{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:29:33Z","timestamp":1777390173063,"version":"3.51.4"},"reference-count":41,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T00:00:00Z","timestamp":1735776000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32160165"],"award-info":[{"award-number":["32160165"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["XZ202201ZR0065G"],"award-info":[{"award-number":["XZ202201ZR0065G"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["24MDQ06"],"award-info":[{"award-number":["24MDQ06"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["Y2024004"],"award-info":[{"award-number":["Y2024004"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["Y2024012"],"award-info":[{"award-number":["Y2024012"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018543","name":"Natural Science Foundation of Tibet Autonomous Region","doi-asserted-by":"publisher","award":["32160165"],"award-info":[{"award-number":["32160165"]}],"id":[{"id":"10.13039\/501100018543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018543","name":"Natural Science Foundation of Tibet Autonomous Region","doi-asserted-by":"publisher","award":["XZ202201ZR0065G"],"award-info":[{"award-number":["XZ202201ZR0065G"]}],"id":[{"id":"10.13039\/501100018543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018543","name":"Natural Science Foundation of Tibet Autonomous Region","doi-asserted-by":"publisher","award":["24MDQ06"],"award-info":[{"award-number":["24MDQ06"]}],"id":[{"id":"10.13039\/501100018543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018543","name":"Natural Science Foundation of Tibet Autonomous Region","doi-asserted-by":"publisher","award":["Y2024004"],"award-info":[{"award-number":["Y2024004"]}],"id":[{"id":"10.13039\/501100018543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018543","name":"Natural Science Foundation of Tibet Autonomous Region","doi-asserted-by":"publisher","award":["Y2024012"],"award-info":[{"award-number":["Y2024012"]}],"id":[{"id":"10.13039\/501100018543","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Youth project of Xizang Minzu University","award":["32160165"],"award-info":[{"award-number":["32160165"]}]},{"name":"Youth project of Xizang Minzu University","award":["XZ202201ZR0065G"],"award-info":[{"award-number":["XZ202201ZR0065G"]}]},{"name":"Youth project of Xizang Minzu University","award":["24MDQ06"],"award-info":[{"award-number":["24MDQ06"]}]},{"name":"Youth project of Xizang Minzu University","award":["Y2024004"],"award-info":[{"award-number":["Y2024004"]}]},{"name":"Youth project of Xizang Minzu University","award":["Y2024012"],"award-info":[{"award-number":["Y2024012"]}]},{"name":"Graduate Research Innovation and Practice Project of Xizang Minzu University","award":["32160165"],"award-info":[{"award-number":["32160165"]}]},{"name":"Graduate Research Innovation and Practice Project of Xizang Minzu University","award":["XZ202201ZR0065G"],"award-info":[{"award-number":["XZ202201ZR0065G"]}]},{"name":"Graduate Research Innovation and Practice Project of Xizang Minzu University","award":["24MDQ06"],"award-info":[{"award-number":["24MDQ06"]}]},{"name":"Graduate Research Innovation and Practice Project of Xizang Minzu University","award":["Y2024004"],"award-info":[{"award-number":["Y2024004"]}]},{"name":"Graduate Research Innovation and Practice Project of Xizang Minzu University","award":["Y2024012"],"award-info":[{"award-number":["Y2024012"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The Qinghai\u2013Tibet Plateau, famously known as the \u201cRoof of the World\u201d, has witnessed a surge in individuals traveling or working there. However, a considerable percentage of these individuals may suffer from acute mountain sickness (AMS), with high-altitude pulmonary edema (HAPE) being a severe and potentially life-threatening manifestation. HAPE disrupts the balance of intrapulmonary tissue fluid, resulting in severe lung function impairment. Current therapeutic interventions for HAPE have limitations and are accompanied by significant side effects. Aldose reductase (AR), a crucial enzyme in the polyol metabolic pathway, has been implicated in various diseases. In this study, we sought to explore the role of AR in HAPE. Utilizing both in vivo and in vitro models, we investigated the impact of AR on hypoxia-induced pulmonary edema, vascular pressure, inflammatory factors, and oxidative stress. Our findings revealed that AR knockdown mitigated hypoxia-induced pulmonary edema, decreased the expression of vascular pressure and inflammatory factors, and enhanced the expression related to oxidative stress. These results indicate that AR may serve as a potential therapeutic target for HAPE, offering a plausible pathological basis and novel drug targets for the prevention and treatment of this condition.<\/jats:p>","DOI":"10.3390\/ijms26010341","type":"journal-article","created":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T07:44:53Z","timestamp":1735803893000},"page":"341","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Aldose Reductase: A Promising Therapeutic Target for High-Altitude Pulmonary Edema"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7494-8078","authenticated-orcid":false,"given":"Dan","family":"Song","sequence":"first","affiliation":[{"name":"Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang 712082, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengjie","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang 712082, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinjie","family":"Zhao","sequence":"additional","affiliation":[{"name":"Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang 712082, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanru","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang 712082, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiyi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang 712082, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohua","family":"Hao","sequence":"additional","affiliation":[{"name":"Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang 712082, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jialu","family":"Yuan","sequence":"additional","affiliation":[{"name":"Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang 712082, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haojie","family":"Tang","sequence":"additional","affiliation":[{"name":"Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang 712082, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.rmed.2018.11.004","article-title":"Research advances in pathogenesis and prophylactic measures of acute high altitude illness","volume":"145","author":"Li","year":"2018","journal-title":"Respir. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1093\/emph\/eoaa052","article-title":"High-altitude pulmonary edema","volume":"9","author":"Woods","year":"2021","journal-title":"Evol. Med. Public Health"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"L155","DOI":"10.1152\/ajplung.00292.2022","article-title":"High-altitude pulmonary edema: The intercellular network hypothesis","volume":"325","author":"Richalet","year":"2023","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/s41572-024-00526-w","article-title":"Altitude illnesses","volume":"10","author":"Gatterer","year":"2024","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Bian, S.Z., Zhang, C., Rao, R.S., Ding, X.H., and Huang, L. (2022). Systemic Blood Predictors of Elevated Pulmonary Artery Pressure Assessed by Non-invasive Echocardiography After Acute Exposure to High Altitude: A Prospective Cohort Study. Front. Cardiovasc. Med., 9.","DOI":"10.3389\/fcvm.2022.866093"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.resp.2011.09.011","article-title":"Pulmonary arterial systolic pressure and susceptibility to high altitude pulmonary edema","volume":"179","author":"Mounier","year":"2011","journal-title":"Respir. Physiol. Neurobiol."},{"key":"ref_7","first-page":"718739","article-title":"Rhodiola crenulata Extract Alleviates Hypoxic Pulmonary Edema in Rats","volume":"2013","author":"Lee","year":"2013","journal-title":"Evid. Based Complement. Alternat Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/s12974-015-0326-4","article-title":"Curcumin prophylaxis mitigates the incidence of hypobaric hypoxia-induced altered ion channels expression and impaired tight junction proteins integrity in rat brain","volume":"12","author":"Sarada","year":"2015","journal-title":"J. Neuroinflamm."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"7776","DOI":"10.3390\/ijms13067776","article-title":"Polydatin attenuates hypoxic pulmonary hypertension and reverses remodeling through protein kinase C mechanisms","volume":"13","author":"Miao","year":"2012","journal-title":"Int. J. Mol. Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.intimp.2016.09.010","article-title":"Protective effects of puerarin on acute lung and cerebrum injury induced by hypobaric hypoxia via the regulation of aquaporin (AQP) via NF-kappaB signaling pathway","volume":"40","author":"Wang","year":"2016","journal-title":"Int. Immunopharmacol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.freeradbiomed.2016.04.020","article-title":"Size restricted silymarin suspension evokes integrated adaptive response against acute hypoxia exposure in rat lung","volume":"96","author":"Paul","year":"2016","journal-title":"Free Radic. Biol. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.abb.2007.04.024","article-title":"Human aldo-keto reductases: Function, gene regulation, and single nucleotide polymorphisms","volume":"464","author":"Penning","year":"2007","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1007\/s12272-021-01343-5","article-title":"Aldose Reductase: A cause and a potential target for the treatment of diabetic complications","volume":"44","author":"Thakur","year":"2021","journal-title":"Arch. Pharm. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1097\/SHK.0b013e318160f03b","article-title":"Endotoxin causes pulmonary hypertension by upregulating smooth muscle endothelin type-B receptors: Role of aldose reductase","volume":"30","author":"Dschietzig","year":"2008","journal-title":"Shock"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s00011-018-1129-8","article-title":"Vascular endothelium dysfunction: A conservative target in metabolic disorders","volume":"67","author":"Jamwal","year":"2018","journal-title":"Inflamm. Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"751","DOI":"10.3892\/ijmm.2020.4812","article-title":"Tat-aldose reductase prevents dopaminergic neuronal cell death by inhibiting oxidative stress and MAPK activation","volume":"47","author":"Cho","year":"2021","journal-title":"Int. J. Mol. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.cbi.2011.02.023","article-title":"Aldose reductase inhibition suppresses oxidative stress-induced inflammatory disorders","volume":"191","author":"Srivastava","year":"2011","journal-title":"Chem. Biol. Interact."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"24089","DOI":"10.1074\/jbc.M111.219733","article-title":"Aldose reductase inhibition prevents hypoxia-induced increase in hypoxia-inducible factor-1alpha (HIF-1alpha) and vascular endothelial growth factor (VEGF) by regulating 26 S proteasome-mediated protein degradation in human colon cancer cells","volume":"286","author":"Tammali","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1093\/nar\/gkq818","article-title":"Tonicity-responsive microRNAs contribute to the maximal induction of osmoregulatory transcription factor OREBP in response to high-NaCl hypertonicity","volume":"39","author":"Huang","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"15593258241282574","DOI":"10.1177\/15593258241282574","article-title":"The Anti-Hypoxic Mechanism of Sesamoside Determined Using Network Pharmacology","volume":"22","author":"Song","year":"2024","journal-title":"Dose Response"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1111\/jre.13180","article-title":"Hypoxia dissociates HDAC6\/FOXO1 complex and aggregates them into nucleus to regulate autophagy and osteogenic differentiation","volume":"58","author":"Xu","year":"2023","journal-title":"J. Periodontal Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"148646","DOI":"10.1016\/j.scitotenv.2021.148646","article-title":"Acute hypoxia effects on Keap1\/Nrf2 (Mafs)-GST pathway related oxidative metabolism in muscle of Japanese flounder (Paralichthys olivaceus)","volume":"795","author":"Liu","year":"2021","journal-title":"Sci. Total Environ."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jare.2021.06.023","article-title":"Activation of Nrf2\/HO-1 signaling: An important molecular mechanism of herbal medicine in the treatment of atherosclerosis via the protection of vascular endothelial cells from oxidative stress","volume":"34","author":"Zhang","year":"2021","journal-title":"J. Adv. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.1074\/jbc.M703490200","article-title":"Activator protein-1 contributes to high NaCl-induced increase in tonicity-responsive enhancer\/osmotic response element-binding protein transactivating activity","volume":"283","author":"Irarrazabal","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Han, Y., Yuan, H., Li, F., Yuan, Y., Zheng, X., Zhang, X., and Sun, J. (2023). Ammidin ameliorates myocardial hypoxia\/reoxygenation injury by inhibiting the ACSL4\/AMPK\/mTOR-mediated ferroptosis pathway. BMC Complement. Med. Ther., 23.","DOI":"10.1186\/s12906-023-04289-x"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Najafi, A., Keykhaee, M., Khorramdelazad, H., Karimi, M.Y., Nejatbakhsh Samimi, L., Aghamohamadi, N., Karimi, M., Falak, R., and Khoobi, M. (2022). Catalase application in cancer therapy: Simultaneous focusing on hypoxia attenuation and macrophage reprogramming. Biomed. Pharmacother., 153.","DOI":"10.1016\/j.biopha.2022.113483"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.freeradbiomed.2018.01.019","article-title":"Mitochondrial rescue prevents glutathione peroxidase-dependent ferroptosis","volume":"117","author":"Jelinek","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1007\/s12640-017-9738-5","article-title":"Methylglyoxal-Induced Protection Response and Toxicity: Role of Glutathione Reductase and Thioredoxin Systems","volume":"32","author":"Schmitz","year":"2017","journal-title":"Neurotox. Res."},{"key":"ref_29","first-page":"441","article-title":"Acute mountain sickness: The clinical characteristics of a cohort of 615 patients","volume":"115","year":"2000","journal-title":"Med. Clin."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1164\/rccm.200308-1200OC","article-title":"Hypoxia causes glucose intolerance in humans","volume":"169","author":"Oltmanns","year":"2004","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_31","first-page":"53","article-title":"Association between physiological responses after exercise at low altitude and acute mountain sickness upon ascent is sex-dependent","volume":"7","author":"Shen","year":"2020","journal-title":"Mil. Med. Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1515\/reveh-2021-0172","article-title":"High Altitude Pulmonary Edema, High Altitude Cerebral Edema, and Acute Mountain Sickness: An enhanced opinion from the High Andes\u2014La Paz, Bolivia 3500 m","volume":"38","year":"2023","journal-title":"Rev. Environ. Health"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Sydykov, A., Mamazhakypov, A., Maripov, A., Kosanovic, D., Weissmann, N., Ghofrani, H.A., Sarybaev, A.S., and Schermuly, R.T. (2021). Pulmonary Hypertension in Acute and Chronic High Altitude Maladaptation Disorders. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph18041692"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"El Alam, S., Pena, E., Aguilera, D., Siques, P., and Brito, J. (2022). Inflammation in Pulmonary Hypertension and Edema Induced by Hypobaric Hypoxia Exposure. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232012656"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Rai, N., Shihan, M., Seeger, W., Schermuly, R.T., and Novoyatleva, T. (2021). Genetic Delivery and Gene Therapy in Pulmonary Hypertension. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22031179"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.pcad.2010.02.004","article-title":"New insights in the pathogenesis of high-altitude pulmonary edema","volume":"52","author":"Scherrer","year":"2010","journal-title":"Prog. Cardiovasc. Dis."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.rmed.2006.06.014","article-title":"Change in plasma vascular endothelial growth factor during onset and recovery from acute mountain sickness","volume":"101","author":"Dorward","year":"2007","journal-title":"Respir. Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1006\/cyto.1999.0533","article-title":"High altitude increases circulating interleukin-6, interleukin-1 receptor antagonist and C-reactive protein","volume":"12","author":"Hartmann","year":"2000","journal-title":"Cytokine"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/0014-4835(90)90102-Z","article-title":"The contributions of Jin H. Kinoshita to aldose reductase research","volume":"50","author":"Kador","year":"1990","journal-title":"Exp. Eye Res."},{"key":"ref_40","first-page":"PL53","article-title":"Restoration of nitric oxide production by aldose reductase inhibitor in human endothelial cells cultured in high-glucose medium","volume":"60","author":"Okuda","year":"1997","journal-title":"Life Sci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"S49","DOI":"10.1038\/sj.ki.5002386","article-title":"The role of protein kinase C activation in diabetic nephropathy","volume":"72","author":"Noh","year":"2007","journal-title":"Kidney Int. Suppl."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/1\/341\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T15:23:49Z","timestamp":1759850629000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/1\/341"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,2]]},"references-count":41,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1]]}},"alternative-id":["ijms26010341"],"URL":"https:\/\/doi.org\/10.3390\/ijms26010341","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,2]]}}}