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Exercise is an important tool to improve prognosis in the post-infarction (MI) population, but the role of exercise on HDL functionality is poorly understood. Sixty-two patients with acute MI were randomized in a supervised exercise program for 12\u201314 weeks (exercise group\u2014EG) or a control group (CG). The main objective of the study was to analyze the role of exercise on esterified cholesterol (EC) and unesterified cholesterol (UC) transfer to HDL. For the total population, the baseline mean rate of EC transfer to HDL was 2.53 \u00b1 0.83 and at the end of follow-up, it was 2.74 \u00b1 0.64 (p = 0.03). The figures for UC were, respectively, 4.08 \u00b1 1.2 and 4.4 \u00b1 1.06 (p = 0.02). The difference (follow-up minus baseline) for EC was 0.15 \u00b1 0.84 for the control group and 0.27 \u00b1 0.69 for the exercise group (p = 0.53); for UC, the figures were 0.28 \u00b1 1.14 and 0.35 \u00b1 0.96 (p = 0.80), respectively, for the control and exercise groups. In post-MI patients, 12\u201314 weeks of supervised exercise did not improve HDL functionality.<\/jats:p>","DOI":"10.3390\/ijms26010419","type":"journal-article","created":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T09:17:02Z","timestamp":1736155022000},"page":"419","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Role of Exercise-Based Cardiac Rehabilitation After Myocardial Infarction on Cholesterol Transfer to HDL"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9680-3689","authenticated-orcid":false,"given":"Jose C.","family":"Nicolau","sequence":"first","affiliation":[{"name":"Instituto do Coracao (InCor) Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo 05508-220, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talia F.","family":"Dalcoquio","sequence":"additional","affiliation":[{"name":"Hospital S\u00edrio-Liban\u00eas, S\u00e3o Paulo 01308-050, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto R.","family":"Giraldez","sequence":"additional","affiliation":[{"name":"Instituto do Coracao (InCor) Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo 05508-220, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3290-2127","authenticated-orcid":false,"given":"Fatima R.","family":"Freitas","sequence":"additional","affiliation":[{"name":"Instituto do Coracao (InCor) Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo 05508-220, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0633-3853","authenticated-orcid":false,"given":"Andre M.","family":"Nicolau","sequence":"additional","affiliation":[{"name":"Instituto do Coracao (InCor) Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo 05508-220, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remo H. 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