{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:42:56Z","timestamp":1789087376118,"version":"build-2803163510"},"reference-count":133,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2024,12,21]],"date-time":"2024-12-21T00:00:00Z","timestamp":1734739200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science and Higher Education of the Russian Federation","award":["075-15-2024-643"],"award-info":[{"award-number":["075-15-2024-643"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Despite their astonishing biological diversity, surprisingly few shared traits connect all or nearly all living organisms. Aging, i.e., the progressive and irreversible decline in the function of multiple cells and tissues, is one of these fundamental features of all organisms, ranging from single-cell creatures to complex animals, alongside variability, adaptation, growth, healing, reproducibility, mobility, and, finally, death. Age is a key determinant for many pathologies, shaping the risks of incidence, severity, and treatment outcomes for cancer, neurodegeneration, heart failure, sarcopenia, atherosclerosis, osteoporosis, and many other diseases. In this review, we aim to systematically investigate the age-related features of the development of several diseases through the lens of multiomics: from genome instability and somatic mutations to pathway alterations and dysregulated metabolism.<\/jats:p>","DOI":"10.3390\/ijms252413671","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T02:39:56Z","timestamp":1734921596000},"page":"13671","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Multiomics of Aging and Aging-Related Diseases"],"prefix":"10.3390","volume":"25","author":[{"given":"Olga I.","family":"Kiseleva","sequence":"first","affiliation":[{"name":"Institute of Biomedical Chemistry, Pogodinskaya Street, 10\/8, 119121 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3658-2490","authenticated-orcid":false,"given":"Viktoriia A.","family":"Arzumanian","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Chemistry, Pogodinskaya Street, 10\/8, 119121 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3277-2406","authenticated-orcid":false,"given":"Yuriy A.","family":"Ikhalaynen","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Chemistry, Pogodinskaya Street, 10\/8, 119121 Moscow, Russia"},{"name":"Chemistry Department, Lomonosov Moscow State University, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3704-0992","authenticated-orcid":false,"given":"Ilya Y.","family":"Kurbatov","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Chemistry, Pogodinskaya Street, 10\/8, 119121 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2152-3222","authenticated-orcid":false,"given":"Polina A.","family":"Kryukova","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Chemistry, Pogodinskaya Street, 10\/8, 119121 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1838-3604","authenticated-orcid":false,"given":"Ekaterina V.","family":"Poverennaya","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Chemistry, Pogodinskaya Street, 10\/8, 119121 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/S0140-6736(16)32381-9","article-title":"Future Life Expectancy in 35 Industrialised Countries: Projections with a Bayesian Model Ensemble","volume":"389","author":"Kontis","year":"2017","journal-title":"Lancet Lond. 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