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Research Fund of National Engineering Research Center of Genetic Medicine, Jinan University (2022)","award":["210715094530570"],"award-info":[{"award-number":["210715094530570"]}]},{"name":"Open Research Fund of National Engineering Research Center of Genetic Medicine, Jinan University (2022)","award":["230330108034335"],"award-info":[{"award-number":["230330108034335"]}]},{"name":"Guangdong Province Young Innovative Talents Program for Ordinary Colleges and Universities","award":["2024A1515012524"],"award-info":[{"award-number":["2024A1515012524"]}]},{"name":"Guangdong Province Young Innovative Talents Program for Ordinary Colleges and Universities","award":["2021A1515010947"],"award-info":[{"award-number":["2021A1515010947"]}]},{"name":"Guangdong Province Young Innovative Talents Program for Ordinary Colleges and Universities","award":["32271376"],"award-info":[{"award-number":["32271376"]}]},{"name":"Guangdong Province Young Innovative Talents Program for Ordinary Colleges and Universities","award":["2021KQNCX085"],"award-info":[{"award-number":["2021KQNCX085"]}]},{"name":"Guangdong Province Young Innovative Talents Program for Ordinary Colleges and Universities","award":["210715094530570"],"award-info":[{"award-number":["210715094530570"]}]},{"name":"Guangdong Province Young Innovative Talents Program for Ordinary Colleges and Universities","award":["230330108034335"],"award-info":[{"award-number":["230330108034335"]}]},{"name":"Shaoguan Science and Technology Planning Project","award":["2024A1515012524"],"award-info":[{"award-number":["2024A1515012524"]}]},{"name":"Shaoguan Science and Technology Planning Project","award":["2021A1515010947"],"award-info":[{"award-number":["2021A1515010947"]}]},{"name":"Shaoguan Science and Technology Planning Project","award":["32271376"],"award-info":[{"award-number":["32271376"]}]},{"name":"Shaoguan Science and Technology Planning Project","award":["2021KQNCX085"],"award-info":[{"award-number":["2021KQNCX085"]}]},{"name":"Shaoguan Science and Technology Planning Project","award":["210715094530570"],"award-info":[{"award-number":["210715094530570"]}]},{"name":"Shaoguan Science and Technology Planning Project","award":["230330108034335"],"award-info":[{"award-number":["230330108034335"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Inflammatory skin diseases comprise a group of skin conditions characterized by damage to skin function due to overactive immune responses. These disorders not only impair the barrier function of the skin but also deteriorate the quality of life and increase the risk of psychiatric issues. Here, a low-modulus phosphatidylserine-exposing microvesicle (deformed PSV, D-PSV) was produced, characterized, and evaluated for its potential therapeutic function against skin diseases. Compared to conventional PSVs (C-PSVs), D-PSVs exhibited a more robust and longer-lasting inhibitory effect on the inflammatory response triggered by lipopolysaccharides and interferon-\u03b3 in a primary bone marrow-derived macrophage model. Transcriptome analysis indicated that the inhibitory effect of D-PSVs was mainly achieved by modulating inflammation-related signaling pathways, leading to a reduction in the expressions of pro-inflammatory genes. In an imiquimod-induced psoriatic dermatitis mouse model, topical application of D-PSVs effectively mitigated inflammation in the skin microenvironment and reduced lesion severity. These improvements were attributed to the superior skin permeability and more persistent adhesion of D-PSVs to macrophages compared with C-PSVs. In summary, this macrophage-targeted microvesicle offers a promising non-invasive approach to managing inflammatory skin diseases by persistently inhibiting M1 macrophage polarization and restoring immune microenvironment balance.<\/jats:p>","DOI":"10.3390\/ijms26010394","type":"journal-article","created":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T08:08:52Z","timestamp":1736150932000},"page":"394","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Low-Modulus Phosphatidylserine-Exposing Microvesicle Alleviates Skin Inflammation via Persistent Blockade of M1 Macrophage Polarization"],"prefix":"10.3390","volume":"26","author":[{"given":"Zihao","family":"Zhang","sequence":"first","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Bioengineering Medicine, Department of Cell Biology, Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yidi","family":"Mo","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Bioengineering Medicine, Department of Cell Biology, Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengxia","family":"Xu","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Bioengineering Medicine, Department of Cell Biology, Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Jiang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Bioengineering Medicine, Department of Cell Biology, Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanshu","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Material Science and Engineering, College of Chemistry and Materials Science, Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yani","family":"ZhuGe","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Bioengineering Medicine, Department of Cell Biology, Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijian","family":"Su","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Bioengineering Medicine, Department of Cell Biology, Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9790-5823","authenticated-orcid":false,"given":"Qi","family":"Xiang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Bioengineering Medicine, Department of Cell Biology, Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Material Science and Engineering, College of Chemistry and Materials Science, Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8080-7637","authenticated-orcid":false,"given":"Guanglin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Material Science and Engineering, College of Chemistry and Materials Science, Jinan University, Guangzhou 510632, China"},{"name":"College of Biology and Agriculture, Shaoguan University, Shaoguan 512005, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,4]]},"reference":[{"key":"ref_1","first-page":"11","article-title":"Diagnosis and Management of Common Inflammatory Skin Diseases in Older Adults","volume":"40","author":"Heinecke","year":"2023","journal-title":"Clin. 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