{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:16:45Z","timestamp":1787314605227,"version":"build-2736575974"},"reference-count":61,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T00:00:00Z","timestamp":1734912000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Norwegian Society for Children\u2019s Cancer","award":["180007"],"award-info":[{"award-number":["180007"]}]},{"name":"Norwegian Society for Children\u2019s Cancer","award":["190004"],"award-info":[{"award-number":["190004"]}]},{"name":"Norwegian Society for Children\u2019s Cancer","award":["226244\/F50"],"award-info":[{"award-number":["226244\/F50"]}]},{"name":"The Research Council of Norway","award":["180007"],"award-info":[{"award-number":["180007"]}]},{"name":"The Research Council of Norway","award":["190004"],"award-info":[{"award-number":["190004"]}]},{"name":"The Research Council of Norway","award":["226244\/F50"],"award-info":[{"award-number":["226244\/F50"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Cryptomeria japonica is a commercially important tree native to Japan. The tree belongs to the ancient genus Cryptomeria and has found important uses as a medicinal plant, as well as a main source of timber in Japan. In recent years, there has been an increased interest in discovering extended uses of C. japonica as a source of novel bioactive natural products with potential applications as lead compounds for active principles of future drugs. The compounds were isolated by a combination of two-phase extraction, XAD-7 Amberlite column chromatography, Sephadex LH-20 column chromatography and preparative High Performance Liquid Chromatography (HPLC). The structures were determined by a combination of several 1D and 2D Nuclear Magnetic Resonance (NMR) experiments and high-resolution mass spectrometry. Here, we report on the isolation and characterization of the novel biflavone glucoside hinokiflavone 7\u2033-O-\u03b2-glucopyranoside, in addition to sixteen known compounds including the flavonols quercetin, quercetin 3-O-\u03b1-rhamnopyranoside and quercetin 3-O-\u03b2-galactopyranoside, the dihydroflavonols taxifolin 3-O-\u03b2-glucopyranoside, taxifolin 7-O-\u03b2-glucopyranoside, the flavanones naringenin, naringenin 7-O-\u03b2-galactopyranoside and eriodictyol 4\u2032-O-\u03b2-glucopyranoside, the flavanol catechin, the biflavonoid amentoflavone, the dihydrochalcone phloretin 2\u2032-O-\u03b2-glucopyranoside, the sesquiterpenoid roseoside, the polyphenolic compounds chlorogenic acid, methyl chlorogenate and the flavanocoumarins catechin-(7,8)-7\u2033-(3,4 dihydroxyphenyl)-dihydro-8\u2033(3H)-pyranone, and mururin A. The compounds exhibited low-to-moderate cytotoxic activity against MOLM-13 leukemia cells.<\/jats:p>","DOI":"10.3390\/ijms252413735","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T05:58:27Z","timestamp":1734933507000},"page":"13735","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Cytotoxic Natural Products from Cryptomeria japonica (Thunb. ex L.) D.Don"],"prefix":"10.3390","volume":"25","author":[{"given":"Bj\u00f8rn Tobiassen","family":"Heieren","sequence":"first","affiliation":[{"name":"Department of Chemistry and Centre for Pharmacy, University of Bergen, N-5007 Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja Strandvoll","family":"Dyrdal","sequence":"additional","affiliation":[{"name":"Department of Clinical Science and Centre for Pharmacy, University of Bergen, N-5009 Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0353-3614","authenticated-orcid":false,"given":"Lars","family":"Herfindal","sequence":"additional","affiliation":[{"name":"Department of Clinical Science and Centre for Pharmacy, University of Bergen, N-5009 Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bjarte","family":"Holmelid","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Centre for Pharmacy, University of Bergen, N-5007 Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2691-6052","authenticated-orcid":false,"given":"Cato","family":"Brede","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Stavanger University Hospital, N-4011 Stavanger, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9089-1502","authenticated-orcid":false,"given":"Heidi Lie","family":"Andersen","sequence":"additional","affiliation":[{"name":"University Gardens, University of Bergen, All\u00e9gt. 41, N-5007 Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torgils","family":"Fossen","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Centre for Pharmacy, University of Bergen, N-5007 Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/s41437-019-0198-y","article-title":"Inferring the demographic history of Japanese cedar, Cryptomeria japonica, using amplicon sequencing","volume":"123","author":"Moriguchi","year":"2019","journal-title":"Heredity"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Ingrouille, M. 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