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There are many drugs that reduce the clinical signs of MS, but none of them cure the disease. Food proteins have been shown to contain encrypted peptides that can be released after hydrolysis and exert numerous biological activities. Recently, we have demonstrated the anti-inflammatory and antioxidant activities of a lupin protein hydrolysate (LPH) both in vitro and in vivo. Therefore, the aim of this study was to evaluate whether LPH is capable of reducing the clinical signs of experimental autoimmune encephalomyelitis (EAE), a mouse model of MS. EAE was induced in female C57BL\/6N mice and they were treated intragastrically with LPH (100 mg\/kg) or vehicle (control group) from day 0 (prophylactic approach) or from the onset of the disease (day 12 post-induction; therapeutic approach) and the clinical score of each mouse was recorded daily. Prophylactic treatment with LPH reduced the clinical score of the mice compared to the control group, as well as the maximum and cumulative scores, without changing the day of onset of the symptoms while the therapeutic intervention did not significantly improve the severity of the disease. For the first time, we demonstrated that prophylactic administration of LPH reduces the severity of MS, suggesting a potential nutraceutical or new functional foods in neuroinflammation. However, further studies are needed to confirm this nutritional effect in a clinical context.<\/jats:p>","DOI":"10.3390\/ijms26010032","type":"journal-article","created":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T09:00:57Z","timestamp":1735030857000},"page":"32","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A Lupin (Lupinus angustifolius) Protein Hydrolysate Decreases the Severity of Experimental Autoimmune Encephalomyelitis: A Preliminary Study"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6547-8078","authenticated-orcid":false,"given":"Ivan","family":"Cruz-Chamorro","sequence":"first","affiliation":[{"name":"Instituto de Biomedicina de Sevilla, IBiS\/Hospital Universitario Virgen del Roc\u00edo\/CSIC\/Universidad de Sevilla, 41013 Seville, Spain"},{"name":"Departamento de Bioqu\u00edmica M\u00e9dica y Biolog\u00eda Molecular e Inmunolog\u00eda, Facultad de Medicina, Universidad de Sevilla, 41009 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9408-0472","authenticated-orcid":false,"given":"Ana Isabel","family":"\u00c1lvarez-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Instituto de Biomedicina de Sevilla, IBiS\/Hospital Universitario Virgen del Roc\u00edo\/CSIC\/Universidad de Sevilla, 41013 Seville, Spain"},{"name":"Departamento de Bioqu\u00edmica M\u00e9dica y Biolog\u00eda Molecular e Inmunolog\u00eda, Facultad de Medicina, Universidad de Sevilla, 41009 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5790-2302","authenticated-orcid":false,"given":"Guillermo","family":"Santos-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Instituto de Biomedicina de Sevilla, IBiS\/Hospital Universitario Virgen del Roc\u00edo\/CSIC\/Universidad de Sevilla, 41013 Seville, Spain"},{"name":"Departamento de Bioqu\u00edmica M\u00e9dica y Biolog\u00eda Molecular e Inmunolog\u00eda, Facultad de Medicina, Universidad de Sevilla, 41009 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1313-0440","authenticated-orcid":false,"given":"Nuria","family":"\u00c1lvarez-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica M\u00e9dica y Biolog\u00eda Molecular e Inmunolog\u00eda, Facultad de Medicina, Universidad de Sevilla, 41009 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justo","family":"Pedroche","sequence":"additional","affiliation":[{"name":"Department of Food & Health, Instituto de la Grasa, CSIC, Ctra, Utrera Km 1, 41013 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5661-8366","authenticated-orcid":false,"given":"Mar\u00eda del Carmen","family":"Mill\u00e1n-Linares","sequence":"additional","affiliation":[{"name":"Department of Food & Health, Instituto de la Grasa, CSIC, Ctra, Utrera Km 1, 41013 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1793-3985","authenticated-orcid":false,"given":"Patricia Judith","family":"Lardone","sequence":"additional","affiliation":[{"name":"Instituto de Biomedicina de Sevilla, IBiS\/Hospital Universitario Virgen del Roc\u00edo\/CSIC\/Universidad de Sevilla, 41013 Seville, Spain"},{"name":"Departamento de Bioqu\u00edmica M\u00e9dica y Biolog\u00eda Molecular e Inmunolog\u00eda, Facultad de Medicina, Universidad de Sevilla, 41009 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8516-0999","authenticated-orcid":false,"given":"Antonio","family":"Carrillo-Vico","sequence":"additional","affiliation":[{"name":"Instituto de Biomedicina de Sevilla, IBiS\/Hospital Universitario Virgen del Roc\u00edo\/CSIC\/Universidad de Sevilla, 41013 Seville, Spain"},{"name":"Departamento de Bioqu\u00edmica M\u00e9dica y Biolog\u00eda Molecular e Inmunolog\u00eda, Facultad de Medicina, Universidad de Sevilla, 41009 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"a028936","DOI":"10.1101\/cshperspect.a028936","article-title":"Multiple sclerosis pathology","volume":"8","author":"Lassmann","year":"2018","journal-title":"Cold Spring Harb. 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