{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:43:44Z","timestamp":1792457024294,"version":"4.5.0"},"reference-count":277,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T00:00:00Z","timestamp":1735776000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Italian Ministry of Health\u2014Ricerca Corrente Annual Program 2025"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The first part of this review highlighted the evolving landscape of atherosclerosis, noting emerging cardiometabolic risk factors, the growing impact of exposomes, and social determinants of health. The prominent role of atherosclerosis in the bidirectional relationship between cardiovascular disease and cancer was also discussed. In this second part, we examine the complex interplay between multimorbid cardio-oncologic patients, cardiometabolic risk factors, and the harmful environments that lend a \u201csyndemic\u201d nature to these chronic diseases. We summarize management strategies targeting disordered cardiometabolic factors to mitigate cardiovascular disease and explore molecular mechanisms enabling more tailored therapies. Importantly, we emphasize the early interception of atherosclerosis through multifactorial interventions that detect subclinical signs (via biomarkers and imaging) to treat modifiable risk factors and prevent clinical events. A concerted preventive effort\u2014referred to by some as a \u201cpreventome\u201d\u2014is essential to reduce the burden of atherosclerosis-driven chronic diseases, shifting from mere chronic disease management to the proactive promotion of \u201cchronic health\u201d.<\/jats:p>","DOI":"10.3390\/ijms26010334","type":"journal-article","created":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T07:44:53Z","timestamp":1735803893000},"page":"334","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Atherosclerosis and the Bidirectional Relationship Between Cancer and Cardiovascular Disease: From Bench to Bedside, Part 2 Management"],"prefix":"10.3390","volume":"26","author":[{"given":"Giuseppina","family":"Gallucci","sequence":"first","affiliation":[{"name":"Independent Researcher, 85025 Melfi, 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Heart J.-Qual. Care Clin. Outcomes"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1161\/CIRCULATIONAHA.122.060911","article-title":"Status of cardiovascular health in US adults and children using the American Heart Association\u2019s new \u201cLife\u2019s essential 8\u201d metrics: Prevalence estimates from the National Health and Nutrition Examination Survey (NHANES), 2013 through 2018","volume":"146","author":"Ning","year":"2022","journal-title":"Circulation"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e032683","DOI":"10.1161\/JAHA.123.032683","article-title":"Association of Cardiovascular Health Metrics and Mortality among Individuals with and without Cancer","volume":"13","author":"Abramov","year":"2024","journal-title":"J. Am. Heart Assoc."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1093\/eurjpc\/zwac195","article-title":"Association of Life\u2019s Simple 7 with incident cardiovascular disease in 53 974 patients with cancer","volume":"29","author":"Kaneko","year":"2022","journal-title":"Eur. J. Prev. Cardiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jaccao.2021.02.003","article-title":"Addressing the \u201cCommon Soil\u201d of Risk Factors for Cardiovascular Disease and Cancer","volume":"3","author":"Hibler","year":"2021","journal-title":"JACC CardioOncol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.1093\/eurheartj\/ehab484","article-title":"2021 ESC Guidelines on cardiovascular disease prevention in clinical practice","volume":"42","author":"Visseren","year":"2021","journal-title":"Eur. Heart J."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e9","DOI":"10.1161\/CIR.0000000000001168","article-title":"2023 AHA\/ACC\/ACCP\/ASPC\/NLA\/PCNA Guideline for the Management of Patients with Chronic Coronary Disease: A Report of the American Heart Association\/American College of Cardiology Joint Committee on Clinical Practice Guidelines","volume":"148","author":"Virani","year":"2023","journal-title":"Circulation"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.jaccao.2022.09.008","article-title":"The Burden of Uncontrolled Cardiovascular Risk Factors in Men with Prostate Cancer: A RADICAL-PC Analysis","volume":"5","author":"Klimis","year":"2023","journal-title":"JACC CardioOncol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e210070","DOI":"10.1001\/jamanetworkopen.2021.0070","article-title":"Assessment and Management of Cardiovascular Risk Factors among US Veterans with Prostate Cancer","volume":"4","author":"Sun","year":"2021","journal-title":"JAMA Netw. Open"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1093\/eurjpc\/zwaa034","article-title":"Cardiovascular risk factors during cancer treatment. Prevalence and prognostic relevance: Insights from the CARDIOTOX registry","volume":"29","author":"Albaladejo","year":"2022","journal-title":"Eur. J. Prev. Cardiol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Weaver, K.E., Dressler, E.V., Smith, S., Nightingale, C.L., Klepin, H.D., Lee, S.C., Wells, B.J., Hundley, W.G., DeMari, J.A., and Price, S.N. (2024). Cardiovascular health assessment in routine cancer follow-up in community settings: Survivor risk awareness and perspectives. BMC Cancer, 24.","DOI":"10.1186\/s12885-024-11912-8"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1093\/eurjpc\/zwad146","article-title":"The underutilization of preventive cardiovascular measures in patients with cancer: An analysis of the Behavioural Risk Factor Surveillance System, 2011\u201322","volume":"30","author":"Sayed","year":"2023","journal-title":"Eur. J. Prev. Cardiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.jaccao.2024.05.015","article-title":"Predictive Performance of Cardiovascular Risk Scores in Cancer Survivors from the UK Biobank","volume":"6","author":"McCracken","year":"2024","journal-title":"JACC CardioOncol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"100409","DOI":"10.1016\/j.esmoop.2022.100409","article-title":"Major advancements in metastatic breast cancer treatment: When expanding options means prolonging survival","volume":"7","author":"Miglietta","year":"2022","journal-title":"ESMO Open"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1056\/NEJMoa1916623","article-title":"The Effect of Advances in Lung-Cancer Treatment on Population Mortality","volume":"383","author":"Howlader","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1093\/jnci\/djz136","article-title":"Measuring Aging and Identifying Aging Phenotypes in Cancer Survivors","volume":"111","author":"Guida","year":"2019","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1093\/jnci\/djaa060","article-title":"Strategies to Prevent or Remediate Cancer and Treatment-Related Aging","volume":"113","author":"Guida","year":"2021","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Gallucci, G., Turazza, F.M., Inno, A., Canale, M.L., Silvestris, N., Far\u00ec, R., Navazio, A., Pinto, C., and Tarantini, L. (2024). Atherosclerosis and the Bidirectional Relationship between Cancer and Cardiovascular Disease: From Bench to Bedside-Part 1. Int. J. Mol. Sci., 25.","DOI":"10.20944\/preprints202403.1185.v1"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"S38","DOI":"10.1016\/j.ypmed.2011.11.012","article-title":"A global view on the development of non communicable diseases","volume":"54","author":"Wagner","year":"2012","journal-title":"Prev. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"105955","DOI":"10.1016\/j.ypmed.2019.105955","article-title":"Clustering of lifestyle risk factors for non-communicable diseases in 304,779 adolescents from 89 countries: A global perspective","volume":"131","author":"Uddin","year":"2020","journal-title":"Prev. Med."},{"key":"ref_21","unstructured":"GBD 2019 Cancer Risk Factors Collaborators (2022). The global burden of cancer attributable to risk factors, 2010\u20132019: A systematic analysis for the Global Burden of Disease Study 2019. Lancet, 400, 563\u2013591."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Jiao, M. (2023). The impact of high-risk lifestyle factors on all-cause mortality in the US non-communicable disease population. BMC Public Health, 23.","DOI":"10.1186\/s12889-023-15319-1"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Global Cardiovascular Risk Consortium, Magnussen, C., Ojeda, F.M., Leong, D.P., Alegre-Diaz, J., Amouyel, P., Aviles-Santa, L., De Bacquer, D., Ballantyne, C.M., and Bernab\u00e9-Ortiz, A. (2023). Global Effect of Modifiable Risk Factors on Cardiovascular Disease and Mortality. N. Engl. J. Med., 389, 1273\u20131285.","DOI":"10.1056\/NEJMoa2206916"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Freisling, H., Viallon, V., Lennon, H., Bagnardi, V., Ricci, C., Butterworth, A.S., Sweeting, M., Muller, D., Romieu, I., and Bazelle, P. (2020). Lifestyle factors and risk of multimorbidity of cancer and cardiometabolic diseases: A multinational cohort study. BMC Med., 18.","DOI":"10.1186\/s12916-019-1474-7"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"106911","DOI":"10.1016\/j.ypmed.2021.106911","article-title":"Clustering of unhealthy lifestyle behaviors, self-rated health and disability","volume":"155","author":"Ortiz","year":"2022","journal-title":"Prev. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e028926","DOI":"10.1161\/JAHA.122.028926","article-title":"Lifestyle Behaviors and Cardiometabolic Diseases by Race and Ethnicity and Social Risk Factors among US Young Adults, 2011 to 2018","volume":"12","author":"Shi","year":"2023","journal-title":"J. Am. Heart Assoc."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.20892\/j.issn.2095-3941.2022.0397","article-title":"The power of a healthy lifestyle for cancer prevention: The example of colorectal cancer","volume":"19","author":"Chen","year":"2022","journal-title":"Cancer Biol. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1002\/cncr.23448","article-title":"Physical and psychological long-term and late effects of cancer","volume":"112","author":"Stein","year":"2008","journal-title":"Cancer"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1016\/S0140-6736(22)00242-2","article-title":"Management of common clinical problems experienced by survivors of cancer","volume":"399","author":"Emery","year":"2022","journal-title":"Lancet"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1093\/jnci\/djab223","article-title":"Survivorship for Individuals Living with Advanced and Metastatic Cancers: National Cancer Institute Meeting Report","volume":"114","author":"Mollica","year":"2022","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s00520-024-08328-2","article-title":"Financial toxicity among people with metastatic cancer: Findings from the Cancer Experience Registry","volume":"32","author":"Mollica","year":"2024","journal-title":"Support. Care Cancer"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e702","DOI":"10.1093\/pubmed\/fdad143","article-title":"Financial toxicity among cancer patients, survivors and their families in the United Kingdom: A scoping review","volume":"45","author":"Ngan","year":"2023","journal-title":"J. Public Health"},{"key":"ref_33","first-page":"236","article-title":"Atherosclerotic cardiovascular disease, cancer, and financial toxicity among adults in the United States","volume":"3","author":"Chouairi","year":"2021","journal-title":"Cardio Oncol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"100640","DOI":"10.1016\/j.ajpc.2024.100640","article-title":"Financial strain is associated with poorer cardiovascular health: The multi-ethnic study of atherosclerosis","volume":"17","author":"Osibogun","year":"2024","journal-title":"Am. J. Prev. Cardiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1186\/s12933-024-02324-w","article-title":"Trends in direct health care costs among US adults with atherosclerotic cardiovascular disease with and without diabetes","volume":"23","author":"Shah","year":"2024","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1016\/j.jacc.2023.03.402","article-title":"Financial toxicity of medical management of heart failure: JACC review topic of the week","volume":"81","author":"Sukumar","year":"2023","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"102992","DOI":"10.1016\/j.esmoop.2024.102992","article-title":"ESMO expert consensus statements on the screening and management of financial toxicity in patients with cancer","volume":"9","author":"Carrera","year":"2024","journal-title":"ESMO Open"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1093\/eurpub\/ckv233","article-title":"Individual socioeconomic status and breast cancer diagnostic stages: A French case-control study","volume":"26","author":"Orsini","year":"2016","journal-title":"Eur. J. Public Health"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1093\/annonc\/mds526","article-title":"Socio-demographic inequalities in stage of cancer diagnosis: Evidence from patients with female breast, lung, colon, rectal, prostate, renal, bladder, melanoma, ovarian and endometrial cancer","volume":"24","author":"Lyratzopoulos","year":"2013","journal-title":"Ann. Oncol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1200\/OP.24.00025","article-title":"Exploring the Relationship among Financial Hardship, Anxiety, and Depression in Patients with Cancer: A Longitudinal Study","volume":"20","author":"Yanez","year":"2024","journal-title":"JCO Oncol. Pract."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2908","DOI":"10.1200\/JCO.23.02099","article-title":"Magnitude and Temporal Variations of Socioeconomic Inequalities in the Quality of Life After Early Breast Cancer: Results from the Multicentric French CANTO Cohort","volume":"42","author":"Sandoval","year":"2024","journal-title":"J. Clin. Oncol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"3161","DOI":"10.1200\/JCO.20.00722","article-title":"Chronic Comorbidities among Survivors of Adolescent and Young Adult Cancer","volume":"38","author":"Chao","year":"2020","journal-title":"J. Clin. Oncol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1200\/JCO.23.01005","article-title":"Prediabetes and Associated Risk of Cardiovascular Events and Chronic Kidney Disease among Adult Survivors of Childhood Cancer in the St Jude Lifetime Cohort","volume":"42","author":"Dixon","year":"2024","journal-title":"J. Clin. Oncol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.cell.2014.10.039","article-title":"Geroscience: Linking aging to chronic disease","volume":"159","author":"Kennedy","year":"2014","journal-title":"Cell"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1038\/s41591-019-0675-0","article-title":"Chronic inflammation in the etiology of disease across the life span","volume":"25","author":"Furman","year":"2019","journal-title":"Nat. Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2662","DOI":"10.1200\/JCO.2014.55.8361","article-title":"Cancer survivorship issues: Life after treatment and implications for an aging population","volume":"32","author":"Rowland","year":"2014","journal-title":"J. Clin. Oncol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1002\/cncr.33981","article-title":"Chronic comorbid conditions among adult cancer survivors in the United States: Results from the National Health Interview Survey, 2002\u20132018","volume":"128","author":"Jiang","year":"2022","journal-title":"Cancer"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"A13066","DOI":"10.1161\/circ.148.suppl_1.13066","article-title":"Abstract 13066: Ten-Year Atherosclerotic Cardiovascular Risk Trajectory among Women Veterans Diagnosed with Breast, Colorectal, Lung and Thyroid Cancer","volume":"148","author":"Whyne","year":"2023","journal-title":"Circulation"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1111\/ajco.12130","article-title":"Identifying important comorbidity among cancer populations using administrative data: Prevalence and impact on survival","volume":"12","author":"Sarfati","year":"2016","journal-title":"Asia Pac. J. Clin. Oncol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.juro.2017.08.005","article-title":"Burden of Multiple Chronic Conditions among Patients with Urological Cancer","volume":"199","author":"Garg","year":"2018","journal-title":"J. Urol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/S0140-6736(19)31674-5","article-title":"Medium and long-term risks of specific cardiovascular diseases in survivors of 20 adult cancers: A population-based cohort study using multiple linked UK electronic health records databases","volume":"394","author":"Strongman","year":"2019","journal-title":"Lancet"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Fowler, H., Belot, A., Ellis, L., Maringe, C., Luque-Fernandez, M.A., Njagi, E.N., Navani, N., Sarfati, D., and Rachet, B. (2020). Comorbidity prevalence among cancer patients: A population-based cohort study of four cancers. BMC Cancer, 20.","DOI":"10.1186\/s12885-019-6472-9"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1038\/s41416-020-0950-3","article-title":"Total burden of disease in cancer patients at diagnosis-a Danish nationwide study of multimorbidity and redeemed medication","volume":"123","author":"Loeppenthin","year":"2020","journal-title":"Br. J. Cancer"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1007\/s00520-020-05529-3","article-title":"Burden of multimorbidity and polypharmacy among cancer survivors: A population-based nested case-control study","volume":"29","author":"Keats","year":"2021","journal-title":"Support. Care Cancer"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Plasencia, G., Gray, S.C., Hall, I.J., and Smith, J.L. (2024). Multimorbidity clusters in adults 50 years or older with and without a history of cancer: National Health Interview Survey, 2018. BMC Geriatr., 24.","DOI":"10.1186\/s12877-023-04603-9"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1161\/CIRCRESAHA.123.323613","article-title":"Environmental Impacts on Cardiovascular Health and Biology: An Overview","volume":"134","author":"Blaustein","year":"2024","journal-title":"Circ. Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/s41569-021-00532-5","article-title":"Transportation noise pollution and cardiovascular disease","volume":"18","author":"Daiber","year":"2021","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/s41569-023-00873-3","article-title":"The contribution of the exposome to the burden of cardiovascular disease","volume":"20","author":"Hahad","year":"2023","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_59","first-page":"99","article-title":"A dose of drugs, a touch of violence, a case of AIDS: Conceptualizing the SAVA syndemic","volume":"24","author":"Singer","year":"1996","journal-title":"Free Inq. Creat. Sociol."},{"key":"ref_60","first-page":"e984","article-title":"Obesity and Cardiovascular Disease: A Scientific Statement from the American Heart Association","volume":"143","author":"Poirier","year":"2021","journal-title":"Circulation"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/S0140-6736(18)32822-8","article-title":"The Global Syndemic of Obesity, Undernutrition, and Climate Change: The Lancet Commission report","volume":"393","author":"Swinburn","year":"2019","journal-title":"Lancet"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Ahima, R.S. (2024). Overview of metabolic syndrome. Metabolic Syndrome: A Comprehensive Textbook, Springer International Publishing.","DOI":"10.1007\/978-3-031-40116-9"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"155326","DOI":"10.1016\/j.metabol.2022.155326","article-title":"Body fatness associations with cancer: Evidence from recent epidemiological studies and future directions","volume":"137","author":"Larsson","year":"2022","journal-title":"Metabolism"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jaccao.2022.01.095","article-title":"Association of Cardiometabolic Disease with Cancer in the Community","volume":"4","author":"Liu","year":"2022","journal-title":"JACC CardioOncol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2712","DOI":"10.1161\/01.CIR.0000018121.67607.CE","article-title":"Obesity accelerates the progression of coronary atherosclerosis in young men","volume":"105","author":"McGill","year":"2002","journal-title":"Circulation"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"155744","DOI":"10.1016\/j.metabol.2023.155744","article-title":"Rising global burden of cancer attributable to high BMI from 2010 to 2019","volume":"152","author":"Tan","year":"2023","journal-title":"Metabolism"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1093\/jnci\/djac192","article-title":"Childhood body mass index trajectories, adult-onset type 2 diabetes, and obesity-related cancers","volume":"115","author":"Jensen","year":"2023","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"e13276","DOI":"10.1111\/obr.13276","article-title":"Associations between body mass index and height during childhood and adolescence and the risk of coronary heart disease in adulthood: A systematic review and meta-analysis","volume":"22","author":"Meyer","year":"2021","journal-title":"Obes. Rev."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1093\/eurheartj\/ehq355","article-title":"Adiposity and cardiovascular risk factors in a large contemporary population of pre-pubertal children","volume":"31","author":"Falaschetti","year":"2010","journal-title":"Eur. Heart J."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1001\/jamapediatrics.2020.0085","article-title":"Obesity Treatment among Adolescents: A Review of Current Evidence and Future Directions","volume":"174","author":"Cardel","year":"2020","journal-title":"JAMA Pediatr."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1056\/NEJMoa2109191","article-title":"Childhood Cardiovascular Risk Factors and Adult Cardiovascular Events","volume":"386","author":"Jacobs","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1161\/CIRCULATIONAHA.123.064296","article-title":"Childhood Non-HDL Cholesterol and LDL Cholesterol and Adult Atherosclerotic Cardiovascular Events","volume":"149","author":"Wu","year":"2024","journal-title":"Circulation"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1161\/CIRCULATIONAHA.114.014310","article-title":"Prevalence, Vascular Distribution, and Multiterritorial Extent of Subclinical Atherosclerosis in a Middle-Aged Cohort: The PESA (Progression of Early Subclinical Atherosclerosis) Study","volume":"131","author":"Laclaustra","year":"2015","journal-title":"Circulation"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1016\/j.jacc.2020.02.026","article-title":"Short-Term Progression of Multiterritorial Subclinical Atherosclerosis","volume":"75","author":"Oliva","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1089\/met.2008.0034","article-title":"The product of fasting glucose and triglycerides as surrogate for identifying insulin resistance in apparently healthy subjects","volume":"6","year":"2008","journal-title":"Metab. Syndr. Relat. Disord."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"3347","DOI":"10.1210\/jc.2010-0288","article-title":"The product of triglycerides and glucose, a simple measure of insulin sensitivity. Comparison with the euglycemic-hyperinsulinemic clamp","volume":"95","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1016\/j.numecd.2022.07.024","article-title":"The accuracy of triglyceride-glucose (TyG) index for the screening of metabolic syndrome in adults: A systematic review and meta-analysis","volume":"32","author":"Nabipoorashrafi","year":"2022","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"D\u2019Elia, L., Masulli, M., Virdis, A., Casiglia, E., Tikhonoff, V., Angeli, F., Barbagallo, C.M., Bombelli, M., Cappelli, F., and Cianci, R. (J. Clin. Endocrinol. Metab., 2024). Triglyceride-glucose Index and Mortality in a Large Regional-based Italian Database (Urrah Project), J. Clin. Endocrinol. Metab., ahead of print.","DOI":"10.1210\/clinem\/dgae170"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s12933-023-01762-2","article-title":"Triglyceride-glucose index and triglyceride to high-density lipoprotein cholesterol ratio as potential cardiovascular disease risk factors: An analysis of UK biobank data","volume":"22","author":"Che","year":"2023","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"e23","DOI":"10.1016\/S2666-7568(22)00247-1","article-title":"Association of the triglyceride glucose index as a measure of insulin resistance with mortality and cardiovascular disease in populations from five continents (PURE study): A prospective cohort study","volume":"4","author":"Abat","year":"2023","journal-title":"Lancet Healthy Longev."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1093\/ije\/dyz053","article-title":"The triglyceride-glucose index as a measure of insulin resistance and risk of obesity-related cancers","volume":"49","author":"Fritz","year":"2020","journal-title":"Int. J. Epidemiol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.clnesp.2022.08.004","article-title":"The relationship between Triglyceride and glycose (TyG) index and the risk of gynaecologic and breast cancers","volume":"51","author":"Shi","year":"2022","journal-title":"Clin. Nutr. ESPEN"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1186\/s12933-023-01906-4","article-title":"Triglyceride-glucose index and coronary artery disease: A systematic review and meta-analysis of risk, severity, and prognosis","volume":"22","author":"Liang","year":"2023","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s12933-021-01268-9","article-title":"Triglyceride-glucose index and the incidence of atherosclerotic cardiovascular diseases: A meta-analysis of cohort studies","volume":"20","author":"Ding","year":"2021","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s12933-022-01511-x","article-title":"Triglyceride-glucose index as a marker in cardiovascular diseases: Landscape and limitations","volume":"21","author":"Tao","year":"2022","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1093\/eurjpc\/zwae089","article-title":"Association of inflammatory markers with incident heart failure or cancer in the HUNT3 and Health ABC population studies","volume":"31","author":"Bertero","year":"2024","journal-title":"Eur. J. Prev. Cardiol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"3901","DOI":"10.1093\/eurheartj\/ehz587","article-title":"The relation between systemic inflammation and incident cancer in patients with stable cardiovascular disease: A cohort study","volume":"40","author":"Ridker","year":"2019","journal-title":"Eur. Heart J."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.ijcard.2019.04.078","article-title":"Increased risk of cancer death in patients with chronic heart failure with a special reference to inflammation-A report from the CHART-2 Study","volume":"290","author":"Oikawa","year":"2019","journal-title":"Int. J. Cardiol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"4719","DOI":"10.1093\/eurheartj\/ehae557","article-title":"Systemic inflammation and health outcomes in patients receiving treatment for atherosclerotic cardiovascular disease","volume":"45","author":"Mazhar","year":"2024","journal-title":"Eur. Heart J."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1002\/ijc.32303","article-title":"The systemic immune-inflammation index is associated with an increased risk of incident cancer-A population-based cohort study","volume":"146","author":"Fest","year":"2020","journal-title":"Int. J. Cancer"},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Deng, X., Liu, D., Li, M., He, J., and Fu, Y. (2024). Association between systemic immune-inflammation index and insulin resistance and mortality. Sci. Rep., 14.","DOI":"10.1038\/s41598-024-51878-y"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"3295","DOI":"10.7150\/jca.25691","article-title":"Prognostic value of Systemic immune-inflammation index in cancer: A meta-analysis","volume":"9","author":"Yang","year":"2018","journal-title":"J. Cancer"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"e13230","DOI":"10.1111\/eci.13230","article-title":"Systemic immune-inflammation index (SII) predicted clinical outcome in patients with coronary artery disease","volume":"50","author":"Yang","year":"2020","journal-title":"Eur. J. Clin. Investig."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1186\/s12933-024-02251-w","article-title":"Is systemic inflammation a missing link between cardiometabolic index with mortality? Evidence from a large population-based study","volume":"23","author":"Xu","year":"2024","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1016\/j.jacc.2024.07.034","article-title":"Quantifying Triglyceride-Rich Lipoprotein Atherogenicity, Associations with Inflammation, and Implications for Risk Assessment Using Non-HDL Cholesterol","volume":"84","author":"Adiels","year":"2024","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1007\/s11154-023-09797-2","article-title":"Towards an adiposity-related disease framework for the diagnosis and management of obesities","volume":"24","author":"Perdomo","year":"2023","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1056\/NEJMra2032804","article-title":"Reassessing Human Adipose Tissue","volume":"386","author":"Cypess","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"2528","DOI":"10.1200\/JCO.19.00286","article-title":"Adipose Tissue Distribution and Cardiovascular Disease Risk among Breast Cancer Survivors","volume":"37","author":"Chen","year":"2019","journal-title":"J. Clin. Oncol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"pkac030","DOI":"10.1093\/jncics\/pkac030","article-title":"Associations of Body Fat Distribution and Cardiometabolic Risk of Testicular Cancer Survivors After Cisplatin-Based Chemotherapy","volume":"6","author":"Wibmer","year":"2022","journal-title":"JNCI Cancer Spectr."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1016\/j.jtho.2021.04.020","article-title":"Visceral Obesity Promotes Lung Cancer Progression-Toward Resolution of the Obesity Paradox in Lung Cancer","volume":"16","author":"Barbi","year":"2021","journal-title":"J. Thorac. Oncol."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Chaplin, A., Rodriguez, R.M., Segura-Sampedro, J.J., Ochogav\u00eda-Segu\u00ed, A., Romaguera, D., and Barcel\u00f3-Coblijn, G. (2022). Insights behind the Relationship between Colorectal Cancer and Obesity: Is Visceral Adipose Tissue the Missing Link?. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232113128"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1200\/JCO.21.00102","article-title":"Sarcopenia in the Older Adult with Cancer","volume":"39","author":"Williams","year":"2021","journal-title":"J. Clin. Oncol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1017\/S0007114520002172","article-title":"Sarcopenic obesity in ageing: Cardiovascular outcomes and mortality","volume":"124","author":"Atkins","year":"2020","journal-title":"Br. J. Nutr."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1016\/j.clnu.2016.03.028","article-title":"Sarcopenia, sarcopenic obesity and inflammation: Results from the 1999\u20132004 National Health and Nutrition Examination Survey","volume":"35","author":"Batsis","year":"2016","journal-title":"Clin. Nutr."},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Bilski, J., Pierzchalski, P., Szczepanik, M., Bonior, J., and Zoladz, J.A. (2022). Multifactorial Mechanism of Sarcopenia and Sarcopenic Obesity. Role of Physical Exercise, Microbiota and Myokines. Cells, 11.","DOI":"10.3390\/cells11010160"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1161\/ATVBAHA.116.307156","article-title":"Relationship Between Low Relative Muscle Mass and Coronary Artery Calcification in Healthy Adults","volume":"36","author":"Ko","year":"2016","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1016\/j.cjca.2021.04.002","article-title":"Low Skeletal Muscle Mass Is Associated with the Presence, Incidence, and Progression of Coronary Artery Calcification","volume":"37","author":"Jun","year":"2021","journal-title":"Can. J. Cardiol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.maturitas.2016.11.006","article-title":"Inflammation and sarcopenia: A systematic review and meta-analysis","volume":"96","author":"Bano","year":"2017","journal-title":"Maturitas"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.exger.2018.06.013","article-title":"Is increased neutrophil lymphocyte ratio remarking the inflammation in sarcopenia?","volume":"110","author":"Kul","year":"2018","journal-title":"Exp. Gerontol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1177\/0003319714520954","article-title":"Relationship of neutrophil-lymphocyte ratio with the presence, severity, and extent of coronary atherosclerosis detected by coronary computed tomography angiography","volume":"66","author":"Fidan","year":"2015","journal-title":"Angiology"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1093\/eurheartj\/ehaa1034","article-title":"The neutrophil-lymphocyte ratio and incident atherosclerotic events: Analyses from five contemporary randomized trials","volume":"42","author":"Adamstein","year":"2021","journal-title":"Eur. Heart J."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1002\/jcsm.12755","article-title":"Predictive impact of sarcopenia in solid cancers treated with immune checkpoint inhibitors: A meta-analysis","volume":"12","author":"Takenaka","year":"2021","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.1007\/s00432-019-03002-1","article-title":"C-reactive protein as an early marker of immune-related adverse events","volume":"145","author":"Abolhassani","year":"2019","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1007\/s00432-021-03550-5","article-title":"Inflammatory markers in autoimmunity induced by checkpoint inhibitors","volume":"147","author":"Husain","year":"2021","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"e2400260","DOI":"10.1200\/PO.24.00260","article-title":"Circulating Lipid Profiles Associated with Resistance to Androgen Deprivation Therapy in Localized Prostate Cancer","volume":"8","author":"Lin","year":"2024","journal-title":"JCO Precis. Oncol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1161\/CIRCULATIONAHA.109.192703","article-title":"Defining and setting national goals for cardiovascular health promotion and disease reduction: The American Heart Association\u2019s strategic Impact Goal through 2020 and beyond","volume":"121","author":"Hong","year":"2010","journal-title":"Circulation"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1161\/CIRCULATIONAHA.121.053730","article-title":"American Heart Association\u2019s Life\u2019s Simple 7: Lifestyle Recommendations, Polygenic Risk, and Lifetime Risk of Coronary Heart Disease","volume":"145","author":"Hasbani","year":"2022","journal-title":"Circulation"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1016\/j.jacc.2018.04.027","article-title":"Influence of Lifestyle on Incident Cardiovascular Disease and Mortality in Patients with Diabetes Mellitus","volume":"71","author":"Liu","year":"2018","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1053\/j.ajkd.2014.09.016","article-title":"Healthy lifestyle and risk of kidney disease progression, atherosclerotic events, and death in CKD: Findings from the Chronic Renal Insufficiency Cohort (CRIC) Study","volume":"65","author":"Ricardo","year":"2015","journal-title":"Am. J. Kidney Dis."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1016\/j.jacc.2017.09.1096","article-title":"Cardiovascular complications of cancer therapy: Best practices in diagnosis, prevention, and management: Part 1","volume":"70","author":"Chang","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"e46","DOI":"10.1161\/HYP.0000000000000224","article-title":"Cancer Therapy-Related Hypertension: A Scientific Statement from the American Heart Association","volume":"80","author":"Cohen","year":"2023","journal-title":"Hypertension"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1161\/HYPERTENSIONAHA.122.17947","article-title":"Established and Emerging Cancer Therapies and Cardiovascular System: Focus on Hypertension-Mechanisms and Mitigation","volume":"80","author":"Haw","year":"2023","journal-title":"Hypertension"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"e000082","DOI":"10.1161\/HCG.0000000000000082","article-title":"Impact of Hormonal Therapies for Treatment of Hormone-Dependent Cancers (Breast and Prostate) on the Cardiovascular System: Effects and Modifications: A Scientific Statement from the American Heart Association","volume":"14","author":"Okwuosa","year":"2021","journal-title":"Circ. Genom. Precis. Med."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s10549-023-06997-x","article-title":"Development of cardiometabolic risk factors following endocrine therapy in women with breast cancer","volume":"201","author":"Kwan","year":"2023","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1038\/s41416-023-02271-5","article-title":"Temporal trends in cardiovascular burden among patients with prostate cancer receiving androgen deprivation therapy: A population-based cohort study","volume":"128","author":"Chan","year":"2023","journal-title":"Br. J. Cancer"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1200\/JCO.22.00083","article-title":"Blood Pressure Classification Using the 2017 ACC\/AHA Guideline and Heart Failure in Patients with Cancer","volume":"41","author":"Kaneko","year":"2023","journal-title":"J. Clin. Oncol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1161\/CIR.0000000000001186","article-title":"A synopsis of the evidence for the science and clinical management of cardiovascular-kidney-metabolic (CKM) syndrome: A scientific statement from the American Heart Association","volume":"148","author":"Ndumele","year":"2023","journal-title":"Circulation"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1161\/CIR.0000000000001184","article-title":"Cardiovascular-kidney-metabolic health: A presidential advisory from the American Heart Association","volume":"148","author":"Ndumele","year":"2023","journal-title":"Circulation"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1161\/CIRCULATIONAHA.122.061991","article-title":"Social and psychosocial determinants of racial and ethnic differences in cardiovascular health in the United States population","volume":"147","author":"Shah","year":"2023","journal-title":"Circulation"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1161\/CIRCULATIONAHA.123.067626","article-title":"Development and Validation of the American Heart Association\u2019s PREVENT Equations","volume":"149","author":"Khan","year":"2024","journal-title":"Circulation"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"4229","DOI":"10.1093\/eurheartj\/ehac244","article-title":"2022 ESC Guidelines on cardio-oncology developed in collaboration with the European Hematology Association (EHA), the European Society for Therapeutic Radiology and Oncology (ESTRO) and the International Cardio-Oncology Society (IC-OS)","volume":"43","author":"Lyon","year":"2022","journal-title":"Eur. Heart J."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1016\/j.jcmg.2022.02.026","article-title":"Evolving Role of Calcium Density in Coronary Artery Calcium Scoring and Atherosclerotic Cardiovascular Disease Risk","volume":"15","author":"Razavi","year":"2022","journal-title":"JACC Cardiovasc. Imaging"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1161\/ATVBAHA.123.320065","article-title":"Eradicating Atherosclerotic Events by Targeting Early Subclinical Disease: It Is Time to Retire the Therapeutic Paradigm of Too Much, Too Late","volume":"44","author":"Williams","year":"2024","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1016\/S0140-6736(24)00596-8","article-title":"Inflammatory risk and cardiovascular events in patients without obstructive coronary artery disease: The ORFAN multicentre, longitudinal cohort study","volume":"403","author":"Chan","year":"2024","journal-title":"Lancet"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1161\/01.CIR.99.2.237","article-title":"C-Reactive protein, a sensitive marker of inflammation, predicts future risk of coronary heart disease in initially healthy middle-aged men: Results from the MONICA (Monitoring Trends and Determinants in Cardiovascular Disease) Augsburg Cohort Study, 1984 to 1992","volume":"99","author":"Koenig","year":"1999","journal-title":"Circulation"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1016\/j.jacc.2009.09.009","article-title":"Hansson GK. Inflammation in atherosclerosis: From pathophysiology to practice","volume":"54","author":"Libby","year":"2009","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1093\/eurheartj\/ehr310","article-title":"Creating controversy where none exists: The important role of C-reactive protein in the CARE, AFCAPS\/TexCAPS, PROVE IT, REVERSAL, A to Z, JUPITER, HEART PROTECTION, and ASCOT trials","volume":"33","author":"Braunwald","year":"2012","journal-title":"Eur. Heart J."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1056\/NEJMoa042378","article-title":"C-reactive protein levels and outcomes after statin therapy","volume":"352","author":"Ridker","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1161\/CIRCULATIONAHA.106.628909","article-title":"Clinical relevance of C-reactive protein during follow-upof patients with acute coronary syndromes in the Aggrastat-to-Zocor Trial","volume":"114","author":"Morrow","year":"2006","journal-title":"Circulation"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1056\/NEJMoa0807646","article-title":"Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein","volume":"359","author":"Ridker","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/S0140-6736(09)60447-5","article-title":"Reduction in C-reactive protein and LDL cholesterol and cardiovascular event rates after initiation of rosuvastatin: A prospective study of the JUPITER trial","volume":"373","author":"Ridker","year":"2009","journal-title":"Lancet"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1093\/cvr\/cvae034","article-title":"Effect of lipid-lowering therapies on C-reactive protein levels: A comprehensive meta-analysis of randomized controlled trials","volume":"120","author":"Xie","year":"2024","journal-title":"Cardiovasc. Res."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1161\/CIRCULATIONAHA.123.066213","article-title":"Inflammation and Cholesterol as Predictors of Cardiovascular Events among 13\u2009970 Contemporary High-Risk Patients with Statin Intolerance","volume":"149","author":"Ridker","year":"2024","journal-title":"Circulation"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1093\/ehjacc\/zuac123","article-title":"Acute LDL-C reduction post ACS: Strike early and strike strong: From evidence to clinical practice. A clinical consensus statement of the Association for Acute CardioVascular Care (ACVC), in collaboration with the European Association of Preventive Cardiology (EAPC) and the European Society of Cardiology Working Group on Cardiovascular Pharmacotherapy","volume":"11","author":"Krychtiuk","year":"2022","journal-title":"Eur. Heart J. Acute Cardiovasc. Care"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1001\/jamacardio.2024.2912","article-title":"Tailoring Risk Prediction Models to Local Populations","volume":"9","author":"Zinzuwadia","year":"2024","journal-title":"JAMA Cardiol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1056\/NEJMra2211889","article-title":"Diets","volume":"390","author":"Yannakoulia","year":"2024","journal-title":"N. Engl. J. Med."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1111\/bph.14778","article-title":"Mediterranean diet and health status: Active ingredients and pharmacological mechanisms","volume":"177","author":"Schwingshackl","year":"2020","journal-title":"Br. J. Pharmacol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1001\/jamainternmed.2015.4838","article-title":"Mediterranean Diet and Invasive Breast Cancer Risk among Women at High Cardiovascular Risk in the PREDIMED Trial: A Randomized Clinical Trial","volume":"175","author":"Toledo","year":"2015","journal-title":"JAMA Intern. Med."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1038\/s41430-024-01442-8","article-title":"Olive oil consumption is associated with lower cancer, cardiovascular and all-cause mortality among Italian adults: Prospective results from the Moli-sani Study and analysis of potential biological mechanisms","volume":"78","author":"Ruggiero","year":"2024","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.clnu.2023.03.018","article-title":"Ultra-processed food consumption and cancer risk: A systematic review and meta-analysis","volume":"42","author":"Isaksen","year":"2023","journal-title":"Clin. Nutr."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"e2411852","DOI":"10.1001\/jamanetworkopen.2024.11852","article-title":"Ultraprocessed Food Consumption and Cardiometabolic Risk Factors in Children","volume":"7","author":"Khoury","year":"2024","journal-title":"JAMA Netw. Open"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3322\/caac.21591","article-title":"American Cancer Society guideline for diet and physical activity for cancer prevention","volume":"70","author":"Rock","year":"2020","journal-title":"CA Cancer J. Clin."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/s41392-022-00974-4","article-title":"Microbiota in health and diseases","volume":"7","author":"Hou","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1001\/jamaoncol.2022.0494","article-title":"The Potential of the Gut Microbiome to Reshape the Cancer Therapy Paradigm: A Review","volume":"8","author":"Liu","year":"2022","journal-title":"JAMA Oncol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1038\/s41396-023-01483-0","article-title":"Potential effects of gut microbiota on host cancers: Focus on immunity, DNA damage, cellular pathways, and anticancer therapy","volume":"17","author":"Sun","year":"2023","journal-title":"ISME J."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1158\/1940-6207.CAPR-23-0091","article-title":"Early-onset Colon Cancer Shows a Distinct Intestinal Microbiome and a Host-Microbe Interaction","volume":"17","author":"Adnan","year":"2024","journal-title":"Cancer Prev. Res."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"3396","DOI":"10.1038\/s41467-024-47523-x","article-title":"Consistent signatures in the human gut microbiome of old-and young-onset colorectal cancer","volume":"15","author":"Qin","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_158","doi-asserted-by":"crossref","unstructured":"Dai, Z., Coker, O.O., Nakatsu, G., Wu, W.K.K., Zhao, L., Chen, Z., Chan, F.K.L., Kristiansen, K., Sung, J.J.Y., and Wong, S.H. (2018). Multi-cohort analysis of colorectal cancer metagenome identified altered bacteria across populations and universal bacterial markers. Microbiome, 6.","DOI":"10.1186\/s40168-018-0451-2"},{"key":"ref_159","doi-asserted-by":"crossref","unstructured":"Fujii, T., Kuzuya, T., Kondo, N., Funasaka, K., Ohno, E., Hirooka, Y., and Tochio, T. (2024). Altered intestinal Streptococcus anginosus and 5\u03b1-reductase gene levels in patients with hepatocellular carcinoma and elevated Bacteroides stercoris in atezolizumab\/bevacizumab non-responders. J. Med. Microbiol., 73.","DOI":"10.1099\/jmm.0.001878"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1158\/2326-6066.CIR-19-1014","article-title":"The Gut Microbiome Is Associated with Clinical Response to Anti-PD-1\/PD-L1 Immunotherapy in Gastrointestinal Cancer","volume":"8","author":"Peng","year":"2020","journal-title":"Cancer Immunol. Res."},{"key":"ref_161","doi-asserted-by":"crossref","unstructured":"Chau, J., Yadav, M., Liu, B., Furqan, M., Dai, Q., Shahi, S., Gupta, A., Mercer, K.N., Eastman, E., and Hejleh, T.A. (2021). Prospective correlation between the patient microbiome with response to and development of immune-mediated adverse effects to immunotherapy in lung cancer. BMC Cancer, 21.","DOI":"10.1186\/s12885-021-08530-z"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1038\/nrc.2017.78","article-title":"Exercise dependent regulation of the tumour microenvironment","volume":"17","author":"Koelwyn","year":"2017","journal-title":"Nat. Rev. Cancer"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"e457","DOI":"10.1016\/S1470-2045(17)30411-4","article-title":"Physical activity, sedentary behaviour, diet, and cancer: An update and emerging new evidence","volume":"18","author":"Kerr","year":"2017","journal-title":"Lancet Oncol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.cell.2014.10.029","article-title":"Integrative biology of exercise","volume":"159","author":"Hawley","year":"2014","journal-title":"Cell"},{"key":"ref_165","unstructured":"U.S. Department of Health, Education, and Welfare (1964). Smoking and Health: Report of the Advisory Committee to the Surgeon General of the Public Health Service, U.S. Department of Health, Education, and Welfare, Public Health Service, Center for Disease Control. PHS Publication No. 1103."},{"key":"ref_166","unstructured":"U.S. Department of Health and Human Services (2014). The Health Consequences of Smoking\u201450 Years of Progress: A Report of the Surgeon General, U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/ijc.23033","article-title":"Tobacco smoking and cancer: A meta-analysis","volume":"122","author":"Gandini","year":"2008","journal-title":"Int. J. Cancer"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.eururo.2015.06.042","article-title":"The Role of Tobacco Smoke in Bladder and Kidney Carcinogenesis: A Comparison of Exposures and Meta-analysis of Incidence and Mortality Risks","volume":"70","author":"Cumberbatch","year":"2016","journal-title":"Eur. Urol."},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"Alouini, S. (2024). Risk Factors Associated with Urothelial Bladder Cancer. Int. J. Environ. Res. Public Health, 21.","DOI":"10.3390\/ijerph21070954"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/j.eururo.2014.08.059","article-title":"A systematic review and meta-analysis of tobacco use and prostate cancer mortality and incidence in prospective cohort studies","volume":"66","author":"Islami","year":"2014","journal-title":"Eur. Urol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1093\/ije\/dyh386","article-title":"Socioeconomic differences in the prevalence of common chronic diseases: An overview of eight European countries","volume":"34","author":"Dalstra","year":"2005","journal-title":"Int. J. Epidemiol."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"e140","DOI":"10.1016\/S2468-2667(19)30248-8","article-title":"Association between socioeconomic status and the development of mental and physical health conditions in adulthood: A multi-cohort study","volume":"5","author":"Batty","year":"2020","journal-title":"Lancet Public Health"},{"key":"ref_173","unstructured":"Coleman-Jensen, A., Rabbit, M.P., Gregory, C.A., and Singh, A. (2019). Household Food Insecurity in the United States in 2019, U.S. Department of Agriculture Economic Research Service. ERR-275."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"e021901","DOI":"10.1161\/JAHA.121.021901","article-title":"Pathways by Which Food Insecurity Is Associated with Atherosclerotic Cardiovascular Disease Risk","volume":"10","author":"Palakshappa","year":"2021","journal-title":"J. Am. Heart Assoc."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"3243","DOI":"10.1016\/j.jacc.2019.04.042","article-title":"Stress-Associated Neurobiological Pathway Linking Socioeconomic Disparities to Cardiovascular Disease","volume":"73","author":"Tawakol","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"101208","DOI":"10.1016\/j.jacadv.2024.101208","article-title":"Anxiety and Depression Associated with Increased Cardiovascular Disease Risk Through Accelerated Development of Risk Factors","volume":"3","author":"Civieri","year":"2024","journal-title":"JACC Adv."},{"key":"ref_177","doi-asserted-by":"crossref","unstructured":"Rico-Uribe, L.A., Caballero, F.F., Mart\u00edn-Mar\u00eda, N., Cabello, M., Ayuso-Mateos, J.L., and Miret, M. (2018). Association of loneliness with all-cause mortality: A meta-analysis. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0190033"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1007\/s00127-020-01889-7","article-title":"Understanding loneliness in the twenty-first century: An update on correlates, risk factors, and potential solutions","volume":"55","author":"Lim","year":"2020","journal-title":"Soc. Psychiatry. Psychiatr. Epidemiol."},{"key":"ref_179","doi-asserted-by":"crossref","unstructured":"Vasan, S., Lim, M.H., Eikelis, N., and Lambert, E. (2024). Investigating the relationship between early cardiovascular disease markers and loneliness in young adults. Sci. Rep., 14.","DOI":"10.1038\/s41598-024-65039-8"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1038\/s41380-019-0595-x","article-title":"Depression and anxiety in relation to cancer incidence and mortality: A systematic review and meta-analysis of cohort studies","volume":"25","author":"Wang","year":"2020","journal-title":"Mol. Psychiatry"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1080\/07347332.2018.1521490","article-title":"Prevalence of psychosocial distress in cancer patients across 55 North American cancer centers","volume":"37","author":"Carlson","year":"2019","journal-title":"J. Psychosoc. Oncol."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/pon.4464","article-title":"One in two cancer patients is significantly distressed: Prevalence and indicators of distress","volume":"27","author":"Mehnert","year":"2018","journal-title":"Psychooncology"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1080\/07357900701506672","article-title":"Renaming \u201cchemobrain\u201d","volume":"25","author":"Hurria","year":"2007","journal-title":"Cancer Investig."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.amepre.2017.06.028","article-title":"Psychological well-being\u2019s link with cardiovascular health in older adults","volume":"53","author":"Boehm","year":"2017","journal-title":"Am. J. Prev. Med."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"106891","DOI":"10.1016\/j.ypmed.2021.106891","article-title":"A systematic review of the bidirectional relationship between depressive symptoms and cardiovascular health","volume":"154","author":"Ogunmoroti","year":"2022","journal-title":"Prev. Med."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1007\/s12265-020-09985-4","article-title":"Association of depression with subclinical coronary atherosclerosis: A systematic review","volume":"14","author":"Khan","year":"2021","journal-title":"J. Cardiovasc. Transl. Res."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1001\/jama.2022.11086","article-title":"Spirituality in Serious Illness and Health","volume":"328","author":"Balboni","year":"2022","journal-title":"JAMA"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"2965","DOI":"10.1093\/eurheartj\/ehab080","article-title":"Heart, mind, and soul: Spirituality in cardiovascular medicine","volume":"42","author":"Chinnaiyan","year":"2021","journal-title":"Eur. Heart J."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1037\/0003-066X.58.1.53","article-title":"Religiosity\/spirituality and health: A critical review of the evidence for biological pathways","volume":"58","author":"Seeman","year":"2003","journal-title":"Am. Psychol."},{"key":"ref_190","unstructured":"Adler, N.E., and Page, A.E.K. (2008). Cancer Care for the Whole Patient: Meeting Psychosocial Health Needs, National Academies Press."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.jamda.2023.01.009","article-title":"Socioeconomic and ethnic inequalities in the progress of multimorbidity and the role of health behaviors","volume":"24","author":"Mira","year":"2023","journal-title":"J. Am. Med. Dir. Assoc."},{"key":"ref_192","doi-asserted-by":"crossref","unstructured":"Luo, H., Zhang, Q., Yu, K., Meng, X., Kan, H., and Chen, R. (2022). Long-term exposure to ambient air pollution is a risk factor for trajectory of cardiometabolic multimorbidity: A prospective study in the UK Biobank. EBioMedicine, 84.","DOI":"10.1016\/j.ebiom.2022.104282"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"110013","DOI":"10.1016\/j.envres.2020.110013","article-title":"Impact of road traffic noise on obesity measures: Observational study of three European cohorts","volume":"191","author":"Cai","year":"2020","journal-title":"Environ. Res."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"122277","DOI":"10.1016\/j.envpol.2023.122277","article-title":"Aircraft and road traffic noise, insulin resistance, and diabetes: The role of neighborhood socioeconomic status in San Diego County","volume":"335","author":"Letellier","year":"2023","journal-title":"Environ. Pollut."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1515\/reveh-2022-0021","article-title":"Noise exposure and the risk of cancer: A comprehensive systematic review","volume":"38","author":"Abbasi","year":"2022","journal-title":"Rev. Environ. Health"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.numecd.2013.05.002","article-title":"Managing the residual cardiovascular disease risk associated with LDL-cholesterol and triglycerides in statin-treated patients: A clinical update","volume":"23","author":"Reiner","year":"2013","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_197","doi-asserted-by":"crossref","unstructured":"Scandinavian Simvastatin Survival Study Group (1994). Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: The Scandinavian Simvastatin Survival Study (4S). Lancet, 344, 1383\u20131389.","DOI":"10.1016\/S0140-6736(94)90566-5"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/S0140-6736(05)67394-1","article-title":"Cholesterol Treatment Trialists\u2019 (CTT) Collaborators. Efficacy and safety of cholesterol-lowering treatment: Prospective meta-analysis of data from 90, 056 participants in 14 randomised trials of statins","volume":"366","author":"Baigent","year":"2005","journal-title":"Lancet"},{"key":"ref_199","doi-asserted-by":"crossref","unstructured":"Cholesterol Treatment Trialists Collaboration, Baigent, C., Blackwell, L., Emberson, J., Holland, L.E., Reith, C., Bhala, N., Peto, R., Barnes, E.H., and Keech, A. (2010). Efficacy and safety of more intensive lowering of LDL cholesterol: A metaanalysis of data from 170,000 participants in 26 randomised trials. Lancet, 376, 1670\u20131681.","DOI":"10.1016\/S0140-6736(10)61350-5"},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1161\/CIRCULATIONAHA.115.019014","article-title":"Long-term safety and efficacy of lowering low-density lipoprotein cholesterol with statin therapy: 20-year follow-up of West of Scotland Coronary Prevention Study","volume":"133","author":"Ford","year":"2016","journal-title":"Circulation"},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1186\/s13046-021-02041-2","article-title":"Statins: A repurposed drug to fight cancer","volume":"40","author":"Jiang","year":"2021","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_202","doi-asserted-by":"crossref","unstructured":"Buccioli, G., Testa, C., Jacchetti, E., Pinoli, P., Carelli, S., Ceri, S., and Raimondi, M.T. (2024). The molecular basis of the anticancer effect of statins. Sci. Rep., 14.","DOI":"10.1038\/s41598-024-71240-6"},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"e005940","DOI":"10.1136\/jitc-2022-005940","article-title":"Statin drugs enhance responses to immune checkpoint blockade in head and neck cancer models","volume":"11","author":"Kansal","year":"2023","journal-title":"J. Immunother. Cancer"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"e005611","DOI":"10.1136\/jitc-2022-005611","article-title":"Statins and immune checkpoint inhibitors: A strategy to improve the efficacy of immunotherapy for cancer?","volume":"10","author":"Vos","year":"2022","journal-title":"J. ImmunoTher. Cancer"},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"e002474","DOI":"10.1136\/jitc-2021-002474","article-title":"Statin-mediated inhibition of RAS prenylation activates ER stress to enhance the immunogenicity of KRAS mutant cancer","volume":"9","author":"Nam","year":"2021","journal-title":"J. Immunother. Cancer"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"3415","DOI":"10.1093\/eurheartj\/ehae177","article-title":"2024 ESC Guidelines for the management of chronic coronary syndromes","volume":"45","author":"Vrints","year":"2024","journal-title":"Eur. Heart J."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1007\/s11883-018-0718-x","article-title":"Pleiotropic Anti-atherosclerotic Effects of PCSK9 Inhibitors from Molecular Biology to Clinical Translation","volume":"20","author":"Karagiannis","year":"2018","journal-title":"Curr. Atheroscler. Rep."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"3957","DOI":"10.1038\/s41467-018-06467-9","article-title":"A Mendelian randomization study of the effects of blood lipids on breast cancer risk","volume":"9","author":"Nowak","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_209","doi-asserted-by":"crossref","unstructured":"Wang, R., Liu, H., He, P., An, D., Guo, X., Zhang, X., and Feng, M. (2022). Inhibition of PCSK9 enhances the antitumor effect of PD-1 inhibitor in colorectal cancer by promoting the infiltration of CD8+ T cells and the exclusion of Treg cells. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.947756"},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.2337\/dc20-0204","article-title":"Association of Type 2 Diabetes with Cancer: A Meta-analysis with Bias Analysis for Unmeasured Confounding in 151 Cohorts Comprising 32 Million People","volume":"43","author":"Ling","year":"2020","journal-title":"Diabetes Care"},{"key":"ref_211","doi-asserted-by":"crossref","unstructured":"Galal, M.A., Al-Rimawi, M., Hajeer, A., Dahman, H., Alouch, S., and Aljada, A. (2024). Metformin: A Dual-Role Player in Cancer Treatment and Prevention. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25074083"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"LBA5002","DOI":"10.1200\/JCO.2024.42.17_suppl.LBA5002","article-title":"A randomized, double-blind, placebo-controlled trial of metformin in reducing progression among men on expectant management for low-risk prostate cancer: The MAST (Metformin Active Surveillance Trial) study","volume":"42","author":"Fleshner","year":"2024","journal-title":"J. Clin. Oncol."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"S1258","DOI":"10.1016\/j.annonc.2024.08.2313","article-title":"LBA70\u2014Adding metformin to androgen deprivation therapy (ADT) for patients (pts) with metastatic hormone sensitive prostate cancer (mHSPC): Overall survival (OS) results from the multi-arm, multi-stage randomized platform trial STAMPEDE","volume":"35","author":"Gillessen","year":"2024","journal-title":"Ann. Oncol."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1001\/jama.2022.6147","article-title":"Effect of Metformin vs. Placebo on Invasive Disease-Free Survival in Patients with Breast Cancer: The MA.32 Randomized Clinical Trial","volume":"327","author":"Goodwin","year":"2022","journal-title":"JAMA"},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"e005632","DOI":"10.1136\/jitc-2022-005632","article-title":"Metformin increases natural killer cell functions in head and neck squamous cell carcinoma through CXCL1 inhibition","volume":"10","author":"Crist","year":"2022","journal-title":"J. Immunother. Cancer"},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"4921","DOI":"10.1158\/1078-0432.CCR-20-0113","article-title":"Low-Dose Metformin Reprograms the Tumor Immune Microenvironment in Human Esophageal Cancer: Results of a Phase II Clinical Trial","volume":"26","author":"Wang","year":"2020","journal-title":"Clin. Cancer Res."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.molcel.2018.07.030","article-title":"Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1","volume":"71","author":"Cha","year":"2018","journal-title":"Mol. Cell"},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"5106","DOI":"10.1038\/s41467-021-25416-7","article-title":"PD-L1 degradation is regulated by electrostatic membrane association of its cytoplasmic domain","volume":"12","author":"Wen","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"110528","DOI":"10.1016\/j.intimp.2023.110528","article-title":"Metformin as a booster of cancer immunotherapy","volume":"121","author":"Panaampon","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"112243","DOI":"10.1016\/j.intimp.2024.112243","article-title":"Clinical evidence for the prognostic impact of metformin in cancer patients treated with immune checkpoint inhibitors","volume":"134","author":"Shen","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1053\/j.gastro.2007.03.054","article-title":"Biology of incretins: GLP-1 and GIP","volume":"132","author":"Baggio","year":"2007","journal-title":"Gastroenterology"},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/s41574-022-00783-3","article-title":"Beyond the pancreas: Contrasting cardiometabolic actions of GIP and GLP1","volume":"19","author":"Hammoud","year":"2023","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cmet.2016.06.009","article-title":"The cardiovascular biology of glucagon-like peptide-1","volume":"24","author":"Drucker","year":"2016","journal-title":"Cell Metab."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1111\/dom.14399","article-title":"Glucagon-like peptide-1 receptor agonists improve biomarkers of inflammation and oxidative stress: A systematic review and meta-analysis of randomised controlled trials","volume":"23","author":"Bray","year":"2021","journal-title":"Diabetes Obes. Metab."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1056\/NEJMoa1411892","article-title":"A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management","volume":"373","author":"Astrup","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1056\/NEJMoa2032183","article-title":"Once-Weekly Semaglutide in Adults with Overweight or Obesity","volume":"384","author":"Wilding","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/S0140-6736(21)00213-0","article-title":"Semaglutide 2\u00b74 mg once a week in adults with overweight or obesity, and type 2 diabetes (STEP 2): A randomised, double-blind, double-dummy, placebo-controlled, phase 3 trial","volume":"397","author":"Davies","year":"2021","journal-title":"Lancet"},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1001\/jama.2021.3224","article-title":"Effect of Continued Weekly Subcutaneous Semaglutide vs. Placebo on Weight Loss Maintenance in Adults with Overweight or Obesity: The STEP 4 Randomized Clinical Trial","volume":"325","author":"Rubino","year":"2021","journal-title":"JAMA"},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"10732748241241158","DOI":"10.1177\/10732748241241158","article-title":"Next Generation Weight Loss Drugs for the Prevention of Cancer?","volume":"31","author":"Carbonell","year":"2024","journal-title":"Cancer Control"},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"e2421305","DOI":"10.1001\/jamanetworkopen.2024.21305","article-title":"Glucagon-Like Peptide 1 Receptor Agonists and 13 Obesity-Associated Cancers in Patients with Type 2 Diabetes","volume":"7","author":"Wang","year":"2024","journal-title":"JAMA Netw. Open"},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1002\/2211-5463.13499","article-title":"Liraglutide enhances the effect of checkpoint blockade through the inhibition of neutrophil extracellular traps in murine lung and liver cancers","volume":"14","author":"Chen","year":"2024","journal-title":"FEBS Open Bio"},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"736","DOI":"10.2967\/jnumed.106.038679","article-title":"GLP-1 receptor expression in human tumors and human normal tissues: Potential for in vivo targeting","volume":"48","author":"Korner","year":"2007","journal-title":"J. Nucl. Med."},{"key":"ref_233","unstructured":"Nordisk, N. (2024, April 19). Ozempic (Semaglutide) Injection, for Subcutaneous Use, Available online: https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2022\/209637s009lbl.pdf."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"384","DOI":"10.2337\/dc22-1148","article-title":"GLP-1 Receptor Agonists and the Risk of Thyroid Cancer","volume":"46","author":"Bezin","year":"2023","journal-title":"Diabetes Care"},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1111\/dom.15382","article-title":"Glucagon-like peptide-1 receptor agonists and risk of thyroid cancer: A systematic review and meta-analysis of randomized controlled trials","volume":"26","author":"Silverii","year":"2024","journal-title":"Diabetes Obes. Metab."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"4043","DOI":"10.1093\/eurheartj\/ehad192","article-title":"2023 ESC Guidelines for the management of cardiovascular disease in patients with diabetes","volume":"44","author":"Marx","year":"2023","journal-title":"Eur. Heart J."},{"key":"ref_237","doi-asserted-by":"crossref","unstructured":"Dutka, M., Bobi\u0144ski, R., Francuz, T., Garczorz, W., Zimmer, K., Ilczak, T., \u0106wiertnia, M., and Hajduga, M.B. (2022). SGLT-2 Inhibitors in Cancer Treatment-Mechanisms of Action and Emerging New Perspectives. Cancers, 14.","DOI":"10.3390\/cancers14235811"},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1186\/s12933-021-01346-y","article-title":"The SGLT-2 inhibitor empagliflozin improves myocardial strain, reduces cardiac fibrosis and pro-inflammatory cytokines in non-diabetic mice treated with doxorubicin","volume":"20","author":"Quagliariello","year":"2021","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_239","doi-asserted-by":"crossref","unstructured":"Quagliariello, V., Canale, M.L., Bisceglia, I., Iovine, M., Paccone, A., Maurea, C., Scherillo, M., Merola, A., Giordano, V., and Palma, G. (2024). Sodium-glucose cotransporter 2 inhibitor dapagliflozin prevents ejection fraction reduction, reduces myocardial and renal NF-\u03baB expression and systemic pro-inflammatory biomarkers in models of short-term doxorubicin cardiotoxicity. Front. Cardiovasc. Med., 11.","DOI":"10.3389\/fcvm.2024.1289663"},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"107300","DOI":"10.1016\/j.vph.2024.107300","article-title":"Empagliflozin restores autophagy and attenuates ponatinib-induced cardiomyocyte senescence and death","volume":"155","author":"Biondi","year":"2024","journal-title":"Vasc. Pharmacol."},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.jchf.2022.03.006","article-title":"Sodium-Glucose Co-Transporter-2 Inhibitors and Cardiac Outcomes among Patients Treated with Anthracyclines","volume":"10","author":"Gongora","year":"2022","journal-title":"JACC Heart Fail."},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jchf.2023.08.026","article-title":"SGLT2 Inhibitor Use and Risk of Clinical Events in Patients with Cancer Therapy-Related Cardiac Dysfunction","volume":"12","author":"Avula","year":"2024","journal-title":"JACC Heart Fail."},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1056\/NEJMoa1707914","article-title":"Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease","volume":"377","author":"Ridker","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.jacc.2012.10.027","article-title":"Low-dose colchicine for secondary prevention of cardiovascular disease","volume":"61","author":"Nidorf","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1056\/NEJMoa1912388","article-title":"Efficacy and Safety of Low-Dose Colchicine after Myocardial Infarction","volume":"381","author":"Tardif","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1056\/NEJMoa2021372","article-title":"Colchicine in Patients with Chronic Coronary Disease","volume":"383","author":"Nidorf","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1016\/S0140-6736(17)32247-X","article-title":"Effect of interleukin-1\u03b2 inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: Exploratory results from a randomised, double-blind, placebo-controlled trial","volume":"390","author":"Ridker","year":"2017","journal-title":"Lancet"},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1200\/JCO.23.00910","article-title":"Canakinumab as Adjuvant Therapy in Patients with Completely Resected Non-Small-Cell Lung Cancer: Results from the CANOPY-A Double-Blind, Randomized Clinical Trial","volume":"42","author":"Garon","year":"2024","journal-title":"J. Clin. Oncol."},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"107451","DOI":"10.1016\/j.lungcan.2023.107451","article-title":"Canakinumab in combination with docetaxel compared with docetaxel alone for the treatment of advanced non-small cell lung cancer following platinum-based doublet chemotherapy and immunotherapy (CANOPY-2): A multicenter, randomized, double-blind, phase 3 trial","volume":"189","author":"Goto","year":"2024","journal-title":"Lung Cancer"},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1200\/JCO.23.00980","article-title":"Canakinumab versus Placebo in Combination with First-Line Pembrolizumab Plus Chemotherapy for Advanced Non-Small-Cell Lung Cancer: Results from the CANOPY-1 Trial","volume":"42","author":"Tan","year":"2024","journal-title":"J. Clin. Oncol."},{"key":"ref_251","doi-asserted-by":"crossref","unstructured":"Bent, R., Moll, L., Grabbe, S., and Bros, M. (2018). Interleukin-1 beta-A friend or foe in malignancies?. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19082155"},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1158\/1078-0432.CCR-05-1603","article-title":"The role of interleukin 1 in growth and metastasis of human cancer xenografts","volume":"12","author":"Elaraj","year":"2006","journal-title":"Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res."},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"e00586-18","DOI":"10.1128\/MCB.00586-18","article-title":"Uncoupling the Senescence-Associated Secretory Phenotype from Cell Cycle Exit via Interleukin-1 Inactivation Unveils Its Protumorigenic Role","volume":"39","author":"Lau","year":"2019","journal-title":"Mol. Cell. Biol."},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"3179","DOI":"10.1158\/0008-5472.CAN-15-2658","article-title":"Membrane IL1\u03b1 Inhibits the Development of Hepatocellular Carcinoma via Promoting T- and NK-cell Activation","volume":"76","author":"Lin","year":"2016","journal-title":"Cancer Res."},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"2352","DOI":"10.1002\/ijc.29297","article-title":"Elevated chronic inflammatory factors and myeloid-derived suppressor cells indicate poor prognosis in advanced melanoma patients","volume":"136","author":"Jiang","year":"2015","journal-title":"Int. J. Cancer"},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1016\/S0140-6736(21)00520-1","article-title":"IL-6 inhibition with ziltivekimab in patients at high atherosclerotic risk (RESCUE): A double-blind, randomised, placebo-controlled, phase 2 trial","volume":"397","author":"Ridker","year":"2021","journal-title":"Lancet"},{"key":"ref_257","doi-asserted-by":"crossref","unstructured":"Ra\u0161kov\u00e1, M., Lacina, L., Kej\u00edk, Z., Venhauerov\u00e1, A., Skali\u010dkov\u00e1, M., Kol\u00e1\u0159, M., Jakubek, M., Rosel, D., Smetana, K., and Br\u00e1bek, J. (2022). The Role of IL-6 in Cancer Cell Invasiveness and Metastasis-Overview and Therapeutic Opportunities. Cells, 11.","DOI":"10.3390\/cells11223698"},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"155976","DOI":"10.1016\/j.cyto.2022.155976","article-title":"Blockade of IL-6 inhibits tumor immune evasion and improves anti-PD-1 immunotherapy","volume":"158","author":"Li","year":"2022","journal-title":"Cytokine"},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1158\/2326-6066.CIR-18-0766","article-title":"IL6 Modulates the Immune Status of the Tumor Microenvironment to Facilitate Metastatic Colonization of Colorectal Cancer Cells","volume":"7","author":"Toyoshima","year":"2019","journal-title":"Cancer Immunol. Res."},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"7355","DOI":"10.2147\/CMAR.S303707","article-title":"Obesity Promotes Tumor Immune Evasion in Ovarian Cancer through Increased Production of Myeloid-Derived Suppressor Cells via IL-6","volume":"13","author":"Yang","year":"2021","journal-title":"Cancer Manag. Res."},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"e007530","DOI":"10.1136\/jitc-2023-007530","article-title":"New perspectives in cancer immunotherapy: Targeting IL-6 cytokine family","volume":"11","author":"Soler","year":"2023","journal-title":"J. Immunother. Cancer"},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.ccell.2022.04.004","article-title":"Interleukin-6 blockade abrogates immunotherapy toxicity and promotes tumor immunity","volume":"40","author":"Hailemichael","year":"2022","journal-title":"Cancer Cell"},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"2924","DOI":"10.1161\/STROKEAHA.114.005991","article-title":"Association of interleukin-6 with the progression of carotid atherosclerosis: A 9-year follow-up study","volume":"45","author":"Okazaki","year":"2014","journal-title":"Stroke"},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1161\/ATVBAHA.124.319980","article-title":"Novel Therapeutics and Upcoming Clinical Trials Targeting Inflammation in Cardiovascular Diseases","volume":"44","author":"Potere","year":"2024","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.atherosclerosis.2017.12.027","article-title":"The NLRP3 inflammasome and the emerging role of colchicine to inhibit atherosclerosis-associated inflammation","volume":"269","author":"Celermajer","year":"2018","journal-title":"Atherosclerosis"},{"key":"ref_266","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.semarthrit.2015.06.013","article-title":"Colchicine\u2014Update on mechanisms of action and therapeutic uses","volume":"45","author":"Leung","year":"2015","journal-title":"Semin. Arthritis Rheum."},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1093\/eurheartj\/ehae208","article-title":"Low-dose colchicine for atherosclerosis: Long-term safety","volume":"45","author":"Nidorf","year":"2024","journal-title":"Eur. Heart J."},{"key":"ref_268","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.jacc.2023.05.055","article-title":"Low-Dose Colchicine for Secondary Prevention of Coronary Artery Disease: JACC Review Topic of the Week","volume":"82","author":"Nelson","year":"2023","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_269","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/art.40344","article-title":"Familial Mediterranean Fever and Incidence of Cancer: An Analysis of 8,534 Israeli Patients with 258,803 Person-Years","volume":"70","author":"Brenner","year":"2018","journal-title":"Arthritis Rheumatol."},{"key":"ref_270","doi-asserted-by":"crossref","first-page":"385","DOI":"10.3109\/03009742.2013.878387","article-title":"Gout patients have an increased risk of developing most cancers, especially urological cancers","volume":"43","author":"Chen","year":"2014","journal-title":"Scand. J. Rheumatol."},{"key":"ref_271","doi-asserted-by":"crossref","first-page":"e1570","DOI":"10.1097\/MD.0000000000001570","article-title":"Colchicine Significantly Reduces Incident Cancer in Gout Male Patients: A 12-Year Cohort Study","volume":"94","author":"Kuo","year":"2015","journal-title":"Medicine"},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"e033700","DOI":"10.1161\/JAHA.123.033700","article-title":"Low-Dose Colchicine Ameliorates Doxorubicin Cardiotoxicity via Promoting Autolysosome Degradation","volume":"13","author":"Peng","year":"2024","journal-title":"J. Am. Heart Assoc."},{"key":"ref_273","doi-asserted-by":"crossref","first-page":"4601","DOI":"10.1093\/eurheartj\/ehae546","article-title":"Colchicine prevents accelerated atherosclerosis in TET2-mutant clonal haematopoiesis","volume":"45","author":"Zuriaga","year":"2024","journal-title":"Eur. Heart J."},{"key":"ref_274","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1038\/s41569-024-01016-y","article-title":"Canonical and non-canonical roles of complement in atherosclerosis","volume":"21","author":"Maffia","year":"2024","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_275","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/s41569-024-01075-1","article-title":"Atheroimmunology: Keeping the immune system in atherosclerosis in check","volume":"21","author":"Monaco","year":"2024","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_276","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1136\/bmj.320.7237.768","article-title":"Human error: Models and management","volume":"320","author":"Reason","year":"2000","journal-title":"BMJ"},{"key":"ref_277","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1161\/CIRCULATIONAHA.124.065473","article-title":"Cardio-Oncology: A New Clinical Frontier and Novel Platform for Cardiovascular Investigation","volume":"150","author":"Moslehi","year":"2024","journal-title":"Circulation"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/1\/334\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T15:23:40Z","timestamp":1759850620000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/1\/334"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,2]]},"references-count":277,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1]]}},"alternative-id":["ijms26010334"],"URL":"https:\/\/doi.org\/10.3390\/ijms26010334","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,2]]}}}