{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:34:37Z","timestamp":1759970077193,"version":"build-2065373602"},"reference-count":47,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T00:00:00Z","timestamp":1736380800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Singapore National Medical Research Council","award":["CS-IRG","OF-IRG","HLCA2022","STaR Award","OF LCG 000207"],"award-info":[{"award-number":["CS-IRG","OF-IRG","HLCA2022","STaR Award","OF LCG 000207"]}]},{"name":"Duke-Duke-NUS Collaboration Pilot Grant","award":["CS-IRG","OF-IRG","HLCA2022","STaR Award","OF LCG 000207"],"award-info":[{"award-number":["CS-IRG","OF-IRG","HLCA2022","STaR Award","OF LCG 000207"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Alzheimer\u2019s disease (AD) is characterised by progressive neurodegeneration with the formation of amyloid beta (A\u03b2) plaques and neurofibrillary tau tangles in the brain parenchyma. The causes of AD have been attributed to a combination of age-related changes within the brain as well as genetic, environmental and lifestyle factors. However, a recent study by Banerjee et al. highlights the possibility that AD may be a transmissible disease and that iatrogenic AD could be environmentally acquired, similar to iatrogenic Creutzfeldt\u2013Jakob disease (iCJD). The study reports that contaminated A\u03b2 in cadaver-derived pituitary growth hormone (c-hGH) therapy, which patients received during childhood inoculation, may accidentally transmit into their brains, triggering neurodegeneration and AD onset in older age. Furthermore, corroborating evidence from various animal model studies and human case reports suggests that AD can be potentially transmissible.<\/jats:p>","DOI":"10.3390\/ijms26020508","type":"journal-article","created":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T07:00:47Z","timestamp":1736406047000},"page":"508","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evidence Suggesting That Alzheimer\u2019s Disease May Be a Transmissible Disorder"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0111-2878","authenticated-orcid":false,"given":"Genevieve","family":"Saw","sequence":"first","affiliation":[{"name":"National Neuroscience Institute, 11 Jalan Tan Tock Seng, Singapore 308433, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5250-214X","authenticated-orcid":false,"given":"Ling-Xiao","family":"Yi","sequence":"additional","affiliation":[{"name":"National Neuroscience Institute, 11 Jalan Tan Tock Seng, Singapore 308433, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eng King","family":"Tan","sequence":"additional","affiliation":[{"name":"National Neuroscience Institute, 11 Jalan Tan Tock Seng, Singapore 308433, Singapore"},{"name":"Department of Neurology, Singapore General Hospital, Outram Road, Singapore 169608, Singapore"},{"name":"Signature Research Program in Neuroscience and Behavioral Disorders, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0251-4163","authenticated-orcid":false,"given":"Zhi Dong","family":"Zhou","sequence":"additional","affiliation":[{"name":"National Neuroscience Institute, 11 Jalan Tan Tock Seng, Singapore 308433, Singapore"},{"name":"Signature Research Program in Neuroscience and Behavioral Disorders, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,9]]},"reference":[{"key":"ref_1","first-page":"209","article-title":"Alzheimer\u2019s disease as neurodegenerative disorder","volume":"60","year":"2006","journal-title":"Postep. 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