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Daylight photodynamic therapy (dPDT), a variant utilizing natural sunlight as the energy source, enhances procedural flexibility by eliminating the need for specialized equipment. dPDT has been effectively used in dermatology to treat various cutaneous disorders, including neoplastic and infectious diseases. Traditionally, skin preparation and photosensitizer application are performed by trained practitioners, limiting the accessibility of dPDT for broader populations. However, recent studies suggest that these preparatory steps can be managed by patients or caregivers, enabling fully self-applied, home-based dPDT protocols. This review systematically examines the current evidence on self-applied dPDT (SA-dPDT), emphasizing molecular mechanisms and its efficacy in managing premalignant and other cutaneous conditions.<\/jats:p>","DOI":"10.3390\/ijms26020628","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T11:31:31Z","timestamp":1736767891000},"page":"628","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Self-Applied Daylight Photodynamic Therapy: A Paradigm Shift?"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9457-8361","authenticated-orcid":false,"given":"Emilio","family":"Garcia-Mouronte","sequence":"first","affiliation":[{"name":"Dermatology Department, Hospital Universitario Ramon y Cajal, Carretera M-607 km 9.1, 28034 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0136-9032","authenticated-orcid":false,"given":"Jorge","family":"Naharro-Rodriguez","sequence":"additional","affiliation":[{"name":"Dermatology Department, Hospital Universitario Ramon y Cajal, Carretera M-607 km 9.1, 28034 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7123-9869","authenticated-orcid":false,"given":"Luis","family":"Alonso-Mtz de Salinas","sequence":"additional","affiliation":[{"name":"Dermatology Department, Hospital Universitario Ramon y Cajal, Carretera M-607 km 9.1, 28034 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6015-9441","authenticated-orcid":false,"given":"Luis Alfonso","family":"P\u00e9rez-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Dermatology Department, Hospital Universitario Ramon y Cajal, Carretera M-607 km 9.1, 28034 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8193-0730","authenticated-orcid":false,"given":"Montserrat","family":"Fern\u00e1ndez-Guarino","sequence":"additional","affiliation":[{"name":"Dermatology Department, Hospital Universitario Ramon y Cajal, Carretera M-607 km 9.1, 28034 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.ad.2015.06.001","article-title":"Spanish-Portuguese Consensus Statement on Use of Daylight-Mediated Photodynamic Therapy with Methyl Aminolevulinate in the Treatment of Actinic Keratosis","volume":"106","author":"Gilaberte","year":"2015","journal-title":"Actas Dermosifiliogr."},{"key":"ref_2","first-page":"377","article-title":"Photodynamic therapy: New indications","volume":"98","author":"Harto","year":"2007","journal-title":"Actas Dermosifiliogr."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.pdpdt.2017.07.002","article-title":"Photodynamic Therapy and Pain: A Systematic Review","volume":"19","author":"Ang","year":"2017","journal-title":"Photodiagn. 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