{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T09:40:22Z","timestamp":1794044422150,"version":"4.8.0"},"reference-count":62,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T00:00:00Z","timestamp":1735257600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Iuliu Ha\u021bieganu University of Medicine and Pharmacy","award":["881\/34\/12.01.2022"],"award-info":[{"award-number":["881\/34\/12.01.2022"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Endometriosis, a chronic hormone-dependent condition affecting 10% of women globally, impacts pelvic organs and occasionally distant sites, causing pain, infertility, and sexual dysfunction. Biomarkers such as IL-8, IL-10, and BDNF influence inflammation, nerve sensitization, and pain. This study investigates their relationship with sexual quality of life, focusing on dyspareunia and related dysfunctions, as assessed using the Female Sexual Function Index (FSFI). Dyspareunia, a prominent symptom of endometriosis, is linked to lower FSFI scores in domains such as desire (mean 3.38), satisfaction (mean 3.28), and pain (mean 3.07). Elevated IL-8 tissue levels negatively correlated with desire (r = \u22120.649, p &lt; 0.05) and satisfaction (r = \u22120.813, p &lt; 0.01). Similarly, higher BDNF tissue levels were associated with increased pain (r = \u22120.435, p &lt; 0.01) and reduced satisfaction (r = \u22120.252, p &lt; 0.05). Patient factors such as higher endometriosis severity scores (mean 26.3, p &lt; 0.05) and surgical history correlated with lower desire and satisfaction. Conversely, physical activity improved pain scores (p &lt; 0.01) and enhanced desire and lubrication (p &lt; 0.05), likely through reduced inflammation and better circulation. These findings highlight the complex interplay between biomarkers, individual factors, and sexual dysfunction in endometriosis, underscoring the need for personalized therapeutic approaches.<\/jats:p>","DOI":"10.3390\/ijms26010162","type":"journal-article","created":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T07:34:19Z","timestamp":1735630459000},"page":"162","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Dyspareunia and Biomarkers: A Case Study of Sexual Dysfunction in Moderate Endometriosis"],"prefix":"10.3390","volume":"26","author":[{"given":"Ionel Daniel","family":"Nati","sequence":"first","affiliation":[{"name":"2nd Department of Obstetric and Ginecology, \u201cIuliu Hatieganu\u201d University of Medicine and Pharmacy, 400610 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Razvan","family":"Ciortea","sequence":"additional","affiliation":[{"name":"2nd Department of Obstetric and Ginecology, \u201cIuliu Hatieganu\u201d University of Medicine and Pharmacy, 400610 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei","family":"Malutan","sequence":"additional","affiliation":[{"name":"2nd Department of Obstetric and Ginecology, \u201cIuliu Hatieganu\u201d University of Medicine and Pharmacy, 400610 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihaela","family":"Oancea","sequence":"additional","affiliation":[{"name":"2nd Department of Obstetric and Ginecology, \u201cIuliu Hatieganu\u201d University of Medicine and Pharmacy, 400610 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian","family":"Iuhas","sequence":"additional","affiliation":[{"name":"2nd Department of Obstetric and Ginecology, \u201cIuliu Hatieganu\u201d University of Medicine and Pharmacy, 400610 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Bucuri","sequence":"additional","affiliation":[{"name":"Emergency Military Clinical Hospital \u201cDr Constantin Papilian\u201d, 400610 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Roman","sequence":"additional","affiliation":[{"name":"2nd Department of Obstetric and Ginecology, \u201cIuliu Hatieganu\u201d University of Medicine and Pharmacy, 400610 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Ormindean","sequence":"additional","affiliation":[{"name":"2nd Department of Obstetric and Ginecology, \u201cIuliu Hatieganu\u201d University of Medicine and Pharmacy, 400610 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leon","family":"Gombos","sequence":"additional","affiliation":[{"name":"Faculty of Physical Education and Sport, Bogdan-Vod\u0103 University of Cluj Napoca, 400394 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Mihu","sequence":"additional","affiliation":[{"name":"2nd Department of Obstetric and Ginecology, \u201cIuliu Hatieganu\u201d University of Medicine and Pharmacy, 400610 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Della Corte, L., Di Filippo, C., Gabrielli, O., Reppuccia, S., La Rosa, V.L., Ragusa, R., Fichera, M., Commodari, E., Bifulco, G., and Giampaolino, P. 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