","journal-title":"Int. Immunopharmacol."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1111\/exd.12685","article-title":"Modulation of HMGB1 translocation and RAGE\/NF\u03baB cascade by quercetin treatment mitigates atopic dermatitis in NC\/Nga transgenic mice","volume":"24","author":"Karuppagounder","year":"2015","journal-title":"Exp. Dermatol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.intimp.2018.04.029","article-title":"Glycyrrhizin ameliorates atopic dermatitis-like symptoms through inhibition of HMGB1","volume":"60","author":"Wang","year":"2018","journal-title":"Int Immunopharmacol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.cyto.2015.05.016","article-title":"Tannic acid modulates NF\u03baB signaling pathway and skin inflammation in NC\/Nga mice through PPAR\u03b3 expression","volume":"76","author":"Karuppagounder","year":"2015","journal-title":"Cytokine"},{"key":"ref_166","doi-asserted-by":"crossref","unstructured":"Chang, Q.X., Lyu, J.L., Wu, P.Y., Wen, K.C., Chang, C.C., and Chiang, H.M. (2023). Coffea arabica Extract Attenuates Atopic Dermatitis-like Skin Lesions by Regulating NLRP3 Inflammasome Expression and Skin Barrier Functions. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241512367"},{"key":"ref_167","doi-asserted-by":"crossref","unstructured":"Huang, W., Huang, X., Yang, L., Han, W., Zhu, Z., Wang, Y., and Chen, R. (2023). Network Pharmacology and Molecular Docking Analysis Exploring the Mechanism of Tripterygium wilfordii in the Treatment of Oral Lichen Planus. Medicina, 59.","DOI":"10.3390\/medicina59081448"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"e39352","DOI":"10.1097\/MD.0000000000039352","article-title":"Network pharmacology and molecular docking analysis predict the mechanisms of Huangbai liniment in treating oral lichen planus","volume":"103","author":"Chang","year":"2024","journal-title":"Medicine"},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"Zhao, Z., Wang, L., Zhang, M., Zhou, C., Wang, Y., Ma, J., and Fan, Y. (2022). Reveals of quercetin\u2019s therapeutic effects on oral lichen planus based on network pharmacology approach and experimental validation. Sci. Rep., 12.","DOI":"10.1038\/s41598-022-04769-z"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1111\/iwj.13909","article-title":"Blocking RAGE improves wound healing in diabetic pigs","volume":"20","author":"Johnson","year":"2023","journal-title":"Int. Wound J."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/S0002-9440(10)61723-3","article-title":"Blockade of receptor for advanced glycation end-products restores effective wound healing in diabetic mice","volume":"159","author":"Goova","year":"2001","journal-title":"Am. J. Pathol."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1089\/wound.2015.0674","article-title":"Soluble Receptor for Advanced Glycation End Products Improves Stromal Cell-Derived Factor-1 Activity in Model Diabetic Environments","volume":"5","author":"Olekson","year":"2016","journal-title":"Adv. Wound Care"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.jconrel.2021.03.032","article-title":"Self-assembled elastin-like polypeptide fusion protein coacervates as competitive inhibitors of advanced glycation end-products enhance diabetic wound healing","volume":"333","author":"Kang","year":"2021","journal-title":"J. Control. Release"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1097\/01.sap.0000122857.49274.8c","article-title":"Use of topical sRAGE in diabetic wounds increases neovascularization and granulation tissue formation","volume":"52","author":"Lee","year":"2004","journal-title":"Ann. Plast. Surg."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.ejps.2012.08.018","article-title":"Topical treatment with anti-oxidants and Au nanoparticles promote healing of diabetic wound through receptor for advance glycation end-products","volume":"47","author":"Chen","year":"2012","journal-title":"Eur J Pharm Sci."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"e2401619","DOI":"10.1002\/adhm.202401619","article-title":"A Multifunctional Nanocomposite Hydrogel Delivery System Based on Dual-Loaded Liposomes for Scarless Wound Healing","volume":"13","author":"Xing","year":"2024","journal-title":"Adv. Healthc. Mater."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1089\/wound.2021.0102","article-title":"Multifunctional Elastin-Like Polypeptide Fusion Protein Coacervates Inhibit Receptor-Mediated Proinflammatory Signals and Promote Angiogenesis in Mouse Diabetic Wounds","volume":"12","author":"Kang","year":"2023","journal-title":"Adv Wound Care"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"448","DOI":"10.2174\/0113816128287155240122121553","article-title":"Underlying Mechanism of Traditional Herbal Formula Chuang-Ling-Ye in the Treatment of Diabetic Foot Ulcer through Network Pharmacology and Molecular Docking","volume":"30","author":"Geng","year":"2024","journal-title":"Curr. Pharm. Des."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.2174\/0113816128288490240322055201","article-title":"Network Pharmacology Study on Herb Pair Bletilla striata-Galla chinensis in the Treatment of Chronic Skin Ulcers","volume":"30","author":"Wang","year":"2024","journal-title":"Curr. Pharm. Des."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"115612","DOI":"10.1016\/j.jep.2022.115612","article-title":"Effect and mechanisms of Polygonatum kingianum (polygonati rhizome) on wound healing in diabetic rats","volume":"298","author":"Qin","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1007\/s00403-024-03021-0","article-title":"Dang-Gui-Si-Ni decoction facilitates wound healing in diabetic foot ulcers by regulating expression of AGEs\/RAGE\/TGF-\u03b2\/Smad2\/3","volume":"316","author":"Zhang","year":"2024","journal-title":"Arch. Dermatol. Res."},{"key":"ref_182","doi-asserted-by":"crossref","unstructured":"Emad, A.M., Mahrous, E.A., Rasheed, D.M., Gomaa, F.A.M., Hamdan, A.M.E., Selim, H.M.R.M., Yousef, E.M., Abo-Zalam, H.B., El-Gazar, A.A., and Ragab, G.M. (2024). Wound Healing Efficacy of Cucurbitaceae Seed Oils in Rats: Comprehensive Phytochemical, Pharmacological, and Histological Studies Tackling AGE\/RAGE and Nrf2\/Ho-1 Cue. Pharmaceuticals, 17.","DOI":"10.3390\/ph17060733"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"2280811","DOI":"10.1080\/07853890.2023.2280811","article-title":"Mechanisms of resveratrol against diabetic wound by network pharmacology and experimental validation","volume":"55","author":"Youjun","year":"2023","journal-title":"Ann. Med."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1055\/s-0033-1351331","article-title":"Effect of aminoguanidine intervention on neutrophils in diabetes inflammatory cells wound healing","volume":"121","author":"Tian","year":"2013","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.sjbs.2020.11.016","article-title":"Attenuation of methylglyoxal-induced glycation and cellular dysfunction in wound healing by Centella cordifolia","volume":"28","author":"Alqahtani","year":"2021","journal-title":"Saudi J. Biol. Sci."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"7951","DOI":"10.12659\/MSM.916950","article-title":"Effect and Mechanism of the Bruton Tyrosine Kinase (Btk) Inhibitor Ibrutinib on Rat Model of Diabetic Foot Ulcers","volume":"25","author":"Yang","year":"2019","journal-title":"Med. Sci. Monit."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1159\/000458734","article-title":"Inhibition of Methylglyoxal-Induced AGEs\/RAGE Expression Contributes to Dermal Protection by N-Acetyl-L-Cysteine","volume":"41","author":"Yang","year":"2017","journal-title":"Cell Physiol. Biochem."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1186\/s13287-020-01681-z","article-title":"Regenerative and protective effects of dMSC-sEVs on high-glucose-induced senescent fibroblasts by suppressing RAGE pathway and activating Smad pathway","volume":"11","author":"Bian","year":"2020","journal-title":"Stem Cell Res. Ther."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.2147\/DMSO.S243549","article-title":"miRNA-221-3p in Endothelial Progenitor Cell-Derived Exosomes Accelerates Skin Wound Healing in Diabetic Mice","volume":"13","author":"Xu","year":"2020","journal-title":"Diabetes Metab. Syndr. Obes."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"3452","DOI":"10.1016\/j.bbagen.2014.09.013","article-title":"Thymosin beta 4 improves dermal burn wound healing via downregulation of receptor of advanced glycation end products in db\/db mice","volume":"1840","author":"Kim","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s12013-010-9077-0","article-title":"Hmgb1 promotes wound healing of 3T3 mouse fibroblasts via RAGE-dependent ERK1\/2 activation","volume":"57","author":"Ranzato","year":"2010","journal-title":"Cell Biochem. Biophys."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s11010-009-0192-4","article-title":"HMGb1 promotes scratch wound closure of HaCaT keratinocytes via ERK1\/2 activation","volume":"332","author":"Ranzato","year":"2009","journal-title":"Mol. Cell Biochem."},{"key":"ref_193","doi-asserted-by":"crossref","unstructured":"Tancharoen, S., Gando, S., Binita, S., Nagasato, T., Kikuchi, K., Nawa, Y., Dararat, P., Yamamoto, M., Narkpinit, S., and Maruyama, I. (2016). HMGB1 Promotes Intraoral Palatal Wound Healing through RAGE-Dependent Mechanisms. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17111961"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/35012626","article-title":"Blockade of RAGE-amphoterin signalling suppresses tumour growth and metastases","volume":"405","author":"Taguchi","year":"2000","journal-title":"Nature"},{"key":"ref_195","doi-asserted-by":"crossref","unstructured":"Zhao, B., Li, Y., Wang, B., Liu, J., Yang, Y., Quan, Q., An, Q., Liang, R., Liu, C., and Yang, C. (2024). Uncovering the Anti-Angiogenic Mechanisms of Centella asiatica via Network Pharmacology and Experimental Validation. Molecules, 29.","DOI":"10.3390\/molecules29020362"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"569","DOI":"10.3892\/etm_00000089","article-title":"Advanced malignant melanoma responds to Prunus mume Sieb. Et. Zucc (Ume) extract: Case report and in vitro study","volume":"1","author":"Matsushita","year":"2010","journal-title":"Exp. Ther. Med."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1111\/php.12615","article-title":"Plantamajoside Inhibits UVB and Advanced Glycation End Products-Induced MMP-1 Expression by Suppressing the MAPK and NF-\u03baB Pathways in HaCaT Cells","volume":"92","author":"Han","year":"2016","journal-title":"Photochem. Photobiol."},{"key":"ref_198","doi-asserted-by":"crossref","unstructured":"Chen, C., Liu, X., Li, L., Guo, M., He, Y., Dong, Y., Meng, H., and Yi, F. (2024). Study of the mechanism by gentiopicroside protects against skin fibroblast glycation damage via the RAGE pathway. Sci. Rep., 14.","DOI":"10.1038\/s41598-024-55525-4"},{"key":"ref_199","doi-asserted-by":"crossref","unstructured":"Lyu, J.L., Liu, Y.J., Wen, K.C., Chiu, C.Y., Lin, Y.H., and Chiang, H.M. (2022). Protective Effect of Djulis (Chenopodium formosanum) Extract against UV- and AGEs-Induced Skin Aging via Alleviating Oxidative Stress and Collagen Degradation. Molecules, 27.","DOI":"10.3390\/molecules27072332"},{"key":"ref_200","unstructured":"Wu, J., and Pan, L. (2022). Study on the effect of Pogostemon cablin Benth on skin aging based on network pharmacology. Curr. Comput. Aided Drug Des."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"763","DOI":"10.2147\/CCID.S344138","article-title":"Mechanism of Ba Zhen Tang Delaying Skin Photoaging Based on Network Pharmacology and Molecular Docking","volume":"15","author":"Han","year":"2022","journal-title":"Clin. Cosmet. Investig. Dermatol."},{"key":"ref_202","doi-asserted-by":"crossref","unstructured":"Li, X., Yang, K., Gao, S., Zhao, J., Liu, G., Chen, Y., Lin, H., Zhao, W., Hu, Z., and Xu, N. (2020). Carnosine Stimulates Macrophage-Mediated Clearance of Senescent Skin Cells Through Activation of the AKT2 Signaling Pathway by CD36 and RAGE. Front. Pharmacol., 11.","DOI":"10.3389\/fphar.2020.593832"},{"key":"ref_203","doi-asserted-by":"crossref","unstructured":"Gu, M.J., Lee, H.W., Yoo, G., Kim, D., Choi, I.W., Kim, Y., and Ha, S.K. (2023). Protective effect of Schizonepeta tenuifolia Briq. ethanolic extract against UVB-induced skin aging and photodamage in hairless mice. Front. Pharmacol., 14.","DOI":"10.3389\/fphar.2023.1176073"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/24\/13570\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:55:00Z","timestamp":1760115300000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/24\/13570"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,18]]},"references-count":203,"journal-issue":{"issue":"24","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["ijms252413570"],"URL":"https:\/\/doi.org\/10.3390\/ijms252413570","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,18]]}}}