{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T20:44:50Z","timestamp":1770842690357,"version":"3.50.1"},"reference-count":68,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Rzeszow","award":["NIG\/30\/2023"],"award-info":[{"award-number":["NIG\/30\/2023"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Degenerative retinal diseases can lead to blindness if left untreated. At present, there are no curative therapies for retinal diseases. Therefore, effective treatment strategies for slowing the progression of retinal diseases and thus improving patients\u2019 life standards are urgently needed. The present study aimed to assess the effect of sinusoidal electromagnetic field (EMF) (50 Hz, 1.3 mT) treatment for 15 and 30 min on spontaneously arising retinal pigment epithelial cells (ARPE-19) and retinal ganglion cells (RGC-5) and its short-term post-treatment significance. Our study indicated the beneficial impact of EMF treatment on the proliferative and migratory capacity of the tested cells. ARPE-19 and RGC-5 cells exposed to an EMF exhibited elevated levels of HO-1, increased N6-methyladenosine (m6A) and N5-methylcytosine (m5C) status mediated by METTL3 and NSUN2, respectively, and changes in levels of DNA damage repair factors, which may contribute to the regenerative properties of ARPE-19 and RGC-5 cells. Overall, this analysis showed that EMF (sinusoidal, 50 Hz, 1.3 mT) treatment may serve as a potential therapeutic strategy for retinal diseases.<\/jats:p>","DOI":"10.3390\/ijms252413606","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T06:50:44Z","timestamp":1734591044000},"page":"13606","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The In Vitro Enhancement of Retinal Cell Viability via m6A and m5C RNA Methylation-Mediated Changes in the Levels of Heme Oxygenase (HO-1) and DNA Damage Repair Molecules Using a 50 Hz Sinusoidal Electromagnetic Field (EMF)"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0620-7195","authenticated-orcid":false,"given":"Gabriela","family":"Betlej","sequence":"first","affiliation":[{"name":"Interdisciplinary Centre for Preclinical and Clinical Research, College of Natural Sciences, University of Rzeszow, Werynia 2a, 36-100 Kolbuszowa, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5510-7938","authenticated-orcid":false,"given":"Ewelina","family":"Bator","sequence":"additional","affiliation":[{"name":"Interdisciplinary Centre for Preclinical and Clinical Research, College of Natural Sciences, University of Rzeszow, Werynia 2a, 36-100 Kolbuszowa, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1344-4033","authenticated-orcid":false,"given":"Anna","family":"Koziorowska","sequence":"additional","affiliation":[{"name":"Interdisciplinary Centre for Preclinical and Clinical Research, College of Natural Sciences, University of Rzeszow, Werynia 2a, 36-100 Kolbuszowa, Poland"},{"name":"Institute of Material Engineering, College of Natural Sciences, University of Rzeszow, Pigonia 1, 35-310 Rzeszow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7468-6063","authenticated-orcid":false,"given":"Marek","family":"Koziorowski","sequence":"additional","affiliation":[{"name":"Interdisciplinary Centre for Preclinical and Clinical Research, College of Natural Sciences, University of Rzeszow, Werynia 2a, 36-100 Kolbuszowa, Poland"},{"name":"Institute of Biotechnology, College of Natural Sciences, University of Rzeszow, Pigonia 1, 35-310 Rzeszow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6016-868X","authenticated-orcid":false,"given":"Iwona","family":"Rzeszutek","sequence":"additional","affiliation":[{"name":"Interdisciplinary Centre for Preclinical and Clinical Research, College of Natural Sciences, University of Rzeszow, Werynia 2a, 36-100 Kolbuszowa, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Ptito, M., Bleau, M., and Bouskila, J. 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