{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T09:55:44Z","timestamp":1791453344820,"version":"4.3.3"},"reference-count":75,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Humanidades, Ciencias y Tecnolog\u00edas","doi-asserted-by":"publisher","award":["CF-2023-I-1400"],"award-info":[{"award-number":["CF-2023-I-1400"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Pulpitis, an inflammation of the dental pulp, is generated by bacterial invasion through different ways as caries. In the establishment and development of this disease, different biological processes are involved. Long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) are transcripts with regulatory capacity participating in different biological functions and have been implicated in different diseases. The aim of this narrative review is to critically analyze available evidence on the biological role of lncRNAs and circRNAs in pulpitis and discuss possible new research prospects. LncRNAs and circRNAs involved in pulpitis were explored, addressing their expression, molecular mechanisms, targets and biological effects studied in animal and in vitro models, as well as in studies in human patients. LncRNAs and circRNAs are emerging as key regulators of diverse biological functions in pulpitis including apoptosis, proliferation, differentiation, oxidative stress, autophagy, ferroptosis, inflammation and immune response. The molecular mechanisms performed by these non-coding RNAs (ncRNAs) involved interactions with miRNAs and the formation of regulatory networks in the context of pulpitis. Further studies more deeply analyzing the participation of lncRNAs and circRNAs in pulpitis will reveal the potential applications of these ncRNAs as biomarkers or their use in therapeutic strategies in pulp inflammation.<\/jats:p>","DOI":"10.3390\/ijms252413603","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T06:50:44Z","timestamp":1734591044000},"page":"13603","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Current Insights into the Roles of LncRNAs and CircRNAs in Pulpitis: A Narrative Review"],"prefix":"10.3390","volume":"25","author":[{"given":"Dulce Martha","family":"Fuchen-Ramos","sequence":"first","affiliation":[{"name":"Facultad de Odontolog\u00eda Mexicali, Centro de Ciencias de la Salud Mexicali, Universidad Aut\u00f3noma de Baja California, Zotoluca s\/n, Fracc. Calafia, Mexicali 21040, BC, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8543-5676","authenticated-orcid":false,"given":"Ana Gabriela","family":"Leija-Montoya","sequence":"additional","affiliation":[{"name":"Facultad de Medicina Mexicali, Universidad Aut\u00f3noma de Baja California, Centro C\u00edvico, Mexicali 21000, BC, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7541-8773","authenticated-orcid":false,"given":"Javier","family":"Gonz\u00e1lez-Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Facultad de Enfermer\u00eda, Universidad Aut\u00f3noma de Baja California, Av. \u00c1lvaro Obreg\u00f3n y Calle \u201cG\u201d S\/N, Col. Nueva, Mexicali 21100, BC, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8389-6866","authenticated-orcid":false,"given":"Mario","family":"Isiordia-Espinoza","sequence":"additional","affiliation":[{"name":"Departamento de Cl\u00ednicas, Divisi\u00f3n de Ciencias Biom\u00e9dicas, Centro Universitario de Los Altos, Universidad de Guadalajara, Av. Rafael Casillas Aceves 1200, Tepatitl\u00e1n de Morelos 47600, JAL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9740-9475","authenticated-orcid":false,"given":"Fernando","family":"Garc\u00eda-Ar\u00e9valo","sequence":"additional","affiliation":[{"name":"Facultad de Odontolog\u00eda Mexicali, Centro de Ciencias de la Salud Mexicali, Universidad Aut\u00f3noma de Baja California, Zotoluca s\/n, Fracc. Calafia, Mexicali 21040, BC, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviana","family":"Pitones-Rubio","sequence":"additional","affiliation":[{"name":"Facultad de Odontolog\u00eda Mexicali, Centro de Ciencias de la Salud Mexicali, Universidad Aut\u00f3noma de Baja California, Zotoluca s\/n, Fracc. Calafia, Mexicali 21040, BC, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Olvera-Sandoval","sequence":"additional","affiliation":[{"name":"Facultad de Medicina Mexicali, Universidad Aut\u00f3noma de Baja California, Centro C\u00edvico, Mexicali 21000, BC, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2520-9794","authenticated-orcid":false,"given":"Isis","family":"Mateos-Corral","sequence":"additional","affiliation":[{"name":"Facultad de Odontolog\u00eda Mexicali, Centro de Ciencias de la Salud Mexicali, Universidad Aut\u00f3noma de Baja California, Zotoluca s\/n, Fracc. Calafia, Mexicali 21040, BC, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0402-3985","authenticated-orcid":false,"given":"Nicol\u00e1s","family":"Seraf\u00edn-Higuera","sequence":"additional","affiliation":[{"name":"Facultad de Odontolog\u00eda Mexicali, Centro de Ciencias de la Salud Mexicali, Universidad Aut\u00f3noma de Baja California, Zotoluca s\/n, Fracc. Calafia, Mexicali 21040, BC, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1177\/00220345221150383","article-title":"Development of Rat Caries-Induced Pulpitis Model for Vital Pulp Therapy","volume":"102","author":"Huang","year":"2023","journal-title":"J. Dent. Res."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Galler, K.M., Weber, M., Korkmaz, Y., Widbiller, M., and Feuerer, M. (2021). Inflammatory Response Mechanisms of the Dentine-Pulp Complex and the Periapical Tissues. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22031480"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.joen.2023.11.016","article-title":"Expression of Selected Inflammatory Mediators with Different Clinical Characteristics of Pulpal Inflammation","volume":"50","author":"Sabeti","year":"2024","journal-title":"J. Endod."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"154896","DOI":"10.1016\/j.cyto.2019.154896","article-title":"Role(s) of Cytokines in Pulpitis: Latest Evidence and Therapeutic Approaches","volume":"126","author":"Khorasani","year":"2020","journal-title":"Cytokine"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e20220313","DOI":"10.1590\/1678-7757-2022-0313","article-title":"The Effect of BMP9 on Inflammation in the Early Stage of Pulpitis","volume":"31","author":"Song","year":"2023","journal-title":"J. Appl. Oral Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"5913","DOI":"10.1007\/s00784-023-05203-y","article-title":"Evaluation of Oxidative Stress Cycle in Healthy and Inflamed Dental Pulp Tissue: A Laboratory Investigation","volume":"27","author":"Ozcan","year":"2023","journal-title":"Clin. Oral Investig."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"AAE (2021). Position Statement on Vital Pulp Therapy. J. Endod., 47, 1340\u20131344.","DOI":"10.1016\/j.joen.2021.07.015"},{"key":"ref_8","unstructured":"(2024, December 10). Endodontic Diagnosis Clinical Newsletter\u2014American Association of Endodontists. Available online: https:\/\/www.aae.org\/specialty\/newsletter\/endodontic-diagnosis\/."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1111\/iej.12793","article-title":"Minimally Invasive Endodontics: A New Diagnostic System for Assessing Pulpitis and Subsequent Treatment Needs","volume":"50","author":"Wolters","year":"2017","journal-title":"Int. Endod. J."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"101606","DOI":"10.1016\/j.smim.2022.101606","article-title":"Non-Coding RNA-Based Regulation of Inflammation","volume":"59","author":"Ashrafizadeh","year":"2022","journal-title":"Semin. Immunol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s10266-022-00762-0","article-title":"MicroRNA and Their Implications in Dental Pulp Inflammation: Current Trends and Future Perspectives","volume":"111","author":"Maqbool","year":"2023","journal-title":"Odontology"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1038\/s41380-023-02377-5","article-title":"Techniques for Investigating lncRNA Transcript Functions in Neurodevelopment","volume":"29","author":"Srinivas","year":"2024","journal-title":"Mol. Psychiatry"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/s41580-022-00566-8","article-title":"Long Non-Coding RNAs: Definitions, Functions, Challenges and Recommendations","volume":"24","author":"Mattick","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1038\/s41467-023-36713-8","article-title":"The TINCR Ubiquitin-like Microprotein Is a Tumor Suppressor in Squamous Cell Carcinoma","volume":"14","author":"Brown","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.cell.2015.01.009","article-title":"A Micropeptide Encoded by a Putative Long Noncoding RNA Regulates Muscle Performance","volume":"160","author":"Anderson","year":"2015","journal-title":"Cell"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/s41580-023-00694-9","article-title":"Transcription Regulation by Long Non-Coding RNAs: Mechanisms and Disease Relevance","volume":"25","author":"Ferrer","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Sweta, S., Dudnakova, T., Sudheer, S., Baker, A.H., and Bhushan, R. (2019). Importance of Long Non-Coding RNAs in the Development and Disease of Skeletal Muscle and Cardiovascular Lineages. Front. Cell Dev. Biol., 7.","DOI":"10.3389\/fcell.2019.00228"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/s41420-024-02002-6","article-title":"Roles of Long Noncoding RNAs in Human Inflammatory Diseases","volume":"10","author":"Zhang","year":"2024","journal-title":"Cell Death Discov."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Chini, A., Guha, P., Malladi, V.S., Guo, Z., and Mandal, S.S. (2023). Novel Long Non-Coding RNAs Associated with Inflammation and Macrophage Activation in Human. Sci. Rep., 13.","DOI":"10.1038\/s41598-023-30568-1"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Martinez-Castillo, M., Elsayed, A.M., L\u00f3pez-Berestein, G., Amero, P., and Rodr\u00edguez-Aguayo, C. (2023). An Overview of the Immune Modulatory Properties of Long Non-Coding RNAs and Their Potential Use as Therapeutic Targets in Cancer. Non-Coding RNA, 9.","DOI":"10.3390\/ncrna9060070"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1080\/15476286.2020.1838783","article-title":"LncRNAs in Adaptive Immunity: Role in Physiological and Pathological Conditions","volume":"18","author":"Zeni","year":"2021","journal-title":"RNA Biol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e1872","DOI":"10.1002\/wrna.1872","article-title":"Current Understandings and Open Hypotheses on Extracellular Circular RNAs","volume":"15","author":"Verwilt","year":"2024","journal-title":"Wiley Interdiscip. Rev. RNA"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Son, C.J., Carnino, J.M., Lee, H., and Jin, Y. (2024). Emerging Roles of Circular RNA in Macrophage Activation and Inflammatory Lung Responses. Cells, 13.","DOI":"10.3390\/cells13171407"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e699","DOI":"10.1002\/mco2.699","article-title":"Circular RNAs in Human Diseases","volume":"5","author":"Wang","year":"2024","journal-title":"MedComm"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Kim, J. (2024). Circular RNAs: Novel Players in Cancer Mechanisms and Therapeutic Strategies. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms251810121"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1186\/s13073-024-01400-w","article-title":"Circular RNA Landscape in Extracellular Vesicles from Human Biofluids","volume":"16","author":"Zhao","year":"2024","journal-title":"Genome Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/s41573-021-00219-z","article-title":"Noncoding RNA Therapeutics\u2014Challenges and Potential Solutions","volume":"20","author":"Winkle","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/s41698-022-00283-7","article-title":"Blood-Derived lncRNAs as Biomarkers for Cancer Diagnosis: The Good, the Bad and the Beauty","volume":"6","author":"Badowski","year":"2022","journal-title":"NPJ Precis. Oncol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/s41576-023-00662-1","article-title":"Non-Coding RNAs in Disease: From Mechanisms to Therapeutics","volume":"25","author":"Nemeth","year":"2024","journal-title":"Nat. Rev. Genet."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Huang, L., Chen, X., Yang, X., Zhang, Y., Liang, Y., and Qiu, X. (2024). Elucidating Epigenetic Mechanisms Governing Odontogenic Differentiation in Dental Pulp Stem Cells: An In-Depth Exploration. Front. Cell Dev. Biol., 12.","DOI":"10.3389\/fcell.2024.1394582"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1186\/s13287-019-1411-x","article-title":"Noncoding RNAs: New Insights into the Odontogenic Differentiation of Dental Tissue-Derived Mesenchymal Stem Cells","volume":"10","author":"Fang","year":"2019","journal-title":"Stem Cell Res. Ther."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1007\/s12015-024-10683-w","article-title":"Circular RNA-Mediated Regulation of Oral Tissue-Derived Stem Cell Differentiation: Implications for Oral Medicine and Orthodontic Applications","volume":"20","author":"Suciu","year":"2024","journal-title":"Stem Cell Rev. Rep."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Jiao, K., Walsh, L.J., Ivanovski, S., and Han, P. (2021). The Emerging Regulatory Role of Circular RNAs in Periodontal Tissues and Cells. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22094636"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.joen.2017.08.022","article-title":"Differential Expression of Long Noncoding RNAs in Normal and Inflamed Human Dental Pulp","volume":"44","author":"Huang","year":"2018","journal-title":"J. Endod."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"8831948","DOI":"10.1155\/2021\/8831948","article-title":"The Genetic and Epigenetic Mechanisms Involved in Irreversible Pulp Neural Inflammation","volume":"2021","author":"Xi","year":"2021","journal-title":"Dis. Markers"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e7135","DOI":"10.7717\/peerj.7135","article-title":"Comprehensive Analysis of an lncRNA-miRNA-mRNA Competing Endogenous RNA Network in Pulpitis","volume":"7","author":"Lei","year":"2019","journal-title":"PeerJ"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/j.joen.2021.07.007","article-title":"Comprehensive Analysis of Differentially Expressed Genes in Clinically Diagnosed Irreversible Pulpitis by Multiplatform Data Integration Using a Robust Rank Aggregation Approach","volume":"47","author":"Liu","year":"2021","journal-title":"J. Endod."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"152","DOI":"10.3892\/mmr.2022.12668","article-title":"Exosome-derived lncRNA-Ankrd26 Promotes Dental Pulp Restoration by Regulating miR-150-TLR4 Signaling","volume":"25","author":"Li","year":"2022","journal-title":"Mol. Med. Rep."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"112495","DOI":"10.1016\/j.yexcr.2021.112495","article-title":"Long Noncoding RNA MEG3 Expressed in Human Dental Pulp Regulates LPS-Induced Inflammation and Odontogenic Differentiation in Pulpitis","volume":"400","author":"Liu","year":"2021","journal-title":"Exp. Cell Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"107497","DOI":"10.1016\/j.intimp.2021.107497","article-title":"NUTM2A-AS1 Silencing Alleviates LPS-Induced Apoptosis and Inflammation in Dental Pulp Cells through Targeting Let-7c-5p\/HMGB1 Axis","volume":"96","author":"Wang","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.bbrc.2021.09.081","article-title":"SNHG7 Promotes the Osteo\/Dentinogenic Differentiation Ability of Human Dental Pulp Stem Cells by Interacting with Hsa-miR-6512-3p in an Inflammatory Microenvironment","volume":"581","author":"Chen","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Gong, W., Hong, L., and Qian, Y. (2023). Identification and Experimental Validation of LINC00582 Associated with B Cell Immune and Development of Pulpitis: Bioinformatics and In Vitro Analysis. Diagnostics, 13.","DOI":"10.3390\/diagnostics13101678"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"e35208","DOI":"10.1016\/j.heliyon.2024.e35208","article-title":"Competing Endogenous RNAs Regulatory Crosstalk Networks: The Messages from the RNA World to Signaling Pathways Directing Cancer Stem Cell Development","volume":"10","author":"Aria","year":"2024","journal-title":"Heliyon"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Xie, Q., Yu, H., Liu, Z., Zhou, B., Fang, F., Qiu, W., and Wu, H. (2023). Identification and Characterization of the Ferroptosis-Related ceRNA Network in Irreversible Pulpitis. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1198053"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: Mechanisms, Biology and Role in Disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Wang, P., and Lu, Y.-Q. (2022). Ferroptosis: A Critical Moderator in the Life Cycle of Immune Cells. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.877634"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Wang, X., Wu, Z., Zhang, Y., Lian, B., Ma, L., and Zhao, J. (2024). Autophagy Induced by Hypoxia in Pulpitis Is Mediated by HIF-1\u03b1\/BNIP3. Arch. Oral. Biol., 159.","DOI":"10.1016\/j.archoralbio.2024.105881"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Wang, Y., Xie, Q., Yu, H., Zhou, B., Guo, X., Wu, B., and Hu, J. (2023). Establishment and Validation of the Autophagy-Related ceRNA Network in Irreversible Pulpitis. BMC Genom., 24.","DOI":"10.1186\/s12864-023-09363-9"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"7222092","DOI":"10.1155\/2022\/7222092","article-title":"Identification of Immune-Related lncRNA Regulatory Network in Pulpitis","volume":"2022","author":"Du","year":"2022","journal-title":"Dis. Markers"},{"key":"ref_50","first-page":"263","article-title":"Long Non-Coding RNA PVT1 Is Involved in the Pathological Mechanism of Pulpitis by Regulating miR-128-3p","volume":"20","author":"Xia","year":"2022","journal-title":"Oral Health Prev. Dent."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3349\/ymj.2022.63.3.229","article-title":"MEG3 LncRNA from Exosomes Released from Cancer-Associated Fibroblasts Enhances Cisplatin Chemoresistance in SCLC via a MiR-15a-5p\/CCNE1 Axis","volume":"63","author":"Sun","year":"2022","journal-title":"Yonsei Med. J."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"12722","DOI":"10.1080\/21655979.2021.2010368","article-title":"Mechanism of M2 Macrophage-Derived Extracellular Vesicles Carrying lncRNA MEG3 in Inflammatory Responses in Ulcerative Colitis","volume":"12","author":"Wang","year":"2021","journal-title":"Bioengineered"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.identj.2022.11.011","article-title":"DUXAP8 Promotes LPS-Induced Cell Injury in Pulpitis by Regulating miR-18b-5p\/HIF3A","volume":"73","author":"Dai","year":"2023","journal-title":"Int. Dent. J."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s41983-022-00479-5","article-title":"Malondialdehyde and Superoxide Dismutase Levels in Patients with Epilepsy: A Case\u2013Control Study","volume":"58","author":"Shehta","year":"2022","journal-title":"Egypt. J. Neurol. Psychiatry Neurosurg."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"3350","DOI":"10.1002\/jcp.29223","article-title":"Differential Expression of lncRNA\/miRNA\/mRNA and Their Related Functional Networks during the Osteogenic\/Odontogenic Differentiation of Dental Pulp Stem Cells","volume":"235","author":"Liu","year":"2020","journal-title":"J. Cell Physiol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"e1312","DOI":"10.1002\/iid3.1312","article-title":"Dysregulation of lncRNA TFAP2A-AS1 Is Involved in the Pathogenesis of Pulpitis by the Regulation of microRNA-32-5p","volume":"12","author":"Liu","year":"2024","journal-title":"Immun. Inflamm. Dis."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/s13287-023-03313-8","article-title":"The Pluripotent Factor OCT4A Enhances the Self-Renewal of Human Dental Pulp Stem Cells by Targeting lncRNA FTX in an LPS-Induced Inflammatory Microenvironment","volume":"14","author":"Hong","year":"2023","journal-title":"Stem Cell Res. Ther."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.jds.2022.06.012","article-title":"Circ_0138960 Knockdown Alleviates Lipopolysaccharide-Induced Inflammatory Response and Injury in Human Dental Pulp Cells by Targeting miR-545-5p\/MYD88 Axis in Pulpitis","volume":"18","author":"Liang","year":"2023","journal-title":"J. Dent. Sci."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.identj.2022.08.001","article-title":"CircFKBP5 Suppresses Apoptosis and Inflammation and Promotes Osteogenic Differentiation","volume":"73","author":"Liang","year":"2023","journal-title":"Int. Dent. J."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Lei, Q., Liang, Z., Lei, Q., Liang, F., Ma, J., Wang, Z., and He, S. (2022). Analysis of circRNAs Profile in TNF-\u03b1 Treated DPSC. BMC Oral Health, 22.","DOI":"10.1186\/s12903-022-02267-2"},{"key":"ref_61","first-page":"148","article-title":"Observation of Inflammation, Oxidative Stress, Mitochondrial Dynamics, and Apoptosis in Dental Pulp Following a Diagnosis of Irreversible Pulpitis","volume":"8","author":"Vaseenon","year":"2023","journal-title":"Eur. Endod. J."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1080\/13880209.2022.2037664","article-title":"Enhancing Osteogenic Potential of hDPSCs by Resveratrol through Reducing Oxidative Stress via the Sirt1\/Nrf2 Pathway","volume":"60","author":"Zhang","year":"2022","journal-title":"Pharm. Biol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/j.joen.2013.06.006","article-title":"Hydrogen Peroxide Induces Apoptosis in Human Dental Pulp Cells via Caspase-9 Dependent Pathway","volume":"39","author":"Wu","year":"2013","journal-title":"J. Endod."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1186\/s12967-019-2078-x","article-title":"CircRNA Expression Profiles in Human Dental Pulp Stromal Cells Undergoing Oxidative Stress","volume":"17","author":"Zhang","year":"2019","journal-title":"J. Transl. Med."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Zhan, L., Jiang, X., and Tang, X. (2024). Comprehensive Review for Non-Coding RNAs: From Mechanisms to Therapeutic Applications. Biochem. Pharmacol., 224.","DOI":"10.1016\/j.bcp.2024.116218"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Krivanek, J., Adameyko, I., and Fried, K. (2017). Heterogeneity and Developmental Connections between Cell Types Inhabiting Teeth. Front. Physiol., 8.","DOI":"10.3389\/fphys.2017.00376"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Ren, H., Wen, Q., Zhao, Q., Wang, N., and Zhao, Y. (2022). Atlas of Human Dental Pulp Cells at Multiple Spatial and Temporal Levels Based on Single-Cell Sequencing Analysis. Front. Physiol., 13.","DOI":"10.3389\/fphys.2022.993478"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"102405","DOI":"10.1016\/j.isci.2021.102405","article-title":"A Single-Cell Atlas of Human Teeth","volume":"24","author":"Pagella","year":"2021","journal-title":"iScience"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Wang, J., Qiao, J., Ma, L., Li, X., Wei, C., Tian, X., and Liu, K. (2023). Identification of the Characteristics of Infiltrating Immune Cells in Pulpitis and Its Potential Molecular Regulation Mechanism by Bioinformatics Method. BMC Oral. Health, 23.","DOI":"10.1186\/s12903-023-03020-z"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/s13045-023-01452-2","article-title":"Exosomal circRNA: Emerging Insights into Cancer Progression and Clinical Application Potential","volume":"16","author":"Zhang","year":"2023","journal-title":"J. Hematol. Oncol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1186\/s12967-024-05554-4","article-title":"A Systematic Review of Non-Coding RNA Therapeutics in Early Clinical Trials: A New Perspective against Cancer","volume":"22","author":"Grillone","year":"2024","journal-title":"J. Transl. Med."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Nappi, F. (2024). Non-Coding RNA-Targeted Therapy: A State-of-the-Art Review. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25073630"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.job.2024.03.006","article-title":"Revolutionizing the Diagnosis of Irreversible Pulpitis\u2014Current Strategies and Future Directions","volume":"66","author":"Bhat","year":"2024","journal-title":"J. Oral Biosci."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Hu, X., Qin, H., Yan, Y., Wu, W., Gong, S., Wang, L., Jiang, R., Zhao, Q., Sun, Y., and Wang, Q. (2022). Exosomal Circular RNAs: Biogenesis, Effect, and Application in Cardiovascular Diseases. Front. Cell Dev. Biol., 10.","DOI":"10.3389\/fcell.2022.948256"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Miao, S., and Zhang, Q. (2023). Circulating circRNA: A Social Butterfly in Tumors. Front. 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