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MV130 is a mucosal-trained immunity-based vaccine used to prevent respiratory tract infections in various clinical settings. Additionally, MV130 may induce innate immune cells that acquire anti-inflammatory properties and promote tolerance, which could have important implications for chronic inflammatory diseases such as ulcerative colitis. This work demonstrated that the prophylactic administration of MV130 substantially mitigated colitis in a mouse model of acute colitis induced by dextran sulphate sodium. MV130 downregulated systemic and local inflammatory responses, maintained the integrity of the intestinal barrier by preserving the enterocyte layer and goblet cells, and reduced the oedema and fibrosis characteristic of the disease. Mechanistically, MV130 significantly reduced the infiltration of neutrophils and pro-inflammatory macrophages in the intestinal wall of the diseased animals and favoured the appearance of M2-polarised macrophages. These results suggest that MV130 might have therapeutic potential for the treatment of ulcerative colitis, reducing the risk of relapse and the progression of disease.<\/jats:p>","DOI":"10.3390\/ijms252413629","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T04:07:40Z","timestamp":1734667660000},"page":"13629","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Mucosal Bacterial Immunotherapy Attenuates the Development of Experimental Colitis by Reducing Inflammation Through the Regulation of Myeloid Cells"],"prefix":"10.3390","volume":"25","author":[{"given":"Eva","family":"Jim\u00e9nez","sequence":"first","affiliation":[{"name":"Department of Cell Biology, Faculty of Medicine, UCM, 28040 Madrid, Spain"},{"name":"Health Research Institute of the Hospital Cl\u00ednico San Carlos (IdISSC), 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Faculty of Medicine, UCM, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5533-1894","authenticated-orcid":false,"given":"Sara","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Faculty of Medicine, UCM, 28040 Madrid, Spain"},{"name":"Health Research Institute of the Hospital Doce de Octubre (i+12), 28041 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa","family":"Saced\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Faculty of Medicine, UCM, 28040 Madrid, Spain"},{"name":"Health Research Institute of the Hospital Cl\u00ednico San Carlos (IdISSC), 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0076-3254","authenticated-orcid":false,"given":"Lidia M.","family":"Fern\u00e1ndez-Sevilla","sequence":"additional","affiliation":[{"name":"Health Research Institute of the Hospital Cl\u00ednico San Carlos (IdISSC), 28040 Madrid, Spain"},{"name":"Department of Basic Health Sciences, Faculty of Health Sciences, University Rey Juan Carlos, 28922 Alcorc\u00f3n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8329-6457","authenticated-orcid":false,"given":"Alberto","family":"Varas","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Faculty of Medicine, UCM, 28040 Madrid, Spain"},{"name":"Health Research Institute of the Hospital Cl\u00ednico San Carlos (IdISSC), 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0134-5321","authenticated-orcid":false,"given":"Jose L.","family":"Subiza","sequence":"additional","affiliation":[{"name":"Inmunotek S.L., Alcal\u00e1 de Henares, 28805 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3112-5944","authenticated-orcid":false,"given":"Jaris","family":"Valencia","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Faculty of Medicine, UCM, 28040 Madrid, Spain"},{"name":"Health Research Institute of the Hospital Cl\u00ednico San Carlos (IdISSC), 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9456-5541","authenticated-orcid":false,"given":"\u00c1ngeles","family":"Vicente","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Faculty of Medicine, UCM, 28040 Madrid, Spain"},{"name":"Health Research Institute of the Hospital Doce de Octubre (i+12), 28041 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1001\/jama.2023.15389","article-title":"Ulcerative Colitis in Adults: A Review","volume":"330","author":"Gros","year":"2023","journal-title":"JAMA"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S0140-6736(23)00966-2","article-title":"Ulcerative colitis","volume":"402","author":"Honap","year":"2023","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1053\/j.gastro.2018.06.043","article-title":"Sex-Based Differences in Incidence of Inflammatory Bowel Diseases-Pooled Analysis of Population-Based Studies from Western Countries","volume":"155","author":"Shah","year":"2018","journal-title":"Gastroenterology"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Saez, A., Herrero-Fernandez, B., Gomez-Bris, R., S\u00e1nchez-Martinez, H., and Gonzalez-Granado, J.M. 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