{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T11:27:33Z","timestamp":1777980453718,"version":"3.51.4"},"reference-count":53,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Medical University of Bialystok","award":["B.SUB.24.502"],"award-info":[{"award-number":["B.SUB.24.502"]}]},{"name":"Medical University of Bialystok","award":["B.SUB.24.165"],"award-info":[{"award-number":["B.SUB.24.165"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Synaptic pathology is crucial in neurodegenerative diseases (NDs), and numerous studies show a correlation between synaptic proteins and the rate of cognitive decline in Alzheimer\u2019s disease, Parkinson\u2019s disease, dementia, and Creutzfeldt\u2013Jacob\u2019s disease. Due to the fact that altered synaptic function is considered a core feature of the pathophysiology of neurodegenerative disorders, synaptic proteins, such as neurogranin, may serve as a biomarker of these diseases. Neurogranin is a postsynaptic protein located in the cell bodies and dendrites of neurons, foremost in the cerebral cortex, hippocampus, and striatum. It has been established that neurogranin is involved in synaptic plasticity and long-term potentiation. Literature data indicate that cerebrospinal fluid neurogranin may be useful as a biomarker for more accurate diagnosis and prognosis of neurodegenerative diseases. In this review, the diagnostic value of cerebrospinal fluid neurogranin in most common neurodegenerative diseases is examined.<\/jats:p>","DOI":"10.3390\/ijms252413578","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T03:59:43Z","timestamp":1734580783000},"page":"13578","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Diagnostic Value of Cerebrospinal Fluid Neurogranin in Neurodegenerative Diseases"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6200-5232","authenticated-orcid":false,"given":"Daria","family":"Krawczuk","sequence":"first","affiliation":[{"name":"Department of Neurodegeneration Diagnostics, Medical University of Bialystok, Waszyngtona 15A, 15-269 Bia\u0142ystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piotr","family":"Mroczko","sequence":"additional","affiliation":[{"name":"Faculty of Law, University of Bialystok, Mickiewicza 1, 15-213 Bia\u0142ystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Izabela","family":"Winkel","sequence":"additional","affiliation":[{"name":"Dementia Disorders Centre, Medical University of Wroclaw, 50-425 \u015acinawa, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4075-8479","authenticated-orcid":false,"given":"Barbara","family":"Mroczko","sequence":"additional","affiliation":[{"name":"Department of Neurodegeneration Diagnostics, Medical University of Bialystok, Waszyngtona 15A, 15-269 Bia\u0142ystok, Poland"},{"name":"Department of Biochemical Diagnostics, Medical University of Bialystok, Waszyngtona 15A, 15-269 Bia\u0142ystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,19]]},"reference":[{"key":"ref_1","first-page":"111","article-title":"Neurogranin: A brain-specific protein","volume":"34","author":"Li","year":"2003","journal-title":"Sheng Li Ke Xue Jin Zhan"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1002\/iub.357","article-title":"Neurogranin, a link between calcium\/calmodulin and protein kinase C signaling in synaptic plasticity","volume":"62","year":"2010","journal-title":"IUBMB Life"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1006\/abbi.1993.1463","article-title":"Characterization of a 7.5-kDa protein kinase C substrate (RC3 protein, neurogranin) from rat brain","volume":"305","author":"Huang","year":"1993","journal-title":"Arch. 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