{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:51:52Z","timestamp":1791499912729,"version":"4.3.4"},"reference-count":55,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T00:00:00Z","timestamp":1736812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"International Centre for Genetic Engineering and Biotechnology (ICGEB)","award":["HDI\/CRP\/009"],"award-info":[{"award-number":["HDI\/CRP\/009"]}]},{"name":"International Centre for Genetic Engineering and Biotechnology (ICGEB)","award":["U113516"],"award-info":[{"award-number":["U113516"]}]},{"name":"National Research Foundation of South Africa","award":["HDI\/CRP\/009"],"award-info":[{"award-number":["HDI\/CRP\/009"]}]},{"name":"National Research Foundation of South Africa","award":["U113516"],"award-info":[{"award-number":["U113516"]}]},{"name":"University of Fort Hare","award":["HDI\/CRP\/009"],"award-info":[{"award-number":["HDI\/CRP\/009"]}]},{"name":"University of Fort Hare","award":["U113516"],"award-info":[{"award-number":["U113516"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Platycarpha glomerata (Thunb.) Less. has recently become a plant species of interest to researchers due to its biological activities and less toxic effects. Therefore, the aim of the study is to evaluate the in vitro anticancer potential and phytochemical constituents of P. glomerata plant extracts. Phytochemical screening and FTIR were carried out using standard methods. The antioxidant activity was accessed by determining its ability to scavenge the DPPH radical and nitric oxide radical, whereas the anticancer activity against prostate (DU-145 and PC-3), human T-lymphocyte (SKU-T), gastric adenocarcinoma (AGS), and human prostatic epithelial (PNTA1) cell line was evaluated using the MTT assay. The phytochemical analysis revealed the presence of tannins, flavonoids, saponins, steroids, terpenoids, and cardiac glycosides. The FTIR spectrum for the aqueous extract displayed characteristic peaks for O\u2013H, C=O, C=C, and =C\u2013H stretch. The aqueous ethanol and methanol extracts showed significant dose-dependent DPPH radical scavenging capacity. The aqueous, ethanol, and methanol extracts showed minimum NO scavenging activity of 4.3%, 9.6%, and 11.7% at 2500 \u00b5g\/mL. The water extract demonstrated good activity against S. aureus, E. coli, and B. pumilus with an MIC of 0.195 mg\/mL. The ethanol and methanol extracts significantly reduced the percentage proliferation of DU-145, PC-3, and SKU-T cells at 100 \u03bcg\/mL. These extracts demonstrated strong dose-dependent DPPH and NO scavenging and antibacterial and cell proliferation inhibition activities. The strong bioactivity of P. glomerata makes it a good candidate for the isolation and identification of active compounds for anticancer and related illnesses.<\/jats:p>","DOI":"10.3390\/ijms26020646","type":"journal-article","created":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T07:35:47Z","timestamp":1736840147000},"page":"646","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Pharmacological Properties of Platycarpha glomerata Extracts\u2014A Plant Used to Treat and Manage Elephantiasis"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7140-8327","authenticated-orcid":false,"given":"Siphamandla Q. N.","family":"Lamula","sequence":"first","affiliation":[{"name":"Infectious Diseases and Medicinal Plants Research Niche Area, Botany Department, Faculty of Science and Agriculture, University of Fort Hare, Private Bag X1314, Alice 5700, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aphelele","family":"Taliwe","sequence":"additional","affiliation":[{"name":"Infectious Diseases and Medicinal Plants Research Niche Area, Botany Department, Faculty of Science and Agriculture, University of Fort Hare, Private Bag X1314, Alice 5700, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1592-9459","authenticated-orcid":false,"given":"Lisa V.","family":"Buwa-Komoreng","sequence":"additional","affiliation":[{"name":"Infectious Diseases and Medicinal Plants Research Niche Area, Botany Department, Faculty of Science and Agriculture, University of Fort Hare, Private Bag X1314, Alice 5700, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Matapo, B.B., Mpabalwani, E.M., Kaonga, P., Chitolongo Simuunza, M., Bakyaita, N., Masaninga, F., Siyumbwa, N., Siziya, S., Shamilimo, F., and Muzongwe, C. 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