{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T16:25:46Z","timestamp":1780676746425,"version":"3.54.1"},"reference-count":122,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,12,29]],"date-time":"2024-12-29T00:00:00Z","timestamp":1735430400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"MCIU","award":["CNS2022-135144"],"award-info":[{"award-number":["CNS2022-135144"]}]},{"name":"MCIU","award":["PID2019-108782RBC21"],"award-info":[{"award-number":["PID2019-108782RBC21"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Fasciolosis is a neglected tropical disease caused by helminth parasites of the genus Fasciola spp., including Fasciola hepatica (F. hepatica) and Fasciola gigantica (F. gigantica), being a major zoonotic problem of human and animal health. Its control with antihelminthics is becoming ineffective due to the increase in parasite resistance. Developing new therapeutic protocols is crucial to a deeper knowledge of the molecular bases in the host\u2013parasite interactions. The high-throughput omics technologies have dramatically provided unprecedented insights into the complexity of the molecular host\u2013parasite crosstalk. MicroRNAs (miRNAs) are key players as critical regulators in numerous biological processes, modifying the gene expression of cells by degradation of messenger RNA (mRNA), regulating transcription and translation functions, protein positioning, cell cycle integrity, differentiation and apoptosis. The large-scale exploration of miRNAs, including the miRNome, has offered great scientific knowledge of steps in fasciolosis, further scrutinizing the pathogenesis, the growth and development of their strains and their interaction with the host for the survival of the different parasite stages. This review compiles the updated knowledge related to miRNAs involved in fasciolosis and the generated miRNome, highlighting the importance of these key molecules in the host\u2013parasite interactions and the pathogenesis of Fasciola spp. directing towards the development of new biotherapeutic protocols for the control of fasciolosis.<\/jats:p>","DOI":"10.3390\/ijms26010204","type":"journal-article","created":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T07:51:57Z","timestamp":1735631517000},"page":"204","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Unraveling the microRNAs Involved in Fasciolosis: Master Regulators of the Host\u2013Parasite Crosstalk"],"prefix":"10.3390","volume":"26","author":[{"given":"Diana Mar\u00eda","family":"Barrero-Torres","sequence":"first","affiliation":[{"name":"Departamento de Anatom\u00eda y Anatom\u00eda Patol\u00f3gica Comparadas y Toxicolog\u00eda, UIC Zoonosis y Enfermedades Emergentes (ENZOEM), Universidad de C\u00f3rdoba, Campus de Rabanales, Edificio Sanidad Animal, 14071 C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2772-6833","authenticated-orcid":false,"given":"Guillem","family":"Herrera-Torres","sequence":"additional","affiliation":[{"name":"Departamento de Anatom\u00eda y Anatom\u00eda Patol\u00f3gica Comparadas y Toxicolog\u00eda, UIC Zoonosis y Enfermedades Emergentes (ENZOEM), Universidad de C\u00f3rdoba, Campus de Rabanales, Edificio Sanidad Animal, 14071 C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"P\u00e9rez","sequence":"additional","affiliation":[{"name":"Departamento de Anatom\u00eda y Anatom\u00eda Patol\u00f3gica Comparadas y Toxicolog\u00eda, UIC Zoonosis y Enfermedades Emergentes (ENZOEM), Universidad de C\u00f3rdoba, Campus de Rabanales, Edificio Sanidad Animal, 14071 C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4298-6894","authenticated-orcid":false,"given":"\u00c1lvaro","family":"Mart\u00ednez-Moreno","sequence":"additional","affiliation":[{"name":"Departamento de Sanidad Animal (\u00c1rea de Parasitolog\u00eda), UIC Zoonosis y Enfermedades Emergentes (ENZOEM), Universidad de C\u00f3rdoba, Campus de Rabanales, Edificio Sanidad Animal, 14071 C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8438-3077","authenticated-orcid":false,"given":"Francisco Javier","family":"Mart\u00ednez-Moreno","sequence":"additional","affiliation":[{"name":"Departamento de Sanidad Animal (\u00c1rea de Parasitolog\u00eda), UIC Zoonosis y Enfermedades Emergentes (ENZOEM), Universidad de C\u00f3rdoba, Campus de Rabanales, Edificio Sanidad Animal, 14071 C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Miguel","family":"Flores-Vel\u00e1zquez","sequence":"additional","affiliation":[{"name":"Departamento de Anatom\u00eda y Anatom\u00eda Patol\u00f3gica Comparadas y Toxicolog\u00eda, UIC Zoonosis y Enfermedades Emergentes (ENZOEM), Universidad de C\u00f3rdoba, Campus de Rabanales, Edificio Sanidad Animal, 14071 C\u00f3rdoba, Spain"},{"name":"Unidad de Anatom\u00eda, Histolog\u00eda y Patolog\u00eda Veterinaria, Escuela de Medicina Veterinaria, Facultad de Ciencias Naturales, Universidad San Sebasti\u00e1n, Campus Puerto Montt, Puerto Montt 5480000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2983-7288","authenticated-orcid":false,"given":"Leandro","family":"Buffoni","sequence":"additional","affiliation":[{"name":"Departamento de Sanidad Animal (\u00c1rea de Parasitolog\u00eda), UIC Zoonosis y Enfermedades Emergentes (ENZOEM), Universidad de C\u00f3rdoba, Campus de Rabanales, Edificio Sanidad Animal, 14071 C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo Jos\u00e9","family":"Rufino-Moya","sequence":"additional","affiliation":[{"name":"Departamento de Sanidad Animal (\u00c1rea de Parasitolog\u00eda), UIC Zoonosis y Enfermedades Emergentes (ENZOEM), Universidad de C\u00f3rdoba, Campus de Rabanales, Edificio Sanidad Animal, 14071 C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Teresa","family":"Ruiz-Campillo","sequence":"additional","affiliation":[{"name":"Departamento de Anatom\u00eda y Anatom\u00eda Patol\u00f3gica Comparadas y Toxicolog\u00eda, UIC Zoonosis y Enfermedades Emergentes (ENZOEM), Universidad de C\u00f3rdoba, Campus de Rabanales, Edificio Sanidad Animal, 14071 C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8850-7388","authenticated-orcid":false,"given":"Ver\u00f3nica","family":"Molina-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Departamento de Anatom\u00eda y Anatom\u00eda Patol\u00f3gica Comparadas y Toxicolog\u00eda, UIC Zoonosis y Enfermedades Emergentes (ENZOEM), Universidad de C\u00f3rdoba, Campus de Rabanales, Edificio Sanidad Animal, 14071 C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,29]]},"reference":[{"key":"ref_1","unstructured":"(2024, September 16). Available online: https:\/\/www.who.int\/teams\/control-of-neglected-tropical-diseases."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1097\/QCO.0b013e3283567b7e","article-title":"New developments in epidemiology, diagnosis, and treatment of fascioliasis","volume":"25","author":"Cabada","year":"2012","journal-title":"Curr. Opin. Infect. Dis."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Nyindo, M., and Lukambagire, A. (2015). Fascioliasis: An Ongoing Zoonotic Trematode Infection. BioMed Res. Int., 2015.","DOI":"10.1155\/2015\/786195"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Rufino-Moya, P.J., Zafra, R., Mart\u00ednez-Moreno, A., Buffoni, L., Valderas, E., P\u00e9rez, J., Molina-Hern\u00e1ndez, V., Ruiz-Campillo, M.T., Herrera-Torres, G., and Mart\u00ednez-Moreno, F.J. (2024). Advancement in Diagnosis, Treatment, and Vaccines against Fasciola hepatica: A Comprehensive Review. Pathogens, 13.","DOI":"10.3390\/pathogens13080669"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.micpath.2017.06.006","article-title":"A review on epidemiology, global prevalence and economical losses of fasciolosis in ruminants","volume":"109","author":"Mehmood","year":"2017","journal-title":"Microb. Pathog."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1136\/vr.105209","article-title":"Lack of efficacy of triclabendazole against Fasciola hepatica is present on sheep farms in three regions of England, and Wales","volume":"184","author":"Kamaludeen","year":"2019","journal-title":"Vet. Rec."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.pt.2016.03.002","article-title":"Current Threat of Triclabendazole Resistance in Fasciola hepatica","volume":"32","author":"Kelley","year":"2016","journal-title":"Trends Parasitol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Davis, C.N., Winters, A., Milic, I., Devitt, A., Cookson, A., Brophy, P.M., and Morphew, R.M. (2020). Evidence of sequestration of triclabendazole and associated metabolites by extracellular vesicles of Fasciola hepatica. Sci. Rep., 10.","DOI":"10.1038\/s41598-020-69970-4"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Beesley, N.J., Cwiklinski, K., Allen, K., Hoyle, R.C., Spithill, T.W., La Course, E.J., Williams, D.J.L., Paterson, S., and Hodgkinson, J.E. (2023). A major locus confers triclabendazole resistance in Fasciola hepatica and shows dominant inheritance. PLoS Pathog., 19.","DOI":"10.1371\/journal.ppat.1011081"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.1080\/21505594.2021.1996520","article-title":"Pathogenicity and virulence of the liver flukes Fasciola hepatica and Fasciola gigantica that cause the zoonosis Fasciolosis","volume":"12","author":"Lalor","year":"2021","journal-title":"Virulence"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Mas-Coma, S., Valero, M.A., and Bargues, M.D. (2022). Human and Animal Fascioliasis: Origins and Worldwide Evolving Scenario. Clin. Microbiol. Rev., 35.","DOI":"10.1128\/cmr.00088-19"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"3258","DOI":"10.1074\/mcp.M115.053934","article-title":"The Extracellular Vesicles of the Helminth Pathogen, Fasciola hepatica: Biogenesis Pathways and Cargo Molecules Involved in Parasite Pathogenesis","volume":"14","author":"Cwiklinski","year":"2015","journal-title":"Mol. Cell. Proteom."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.molimm.2021.06.017","article-title":"Helminth extracellular vesicles: Interactions with the host immune system","volume":"137","author":"Durey","year":"2021","journal-title":"Mol. Immunol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/s13071-015-0715-7","article-title":"Transcriptional analysis identifies key genes involved in metabolism, fibrosis\/tissue repair and the immune response against Fasciola hepatica in sheep liver","volume":"8","author":"Ansell","year":"2015","journal-title":"Parasites Vectors"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.biotechadv.2009.12.003","article-title":"Elucidating the transcriptome of Fasciola hepatica\u2014A key to fundamental and biotechnological discoveries for a neglected parasite","volume":"28","author":"Young","year":"2010","journal-title":"Biotechnol. Adv."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Cwiklinski, K., Dalton, J.P., Dufresne, P.J., La Course, J., Williams, D.J., Hodgkinson, J., and Paterson, S. (2015). The Fasciola hepatica genome: Gene duplication and polymorphism reveals adaptation to the host environment and the capacity for rapid evolution. Genome Biol., 16.","DOI":"10.1186\/s13059-015-0632-2"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.ijpara.2017.12.001","article-title":"Advances in Fasciola hepatica research using \u2018omics\u2019 technologies","volume":"48","author":"Cwiklinski","year":"2018","journal-title":"Int. J. Parasitol."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Ricafrente, A., Cwiklinski, K., Nguyen, H., Dalton, J.P., Tran, N., and Donnelly, S. (2022). Stage-specific miRNAs regulate gene expression associated with growth, development and parasite-host interaction during the intra-mammalian migration of the zoonotic helminth parasite Fasciola hepatica. BMC Genom., 23.","DOI":"10.1186\/s12864-022-08644-z"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Arora, N., Tripathi, S., Singh, A.K., Mondal, P., Mishra, A., and Prasad, A. (2017). Micromanagement of Immune System: Role of miRNAs in Helminthic Infections. Front. Microbiol., 8.","DOI":"10.3389\/fmicb.2017.00586"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Chowdhury, S., Ricafrente, A., Cwiklinski, K., Sais, D., Dalton, J.P., Tran, N., and Donnelly, S. (2024). Exploring the utility of circulating miRNAs as diagnostic biomarkers of fasciolosis. Sci. Rep., 14.","DOI":"10.1038\/s41598-024-57704-9"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: Genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/nrg2504","article-title":"Small silencing RNAs: An expanding universe","volume":"10","author":"Ghildiyal","year":"2009","journal-title":"Nat. Rev. Genet."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/nrm3838","article-title":"Regulation of microRNA biogenesis","volume":"15","author":"Ha","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1097\/TP.0b013e3181e913c2","article-title":"MicroRNAs: Small RNAs with big effects","volume":"90","author":"Anglicheau","year":"2010","journal-title":"Transplantation"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.lfs.2017.07.017","article-title":"Role of miRNAs in development and disease: Lessons learnt from small organisms","volume":"185","author":"Chandra","year":"2017","journal-title":"Life Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mrfmmm.2011.03.009","article-title":"MicroRNA history: Discovery, recent applications, and next frontiers","volume":"717","author":"Almeida","year":"2011","journal-title":"Mutat. Res."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Rojas-Pirela, M., Andrade-Alvi\u00e1rez, D., Medina, L., Castillo, C., Liempi, A., Guerrero-Mu\u00f1oz, J., Ortega, Y., Maya, J.D., Rojas, V., and Qui\u00f1ones, W. (2022). MicroRNAs: Master regulators in host-parasitic protist intertactions. Open. Biol., 12.","DOI":"10.1098\/rsob.210395"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Rojas-Pirela, M., Andrade-Alvi\u00e1rez, D., Qui\u00f1ones, W., Rojas, M.V., Castillo, C., Liempi, A., Medina, L., Guerrero-Mu\u00f1oz, J., Fern\u00e1ndez-Moya, A., and Ortega, Y.A. (2022). microRNAs: Critical Players during Helminth Infections. Microorganisms, 11.","DOI":"10.3390\/microorganisms11010061"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1093\/nar\/gkh023","article-title":"The microRNA Registry","volume":"32","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1093\/nar\/gkq1027","article-title":"miRBase: Integrating microRNA annotation and deep-sequencing data","volume":"39","author":"Kozomara","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"D160","DOI":"10.1093\/nar\/gkx851","article-title":"miRCarta: A central repository for collecting miRNA candidates","volume":"46","author":"Backes","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"baz099","DOI":"10.1093\/database\/baz099","article-title":"RumimiR: A detailed microRNA database focused on ruminant species","volume":"2019","author":"Bourdon","year":"2019","journal-title":"Database"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"D204","DOI":"10.1093\/nar\/gkab1101","article-title":"MirGeneDB 2.1: Toward a complete sampling of all major animal phyla","volume":"50","author":"Fromm","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Xu, M., Ai, L., Fu, J., Nisbet, A.J., Liu, Q., Chen, M., Zhou, D., and Zhu, X.Q. (2012). Comparative characterization of microRNAs from the liver flukes Fasciola gigantica and F. hepatica. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0053387"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Tran, N., Ricafrente, A., To, J., Lund, M., Marques, T.M., Gama-Carvalho, M., Cwiklinski, K., Dalton, J.P., and Donnely, S. (2021). Fasciola hepatica hijacks host macrophages miRNA machinery to modulate early innate immune responses. Sci. Rep., 11.","DOI":"10.1038\/s41598-021-86125-1"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.vetpar.2015.06.003","article-title":"Application of small RNA technology for improved control of parasitic helminths","volume":"212","author":"Britton","year":"2015","journal-title":"Vet. Parasitol."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Ricafrente, A., Nguyen, H., Tran, N., and Donnelly, S. (2021). An Evaluation of the Fasciola hepatica miRnome Predicts a Targeted Regulation of Mammalian Innate Immune Responses. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.608686"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Fontenla, S., Langleib, M., de la Torre-Escudero, E., Dom\u00ednguez, M.F., Robinson, M.W., and Tort, J. (2022). Role of Fasciola hepatica Small RNAs in the Interaction With the Mammalian Host. Front. Cell. Infect. Microbiol., 11.","DOI":"10.3389\/fcimb.2021.812141"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"462","DOI":"10.3390\/cancers5020462","article-title":"Regulatory Roles for Long ncRNA and mRNA","volume":"5","author":"Karapetyan","year":"2013","journal-title":"Cancers"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/338313a0","article-title":"The Caenorhabditis elegans heterochromic gene lin-14 encodes a nuclear protein that forms a temporal developmental switch","volume":"338","author":"Ruvkun","year":"1989","journal-title":"Nature"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/0092-8674(93)90529-Y","article-title":"The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementary to lin-14","volume":"75","author":"Lee","year":"1993","journal-title":"Cell"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/0092-8674(93)90530-4","article-title":"Posttranscriptional regulation of heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans","volume":"75","author":"Wightman","year":"1993","journal-title":"Cell"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1038\/35888","article-title":"Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans","volume":"391","author":"Fire","year":"1998","journal-title":"Nature"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"8687","DOI":"10.1073\/pnas.96.15.8687","article-title":"Transient expression of DNA and RNA in parasitic helminths by using particle bombardment","volume":"96","author":"Davis","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/35040556","article-title":"Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA","volume":"408","author":"Pasquinelli","year":"2000","journal-title":"Nature"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1038\/35002607","article-title":"The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans","volume":"403","author":"Reinhart","year":"2000","journal-title":"Nature"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1126\/science.1064921","article-title":"Identification of novel genes coding for small expressed RNAs","volume":"294","author":"Rauhut","year":"2001","journal-title":"Science"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"15524","DOI":"10.1073\/pnas.242606799","article-title":"Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia","volume":"99","author":"Calin","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"3183","DOI":"10.1182\/blood-2007-07-098749","article-title":"MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia","volume":"111","author":"Volinia","year":"2008","journal-title":"Blood"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"5078","DOI":"10.1182\/blood-2008-01-133355","article-title":"MicroRNA expression profiling in relation to the genetic heterogeneity of acute myeloid leukemia","volume":"111","author":"Sun","year":"2008","journal-title":"Blood"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nature01957","article-title":"The nuclear RNase III Drosha initiates microRNA processing","volume":"425","author":"Lee","year":"2003","journal-title":"Nature"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"D140","DOI":"10.1093\/nar\/gkj112","article-title":"miRbase: microRNA sequences, targets and gene nomenclature","volume":"34","author":"Grocock","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.ijpara.2005.06.001","article-title":"Development of methods for RNA interference in the sheep gastrointestinal parasite, Trichostrongylus colubriformis","volume":"35","author":"Issa","year":"2005","journal-title":"Int. J. Parasitol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1111\/j.1745-7270.2005.00058.x","article-title":"Dose-dependent inhibition of gynecophoral canal protein gene expression in vitro in the schistosome (Schistosoma japonicum) by RNA interference","volume":"37","author":"Cheng","year":"2005","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.ijpara.2007.10.007","article-title":"The silencing of cysteine proteases in Fasciola hepatica newly excysted juveniles using RNA interference reduces gut penetration","volume":"38","author":"McGonigle","year":"2008","journal-title":"Int. J. Parasitol."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Shao, H., Li, X., Nolan, T.J., Massey, H.C., Pearce, E.J., and Lok, J.B. (2012). Transposon-mediated chromosomal integration of transgenes in the parasitic nematode Strongyloides ratti and establishment of stable transgenic lines. PLoS Pathog., 8.","DOI":"10.1371\/journal.ppat.1002871"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Gang, S.S., Castelletto, M.L., Bryant, A.S., Yang, E., Mancuso, N., Lopez, J.B., Pellegrini, M., and Hallem, E.A. (2017). Targeted mutagenesis in a human-parasitic nematode. PLoS Pathog., 13.","DOI":"10.1371\/journal.ppat.1006675"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/s12943-019-1052-9","article-title":"The emerging role of the piRNA\/piwi complex in cancer","volume":"18","author":"Liu","year":"2019","journal-title":"Mol. Cancer"},{"key":"ref_59","unstructured":"(2024, November 04). Available online: https:\/\/www.nobelprize.org\/prizes\/medicine\/2024\/press-release\/."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/s13071-022-05211-z","article-title":"Transgenesis in parasitic helminths: A brief history and prospects for the future","volume":"15","author":"Quinzo","year":"2022","journal-title":"Parasit Vectors"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1093\/bfgp\/elz002","article-title":"Interplay between miRNAs and host genes and their role in cancer","volume":"18","author":"Liu","year":"2019","journal-title":"Brief Funct. Genom."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/bs.ircmb.2017.03.007","article-title":"Macro View of MicroRNAs: The Discovery of MicroRNAs and Their Role in Hematopoiesis and Hematologic Disease","volume":"334","author":"Weiss","year":"2017","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"O\u2019Brien, J., Hayder, H., Zayed, Y., and Peng, C. (2018). Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation. Front. Endocrinol., 9.","DOI":"10.3389\/fendo.2018.00402"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/s41580-018-0059-1","article-title":"Regulation of microRNA biogenesis and its crosstalk with other cellular pathways","volume":"20","author":"Treiber","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nature03049","article-title":"Processing of primary microRNAs by the Microprocessor complex","volume":"432","author":"Denli","year":"2004","journal-title":"Nature"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"5451","DOI":"10.1002\/jcp.27486","article-title":"An overview of microRNAs: Biology, functions, therapeutics, and analysis methods","volume":"234","author":"Saliminejad","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.ijpara.2015.06.002","article-title":"The revised microRNA complement of Fasciola hepatica reveals a plethora of overlooked microRNAs and evidence for enrichment of immune-regulatory microRNAs in extracellular vesicles","volume":"45","author":"Fromm","year":"2015","journal-title":"Int. J. Parasitol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.ijpara.2015.06.007","article-title":"The miRnome of Fasciola hepatica juveniles endorses the existence of a reduced set of highly divergent micro RNAs in parasitic flatworms","volume":"45","author":"Fontenla","year":"2015","journal-title":"Int. J. Parasitol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"e12399","DOI":"10.1111\/pim.12399","article-title":"On the presence and immunoregulatory functions of extracellular microRNAs in the trematode Fasciola hepatica","volume":"39","author":"Fromm","year":"2017","journal-title":"Parasite Immunol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"104528","DOI":"10.1016\/j.meegid.2020.104528","article-title":"EV-transported microRNAs of Schistosoma mansoni and Fasciola hepatica: Potential targets in definitive hosts","volume":"85","author":"Ovchinnikov","year":"2020","journal-title":"Infect. Genet. Evol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.ijpara.2020.10.009","article-title":"Differential expression of microRNAs and t RNA fragments mediate the adaptation of the liver fluke Fasciola gigantica to its intermediate snail and definitive mammalian hosts","volume":"51","author":"Hu","year":"2021","journal-title":"Int. J. Parasitol."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Herron, C.M., O\u2019Connor, A., Robb, E., McCammick, E., Hill, C., Marks, N., Robinson, M.W., Maula, A.G., and McVeigh, P. (2022). Developmental Regulation and Functional Prediction of microRNAs in an Expanded Fasciola hepatica miRNome. Front. Cell. Infect. Microbiol., 12.","DOI":"10.3389\/fcimb.2022.811123"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1261\/rna.2183803","article-title":"A uniform system for microRNA annotation","volume":"9","author":"Ambros","year":"2003","journal-title":"RNA"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.ijpara.2020.03.011","article-title":"Diversity of extracellular vesicles from different developmental stages of Fasciola hepatica","volume":"50","author":"Trelis","year":"2020","journal-title":"Int. J. Parasitol."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Cai, P., Hou, N., Piao, X., Liu, S., Liu, H., Yang, F., Wang, J., Jin, Q., Wang, H., and Chen, Q. (2011). Profiles of small non-coding RNAs in Schistosoma japonicum during development. PLoS Negl. Trop. Dis., 5.","DOI":"10.1371\/journal.pntd.0001256"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1016\/j.ijpara.2018.07.005","article-title":"Identification and expression profiling of microRNAs in Hymenolepis","volume":"49","author":"Macchiaroli","year":"2019","journal-title":"Int. J. Parasitol."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Robb, E., McCammick, E.M., Wells, D., McVeigh, P., Gardiner, E., Armstrong, R., McCusker, P., Mousley, A., Clarke, N., and Marks, N.J. (2022). Transcriptomic analysis supports a role for the nervous system in regulating growth and development of Fasciola hepatica juveniles. PLoS Negl. Trop. Dis., 16.","DOI":"10.1101\/2022.01.13.476286"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.jinsphys.2013.09.003","article-title":"Subtle roles of microRNAs let-7, miR-100 and miR-125 on wing morphogenesis in hemimetabolan metamorphosis","volume":"59","author":"Rubio","year":"2013","journal-title":"J. Insect. Physiol."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Shi, W., He, J., Mei, X., Lu, K., Zeng, Z., Zhang, Y., Sheng, Z., Elsheikha, H.M., Huang, W., and Zhu, X. (2020). Dysregulation of hepatic microRNA expression in C57BL\/6 mice affected by excretory-secretory products of Fasciola gigantica. PLoS Negl. Trop. Dis., 14.","DOI":"10.1371\/journal.pntd.0008951"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1111\/j.1365-2567.2011.03449.x","article-title":"C-type lectins on macrophages participate in the immunomodulatory response to Fasciola hepatica products","volume":"133","author":"Guasconi","year":"2011","journal-title":"Immunology"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.vetpar.2018.05.019","article-title":"Study of peritoneal macrophage immunophenotype in sheep experimentally infected with Fasciola hepatica","volume":"257","author":"Pacheco","year":"2018","journal-title":"Vet. Parasitol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.vetpar.2013.04.008","article-title":"Immunomodulatory molecules of Fasciola hepatica: Candidates for both vaccine and immunotherapeutic development","volume":"195","author":"Dalton","year":"2013","journal-title":"Vet. Parasitol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"5005","DOI":"10.1128\/IAI.02541-14","article-title":"Fasciola hepatica Fatty Acid Binding Protein Induces the Alternative Activation of Human Macrophages","volume":"82","author":"Espino","year":"2014","journal-title":"Infect. Immun."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s13567-022-01129-7","article-title":"Fasciola hepatica primoinfections and reinfections in sheep drive distinct Th1\/Th2\/Treg immune responses in liver and hepatic lymph node at early and late stages","volume":"54","author":"Abril","year":"2023","journal-title":"Vet. Res."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"371","DOI":"10.4161\/rna.23716","article-title":"microRNAs in parasites and parasite infection","volume":"10","author":"Zheng","year":"2013","journal-title":"RNA Biol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.molimm.2021.03.011","article-title":"The challenging world of extracellular RNAs of helminth parasites","volume":"234","author":"Cucher","year":"2021","journal-title":"Mol. Immunol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"5029","DOI":"10.4049\/jimmunol.0903463","article-title":"Estradiol suppresses NF-kappa B activation through coordinated regulation of let-7a and miR-125b in primary human macrophages","volume":"184","author":"Murphy","year":"2010","journal-title":"J. Immunol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"3125","DOI":"10.1182\/blood-2016-02-697003","article-title":"miR-125b controls monocyte adaptation to inflammation through mitochondrial metabolism and dynamics","volume":"128","author":"Roubert","year":"2016","journal-title":"Blood"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"5062","DOI":"10.4049\/jimmunol.1102001","article-title":"MicroRNA-125b potentiates macrophage activation","volume":"187","author":"Chaudhuri","year":"2011","journal-title":"J. Immunol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1080\/15476286.2024.2408706","article-title":"Both host and parasite non-coding RNAs co-ordinate the regularion of macrophage gene expression to reduce pro-inflammatory immune responses and promote tissue repair pathways during infection with Fasciola hepatica","volume":"21","author":"Sais","year":"2024","journal-title":"RNA Biol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/j.celrep.2018.03.097","article-title":"The NLRP3 inflammasome suppresses protective immunity to gastrointestinal helminth infection","volume":"23","author":"Alhallaf","year":"2018","journal-title":"Cell Rep."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"e00683-20","DOI":"10.1128\/IAI.00683-20","article-title":"Purinergic P2X7 receptor mediates the elimination of Trichinella spiralis by activating nf-\u03baB\/NLRP3\/IL-1\u03b2 pathway in macrophages","volume":"89","author":"Guan","year":"2021","journal-title":"Infect Immun."},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"De la Torre-Escudero, E., Gerlach, J.Q., Bennet, A.P.S., Cwiklinski, K., Jewhurst, H.L., Huson, K.M., Joshi, L., Kilcoyne, M., O\u2019Neill, S., and Dalton, J.P. (2019). Surface molecules of extracellular vesicles secreted by the helminth pathogen Fasciola hepatica direct their internalisation by host cells. PLoS Negl. Trop. Dis., 13.","DOI":"10.1371\/journal.pntd.0007087"},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Liu, J., Zhu, L., Wang, J., Qiu, L., Chen, Y., Davis, R.E., and Cheng, G. (2019). Schistosoma japonicum extracellular vesicle miRNA cargo regulates host macrophage functions facilitating parasitism. PLoS Pathog., 15.","DOI":"10.1371\/journal.ppat.1007817"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1186\/s13071-022-05278-8","article-title":"Human tumor necrosis factor alpha affects the egg-laying dynamics and glucose metabolism of Schistosoma mansoni adult worms in vitro","volume":"15","author":"Bertevello","year":"2022","journal-title":"Parasites Vectors"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.cub.2013.01.072","article-title":"Bantam miRNA promotes systemic growth by connecting insulin signaling and ecdysone production","volume":"23","author":"Boulan","year":"2013","journal-title":"Curr. Biol."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Hoy, A.M., Lundie, R.J., Ivens, A., Quintana, J.F., Nausch, N., Forster, T., Jones, F., and Kabatereine, N.B. (2014). Parasite-Derived MicroRNAs in Host Serum as Novel Biomarkers of Helminth Infection. PLoS Negl. Trop. Dis., 8.","DOI":"10.1371\/journal.pntd.0002701"},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Xue, X., Sun, J., Zhang, Q., Wanf, Z., Huang, Y., and Pan, W. (2008). Identification and characterization of novel microRNAs from Schistosoma japonicum. PLoS ONE, 3.","DOI":"10.1371\/journal.pone.0004034"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"4967","DOI":"10.1038\/onc.2013.492","article-title":"MicroRNAs and cancer stem cells: The sword and the shield","volume":"33","author":"Sun","year":"2014","journal-title":"Oncogene"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"6542","DOI":"10.4049\/jimmunol.1202496","article-title":"MicroRNA let-7c regulates macrophage polarization","volume":"190","author":"Banerjee","year":"2013","journal-title":"J. Immunol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/s41467-017-02406-2","article-title":"Circulating exosomes suppress the induction of regulatory T cells via let-7i in multiple sclerosis","volume":"9","author":"Kimura","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Montaner, S., Galiano, A., Trelis, M., Martin-Jaular, L., del Portillo, H.A., Bernal, D., and Marcilla, A. (2014). The Role of Extracellular Vesicles in Modulating the Host Immune Response during Parasitic Infections. Front. Immunol., 5.","DOI":"10.3389\/fimmu.2014.00433"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"5488","DOI":"10.1038\/ncomms6488","article-title":"Exosomes secreted by nematode parasites transfer small RNAs to mammalian cells and modulate innate immunity","volume":"5","author":"Buck","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Wu, J., Liao, Y., Li, D., Zhu, Z., Zhang, L., Wu, Z., He, P., and Wang, L. (2022). Extracellular vesicles derived from Trichinella Spiralis larvae promote the polarization of macrophages to M2b type and inhibit the activation of fibroblasts. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.974332"},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"B\u0105ska, P., Majewska, A., Zygner, W., D\u0142ugosz, E., and Wi\u015bniewski, M. (2024). Fasciola hepatica Excretory-Secretory Products (Fh-ES) Either Do Not Affect miRNA Expression Profile in THP-1 Macrophages or the Changes Are Undetectable by a Microarray Technique. Pathogens, 13.","DOI":"10.3390\/pathogens13100854"},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Wang, S., Chen, D., He, J., Zheng, W., Tian, A., Zhao, G., Elsheikha, H.M., and Zhu, X. (2021). Fasciola gigantica-Derived Excretory-Secretory Products Alter the Expression of mRNAs, miRNAs, lncRNAs, and circRNAs Involved in the Immune Response and Metabolism in Goat Peripheral Blood Mononuclear Cells. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.653755"},{"key":"ref_107","first-page":"587","article-title":"Comparison Between Next-Generation Sequencing and Microarrays for miRNA Expression in Cancer Samples","volume":"47","year":"2023","journal-title":"Natl. Acad. Sci. Lett."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Guo, X., and Guo, A. (2019). Profiling circulating microRNAs in serum of Fasciola gigantica-infected buffalo. Mol. Biochem. Parasitol., 232.","DOI":"10.1016\/j.molbiopara.2019.111201"},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Ricciardi, A., Bennuru, S., Tariq, S., Kaur, S., Wu, W., Elkahloun, A.G., Arakelyan, A., Shaik, J., Dorward, D.W., and Nutman, T.B. (2021). Extracellular vesicles released from the filarial parasite Brugia malayi downregulate the host m TOR pathway. PLoS Negl. Trop. Dis., 15.","DOI":"10.1371\/journal.pntd.0008884"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.intimp.2016.03.015","article-title":"Effects of Echinococcus multilocularis miR-71 mimics on murine macrophage RAW264.7 cells","volume":"34","author":"Zheng","year":"2016","journal-title":"Int. Immunopharmacol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/cmi.2014.67","article-title":"miRNA-24 and miRNA-466I-5p controls inflammation in rat hepatocytes","volume":"12","author":"Saravanan","year":"2014","journal-title":"Cell. Mol. Immunol."},{"key":"ref_112","first-page":"e33881","article-title":"The Liver MicroRNA Expression Profiles Associated with Chronic Hepatitis C Virus (HCV) Genotype-4 Infection: A Preliminary Study","volume":"16","author":"Helwa","year":"2016","journal-title":"Hepat. Mon."},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Guidi, R., Wedeles, C.J., and Wilson, M.S. (2020). ncRNAs in Type-2 Immunity. Noncoding RNA, 6.","DOI":"10.3390\/ncrna6010010"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"105255","DOI":"10.1016\/j.actatropica.2019.105255","article-title":"Parasite-derived microRNAs in plasma as novel promising biomarkers for the early detection of hydatid cyst infection and post-surgery follow-up","volume":"202","author":"Alizadeh","year":"2020","journal-title":"Acta Trop."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"E2366","DOI":"10.1073\/pnas.1422858112","article-title":"Caenorhabditis elegans microRNAs of the let-7 family act in innate immune response circuits and confer robust developmental timing against pathogen stress","volume":"112","author":"Ren","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Stark, A., Brennecke, J., Russell, R.B., and Cohen, S.M. (2003). Identification of Drosophila MicroRNA targets. PLoS Biol., 1.","DOI":"10.1371\/journal.pbio.0000060"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.21037\/jgo-20-418","article-title":"miR-133a-5p suppresses gastric cancer through TCF4 down-regulation","volume":"12","author":"He","year":"2021","journal-title":"J. Gastrointest. Oncol."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Shandilya, U.K., Sharma, A., Naylor, D., Canovas, A., Mallard, B., and Karrow, N.A. (2023). Expression Profile of miRNA from High, Middle and Low Stress-Responding Sheep during Bacterial Endotoxin Challenge. Animals, 13.","DOI":"10.3390\/ani13030508"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1017\/S0031182019001689","article-title":"Small RNAs in parasitic nematodes\u2014Forms and functions","volume":"147","author":"Britton","year":"2020","journal-title":"Parasitology"},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"McVeigh, P., McCammick, E., Robb, E., Brophy, P., Morphew, R.M., Marks, N.J., and Maule, A.G. (2023). Discovery of long non-coding RNAs in the liver fluke, Fasciola hepatica. PLoS Negl. Trop. Dis., 17.","DOI":"10.1101\/2023.03.07.531498"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"2874","DOI":"10.1002\/1873-3468.13085","article-title":"Interactions between short and long noncoding RNAs","volume":"592","author":"Ulitsky","year":"2018","journal-title":"FEBS Lett."},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Zhang, M., He, P., and Bian, Z. (2021). Long Noncoding RNAs in Neurodegenerative Diseases: Pathogenesis and Potential Implications as Clinical Biomarkers. Front. Mol. Neurosci., 14.","DOI":"10.3389\/fnmol.2021.685143"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/1\/204\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:56:07Z","timestamp":1760115367000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/1\/204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,29]]},"references-count":122,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1]]}},"alternative-id":["ijms26010204"],"URL":"https:\/\/doi.org\/10.3390\/ijms26010204","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,29]]}}}