{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T19:31:48Z","timestamp":1789500708064,"version":"build-2803163510"},"reference-count":334,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T00:00:00Z","timestamp":1736726400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Cancer stem cells (CSC) are known to be the main source of tumor relapse, metastasis, or multidrug resistance and the mechanisms to counteract or eradicate them and their activity remain elusive. There are different hypotheses that claim that the origin of CSC might be in regular stem cells (SC) and, due to accumulation of mutations, these normal cells become malignant, or the source of CSC might be in any malignant cell that, under certain environmental circumstances, acquires all the qualities to become CSC. Multiple studies indicate that lifestyle and diet might represent a source of wellbeing that can prevent and ameliorate the malignant phenotype of CSC. In this review, after a brief introduction to SC and CSC, we analyze the effects of phenolic and non-phenolic dietary compounds and we highlight the molecular mechanisms that are shown to link diets to CSC activation in colon, breast, and prostate cancer. We focus the analysis on specific markers such as sphere formation, CD surface markers, epithelial\u2013mesenchymal transition (EMT), Oct4, Nanog, Sox2, and aldehyde dehydrogenase 1 (ALDH1) and on the major signaling pathways such as PI3K\/Akt\/mTOR, NF-\u03baB, Notch, Hedgehog, and Wnt\/\u03b2-catenin in CSC. In conclusion, a better understanding of how bioactive compounds in our diets influence the dynamics of CSC can raise valuable awareness towards reducing cancer risk.<\/jats:p>","DOI":"10.3390\/ijms26020631","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T11:31:31Z","timestamp":1736767891000},"page":"631","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Molecular Mechanisms of Dietary Compounds in Cancer Stem Cells from Solid Tumors: Insights into Colorectal, Breast, and Prostate Cancer"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4948-5454","authenticated-orcid":false,"given":"Alexandru","family":"Filippi","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Biophysics, \u201cCarol Davila\u201d University of Medicine and Pharmacy of Bucharest, 050474 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3824-4222","authenticated-orcid":false,"given":"Teodora","family":"Deculescu-Ioni\u021b\u0103","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Phytochemistry and Phytotherapy, \u201cCarol Davila\u201d University of Medicine and Pharmacy of Bucharest, 050474 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9439-9432","authenticated-orcid":false,"given":"Ariana","family":"Hudi\u021b\u0103","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, University of Bucharest, 050095 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7968-1643","authenticated-orcid":false,"given":"Oana","family":"Baldasici","sequence":"additional","affiliation":[{"name":"Department of Genetics, Genomics and Experimental Pathology, The Oncology Institute \u201cProf. Dr. Ion Chiricu\u021b\u0103\u201d, 400015 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8093-1750","authenticated-orcid":false,"given":"Bianca","family":"G\u0103l\u0103\u021beanu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, University of Bucharest, 050095 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1381-0649","authenticated-orcid":false,"given":"Maria-Magdalena","family":"Mocanu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biophysics, \u201cCarol Davila\u201d University of Medicine and Pharmacy of Bucharest, 050474 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.stem.2012.05.007","article-title":"Cancer stem cells: Current status and evolving complexities","volume":"10","author":"Visvader","year":"2012","journal-title":"Cell Stem Cell"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1038\/nm.4409","article-title":"Cancer stem cells revisited","volume":"23","author":"Batlle","year":"2017","journal-title":"Nat. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.stem.2018.12.009","article-title":"Cancer Stem Cells: The Architects of the Tumor Ecosystem","volume":"24","author":"Prager","year":"2019","journal-title":"Cell Stem Cell"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s13287-019-1165-5","article-title":"Stem cells: Past, present, and future","volume":"10","author":"Zakrzewski","year":"2019","journal-title":"Stem Cell Res. Ther."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.stem.2015.02.015","article-title":"The cancer stem cell niche: How essential is the niche in regulating stemness of tumor cells?","volume":"16","author":"Plaks","year":"2015","journal-title":"Cell Stem Cell"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1146\/annurev-pathol-012615-044438","article-title":"Cancer Stem Cells: Basic Concepts and Therapeutic Implications","volume":"11","author":"Nassar","year":"2016","journal-title":"Annu. Rev. Pathol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.4252\/wjsc.v12.i11.1307","article-title":"Stem cell quiescence and its clinical relevance","volume":"12","author":"Luo","year":"2020","journal-title":"World J. Stem Cells"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"107985","DOI":"10.1016\/j.pharmthera.2021.107985","article-title":"Cell plasticity, senescence, and quiescence in cancer stem cells: Biological and therapeutic implications","volume":"231","author":"Paul","year":"2022","journal-title":"Pharmacol. Ther."},{"key":"ref_9","first-page":"1442","article-title":"Impact of Lifestyle on Health","volume":"44","author":"Farhud","year":"2015","journal-title":"Iran. J. Public Health"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Viallon, V., Freisling, H., Matta, K., Nannsen, A.O., Dahm, C.C., Tjonneland, A., Eriksen, A.K., Kaaks, R., Katzke, V.A., and Schulze, M.B. (2024). On the use of the healthy lifestyle index to investigate specific disease outcomes. Sci. Rep., 14.","DOI":"10.1038\/s41598-024-66772-w"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Hu, P., Zheng, M., Huang, J., Fan, H.Y., Fan, C.J., Ruan, H.H., Yuan, Y.S., Zhao, W., Wang, H.H.X., and Deng, H. (2022). Effect of healthy lifestyle index and lifestyle patterns on the risk of mortality: A community-based cohort study. Front. Med., 9.","DOI":"10.3389\/fmed.2022.920760"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Brivio, F., Vigano, A., Paterna, A., Palena, N., and Greco, A. (2023). Narrative Review and Analysis of the Use of \u201cLifestyle\u201d in Health Psychology. Int. J. Environ. Res. Public Health, 20.","DOI":"10.3390\/ijerph20054427"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1177\/15598276231174863","article-title":"Nature As Medicine: The 7th (Unofficial) Pillar of Lifestyle Medicine","volume":"17","author":"Sundermann","year":"2023","journal-title":"Am. J. Lifestyle Med."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Chen, Y., Wang, X.Q., Zhang, Q., Zhu, J.Y., Li, Y., Xie, C.F., Li, X.T., Wu, J.S., Geng, S.S., and Zhong, C.Y. (2017). (-)-Epigallocatechin-3-Gallate Inhibits Colorectal Cancer Stem Cells by Suppressing Wnt\/beta-Catenin Pathway. Nutrients, 9.","DOI":"10.3390\/nu9060572"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"16158","DOI":"10.18632\/oncotarget.7567","article-title":"Epigallocatechin-3-gallate targets cancer stem-like cells and enhances 5-fluorouracil chemosensitivity in colorectal cancer","volume":"7","author":"Toden","year":"2016","journal-title":"Oncotarget"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Lee, J., Kim, Y.S., Lee, J., Heo, S.C., Lee, K.L., Choi, S.W., and Kim, Y. (2016). Walnut Phenolic Extract and Its Bioactive Compounds Suppress Colon Cancer Cell Growth by Regulating Colon Cancer Stemness. Nutrients, 8.","DOI":"10.3390\/nu8070439"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s40778-016-0056-2","article-title":"Extracellular Matrix Regulation of Stem Cell Behavior","volume":"2","author":"Ahmed","year":"2016","journal-title":"Curr. Stem Cell Rep."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"dev201510","DOI":"10.1242\/dev.201510","article-title":"Macrophage-stem cell crosstalk: Regulation of the stem cell niche","volume":"150","author":"Manneken","year":"2023","journal-title":"Development"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.blre.2004.03.001","article-title":"Stem cell plasticity","volume":"19","author":"Lakshmipathy","year":"2005","journal-title":"Blood Rev."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13619-020-00061-5","article-title":"The cellular niche for intestinal stem cells: A team effort","volume":"10","author":"Zhu","year":"2021","journal-title":"Cell Regen."},{"key":"ref_21","first-page":"209","article-title":"Prostate epithelial stem and progenitor cells","volume":"2","author":"Kwon","year":"2014","journal-title":"Am. J. Clin. Exp. Urol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.1442-2042.2008.02047.x","article-title":"Prostate stem cells: The niche and cell markers","volume":"15","author":"Takao","year":"2008","journal-title":"Int. J. Urol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1126\/science.aay0267","article-title":"Regenerative potential of prostate luminal cells revealed by single-cell analysis","volume":"368","author":"Karthaus","year":"2020","journal-title":"Science"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Celia-Terrassa, T. (2018). Mammary Stem Cells and Breast Cancer Stem Cells: Molecular Connections and Clinical Implications. Biomedicines, 6.","DOI":"10.3390\/biomedicines6020050"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/nature12948","article-title":"In situ identification of bipotent stem cells in the mammary gland","volume":"506","author":"Rios","year":"2014","journal-title":"Nature"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"3382","DOI":"10.1158\/0008-5472.CAN-08-4418","article-title":"Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis","volume":"69","author":"Huang","year":"2009","journal-title":"Cancer Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.stem.2007.08.014","article-title":"ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome","volume":"1","author":"Ginestier","year":"2007","journal-title":"Cell Stem Cell"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1053\/j.gastro.2009.04.021","article-title":"Prominin1 (CD133) as an intestinal stem cell marker: Promise and nuance","volume":"136","author":"Montgomery","year":"2009","journal-title":"Gastroenterology"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1002\/dvdy.22539","article-title":"Stem cell marker prominin-1 regulates branching morphogenesis, but not regenerative capacity, in the mammary gland","volume":"240","author":"Anderson","year":"2011","journal-title":"Dev. Dyn."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/nature04372","article-title":"Generation of a functional mammary gland from a single stem cell","volume":"439","author":"Shackleton","year":"2006","journal-title":"Nature"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1634\/stemcells.2007-0309","article-title":"Characterization of adult prostatic progenitor\/stem cells exhibiting self-renewal and multilineage differentiation","volume":"26","author":"Barclay","year":"2008","journal-title":"Stem Cells"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1038\/nature04496","article-title":"Purification and unique properties of mammary epithelial stem cells","volume":"439","author":"Stingl","year":"2006","journal-title":"Nature"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"3079","DOI":"10.1038\/emboj.2012.166","article-title":"The Lgr5 intestinal stem cell signature: Robust expression of proposed quiescent \u2018+4\u2019 cell markers","volume":"31","author":"Munoz","year":"2012","journal-title":"EMBO J."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1053\/j.gastro.2009.05.035","article-title":"OLFM4 is a robust marker for stem cells in human intestine and marks a subset of colorectal cancer cells","volume":"137","author":"Haegebarth","year":"2009","journal-title":"Gastroenterology"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1006\/dbio.2002.0625","article-title":"Sca-1(pos) cells in the mouse mammary gland represent an enriched progenitor cell population","volume":"245","author":"Welm","year":"2002","journal-title":"Dev. Biol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1038\/ng.165","article-title":"Bmi1 is expressed in vivo in intestinal stem cells","volume":"40","author":"Sangiorgi","year":"2008","journal-title":"Nat. Genet."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s00018-020-03602-y","article-title":"The quest of cell surface markers for stem cell therapy","volume":"78","author":"Meyfour","year":"2021","journal-title":"Cell Mol. Life Sci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.tcb.2021.03.012","article-title":"How should we define mammary stem cells?","volume":"31","author":"Watson","year":"2021","journal-title":"Trends Cell Biol."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Espinosa-Sanchez, A., Suarez-Martinez, E., Sanchez-Diaz, L., and Carnero, A. (2020). Therapeutic Targeting of Signaling Pathways Related to Cancer Stemness. Front. Oncol., 10.","DOI":"10.3389\/fonc.2020.01533"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/bs.pmbts.2017.11.017","article-title":"Wnt Signaling in Adult Epithelial Stem Cells and Cancer","volume":"153","author":"Tan","year":"2018","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/bs.pmbts.2017.11.007","article-title":"Wnt Signaling in Stem Cells and Cancer Stem Cells: A Tale of Two Coactivators","volume":"153","author":"Kahn","year":"2018","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Katagiri, T., and Watabe, T. (2016). Bone Morphogenetic Proteins. Cold Spring Harb. Perspect. Biol., 8.","DOI":"10.1101\/cshperspect.a021899"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"13824","DOI":"10.1038\/ncomms13824","article-title":"BMP restricts stemness of intestinal Lgr5(+) stem cells by directly suppressing their signature genes","volume":"8","author":"Qi","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/978-3-319-89512-3_12","article-title":"Notch and Stem Cells","volume":"1066","author":"Bigas","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1248012","DOI":"10.1126\/science.1248012","article-title":"Stem cell signaling. An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control","volume":"346","author":"Clevers","year":"2014","journal-title":"Science"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1146\/annurev-cellbio-120319-023657","article-title":"Cell Biology of Canonical Wnt Signaling","volume":"37","author":"Albrecht","year":"2021","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/s41392-022-00934-y","article-title":"Notch signaling pathway: Architecture, disease, and therapeutics","volume":"7","author":"Zhou","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1053\/j.gastro.2011.01.005","article-title":"Dll1- and dll4-mediated notch signaling are required for homeostasis of intestinal stem cells","volume":"140","author":"Pellegrinet","year":"2011","journal-title":"Gastroenterology"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/embor.2008.7","article-title":"Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2","volume":"9","author":"Riccio","year":"2008","journal-title":"EMBO Rep."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Xing, W., Yang, J., Zheng, Y., Yao, L., Peng, X., Chen, Y., and Yang, C. (2024). The Role of the Notch Signaling Pathway in the Differentiation of Human Umbilical Cord-Derived Mesenchymal Stem Cells. Front. Biosci., 29.","DOI":"10.31083\/j.fbl2902074"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/ni1164","article-title":"Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance","volume":"6","author":"Duncan","year":"2005","journal-title":"Nat. Immunol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/s41420-024-02192-z","article-title":"p21 Regulates Wnt-Notch balance via DREAM\/MMB\/Rb-E2F1 and maintains intestinal stem cell homeostasis","volume":"10","author":"Jiang","year":"2024","journal-title":"Cell Death Discov."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1038\/s41586-020-2632-y","article-title":"Heterotypic cell-cell communication regulates glandular stem cell multipotency","volume":"584","author":"Centonze","year":"2020","journal-title":"Nature"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nature09637","article-title":"Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts","volume":"469","author":"Sato","year":"2011","journal-title":"Nature"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1146\/annurev-physiol-021119-034500","article-title":"BMP Signaling in Development, Stem Cells, and Diseases of the Gastrointestinal Tract","volume":"82","author":"Zhang","year":"2020","journal-title":"Annu. Rev. Physiol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/s41422-023-00918-9","article-title":"The roles and regulatory mechanisms of TGF-beta and BMP signaling in bone and cartilage development, homeostasis and disease","volume":"34","author":"Wu","year":"2024","journal-title":"Cell Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1002\/path.1187","article-title":"An introduction to stem cells","volume":"197","author":"Alison","year":"2002","journal-title":"J. Pathol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.cell.2011.07.026","article-title":"Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells","volume":"146","author":"Gupta","year":"2011","journal-title":"Cell"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Nair, N., Calle, A.S., Zahra, M.H., Prieto-Vila, M., Oo, A.K.K., Hurley, L., Vaidyanath, A., Seno, A., Masuda, J., and Iwasaki, Y. (2017). A cancer stem cell model as the point of origin of cancer-associated fibroblasts in tumor microenvironment. Sci. Rep., 7.","DOI":"10.1038\/s41598-017-07144-5"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.cell.2018.01.009","article-title":"CD10(+)GPR77(+) Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness","volume":"172","author":"Su","year":"2018","journal-title":"Cell"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/s12935-022-02527-9","article-title":"Tumor-associated macrophage derived IL-6 enriches cancer stem cell population and promotes breast tumor progression via Stat-3 pathway","volume":"22","author":"Radharani","year":"2022","journal-title":"Cancer Cell Int."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1038\/ncb3041","article-title":"A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages","volume":"16","author":"Lu","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"151628","DOI":"10.1016\/j.acthis.2020.151628","article-title":"Tumor-associated macrophages derived from cancer stem cells","volume":"122","author":"Osman","year":"2020","journal-title":"Acta Histochem."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"5416923","DOI":"10.1155\/2018\/5416923","article-title":"Cancer Stem Cells (CSCs) in Drug Resistance and their Therapeutic Implications in Cancer Treatment","volume":"2018","author":"Phi","year":"2018","journal-title":"Stem Cells Int."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Marzagalli, M., Fontana, F., Raimondi, M., and Limonta, P. (2021). Cancer Stem Cells-Key Players in Tumor Relapse. Cancers, 13.","DOI":"10.3390\/cancers13030376"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"4624","DOI":"10.1158\/0008-5472.CAN-09-3619","article-title":"CD44posCD49fhiCD133\/2hi defines xenograft-initiating cells in estrogen receptor-negative breast cancer","volume":"70","author":"Meyer","year":"2010","journal-title":"Cancer Res."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1136\/jclinpath-2012-201169","article-title":"Cancer stem cells markers CD44, CD24 and ALDH1 in breast cancer special histological types","volume":"66","author":"Caetano","year":"2013","journal-title":"J. Clin. Pathol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1038\/onc.2011.338","article-title":"Sox2 expression in breast tumours and activation in breast cancer stem cells","volume":"31","author":"Leis","year":"2012","journal-title":"Oncogene"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.ejca.2006.01.037","article-title":"Prostate cancer stem cells","volume":"42","author":"Collins","year":"2006","journal-title":"Eur. J. Cancer"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"10946","DOI":"10.1158\/0008-5472.CAN-05-2018","article-title":"Prospective identification of tumorigenic prostate cancer stem cells","volume":"65","author":"Collins","year":"2005","journal-title":"Cancer Res."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"2610","DOI":"10.1073\/pnas.0913873107","article-title":"Basal epithelial stem cells are efficient targets for prostate cancer initiation","volume":"107","author":"Lawson","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1097\/PAT.0000000000000325","article-title":"Cancer stem cell markers in prostate cancer: An immunohistochemical study of ALDH1, SOX2 and EZH2","volume":"47","author":"Matsika","year":"2015","journal-title":"Pathology"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nature05384","article-title":"Identification and expansion of human colon-cancer-initiating cells","volume":"445","author":"Lombardi","year":"2007","journal-title":"Nature"},{"key":"ref_74","first-page":"204","article-title":"Identification of High-Risk Aberrant Crypt Foci and Mucin-Depleted Foci in the Human Colon With Study of Colon Cancer Stem Cell Markers","volume":"16","author":"Gupta","year":"2017","journal-title":"Clin. Color. Cancer"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"425","DOI":"10.3892\/ijo.2013.1955","article-title":"CD49f-positive cell population efficiently enriches colon cancer-initiating cells","volume":"43","author":"Haraguchi","year":"2013","journal-title":"Int. J. Oncol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s40169-018-0198-1","article-title":"The role of CD133 in cancer: A concise review","volume":"7","author":"Glumac","year":"2018","journal-title":"Clin. Transl. Med."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"109377","DOI":"10.1016\/j.cellsig.2019.109377","article-title":"Hyaluronan-CD44 axis orchestrates cancer stem cell functions","volume":"63","author":"Skandalis","year":"2019","journal-title":"Cell Signal."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Wei, Y., Li, Y., Chen, Y., Liu, P., Huang, S., Zhang, Y., Sun, Y., Wu, Z., Hu, M., and Wu, Q. (2022). ALDH1: A potential therapeutic target for cancer stem cells in solid tumors. Front. Oncol., 12.","DOI":"10.3389\/fonc.2022.1026278"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"e176","DOI":"10.1002\/mco2.176","article-title":"Signaling pathways in the regulation of cancer stem cells and associated targeted therapy","volume":"3","author":"Manni","year":"2022","journal-title":"MedComm (2020)"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1146\/annurev-pathol-011110-130235","article-title":"Molecular genetics of colorectal cancer","volume":"6","author":"Fearon","year":"2011","journal-title":"Annu. Rev. Pathol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/nature11282","article-title":"Recurrent R-spondin fusions in colon cancer","volume":"488","author":"Seshagiri","year":"2012","journal-title":"Nature"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1038\/ng.3127","article-title":"RNF43 is frequently mutated in colorectal and endometrial cancers","volume":"46","author":"Giannakis","year":"2014","journal-title":"Nat. Genet."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s12964-018-0220-7","article-title":"A highlight on Sonic hedgehog pathway","volume":"16","author":"Carballo","year":"2018","journal-title":"Cell Commun. Signal."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/nature02962","article-title":"Hedgehog signalling in prostate regeneration, neoplasia and metastasis","volume":"431","author":"Karhadkar","year":"2004","journal-title":"Nature"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"6063","DOI":"10.1158\/0008-5472.CAN-06-0054","article-title":"Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells","volume":"66","author":"Liu","year":"2006","journal-title":"Cancer Res."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/nrm2009","article-title":"Notch signalling: A simple pathway becomes complex","volume":"7","author":"Bray","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/nrc3035","article-title":"Notch signalling in solid tumours: A little bit of everything but not all the time","volume":"11","author":"Ranganathan","year":"2011","journal-title":"Nat. Rev. Cancer"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1158\/0008-5472.CAN-05-3054","article-title":"Aberrant activation of notch signaling in human breast cancer","volume":"66","author":"Stylianou","year":"2006","journal-title":"Cancer Res."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.ccr.2010.12.022","article-title":"Tumor-derived JAGGED1 promotes osteolytic bone metastasis of breast cancer by engaging notch signaling in bone cells","volume":"19","author":"Sethi","year":"2011","journal-title":"Cancer Cell"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1158\/0008-5472.CAN-09-2557","article-title":"NOTCH signaling is required for formation and self-renewal of tumor-initiating cells and for repression of secretory cell differentiation in colon cancer","volume":"70","author":"Sikandar","year":"2010","journal-title":"Cancer Res."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Tyagi, A., Sharma, A.K., and Damodaran, C. (2020). A Review on Notch Signaling and Colorectal Cancer. Cells, 9.","DOI":"10.3390\/cells9061549"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.ccr.2012.12.021","article-title":"Endothelial cells promote the colorectal cancer stem cell phenotype through a soluble form of Jagged-1","volume":"23","author":"Lu","year":"2013","journal-title":"Cancer Cell"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s13619-023-00181-8","article-title":"BMP signaling in cancer stemness and differentiation","volume":"12","author":"Zhou","year":"2023","journal-title":"Cell Regen."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1038\/nature07733","article-title":"Association of reactive oxygen species levels and radioresistance in cancer stem cells","volume":"458","author":"Diehn","year":"2009","journal-title":"Nature"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"3904645","DOI":"10.1155\/2019\/3904645","article-title":"Aldehyde Dehydrogenases: Not Just Markers, but Functional Regulators of Stem Cells","volume":"2019","author":"Vassalli","year":"2019","journal-title":"Stem Cells Int."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Tuy, K., Rickenbacker, L., and Hjelmeland, A.B. (2021). Reactive oxygen species produced by altered tumor metabolism impacts cancer stem cell maintenance. Redox Biol., 44.","DOI":"10.1016\/j.redox.2021.101953"},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Liskova, A., Kubatka, P., Samec, M., Zubor, P., Mlyncek, M., Bielik, T., Samuel, S.M., Zulli, A., Kwon, T.K., and Busselberg, D. (2019). Dietary Phytochemicals Targeting Cancer Stem Cells. Molecules, 24.","DOI":"10.3390\/molecules24050899"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3390\/psychiatryint1020014","article-title":"Association of Mediterranean Diet Adherence, Functional Food Consumption and Anthropometric Characteristics with Anxiety and Depression Indexes in a Sample of Healthy Greek Adults: A Cross-Sectional Study","volume":"1","author":"Elmaliklis","year":"2020","journal-title":"Psychiatry Int."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Mentella, M.C., Scaldaferri, F., Ricci, C., Gasbarrini, A., and Miggiano, G.A.D. (2019). Cancer and Mediterranean Diet: A Review. Nutrients, 11.","DOI":"10.3390\/nu11092059"},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Ganesan, K., Jayachandran, M., and Xu, B. (2020). Diet-Derived Phytochemicals Targeting Colon Cancer Stem Cells and Microbiota in Colorectal Cancer. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21113976"},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Prajapati, K.S., Gupta, S., and Kumar, S. (2022). Targeting Breast Cancer-Derived Stem Cells by Dietary Phytochemicals: A Strategy for Cancer Prevention and Treatment. Cancers, 14.","DOI":"10.3390\/cancers14122864"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.maturitas.2020.03.008","article-title":"Mediterranean diet and health: A systematic review of epidemiological studies and intervention trials","volume":"136","author":"Tarin","year":"2020","journal-title":"Maturitas"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s11101-015-9443-z","article-title":"Phenolic compounds in fruits and beverages consumed as part of the mediterranean diet: Their role in prevention of chronic diseases","volume":"15","author":"Aguilera","year":"2015","journal-title":"Phytochem. Rev."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1080\/09637486.2017.1285870","article-title":"Dietary sources of polyphenols in the Mediterranean healthy Eating, Aging and Lifestyle (MEAL) study cohort","volume":"68","author":"Godos","year":"2017","journal-title":"Int. J. Food Sci. Nutr."},{"key":"ref_105","first-page":"1934578X1100600924","article-title":"Dietary Burden of Phenolics per Serving of \u201cMountain Tea\u201d (Sideritis) from Macedonia and Correlation to Antioxidant Activity","volume":"6","author":"Petreska","year":"2011","journal-title":"Nat. Prod. Commun."},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Mazurakova, A., Koklesova, L., Vybohova, D., Samec, M., Kudela, E., Biringer, K., Sudomova, M., Hassan, S.T.S., Kello, M., and Busselberg, D. (2023). Therapy-resistant breast cancer in focus: Clinically relevant mitigation by flavonoids targeting cancer stem cells. Front. Pharmacol., 14.","DOI":"10.3389\/fphar.2023.1160068"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1038\/sj.ejcn.1601472","article-title":"Identification and quantitation of major carotenoids in selected components of the Mediterranean diet: Green leafy vegetables, figs and olive oil","volume":"56","author":"Su","year":"2002","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_108","first-page":"89","article-title":"Estimation of Carotenoid Contents of Selected Mediterranean Legumes by HPLC","volume":"10","year":"2014","journal-title":"World J. Med. Sci."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"7925","DOI":"10.3390\/nu7095371","article-title":"Food Processing and the Mediterranean Diet","volume":"7","author":"Hoffman","year":"2015","journal-title":"Nutrients"},{"key":"ref_110","first-page":"E12","article-title":"Foods of the Mediterranean diet: Garlic and Mediterranean legumes","volume":"63","author":"Naureen","year":"2022","journal-title":"J. Prev. Med. Hyg."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Talib, W.H., AlHur, M.J., Al Naimat, S., Ahmad, R.E., Al-Yasari, A.H., Al-Dalaeen, A., Thiab, S., and Mahmod, A.I. (2022). Anticancer Effect of Spices Used in Mediterranean Diet: Preventive and Therapeutic Potentials. Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.905658"},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Merra, G., Noce, A., Marrone, G., Cintoni, M., Tarsitano, M.G., Capacci, A., and De Lorenzo, A. (2020). Influence of Mediterranean Diet on Human Gut Microbiota. Nutrients, 13.","DOI":"10.3390\/nu13010007"},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Hernandez-Lopez, I., Ortiz-Sola, J., Alamprese, C., Barros, L., Shelef, O., Basheer, L., Rivera, A., Abadias, M., and Aguilo-Aguayo, I. (2022). Valorization of Local Legumes and Nuts as Key Components of the Mediterranean Diet. Foods, 11.","DOI":"10.3390\/foods11233858"},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Sohn, S.I., Rathinapriya, P., Balaji, S., Jaya Balan, D., Swetha, T.K., Durgadevi, R., Alagulakshmi, S., Singaraj, P., and Pandian, S. (2021). Phytosterols in Seaweeds: An Overview on Biosynthesis to Biomedical Applications. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222312691"},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Wang, M., Firrman, J., Liu, L., and Yam, K. (2019). A Review on Flavonoid Apigenin: Dietary Intake, ADME, Antimicrobial Effects, and Interactions with Human Gut Microbiota. Biomed. Res. Int., 2019.","DOI":"10.1155\/2019\/7010467"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"e26701","DOI":"10.1016\/j.heliyon.2024.e26701","article-title":"Revisiting luteolin: An updated review on its anticancer potential","volume":"10","author":"Rauf","year":"2024","journal-title":"Heliyon"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/s41420-018-0124-8","article-title":"Apigenin suppresses the stem cell-like properties of triple-negative breast cancer cells by inhibiting YAP\/TAZ activity","volume":"4","author":"Li","year":"2018","journal-title":"Cell Death Discov."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"3225","DOI":"10.1007\/s11030-022-10384-x","article-title":"Kaempferol and Apigenin suppresses the stemness properties of TNBC cells by modulating Sirtuins","volume":"26","author":"Sharma","year":"2022","journal-title":"Mol. Divers."},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Vuoso, D.C., D\u2019Angelo, S., Ferraro, R., Caserta, S., Guido, S., Cammarota, M., Porcelli, M., and Cacciapuoti, G. (2020). Annurca apple polyphenol extract promotes mesenchymal-to-epithelial transition and inhibits migration in triple-negative breast cancer cells through ROS\/JNK signaling. Sci. Rep., 10.","DOI":"10.1038\/s41598-020-73092-2"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"155418","DOI":"10.1016\/j.phymed.2024.155418","article-title":"Scutellarin, a flavonoid compound from Scutellaria barbata, suppresses growth of breast cancer stem cells in vitro and in tumor-bearing mice","volume":"128","author":"Ma","year":"2024","journal-title":"Phytomedicine"},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Mei, X., Ouyang, H., Zhang, H., Jia, W., Lu, B., Zhang, J., and Ji, L. (2023). Scutellarin suppresses the metastasis of triple-negative breast cancer via targeting TNFalpha\/TNFR2-RUNX1-triggered G-CSF expression in endothelial cells. Biochem. Pharmacol., 217.","DOI":"10.1016\/j.bcp.2023.115808"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1007\/s10637-019-00774-8","article-title":"Midkine silencing enhances the anti-prostate cancer stem cell activity of the flavone apigenin: Cooperation on signaling pathways regulated by ERK, p38, PTEN, PARP, and NF-kappaB","volume":"38","author":"Erdogan","year":"2020","journal-title":"Investig. New Drugs"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1186\/s40064-015-1242-x","article-title":"Luteolin inhibits progestin-dependent angiogenesis, stem cell-like characteristics, and growth of human breast cancer xenografts","volume":"4","author":"Cook","year":"2015","journal-title":"Springerplus"},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Tsai, K.J., Tsai, H.Y., Tsai, C.C., Chen, T.Y., Hsieh, T.H., Chen, C.L., Mbuyisa, L., Huang, Y.B., and Lin, M.W. (2021). Luteolin Inhibits Breast Cancer Stemness and Enhances Chemosensitivity through the Nrf2-Mediated Pathway. Molecules, 26.","DOI":"10.3390\/molecules26216452"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"6367","DOI":"10.21873\/anticanres.11234","article-title":"Dietary Flavonoids Luteolin and Quercetin Suppressed Cancer Stem Cell Properties and Metastatic Potential of Isolated Prostate Cancer Cells","volume":"36","author":"Tsai","year":"2016","journal-title":"Anticancer Res."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1002\/ptr.6081","article-title":"Quercetin reversed MDR in breast cancer cells through down-regulating P-gp expression and eliminating cancer stem cells mediated by YB-1 nuclear translocation","volume":"32","author":"Li","year":"2018","journal-title":"Phytother. Res."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.lfs.2018.01.014","article-title":"Quercetin suppresses breast cancer stem cells (CD44(+)\/CD24(-)) by inhibiting the PI3K\/Akt\/mTOR-signaling pathway","volume":"196","author":"Li","year":"2018","journal-title":"Life Sci."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"4145","DOI":"10.31557\/APJCP.2022.23.12.4145","article-title":"Quercetin Effects on Cell Cycle Arrest and Apoptosis and Doxorubicin Activity in T47D Cancer Stem Cells","volume":"23","author":"Azizi","year":"2022","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"160","DOI":"10.15430\/JCP.2023.28.4.160","article-title":"Potent Suppression of Prostate Cancer Cell Growth and Eradication of Cancer Stem Cells by CD44-targeted Nanoliposome-quercetin Nanoparticles","volume":"28","author":"Turkekul","year":"2023","journal-title":"J. Cancer Prev."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"14025","DOI":"10.1007\/s13277-016-5277-6","article-title":"Quercetin modulates Wnt signaling components in prostate cancer cell line by inhibiting cell viability, migration, and metastases","volume":"37","author":"Baruah","year":"2016","journal-title":"Tumour Biol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.biopha.2018.08.061","article-title":"Midkine downregulation increases the efficacy of quercetin on prostate cancer stem cell survival and migration through PI3K\/AKT and MAPK\/ERK pathway","volume":"107","author":"Erdogan","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"154029","DOI":"10.1016\/j.prp.2022.154029","article-title":"Kaempferol attenuates viability of ex-vivo cultured post-NACT breast tumor explants through downregulation of p53 induced stemness, inflammation and apoptosis evasion pathways","volume":"237","author":"Nandi","year":"2022","journal-title":"Pathol. Res. Pract."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"115887","DOI":"10.1016\/j.taap.2022.115887","article-title":"Deregulation of the CD44-NANOG-MDR1 associated chemoresistance pathways of breast cancer stem cells potentiates the anti-cancer effect of Kaempferol in synergism with Verapamil","volume":"437","author":"Nandi","year":"2022","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Song, X., Tan, L., Wang, M., Ren, C., Guo, C., Yang, B., Ren, Y., Cao, Z., Li, Y., and Pei, J. (2021). Myricetin: A review of the most recent research. Biomed. Pharmacother., 134.","DOI":"10.1016\/j.biopha.2020.111017"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1186\/s13046-019-1201-4","article-title":"ROS-mediated activation and mitochondrial translocation of CaMKII contributes to Drp1-dependent mitochondrial fission and apoptosis in triple-negative breast cancer cells by isorhamnetin and chloroquine","volume":"38","author":"Hu","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s43046-023-00166-3","article-title":"In vitro synergistic effect of hesperidin and doxorubicin downregulates epithelial-mesenchymal transition in highly metastatic breast cancer cells","volume":"35","author":"Amalina","year":"2023","journal-title":"J. Egypt. Natl. Canc Inst."},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Hermawan, A., Khumaira, A., Ikawati, M., Putri, H., Jenie, R.I., Angraini, S.M., and Muflikhasari, H.A. (2021). Identification of key genes of hesperidin in inhibition of breast cancer stem cells by functional network analysis. Comput. Biol. Chem., 90.","DOI":"10.1016\/j.compbiolchem.2020.107427"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"4908","DOI":"10.3390\/cimb45060312","article-title":"Synergistic Chemopreventive Effects of a Novel Combined Plant Extract Comprising Gallic Acid and Hesperidin on Colorectal Cancer","volume":"45","author":"Chen","year":"2023","journal-title":"Curr. Issues Mol. Biol."},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Zamanian, M.Y., Golmohammadi, M., Abdullaev, B., Garcia, M.O., Alazbjee, A.A.A., Kumar, A., Mohaamed, S.S., Hussien, B.M., Khalaj, F., and Hodaei, S.M. (2024). A narrative review on therapeutic potential of naringenin in colorectal cancer: Focusing on molecular and biochemical processes. Cell Biochem. Funct., 42.","DOI":"10.1002\/cbf.4011"},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Turdo, A., Glaviano, A., Pepe, G., Calapa, F., Raimondo, S., Fiori, M.E., Carbone, D., Basilicata, M.G., Di Sarno, V., and Ostacolo, C. (2021). Nobiletin and Xanthohumol Sensitize Colorectal Cancer Stem Cells to Standard Chemotherapy. Cancers, 13.","DOI":"10.3390\/cancers13163927"},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Ko, Y.C., Choi, H.S., Liu, R., Kim, J.H., Kim, S.L., Yun, B.S., and Lee, D.S. (2020). Inhibitory Effects of Tangeretin, A Citrus Peel-Derived Flavonoid, on Breast Cancer Stem Cell Formation through Suppression of Stat3 Signaling. Molecules, 25.","DOI":"10.3390\/molecules25112599"},{"key":"ref_142","first-page":"433","article-title":"Dietary flavonoid tangeretin induces reprogramming of epithelial to mesenchymal transition in prostate cancer cells by targeting the PI3K\/Akt\/mTOR signaling pathway","volume":"15","author":"Zhu","year":"2018","journal-title":"Oncol. Lett."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1186\/scrt357","article-title":"Genistein decreases the breast cancer stem-like cell population through Hedgehog pathway","volume":"4","author":"Fan","year":"2013","journal-title":"Stem Cell Res. Ther."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1002\/biof.1298","article-title":"Genistein regulates tumor microenvironment and exhibits anticancer effect in dimethyl hydrazine-induced experimental colon carcinogenesis","volume":"42","author":"Sekar","year":"2016","journal-title":"Biofactors"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"436","DOI":"10.4162\/nrp.2024.18.3.436","article-title":"A combination of myokines and genistein suppresses cancer stemness in MCF-7 human breast cancer cells","volume":"18","author":"Kwon","year":"2024","journal-title":"Nutr. Res. Pract."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1093\/carcin\/bgr317","article-title":"Repression of mammosphere formation of human breast cancer cells by soy isoflavone genistein and blueberry polyphenolic acids suggests diet-mediated targeting of cancer stem-like\/progenitor cells","volume":"33","author":"Montales","year":"2012","journal-title":"Carcinogenesis"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.canlet.2012.03.037","article-title":"Genistein inhibits the stemness properties of prostate cancer cells through targeting Hedgehog-Gli1 pathway","volume":"323","author":"Zhang","year":"2012","journal-title":"Cancer Lett."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.3892\/etm.2017.4638","article-title":"Expression of prostate stem cell antigen is downregulated during flavonoid-induced cytotoxicity in prostate cancer cells","volume":"14","author":"Zhang","year":"2017","journal-title":"Exp. Ther. Med."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"58","DOI":"10.4162\/nrp.2019.13.1.58","article-title":"Walnut phenolic extracts reduce telomere length and telomerase activity in a colon cancer stem cell model","volume":"13","author":"Shin","year":"2019","journal-title":"Nutr. Res. Pract."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1002\/mc.22870","article-title":"Catechol derived from aronia juice through lactic acid bacteria fermentation inhibits breast cancer stem cell formation via modulation Stat3\/IL-6 signaling pathway","volume":"57","author":"Choi","year":"2018","journal-title":"Mol. Carcinog."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"3020","DOI":"10.1158\/1055-9965.EPI-08-0528","article-title":"Green tea extracts for the prevention of metachronous colorectal adenomas: A pilot study","volume":"17","author":"Shimizu","year":"2008","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1750-2187-5-14","article-title":"The dietary bioflavonoid quercetin synergizes with epigallocathechin gallate (EGCG) to inhibit prostate cancer stem cell characteristics, invasion, migration and epithelial-mesenchymal transition","volume":"5","author":"Tang","year":"2010","journal-title":"J. Mol. Signal."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.fct.2016.03.011","article-title":"In vivo relevant mixed urolithins and ellagic acid inhibit phenotypic and molecular colon cancer stem cell features: A new potentiality for ellagitannin metabolites against cancer","volume":"92","author":"Karmokar","year":"2016","journal-title":"Food Chem. Toxicol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.bjp.2017.05.010","article-title":"Punica granatum suppresses colon cancer through downregulation of Wnt\/\u03b2-Catenin in rat model","volume":"27","author":"Ahmed","year":"2017","journal-title":"Rev. Bras. Farmacogn."},{"key":"ref_155","first-page":"1087","article-title":"Pomegranate extract inhibits the proliferation and viability of MMTV-Wnt-1 mouse mammary cancer stem cells in vitro","volume":"24","author":"Dai","year":"2010","journal-title":"Oncol. Rep."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"86","DOI":"10.14715\/cmb\/2018.64.7.15","article-title":"Pomegranate peel extract inhibits expression of \u00ce\u00b2-catenin, epithelial mesenchymal transition, and metastasis in triple negative breast cancer cells","volume":"64","author":"Bagheri","year":"2018","journal-title":"Cell. Mol. Biol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1080\/01635581.2017.1359318","article-title":"Pomegranate Extract Alters Breast Cancer Stem Cell Properties in Association with Inhibition of Epithelial-to-Mesenchymal Transition","volume":"69","author":"Nallanthighal","year":"2017","journal-title":"Nutr. Cancer"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1007\/s11130-019-00776-0","article-title":"Pomegranate Juice and Peel Extracts are Able to Inhibit Proliferation, Migration and Colony Formation of Prostate Cancer Cell Lines and Modulate the Akt\/mTOR\/S6K Signaling Pathway","volume":"75","author":"Chaves","year":"2020","journal-title":"Plant Foods Hum. Nutr."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1016\/j.jnutbio.2015.08.005","article-title":"Anthocyanin-containing purple-fleshed potatoes suppress colon tumorigenesis via elimination of colon cancer stem cells","volume":"26","author":"Charepalli","year":"2015","journal-title":"J. Nutr. Biochem."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"47872","DOI":"10.1021\/acsomega.4c08947","article-title":"miR-210 Mediated Hypoxic Responses in Pancreatic Ductal Adenocarcinoma","volume":"9","author":"Mortoglou","year":"2024","journal-title":"ACS Omega"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.3892\/or.2012.2015","article-title":"miR-143 and miR-145 inhibit stem cell characteristics of PC-3 prostate cancer cells","volume":"28","author":"Huang","year":"2012","journal-title":"Oncol. Rep."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s12967-016-0770-7","article-title":"Role of a polyphenol-enriched preparation on chemoprevention of mammary carcinoma through cancer stem cells and inflammatory pathways modulation","volume":"14","author":"Vuong","year":"2016","journal-title":"J. Transl. Med."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.fct.2015.03.013","article-title":"A bioguided identification of the active compounds that contribute to the antiproliferative\/cytotoxic effects of rosemary extract on colon cancer cells","volume":"80","author":"Cifuentes","year":"2015","journal-title":"Food Chem. Toxicol."},{"key":"ref_164","doi-asserted-by":"crossref","unstructured":"Wang, W., Zhang, Y., Huang, X., Li, D., Lin, Q., Zhuang, H., and Li, H. (2024). The role of the miR-30a-5p\/BCL2L11 pathway in rosmarinic acid-induced apoptosis in MDA-MB-231-derived breast cancer stem-like cells. Front. Pharmacol., 15.","DOI":"10.3389\/fphar.2024.1445034"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"9458716","DOI":"10.1155\/2024\/9458716","article-title":"Green Tea Leaves and Rosemary Extracts Selectively Induce Cell Death in Triple-Negative Breast Cancer Cells and Cancer Stem Cells and Enhance the Efficacy of Common Chemotherapeutics","volume":"2024","author":"Raad","year":"2024","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1007\/s00394-016-1181-5","article-title":"Oregano demonstrates distinct tumour-suppressive effects in the breast carcinoma model","volume":"56","author":"Kubatka","year":"2017","journal-title":"Eur. J. Nutr."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"2167-0412","DOI":"10.35248\/2167-0412.19.8.335","article-title":"Biochemical Fingerprint of Greek Sideritis spp.: Implications for Potential Drug Discovery and Advanced Breeding Strategies","volume":"8","author":"Trikka","year":"2019","journal-title":"Med. Aromat. Plants"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s40199-018-0210-8","article-title":"Effect of Cinnamic acid and FOLFOX in diminishing side population and downregulating cancer stem cell markers in colon cancer cell line HT-29","volume":"26","author":"Soltanian","year":"2018","journal-title":"Daru"},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"Villota, H., Santa-Gonzalez, G.A., Uribe, D., Henao, I.C., Arroyave-Ospina, J.C., Barrera-Causil, C.J., and Pedroza-Diaz, J. (2022). Modulatory Effect of Chlorogenic Acid and Coffee Extracts on Wnt\/beta-Catenin Pathway in Colorectal Cancer Cells. Nutrients, 14.","DOI":"10.3390\/nu14224880"},{"key":"ref_170","first-page":"1934578X231193848","article-title":"Caffeic Acid Inhibits Proliferation, Migration, and Stemness of DU-145 Prostate Cancer Cells","volume":"18","author":"Aikins","year":"2023","journal-title":"Nat. Prod. Commun."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"271","DOI":"10.3892\/or.2016.4804","article-title":"Ferulic acid exerts antitumor activity and inhibits metastasis in breast cancer cells by regulating epithelial to mesenchymal transition","volume":"36","author":"Zhang","year":"2016","journal-title":"Oncol. Rep."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/biof.1398","article-title":"Targeting cancer stem cells and signaling pathways by resveratrol and pterostilbene","volume":"44","author":"Zhang","year":"2018","journal-title":"Biofactors"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.crfs.2020.10.004","article-title":"Resveratrol, cancer and cancer stem cells: A review on past to future","volume":"3","author":"Bhaskara","year":"2020","journal-title":"Curr. Res. Food Sci."},{"key":"ref_174","doi-asserted-by":"crossref","unstructured":"Alrafas, H.R., Busbee, P.B., Chitrala, K.N., Nagarkatti, M., and Nagarkatti, P. (2020). Alterations in the Gut Microbiome and Suppression of Histone Deacetylases by Resveratrol Are Associated with Attenuation of Colonic Inflammation and Protection Against Colorectal Cancer. J. Clin. Med., 9.","DOI":"10.3390\/jcm9061796"},{"key":"ref_175","doi-asserted-by":"crossref","unstructured":"Buhrmann, C., Yazdi, M., Popper, B., Shayan, P., Goel, A., Aggarwal, B.B., and Shakibaei, M. (2018). Resveratrol Chemosensitizes TNF-beta-Induced Survival of 5-FU-Treated Colorectal Cancer Cells. Nutrients, 10.","DOI":"10.3390\/nu10070888"},{"key":"ref_176","doi-asserted-by":"crossref","unstructured":"Reddivari, L., Charepalli, V., Radhakrishnan, S., Vadde, R., Elias, R.J., Lambert, J.D., and Vanamala, J.K. (2016). Grape compounds suppress colon cancer stem cells in vitro and in a rodent model of colon carcinogenesis. BMC Complement. Altern. Med., 16.","DOI":"10.1186\/s12906-016-1254-2"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"25","DOI":"10.2147\/CMAR.S4544","article-title":"Results of a phase I pilot clinical trial examining the effect of plant-derived resveratrol and grape powder on Wnt pathway target gene expression in colonic mucosa and colon cancer","volume":"1","author":"Nguyen","year":"2009","journal-title":"Cancer Manag. Res."},{"key":"ref_178","doi-asserted-by":"crossref","unstructured":"Fu, Y., Chang, H., Peng, X., Bai, Q., Yi, L., Zhou, Y., Zhu, J., and Mi, M. (2014). Resveratrol inhibits breast cancer stem-like cells and induces autophagy via suppressing Wnt\/beta-catenin signaling pathway. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0102535"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s10549-010-1300-6","article-title":"Resveratrol suppresses growth of cancer stem-like cells by inhibiting fatty acid synthase","volume":"130","author":"Pandey","year":"2011","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_180","doi-asserted-by":"crossref","unstructured":"Sun, Y., Zhou, Q.M., Lu, Y.Y., Zhang, H., Chen, Q.L., Zhao, M., and Su, S.B. (2019). Resveratrol Inhibits the Migration and Metastasis of MDA-MB-231 Human Breast Cancer by Reversing TGF-beta1-Induced Epithelial-Mesenchymal Transition. Molecules, 24.","DOI":"10.3390\/molecules24061131"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1002\/mnfr.201200549","article-title":"Pterostilbene, a bioactive component of blueberries, suppresses the generation of breast cancer stem cells within tumor microenvironment and metastasis via modulating NF-kappaB\/microRNA 448 circuit","volume":"57","author":"Mak","year":"2013","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_182","doi-asserted-by":"crossref","unstructured":"Rodriguez-Garcia, C., Sanchez-Quesada, C., Toledo, E., Delgado-Rodriguez, M., and Gaforio, J.J. (2019). Naturally Lignan-Rich Foods: A Dietary Tool for Health Promotion?. Molecules, 24.","DOI":"10.3390\/molecules24050917"},{"key":"ref_183","doi-asserted-by":"crossref","unstructured":"Nguyen, M., and Osipo, C. (2022). Targeting Breast Cancer Stem Cells Using Naturally Occurring Phytoestrogens. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23126813"},{"key":"ref_184","first-page":"205","article-title":"A Mini Review on Components of Flax Seed and Their Effects on Breast Cancer","volume":"30","author":"Bayar","year":"2024","journal-title":"J. Agric. Sci."},{"key":"ref_185","doi-asserted-by":"crossref","unstructured":"Jang, W.Y., Kim, M.Y., and Cho, J.Y. (2022). Antioxidant, Anti-Inflammatory, Anti-Menopausal, and Anti-Cancer Effects of Lignans and Their Metabolites. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232415482"},{"key":"ref_186","doi-asserted-by":"crossref","unstructured":"Mahajan, A., Sharma, N., Ulhe, A., Patil, R., Hegde, M., and Mali, A. (2024). From dietary lignans to cancer therapy: Integrative systems analysis of enterolactone\u2019s molecular targets and signaling pathways in combatting cancer stem cells in triple-negative breast cancer. Food Biosci., 58.","DOI":"10.1016\/j.fbio.2024.103732"},{"key":"ref_187","doi-asserted-by":"crossref","unstructured":"Taibi, A., Lin, Z., Tsao, R., Thompson, L.U., and Comelli, E.M. (2019). Effects of Flaxseed and Its Components on Mammary Gland MiRNome: Identification of Potential Biomarkers to Prevent Breast Cancer Development. Nutrients, 11.","DOI":"10.3390\/nu11112656"},{"key":"ref_188","doi-asserted-by":"crossref","unstructured":"Memmola, R., Petrillo, A., Di Lorenzo, S., Altuna, S.C., Habeeb, B.S., Soggiu, A., Bonizzi, L., Garrone, O., and Ghidini, M. (2022). Correlation between Olive Oil Intake and Gut Microbiota in Colorectal Cancer Prevention. Nutrients, 14.","DOI":"10.3390\/nu14183749"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1089\/rej.2011.1203","article-title":"Phenolic secoiridoids in extra virgin olive oil impede fibrogenic and oncogenic epithelial-to-mesenchymal transition: Extra virgin olive oil as a source of novel antiaging phytochemicals","volume":"15","author":"Cufi","year":"2012","journal-title":"Rejuvenation Res."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.fct.2014.11.004","article-title":"The use of plant-derived bioactive compounds to target cancer stem cells and modulate tumor microenvironment","volume":"75","author":"Pistollato","year":"2015","journal-title":"Food Chem. Toxicol."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s40199-024-00512-3","article-title":"Targeting resistant breast cancer stem cells in a three-dimensional culture model with oleuropein encapsulated in methacrylated alginate microparticles","volume":"32","author":"Tutar","year":"2024","journal-title":"Daru"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"3207","DOI":"10.1007\/s00394-018-1864-1","article-title":"Hydroxytyrosol inhibits cancer stem cells and the metastatic capacity of triple-negative breast cancer cell lines by the simultaneous targeting of epithelial-to-mesenchymal transition, Wnt\/beta-catenin and TGFbeta signaling pathways","volume":"58","author":"Marchal","year":"2019","journal-title":"Eur. J. Nutr."},{"key":"ref_193","doi-asserted-by":"crossref","unstructured":"Leon-Gonzalez, A.J., Saez-Martinez, P., Jimenez-Vacas, J.M., Herrero-Aguayo, V., Montero-Hidalgo, A.J., Gomez-Gomez, E., Madrona, A., Castano, J.P., Espartero, J.L., and Gahete, M.D. (2021). Comparative Cytotoxic Activity of Hydroxytyrosol and Its Semisynthetic Lipophilic Derivatives in Prostate Cancer Cells. Antioxidants, 10.","DOI":"10.3390\/antiox10091348"},{"key":"ref_194","first-page":"970","article-title":"Natural and herbal compounds targeting breast cancer, a review based on cancer stem cells","volume":"23","author":"Bozorgi","year":"2020","journal-title":"Iran. J. Basic. Med. Sci."},{"key":"ref_195","doi-asserted-by":"crossref","unstructured":"Mbese, Z., Khwaza, V., and Aderibigbe, B.A. (2019). Curcumin and Its Derivatives as Potential Therapeutic Agents in Prostate, Colon and Breast Cancers. Molecules, 24.","DOI":"10.3390\/molecules24234386"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/s12935-015-0241-x","article-title":"Targeting colorectal cancer stem cells using curcumin and curcumin analogues: Insights into the mechanism of the therapeutic efficacy","volume":"15","author":"Ramasamy","year":"2015","journal-title":"Cancer Cell Int."},{"key":"ref_197","first-page":"1343","article-title":"Curcumin attenuates resistance to irinotecan via induction of apoptosis of cancer stem cells in chemoresistant colon cancer cells","volume":"53","author":"Su","year":"2018","journal-title":"Int. J. Oncol."},{"key":"ref_198","doi-asserted-by":"crossref","unstructured":"Shakibaei, M., Buhrmann, C., Kraehe, P., Shayan, P., Lueders, C., and Goel, A. (2014). Curcumin chemosensitizes 5-fluorouracil resistant MMR-deficient human colon cancer cells in high density cultures. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0085397"},{"key":"ref_199","first-page":"4487","article-title":"Novel micelle formulation of curcumin for enhancing antitumor activity and inhibiting colorectal cancer stem cells","volume":"7","author":"Wang","year":"2012","journal-title":"Int. J. Nanomed."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.1158\/0008-5472.CAN-13-3536","article-title":"Curcumin promotes autophagic survival of a subset of colon cancer stem cells, which are ablated by DCLK1-siRNA","volume":"74","author":"Kantara","year":"2014","journal-title":"Cancer Res."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.canlet.2015.05.005","article-title":"Curcumin inhibits cancer stem cell phenotypes in ex vivo models of colorectal liver metastases, and is clinically safe and tolerable in combination with FOLFOX chemotherapy","volume":"364","author":"James","year":"2015","journal-title":"Cancer Lett."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1158\/0008-5472.CAN-13-1778","article-title":"Curcumin targets breast cancer stem-like cells with microtentacles that persist in mammospheres and promote reattachment","volume":"74","author":"Charpentier","year":"2014","journal-title":"Cancer Res."},{"key":"ref_203","first-page":"2741","article-title":"Effect of curcumin on the cell surface markers CD44 and CD24 in breast cancer","volume":"39","author":"Calaf","year":"2018","journal-title":"Oncol. Rep."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1097\/CAD.0000000000000584","article-title":"Sonic hedgehog and Wnt\/beta-catenin pathways mediate curcumin inhibition of breast cancer stem cells","volume":"29","author":"Li","year":"2018","journal-title":"Anticancer Drugs"},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1080\/10717544.2017.1381198","article-title":"Curcumin: A calixarene derivative micelle potentiates anti-breast cancer stem cells effects in xenografted, triple-negative breast cancer mouse models","volume":"24","author":"Chen","year":"2017","journal-title":"Drug Deliv."},{"key":"ref_206","doi-asserted-by":"crossref","unstructured":"Ros, M., Riesco-Llach, G., Polonio-Alcala, E., Morla-Barcelo, P.M., Ruiz-Martinez, S., Feliu, L., Planas, M., and Puig, T. (2024). Inhibition of Cancer Stem-like Cells by Curcumin and Other Polyphenol Derivatives in MDA-MB-231 TNBC Cells. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25137446"},{"key":"ref_207","first-page":"480","article-title":"Curcumin rescues breast cells from epithelial-mesenchymal transition and invasion induced by anti-miR-34a","volume":"56","author":"Gallardo","year":"2020","journal-title":"Int. J. Oncol."},{"key":"ref_208","first-page":"1243","article-title":"Curcumin for the Prevention of Epithelial-Mesenchymal Transition in Endoxifen-Treated MCF-7 Breast Cancer Cel","volume":"19","author":"Paramita","year":"2018","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1055\/a-1201-2602","article-title":"The Inhibitory Effect of Curcumin on Hypoxia Inducer Factors (Hifs) as a Regulatory Factor in the Growth of Tumor Cells in Breast Cancer Stem-Like Cells","volume":"70","author":"Sarighieh","year":"2020","journal-title":"Drug Res."},{"key":"ref_210","doi-asserted-by":"crossref","unstructured":"Yang, K., Liao, Z., Wu, Y., Li, M., Guo, T., Lin, J., Li, Y., and Hu, C. (2020). Curcumin and Glu-GNPs Induce Radiosensitivity against Breast Cancer Stem-Like Cells. Biomed. Res. Int., 2020.","DOI":"10.1155\/2020\/3189217"},{"key":"ref_211","doi-asserted-by":"crossref","unstructured":"Zhou, Q., Ye, M., Lu, Y., Zhang, H., Chen, Q., Huang, S., and Su, S. (2015). Curcumin Improves the Tumoricidal Effect of Mitomycin C by Suppressing ABCG2 Expression in Stem Cell-Like Breast Cancer Cells. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0136694"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"4021","DOI":"10.2147\/DDDT.S210949","article-title":"Delivery Of Curcumin Nanoliposomes Using Surface Modified With CD133 Aptamers For Prostate Cancer","volume":"13","author":"Ma","year":"2019","journal-title":"Drug Des. Devel Ther."},{"key":"ref_213","first-page":"429","article-title":"Cytotoxicity of curcumin against CD44(+\/\u2212) prostate cancer cells: Roles of miR-383 and miR-708","volume":"13","author":"Panahizadeh","year":"2023","journal-title":"Avicenna J. Phytomed."},{"key":"ref_214","first-page":"109","article-title":"Regulation of Breast Cancer Stem Cells Associated-miRNAs by Ginger and Persimmon Extracts","volume":"15","author":"Khazbak","year":"2023","journal-title":"Egypt. Acad. J. Biol. Sci. C Physiol. Mol. Biol."},{"key":"ref_215","doi-asserted-by":"crossref","unstructured":"Sp, N., Kang, D.Y., Lee, J.M., Bae, S.W., and Jang, K.J. (2021). Potential Antitumor Effects of 6-Gingerol in p53-Dependent Mitochondrial Apoptosis and Inhibition of Tumor Sphere Formation in Breast Cancer Cells. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22094660"},{"key":"ref_216","doi-asserted-by":"crossref","unstructured":"Visan, S., Soritau, O., Tatomir, C., Baldasici, O., Balacescu, L., Balacescu, O., Muntean, P., Gherasim, C., and Pintea, A. (2023). The Bioactive Properties of Carotenoids from Lipophilic Sea buckthorn Extract (Hippophae rhamnoides L.) in Breast Cancer Cell Lines. Molecules, 28.","DOI":"10.3390\/molecules28114486"},{"key":"ref_217","doi-asserted-by":"crossref","unstructured":"Lee, W.S., Shin, J.S., Jang, S.Y., Chung, K.S., Kim, S.D., Cho, C.W., Hong, H.D., Rhee, Y.K., and Lee, K.T. (2024). Anti-Metastatic Effects of Standardized Polysaccharide Fraction from Diospyros kaki Leaves via GSK3beta\/beta-Catenin and JNK Inactivation in Human Colon Cancer Cells. Polymers, 16.","DOI":"10.3390\/polym16091275"},{"key":"ref_218","doi-asserted-by":"crossref","unstructured":"Artusa, V., Calabrone, L., Mortara, L., Peri, F., and Bruno, A. (2023). Microbiota-Derived Natural Products Targeting Cancer Stem Cells: Inside the Gut Pharma Factory. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24054997"},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1158\/1940-6207.CAPR-14-0182","article-title":"Dietary tomato and lycopene impact androgen signaling- and carcinogenesis-related gene expression during early TRAMP prostate carcinogenesis","volume":"7","author":"Wan","year":"2014","journal-title":"Cancer Prev. Res."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.bbrc.2022.04.126","article-title":"Lycopene enhances the sensitivity of castration-resistant prostate cancer to enzalutamide through the AKT\/EZH2\/ androgen receptor signaling pathway","volume":"613","author":"Chen","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"224","DOI":"10.15430\/JCP.2019.24.4.224","article-title":"Effects of beta-carotene on Expression of Selected MicroRNAs, Histone Acetylation, and DNA Methylation in Colon Cancer Stem Cells","volume":"24","author":"Kim","year":"2019","journal-title":"J. Cancer Prev."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"161","DOI":"10.4162\/nrp.2022.16.2.161","article-title":"beta-carotene regulates cancer stemness in colon cancer in vivo and in vitro","volume":"16","author":"Lee","year":"2022","journal-title":"Nutr. Res. Pract."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"62","DOI":"10.4162\/nrp.2024.18.1.62","article-title":"Combination of oxaliplatin and beta-carotene suppresses colorectal cancer by regulating cell cycle, apoptosis, and cancer stemness in vitro","volume":"18","author":"Lee","year":"2024","journal-title":"Nutr. Res. Pract."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1021\/acs.molpharmaceut.2c00876","article-title":"Combining beta-Carotene with 5-FU via Polymeric Nanoparticles as a Novel Therapeutic Strategy to Overcome uL3-Mediated Chemoresistance in p53-Deleted Colorectal Cancer Cells","volume":"20","author":"Carotenuto","year":"2023","journal-title":"Mol. Pharm."},{"key":"ref_225","first-page":"2119","article-title":"Lutein inhibits proliferation, invasion and migration of hypoxic breast cancer cells via downregulation of HES1","volume":"52","author":"Li","year":"2018","journal-title":"Int. J. Oncol."},{"key":"ref_226","doi-asserted-by":"crossref","unstructured":"Ahn, Y.T., Kim, M.S., Kim, Y.S., and An, W.G. (2020). Astaxanthin Reduces Stemness Markers in BT20 and T47D Breast Cancer Stem Cells by Inhibiting Expression of Pontin and Mutant p53. Mar. Drugs, 18.","DOI":"10.3390\/md18110577"},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/1475-2867-13-39","article-title":"Assessment of potential anti-cancer stem cell activity of marine algal compounds using an in vitro mammosphere assay","volume":"13","author":"Sterrenberg","year":"2013","journal-title":"Cancer Cell Int."},{"key":"ref_228","doi-asserted-by":"crossref","unstructured":"Gullu, N., Kobelt, D., Brim, H., Rahman, S., Timm, L., Smith, J., Soleimani, A., Di Marco, S., Bisti, S., and Ashktorab, H. (2020). Saffron Crudes and Compounds Restrict MACC1-Dependent Cell Proliferation and Migration of Colorectal Cancer Cells. Cells, 9.","DOI":"10.3390\/cells9081829"},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1097\/MS9.0000000000001691","article-title":"Crocin inhibit the metastasis of MDA-MB-231 cell line by suppressing epithelial to mesenchymal transition through WNT\/beta-catenin signalling pathway","volume":"86","author":"Ghorbanzadeh","year":"2024","journal-title":"Ann. Med. Surg."},{"key":"ref_230","doi-asserted-by":"crossref","unstructured":"Khan, M., Hearn, K., Parry, C., Rashid, M., Brim, H., Ashktorab, H., and Kwabi-Addo, B. (2023). Mechanism of Antitumor Effects of Saffron in Human Prostate Cancer Cells. Nutrients, 16.","DOI":"10.3390\/nu16010114"},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"94","DOI":"10.3892\/or.2024.8753","article-title":"Ursolic acid inhibits the proliferation of triple-negative breast cancer stem-like cells through NRF2-mediated ferroptosis","volume":"52","author":"Yang","year":"2024","journal-title":"Oncol. Rep."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"434","DOI":"10.3746\/pnf.2021.26.4.434","article-title":"Ursolic Acid Decreases the Proliferation of MCF-7 Cell-Derived Breast Cancer Stem-Like Cells by Modulating the ERK and PI3K\/AKT Signaling Pathways","volume":"26","author":"Kim","year":"2021","journal-title":"Prev. Nutr. Food Sci."},{"key":"ref_233","doi-asserted-by":"crossref","unstructured":"Liao, W.L., Liu, Y.F., Ying, T.H., Shieh, J.C., Hung, Y.T., Lee, H.J., Shen, C.Y., and Cheng, C.W. (2022). Inhibitory Effects of Ursolic Acid on the Stemness and Progression of Human Breast Cancer Cells by Modulating Argonaute-2. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24010366"},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.32604\/biocell.2024.051074","article-title":"Oleanolic acid inhibits colon cancer cell stemness and reverses chemoresistance by suppressing JAK2\/STAT3 signaling pathway","volume":"48","author":"Chen","year":"2024","journal-title":"Biocell"},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"100418","DOI":"10.1016\/j.fochx.2022.100418","article-title":"Nuts as functional foods: Variation of nutritional and phytochemical profiles and their in vitro bioactive properties","volume":"15","author":"Wojdylo","year":"2022","journal-title":"Food Chem. X"},{"key":"ref_236","doi-asserted-by":"crossref","unstructured":"Aggarwal, V., Kashyap, D., Sak, K., Tuli, H.S., Jain, A., Chaudhary, A., Garg, V.K., Sethi, G., and Yerer, M.B. (2019). Molecular Mechanisms of Action of Tocotrienols in Cancer: Recent Trends and Advancements. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20030656"},{"key":"ref_237","doi-asserted-by":"crossref","unstructured":"Gu, W., Prasadam, I., Yu, M., Zhang, F., Ling, P., Xiao, Y., and Yu, C. (2015). Gamma tocotrienol targets tyrosine phosphatase SHP2 in mammospheres resulting in cell death through RAS\/ERK pathway. BMC Cancer, 15.","DOI":"10.1186\/s12885-015-1614-1"},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1111\/cpr.12270","article-title":"gamma-Tocotrienol reversal of epithelial-to-mesenchymal transition in human breast cancer cells is associated with inhibition of canonical Wnt signalling","volume":"49","author":"Ahmed","year":"2016","journal-title":"Cell Prolif."},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1002\/ijc.25546","article-title":"Gamma-tocotrienol as an effective agent in targeting prostate cancer stem cell-like population","volume":"128","author":"Luk","year":"2011","journal-title":"Int. J. Cancer"},{"key":"ref_240","first-page":"1391","article-title":"Suppressive Effect of Delta-Tocotrienol on Hypoxia Adaptation of Prostate Cancer Stem-like Cells","volume":"38","author":"Kaneko","year":"2018","journal-title":"Anticancer. Res."},{"key":"ref_241","doi-asserted-by":"crossref","unstructured":"Dacrema, M., Ali, A., Ullah, H., Khan, A., Di Minno, A., Xiao, J., Martins, A.M.C., and Daglia, M. (2022). Spice-Derived Bioactive Compounds Confer Colorectal Cancer Prevention via Modulation of Gut Microbiota. Cancers, 14.","DOI":"10.3390\/cancers14225682"},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/s10555-023-10117-y","article-title":"Short-chain fatty acids in cancer pathogenesis","volume":"42","author":"Feitelson","year":"2023","journal-title":"Cancer Metastasis Rev."},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.mcp.2015.09.004","article-title":"Quantum dot nanoprobe-based high-content monitoring of notch pathway inhibition of breast cancer stem cell by capsaicin","volume":"29","author":"Shim","year":"2015","journal-title":"Mol. Cell Probes"},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1002\/ptr.6563","article-title":"Capsaicin suppressed activity of prostate cancer stem cells by inhibition of Wnt\/beta-catenin pathway","volume":"34","author":"Zhu","year":"2020","journal-title":"Phytother. Res."},{"key":"ref_245","doi-asserted-by":"crossref","unstructured":"Hakeem, A.N., El-Kersh, D.M., Hammam, O., Elhosseiny, A., Zaki, A., Kamel, K., Yasser, L., Barsom, M., Ahmed, M., and Gamal, M. (2024). Piperine enhances doxorubicin sensitivity in triple-negative breast cancer by targeting the PI3K\/Akt\/mTOR pathway and cancer stem cells. Sci. Rep., 14.","DOI":"10.1038\/s41598-024-65508-0"},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.sajb.2024.01.065","article-title":"Standardized extract and its compounds from fruits of Piper longum suppress MDA-MB-231 cancer stem cells via down-regulation of intracellular signals","volume":"167","author":"Ly","year":"2024","journal-title":"S. Afr. J. Bot."},{"key":"ref_247","doi-asserted-by":"crossref","unstructured":"Talib, W.H., Baban, M.M., Azzam, A.O., Issa, J.J., Ali, A.Y., AlSuwais, A.K., Allala, S., and Al Kury, L.T. (2024). Allicin and Cancer Hallmarks. Molecules, 29.","DOI":"10.3390\/molecules29061320"},{"key":"ref_248","doi-asserted-by":"crossref","unstructured":"Brugnoli, F., Tedeschi, P., Grassilli, S., Maietti, A., Brandolini, V., and Bertagnolo, V. (2021). Ethanol-based garlic extract prevents malignant evolution of non-invasive breast tumor cells induced by moderate hypoxia. Biomed. Pharmacother., 142.","DOI":"10.1016\/j.biopha.2021.112052"},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"13495","DOI":"10.1074\/jbc.M116.715219","article-title":"Forkhead Box Q1 Is a Novel Target of Breast Cancer Stem Cell Inhibition by Diallyl Trisulfide","volume":"291","author":"Kim","year":"2016","journal-title":"J. Biol. Chem."},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"4134","DOI":"10.1002\/jcb.26613","article-title":"Diallyl Trisulfide inhibits breast cancer stem cells via suppression of Wnt\/beta-catenin pathway","volume":"119","author":"Li","year":"2018","journal-title":"J. Cell Biochem."},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"592","DOI":"10.2174\/1568009617666171024165657","article-title":"Diallyl Disulfide Inhibits Breast Cancer Stem Cell Progression and Glucose Metabolism by Targeting CD44\/PKM2\/AMPK Signaling","volume":"18","author":"Xie","year":"2018","journal-title":"Curr. Cancer Drug Targets"},{"key":"ref_252","doi-asserted-by":"crossref","unstructured":"Shoaib, S., Ansari, M.A., Ghazwani, M., Hani, U., Jamous, Y.F., Alali, Z., Wahab, S., Ahmad, W., Weir, S.A., and Alomary, M.N. (2023). Prospective Epigenetic Actions of Organo-Sulfur Compounds against Cancer: Perspectives and Molecular Mechanisms. Cancers, 15.","DOI":"10.3390\/cancers15030697"},{"key":"ref_253","doi-asserted-by":"crossref","unstructured":"Miekus, N., Marszalek, K., Podlacha, M., Iqbal, A., Puchalski, C., and Swiergiel, A.H. (2020). Health Benefits of Plant-Derived Sulfur Compounds, Glucosinolates, and Organosulfur Compounds. Molecules, 25.","DOI":"10.3390\/molecules25173804"},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"153493","DOI":"10.1016\/j.phymed.2021.153493","article-title":"Cancer-preventive effect of phenethyl isothiocyanate through tumor microenvironment regulation in a colorectal cancer stem cell xenograft model","volume":"84","author":"Shin","year":"2021","journal-title":"Phytomedicine"},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"337","DOI":"10.3892\/or.2020.7860","article-title":"Phenethyl isothiocyanate reduces breast cancer stem cell-like properties by epigenetic reactivation of CDH1","volume":"45","author":"Zhang","year":"2021","journal-title":"Oncol. Rep."},{"key":"ref_256","doi-asserted-by":"crossref","unstructured":"Pereira, L.P., Silva, P., Duarte, M., Rodrigues, L., Duarte, C.M., Albuquerque, C., and Serra, A.T. (2017). Targeting Colorectal Cancer Proliferation, Stemness and Metastatic Potential Using Brassicaceae Extracts Enriched in Isothiocyanates: A 3D Cell Model-Based Study. Nutrients, 9.","DOI":"10.3390\/nu9040368"},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"2580","DOI":"10.1158\/1078-0432.CCR-09-2937","article-title":"Sulforaphane, a dietary component of broccoli\/broccoli sprouts, inhibits breast cancer stem cells","volume":"16","author":"Li","year":"2010","journal-title":"Clin. Cancer Res."},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"4896","DOI":"10.1038\/s41388-020-1335-z","article-title":"Targeting STAT3 signaling using stabilised sulforaphane (SFX-01) inhibits endocrine resistant stem-like cells in ER-positive breast cancer","volume":"39","author":"Simoes","year":"2020","journal-title":"Oncogene"},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.canlet.2017.02.023","article-title":"Sulforaphane enhances the anticancer activity of taxanes against triple negative breast cancer by killing cancer stem cells","volume":"394","author":"Burnett","year":"2017","journal-title":"Cancer Lett."},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1002\/jcb.25541","article-title":"Sulforaphane Inhibits c-Myc-Mediated Prostate Cancer Stem-Like Traits","volume":"117","author":"Vyas","year":"2016","journal-title":"J. Cell Biochem."},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.3892\/ijo.2014.2335","article-title":"Sulforaphane and TRAIL induce a synergistic elimination of advanced prostate cancer stem-like cells","volume":"44","author":"Labsch","year":"2014","journal-title":"Int. J. Oncol."},{"key":"ref_262","first-page":"307","article-title":"n-3 PUFAs as Modulators of Stem Cells in Prevention of Colorectal Cancer","volume":"8","author":"Kansal","year":"2012","journal-title":"Curr. Color. Cancer Rep."},{"key":"ref_263","doi-asserted-by":"crossref","unstructured":"Goncalves, B., Pinto, T., Aires, A., Morais, M.C., Bacelar, E., Anjos, R., Ferreira-Cardoso, J., Oliveira, I., Vilela, A., and Cosme, F. (2023). Composition of Nuts and Their Potential Health Benefits-An Overview. Foods, 12.","DOI":"10.3390\/foods12050942"},{"key":"ref_264","doi-asserted-by":"crossref","unstructured":"De Carlo, F., Witte, T.R., Hardman, W.E., and Claudio, P.P. (2013). Omega-3 eicosapentaenoic acid decreases CD133 colon cancer stem-like cell marker expression while increasing sensitivity to chemotherapy. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0069760"},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.jnutbio.2012.03.023","article-title":"N-3 PUFAs have antiproliferative and apoptotic effects on human colorectal cancer stem-like cells in vitro","volume":"24","author":"Yang","year":"2013","journal-title":"J. Nutr. Biochem."},{"key":"ref_266","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s13402-015-0254-4","article-title":"Treatment of LS174T colorectal cancer stem-like cells with n-3 PUFAs induces growth suppression through inhibition of survivin expression and induction of caspase-3 activation","volume":"39","author":"Sam","year":"2016","journal-title":"Cell Oncol."},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s12263-018-0596-4","article-title":"Omega-3 fatty acid DHA modulates p53, survivin, and microRNA-16-1 expression in KRAS-mutant colorectal cancer stem-like cells","volume":"13","author":"Sam","year":"2018","journal-title":"Genes. Nutr."},{"key":"ref_268","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s00280-020-04157-2","article-title":"Cyclooxygenase activity mediates colorectal cancer cell resistance to the omega-3 polyunsaturated fatty acid eicosapentaenoic acid","volume":"87","author":"Volpato","year":"2021","journal-title":"Cancer Chemother. Pharmacol."},{"key":"ref_269","doi-asserted-by":"crossref","first-page":"7053","DOI":"10.7150\/thno.41388","article-title":"Lipid metabolism alteration contributes to and maintains the properties of cancer stem cells","volume":"10","author":"Li","year":"2020","journal-title":"Theranostics"},{"key":"ref_270","doi-asserted-by":"crossref","first-page":"106224","DOI":"10.1016\/j.jff.2024.106224","article-title":"Oleic acid inhibits the migration and invasion of breast cancer cells with stemness characteristics through oxidative stress-mediated attenuation of the FAK\/AKT\/NF-\u03baB pathway","volume":"116","author":"Kim","year":"2024","journal-title":"J. Funct. Foods"},{"key":"ref_271","doi-asserted-by":"crossref","unstructured":"Kim, H.S., Jung, M., Choi, S.K., Moon, W.K., and Kim, S.J. (2016). Different Biological Action of Oleic Acid in ALDHhigh and ALDHlow Subpopulations Separated from Ductal Carcinoma In Situ of Breast Cancer. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0160835"},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1186\/s12935-022-02824-3","article-title":"Oleic acid from cancer-associated fibroblast promotes cancer cell stemness by stearoyl-CoA desaturase under glucose-deficient condition","volume":"22","author":"Hwang","year":"2022","journal-title":"Cancer Cell Int."},{"key":"ref_273","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.bbrc.2019.08.137","article-title":"Clinical and biochemical relevance of monounsaturated fatty acid metabolism targeting strategy for cancer stem cell elimination in colon cancer","volume":"519","author":"Choi","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_274","doi-asserted-by":"crossref","unstructured":"Choudhury, P., Barua, A., Roy, A., Pattanayak, R., Bhattacharyya, M., and Saha, P. (2020). Eugenol restricts Cancer Stem Cell population by degradation of beta-catenin via N-terminal Ser37 phosphorylation-an in vivo and in vitro experimental evaluation. Chem. Biol. Interact., 316.","DOI":"10.1016\/j.cbi.2020.108938"},{"key":"ref_275","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/mc.22758","article-title":"Eugenol potentiates cisplatin anti-cancer activity through inhibition of ALDH-positive breast cancer stem cells and the NF-kappaB signaling pathway","volume":"57","author":"Islam","year":"2018","journal-title":"Mol. Carcinog."},{"key":"ref_276","doi-asserted-by":"crossref","first-page":"111500","DOI":"10.1016\/j.yexcr.2019.111500","article-title":"Cinnamaldehyde enhances apoptotic effect of oxaliplatin and reverses epithelial-mesenchymal transition and stemnness in hypoxic colorectal cancer cells","volume":"383","author":"Wu","year":"2019","journal-title":"Exp. Cell Res."},{"key":"ref_277","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1007\/s10549-012-2388-7","article-title":"2-Hydroxycinnamaldehyde inhibits the epithelial-mesenchymal transition in breast cancer cells","volume":"137","author":"Ismail","year":"2013","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_278","doi-asserted-by":"crossref","first-page":"522","DOI":"10.5306\/wjco.v12.i7.522","article-title":"Therapeutic potential of thymoquinone in combination therapy against cancer and cancer stem cells","volume":"12","author":"Fatfat","year":"2021","journal-title":"World J. Clin. Oncol."},{"key":"ref_279","doi-asserted-by":"crossref","unstructured":"Karim, S., Burzangi, A.S., Ahmad, A., Siddiqui, N.A., Ibrahim, I.M., Sharma, P., Abualsunun, W.A., and Gabr, G.A. (2022). PI3K-AKT Pathway Modulation by Thymoquinone Limits Tumor Growth and Glycolytic Metabolism in Colorectal Cancer. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23042305"},{"key":"ref_280","doi-asserted-by":"crossref","unstructured":"Bashmail, H.A., Alamoudi, A.A., Noorwali, A., Hegazy, G.A., Ajabnoor, G.M., and Al-Abd, A.M. (2020). Thymoquinone Enhances Paclitaxel Anti-Breast Cancer Activity via Inhibiting Tumor-Associated Stem Cells Despite Apparent Mathematical Antagonism. Molecules, 25.","DOI":"10.3390\/molecules25020426"},{"key":"ref_281","doi-asserted-by":"crossref","first-page":"211","DOI":"10.5530\/ijpi.2020.2.39","article-title":"Combination of Docetaxel with Thymoquinone in Nanoemulsion Impedes the Migration of Breast Cancer Stem Cells","volume":"10","author":"Alkhatib","year":"2020","journal-title":"Int. J. Pharm. Investig."},{"key":"ref_282","doi-asserted-by":"crossref","unstructured":"Haiaty, S., Rashidi, M.R., Akbarzadeh, M., Bazmani, A., Mostafazadeh, M., Nikanfar, S., Zibaei, Z., Rahbarghazi, R., and Nouri, M. (2021). Thymoquinone inhibited vasculogenic capacity and promoted mesenchymal-epithelial transition of human breast cancer stem cells. BMC Complement. Med. Ther., 21.","DOI":"10.1186\/s12906-021-03246-w"},{"key":"ref_283","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.18632\/oncotarget.27426","article-title":"Thymoquinone induces apoptosis and DNA damage in 5-Fluorouracil-resistant colorectal cancer stem\/progenitor cells","volume":"11","author":"Ballout","year":"2020","journal-title":"Oncotarget"},{"key":"ref_284","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1002\/fft2.92","article-title":"Possible actions of inulin as prebiotic polysaccharide: A review","volume":"2","author":"Teferra","year":"2021","journal-title":"Food Front."},{"key":"ref_285","doi-asserted-by":"crossref","unstructured":"Sheng, W., Ji, G., and Zhang, L. (2023). Immunomodulatory effects of inulin and its intestinal metabolites. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1224092"},{"key":"ref_286","doi-asserted-by":"crossref","unstructured":"Zhang, W., An, Y., Qin, X., Wu, X., Wang, X., Hou, H., Song, X., Liu, T., Wang, B., and Huang, X. (2021). Gut Microbiota-Derived Metabolites in Colorectal Cancer: The Bad and the Challenges. Front. Oncol., 11.","DOI":"10.3389\/fonc.2021.739648"},{"key":"ref_287","doi-asserted-by":"crossref","unstructured":"He, Y., Ling, Y., Zhang, Z., Mertens, R.T., Cao, Q., Xu, X., Guo, K., Shi, Q., Zhang, X., and Huo, L. (2023). Butyrate reverses ferroptosis resistance in colorectal cancer by inducing c-Fos-dependent xCT suppression. Redox Biol., 65.","DOI":"10.1016\/j.redox.2023.102822"},{"key":"ref_288","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/nrclinonc.2010.196","article-title":"Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways","volume":"8","author":"Takebe","year":"2011","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"ref_289","doi-asserted-by":"crossref","unstructured":"Zheng, Y., Wang, L., Yin, L., Yao, Z., Tong, R., Xue, J., and Lu, Y. (2022). Lung Cancer Stem Cell Markers as Therapeutic Targets: An Update on Signaling Pathways and Therapies. Front. Oncol., 12.","DOI":"10.3389\/fonc.2022.873994"},{"key":"ref_290","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1186\/s12943-023-01877-w","article-title":"Regulation and signaling pathways in cancer stem cells: Implications for targeted therapy for cancer","volume":"22","author":"Zeng","year":"2023","journal-title":"Mol. Cancer"},{"key":"ref_291","doi-asserted-by":"crossref","first-page":"5","DOI":"10.21037\/sci.2018.02.02","article-title":"Targeting Notch signalling pathway of cancer stem cells","volume":"5","author":"Venkatesh","year":"2018","journal-title":"Stem Cell Investig."},{"key":"ref_292","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41392-021-00762-6","article-title":"Wnt\/beta-catenin signalling: Function, biological mechanisms, and therapeutic opportunities","volume":"7","author":"Liu","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_293","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s13045-020-00901-6","article-title":"Emerging agents that target signaling pathways in cancer stem cells","volume":"13","author":"Yang","year":"2020","journal-title":"J. Hematol. Oncol."},{"key":"ref_294","doi-asserted-by":"crossref","first-page":"17023","DOI":"10.1038\/sigtrans.2017.23","article-title":"NF-kappaB signaling in inflammation","volume":"2","author":"Liu","year":"2017","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_295","doi-asserted-by":"crossref","unstructured":"Rinkenbaugh, A.L., and Baldwin, A.S. (2016). The NF-kappaB Pathway and Cancer Stem Cells. Cells, 5.","DOI":"10.3390\/cells5020016"},{"key":"ref_296","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/s41392-023-01608-z","article-title":"Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease","volume":"8","author":"Panwar","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_297","doi-asserted-by":"crossref","unstructured":"Galoczova, M., Coates, P., and Vojtesek, B. (2018). STAT3, stem cells, cancer stem cells and p63. Cell Mol. Biol. Lett., 23.","DOI":"10.1186\/s11658-018-0078-0"},{"key":"ref_298","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/s41392-021-00791-1","article-title":"The JAK\/STAT signaling pathway: From bench to clinic","volume":"6","author":"Hu","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_299","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1007\/s11130-019-00760-8","article-title":"Cinnamon Shows Antidiabetic Properties that Are Species-Specific: Effects on Enzyme Activity Inhibition and Starch Digestion","volume":"74","author":"Hayward","year":"2019","journal-title":"Plant Foods Hum. Nutr."},{"key":"ref_300","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/s41392-020-0110-5","article-title":"Targeting cancer stem cell pathways for cancer therapy","volume":"5","author":"Yang","year":"2020","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_301","doi-asserted-by":"crossref","unstructured":"Kim, D.H., Xing, T., Yang, Z., Dudek, R., Lu, Q., and Chen, Y.H. (2017). Epithelial Mesenchymal Transition in Embryonic Development, Tissue Repair and Cancer: A Comprehensive Overview. J. Clin. Med., 7.","DOI":"10.3390\/jcm7010001"},{"key":"ref_302","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/nrclinonc.2017.44","article-title":"EMT, CSCs, and drug resistance: The mechanistic link and clinical implications","volume":"14","author":"Shibue","year":"2017","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"ref_303","doi-asserted-by":"crossref","unstructured":"Tanabe, S., Quader, S., Cabral, H., and Ono, R. (2020). Interplay of EMT and CSC in Cancer and the Potential Therapeutic Strategies. Front. Pharmacol., 11.","DOI":"10.3389\/fphar.2020.00904"},{"key":"ref_304","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1634\/stemcells.2007-0440","article-title":"Isolation and molecular characterization of cancer stem cells in MMTV-Wnt-1 murine breast tumors","volume":"26","author":"Cho","year":"2008","journal-title":"Stem Cells"},{"key":"ref_305","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/s41392-024-01851-y","article-title":"Cancer stem cells: Advances in knowledge and implications for cancer therapy","volume":"9","author":"Chu","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_306","doi-asserted-by":"crossref","first-page":"217","DOI":"10.3109\/03009734.2012.659294","article-title":"Cancer cell differentiation heterogeneity and aggressive behavior in solid tumors","volume":"117","author":"Jogi","year":"2012","journal-title":"Ups. J. Med. Sci."},{"key":"ref_307","doi-asserted-by":"crossref","first-page":"4789","DOI":"10.2147\/CMAR.S253369","article-title":"Biochemical Markers of Colorectal Cancer\u2014Present and Future","volume":"12","author":"Jelski","year":"2020","journal-title":"Cancer Manag. Res."},{"key":"ref_308","doi-asserted-by":"crossref","unstructured":"Gao, Y., Wang, J., Zhou, Y., Sheng, S., Qian, S.Y., and Huo, X. (2018). Evaluation of Serum CEA, CA19-9, CA72-4, CA125 and Ferritin as Diagnostic Markers and Factors of Clinical Parameters for Colorectal Cancer. Sci. Rep., 8.","DOI":"10.1038\/s41598-018-21048-y"},{"key":"ref_309","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1097\/MOU.0000000000000128","article-title":"Serum markers in prostate cancer detection","volume":"25","author":"Bratt","year":"2015","journal-title":"Curr. Opin. Urol."},{"key":"ref_310","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.jons.2017.01.001","article-title":"Tumor markers of breast cancer: New prospectives","volume":"3","author":"Kabel","year":"2017","journal-title":"J. Oncol. Sci."},{"key":"ref_311","doi-asserted-by":"crossref","first-page":"15065","DOI":"10.1038\/nrdp.2015.65","article-title":"Colorectal cancer","volume":"1","author":"Kuipers","year":"2015","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_312","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.yasu.2013.03.001","article-title":"What is the optimal means of staging colon cancer?","volume":"47","author":"Arena","year":"2013","journal-title":"Adv. Surg."},{"key":"ref_313","doi-asserted-by":"crossref","first-page":"103781","DOI":"10.1016\/j.critrevonc.2022.103781","article-title":"The current staging and classification systems of breast cancer and their pitfalls: Is it possible to integrate the complexity of this neoplasm into a unified staging system?","volume":"178","author":"Araujo","year":"2022","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"ref_314","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3348\/kjr.2018.0231","article-title":"Introduction of a New Staging System of Breast Cancer for Radiologists: An Emphasis on the Prognostic Stage","volume":"20","author":"Koh","year":"2019","journal-title":"Korean J. Radiol."},{"key":"ref_315","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/s41585-018-0060-7","article-title":"Landmarks in prostate cancer","volume":"15","author":"Sathianathen","year":"2018","journal-title":"Nat. Rev. Urol."},{"key":"ref_316","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/nrc.2017.103","article-title":"Differentiation therapy revisited","volume":"18","year":"2018","journal-title":"Nat. Rev. Cancer"},{"key":"ref_317","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1056\/NEJMoa1300874","article-title":"Retinoic acid and arsenic trioxide for acute promyelocytic leukemia","volume":"369","author":"Avvisati","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"ref_318","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1007\/s00280-018-3654-0","article-title":"A phase 1 dose-escalation study on the safety, tolerability and activity of liposomal curcumin (LipocurcTM) in patients with locally advanced or metastatic cancer","volume":"82","author":"Greil","year":"2018","journal-title":"Cancer Chemother. Pharmacol."},{"key":"ref_319","doi-asserted-by":"crossref","first-page":"8","DOI":"10.4161\/cbt.9.1.10392","article-title":"Phase I dose escalation trial of docetaxel plus curcumin in patients with advanced and metastatic breast cancer","volume":"9","author":"Kwiatkowski","year":"2010","journal-title":"Cancer Biol. Ther."},{"key":"ref_320","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1177\/153537020222701007","article-title":"Effects of lycopene supplementation in patients with localized prostate cancer","volume":"227","author":"Kucuk","year":"2002","journal-title":"Exp. Biol. Med."},{"key":"ref_321","doi-asserted-by":"crossref","unstructured":"Zhuang, E., Uchio, E., Lilly, M., Zi, X., and Fruehauf, J.P. (2021). A phase II study of docetaxel plus lycopene in metastatic castrate resistant prostate cancer. Biomed. Pharmacother., 143.","DOI":"10.1016\/j.biopha.2021.112226"},{"key":"ref_322","doi-asserted-by":"crossref","first-page":"e1627","DOI":"10.1002\/ctm2.1627","article-title":"A phase I study of docetaxel plus synthetic lycopene in metastatic prostate cancer patients","volume":"14","author":"Lilly","year":"2024","journal-title":"Clin. Transl. Med."},{"key":"ref_323","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1475-2891-14-9","article-title":"Prospective double-blind randomized study on the efficacy and safety of an n-3 fatty acid enriched intravenous fat emulsion in postsurgical gastric and colorectal cancer patients","volume":"14","author":"Ma","year":"2015","journal-title":"Nutr. J."},{"key":"ref_324","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1093\/ajcn\/nqz281","article-title":"Effects of perioperative intravenous omega-3 fatty acids in colon cancer patients: A randomized, double-blind, placebo-controlled clinical trial","volume":"111","author":"Bakker","year":"2020","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_325","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.3889\/oamjms.2018.333","article-title":"Comparison of the Effects of Omega 3 and Vitamin E on Palcitaxel-Induced Peripheral Neuropathy","volume":"6","author":"Anoushirvani","year":"2018","journal-title":"Open Access Maced. J. Med. Sci."},{"key":"ref_326","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1007\/s00520-023-08082-x","article-title":"A pilot randomized, placebo-controlled, double-blind study of omega-3 fatty acids to prevent paclitaxel-associated acute pain syndrome in breast cancer patients: Alliance A22_Pilot2","volume":"31","author":"Tawfik","year":"2023","journal-title":"Support. Care Cancer"},{"key":"ref_327","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1136\/gutjnl-2017-315242","article-title":"Calcium and vitamin D supplementation and increased risk of serrated polyps: Results from a randomised clinical trial","volume":"68","author":"Crockett","year":"2019","journal-title":"Gut"},{"key":"ref_328","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1007\/s10549-017-4562-4","article-title":"Vitamin D supplementation decreases serum 27-hydroxycholesterol in a pilot breast cancer trial","volume":"167","author":"Going","year":"2018","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_329","doi-asserted-by":"crossref","first-page":"8680","DOI":"10.1158\/1078-0432.CCR-05-1237","article-title":"Phase I\/II study of 19-nor-1alpha-25-dihydroxyvitamin D2 (paricalcitol) in advanced, androgen-insensitive prostate cancer","volume":"11","author":"Schwartz","year":"2005","journal-title":"Clin. Cancer Res."},{"key":"ref_330","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.2217\/pgs-2016-0025","article-title":"Systems analysis of the prostate transcriptome in African-American men compared with European-American men","volume":"17","author":"Hardiman","year":"2016","journal-title":"Pharmacogenomics"},{"key":"ref_331","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1210\/jc.2012-1451","article-title":"Vitamin D3 supplementation at 4000 international units per day for one year results in a decrease of positive cores at repeat biopsy in subjects with low-risk prostate cancer under active surveillance","volume":"97","author":"Marshall","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_332","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1007\/s00262-006-0224-9","article-title":"Phase II study of interleukin-2 and 13-cis-retinoic acid as maintenance therapy in metastatic colorectal cancer","volume":"56","author":"Recchia","year":"2007","journal-title":"Cancer Immunol. Immunother."},{"key":"ref_333","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1007\/s10637-010-9478-3","article-title":"A pilot phase II trial of all-trans retinoic acid (Vesanoid) and paclitaxel (Taxol) in patients with recurrent or metastatic breast cancer","volume":"29","author":"Bryan","year":"2011","journal-title":"Investig. New Drugs"},{"key":"ref_334","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1200\/JCO.2002.20.2.538","article-title":"13-cis retinoic acid and complete androgen blockade in advanced hormone-naive prostate cancer patients: Report of a phase II randomized study","volume":"20","author":"Ferrari","year":"2002","journal-title":"J. Clin. Oncol."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/2\/631\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T10:28:05Z","timestamp":1759919285000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/2\/631"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,13]]},"references-count":334,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,1]]}},"alternative-id":["ijms26020631"],"URL":"https:\/\/doi.org\/10.3390\/ijms26020631","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,13]]}}}