{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:49:48Z","timestamp":1791848988441,"version":"4.3.4"},"reference-count":145,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T00:00:00Z","timestamp":1735776000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"2024 Education Science The 14th Five Year Plan Project of Hunan Province","award":["XJK24BTW003"],"award-info":[{"award-number":["XJK24BTW003"]}]},{"name":"2024 Education Science The 14th Five Year Plan Project of Hunan Province","award":["22YJC890038"],"award-info":[{"award-number":["22YJC890038"]}]},{"name":"2024 Education Science The 14th Five Year Plan Project of Hunan Province","award":["21B0066"],"award-info":[{"award-number":["21B0066"]}]},{"name":"2024 Education Science The 14th Five Year Plan Project of Hunan Province","award":["CX20230492"],"award-info":[{"award-number":["CX20230492"]}]},{"name":"2024 Education Science The 14th Five Year Plan Project of Hunan Province","award":["CX20240504"],"award-info":[{"award-number":["CX20240504"]}]},{"name":"The Ministry of Education of Humanities and Social Science Project, China","award":["XJK24BTW003"],"award-info":[{"award-number":["XJK24BTW003"]}]},{"name":"The Ministry of Education of Humanities and Social Science Project, China","award":["22YJC890038"],"award-info":[{"award-number":["22YJC890038"]}]},{"name":"The Ministry of Education of Humanities and Social Science Project, China","award":["21B0066"],"award-info":[{"award-number":["21B0066"]}]},{"name":"The Ministry of Education of Humanities and Social Science Project, China","award":["CX20230492"],"award-info":[{"award-number":["CX20230492"]}]},{"name":"The Ministry of Education of Humanities and Social Science Project, China","award":["CX20240504"],"award-info":[{"award-number":["CX20240504"]}]},{"name":"Research Foundation of the Hunan Province Education Department","award":["XJK24BTW003"],"award-info":[{"award-number":["XJK24BTW003"]}]},{"name":"Research Foundation of the Hunan Province Education Department","award":["22YJC890038"],"award-info":[{"award-number":["22YJC890038"]}]},{"name":"Research Foundation of the Hunan Province Education Department","award":["21B0066"],"award-info":[{"award-number":["21B0066"]}]},{"name":"Research Foundation of the Hunan Province Education Department","award":["CX20230492"],"award-info":[{"award-number":["CX20230492"]}]},{"name":"Research Foundation of the Hunan Province Education Department","award":["CX20240504"],"award-info":[{"award-number":["CX20240504"]}]},{"name":"Postgraduate Scientific Research Innovation Project of Hunan Province","award":["XJK24BTW003"],"award-info":[{"award-number":["XJK24BTW003"]}]},{"name":"Postgraduate Scientific Research Innovation Project of Hunan Province","award":["22YJC890038"],"award-info":[{"award-number":["22YJC890038"]}]},{"name":"Postgraduate Scientific Research Innovation Project of Hunan Province","award":["21B0066"],"award-info":[{"award-number":["21B0066"]}]},{"name":"Postgraduate Scientific Research Innovation Project of Hunan Province","award":["CX20230492"],"award-info":[{"award-number":["CX20230492"]}]},{"name":"Postgraduate Scientific Research Innovation Project of Hunan Province","award":["CX20240504"],"award-info":[{"award-number":["CX20240504"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Myopia is one of the dominant causes of visual impairment in the world. Pathological myopia could even lead to other serious eye diseases. Researchers have reached a consensus that myopia could be caused by both environmental and genetic risk factors. Exploring the pathological mechanism of myopia can provide a scientific basis for developing measures to delay the progression of myopia or even treat it. Recent advances highlight that scleral hypoxia could be an important factor in promoting myopia. In this review, we summarized the role of scleral hypoxia in the pathology of myopia and also provided interventions for myopia that target scleral hypoxia directly or indirectly. We hope this review will aid in the development of novel therapeutic strategies and drugs for myopia.<\/jats:p>","DOI":"10.3390\/ijms26010332","type":"journal-article","created":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T07:44:53Z","timestamp":1735803893000},"page":"332","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["An Evidence-Based Narrative Review of Scleral Hypoxia Theory in Myopia: From Mechanisms to Treatments"],"prefix":"10.3390","volume":"26","author":[{"given":"Qin","family":"Xiao","sequence":"first","affiliation":[{"name":"College of Physical Education, Hunan Normal University, Changsha 410012, China"},{"name":"College of Physical Education, Hunan First Normal University, Changsha 410205, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Physical Education, Hunan Normal University, Changsha 410012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0724-6989","authenticated-orcid":false,"given":"Zhang-Lin","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Physical Education, Hunan Normal University, Changsha 410012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Yi","family":"Zou","sequence":"additional","affiliation":[{"name":"College of Physical Education, Hunan Normal University, Changsha 410012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Fa","family":"Tang","sequence":"additional","affiliation":[{"name":"College of Physical Education, Hunan Normal University, Changsha 410012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/j.ophtha.2016.01.006","article-title":"Global Prevalence of Myopia and High Myopia and Temporal Trends from 2000 through 2050","volume":"123","author":"Holden","year":"2016","journal-title":"Ophthalmology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1167\/iovs.63.12.20","article-title":"Vascular Changes of the Choroid and Their Correlations With Visual Acuity in Pathological Myopia","volume":"63","author":"Wang","year":"2022","journal-title":"Investig. 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