{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:44:18Z","timestamp":1791567858637,"version":"4.3.4"},"reference-count":189,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T00:00:00Z","timestamp":1736899200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministerio de Ciencia e Innovaci\u00f3n, Acci\u00f3n estrat\u00e9gica en Salud","award":["PI23\/00207"],"award-info":[{"award-number":["PI23\/00207"]}]},{"name":"Ministerio de Ciencia e Innovaci\u00f3n, Acci\u00f3n estrat\u00e9gica en Salud","award":["1785344099"],"award-info":[{"award-number":["1785344099"]}]},{"name":"Ministerio de Ciencia e Innovaci\u00f3n, Acci\u00f3n estrat\u00e9gica en Salud","award":["26-23"],"award-info":[{"award-number":["26-23"]}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI23\/00207"],"award-info":[{"award-number":["PI23\/00207"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["1785344099"],"award-info":[{"award-number":["1785344099"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["26-23"],"award-info":[{"award-number":["26-23"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"name":"FIBHULP (Proyectos Luis \u00c1lvarez)","award":["PI23\/00207"],"award-info":[{"award-number":["PI23\/00207"]}]},{"name":"FIBHULP (Proyectos Luis \u00c1lvarez)","award":["1785344099"],"award-info":[{"award-number":["1785344099"]}]},{"name":"FIBHULP (Proyectos Luis \u00c1lvarez)","award":["26-23"],"award-info":[{"award-number":["26-23"]}]},{"name":"European Social Fund","award":["PI23\/00207"],"award-info":[{"award-number":["PI23\/00207"]}]},{"name":"European Social Fund","award":["1785344099"],"award-info":[{"award-number":["1785344099"]}]},{"name":"European Social Fund","award":["26-23"],"award-info":[{"award-number":["26-23"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The World Health Organization estimates that approximately 285 million people suffer from visual impairments, around 5% of which are caused by corneal pathologies. Currently, the most common clinical treatment consists of a corneal transplant (keratoplasty) from a human donor. However, worldwide demand for donor corneas amply exceeds the available supply. Lamellar keratoplasty (transplantation replacement of only one of the three layers of the cornea) is partially solving the problem of cornea undersupply. Obviously, cell therapy applied to every one of these layers will expand current therapeutic options, reducing the cost of ophthalmological interventions and increasing the effectiveness of surgery. Mesenchymal stem cells (MSCs) are adult stem cells with the capacity for self-renewal and differentiation into different cell lineages. They can be obtained from many human tissues, such as bone marrow, umbilical cord, adipose tissue, dental pulp, skin, and cornea. Their ease of collection and advantages over embryonic stem cells or induced pluripotent stem cells make them a very practical source for experimental and potential clinical applications. In this review, we focus on recent advances using MSCs from different sources to replace the damaged cells of the three corneal layers, at both the preclinical and clinical levels for specific corneal diseases.<\/jats:p>","DOI":"10.3390\/ijms26020695","type":"journal-article","created":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T09:01:02Z","timestamp":1736931662000},"page":"695","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Biomedical Application of MSCs in Corneal Regeneration and Repair"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9002-6519","authenticated-orcid":false,"given":"Maria P.","family":"De Miguel","sequence":"first","affiliation":[{"name":"Cell Engineering Laboratory, La Paz University Hospital Health Research Institute, IdiPAZ, 28046 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4937-6901","authenticated-orcid":false,"given":"Marta","family":"Cadenas-Martin","sequence":"additional","affiliation":[{"name":"Cell Engineering Laboratory, La Paz University Hospital Health Research Institute, IdiPAZ, 28046 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9661-8515","authenticated-orcid":false,"given":"Martha","family":"Stokking","sequence":"additional","affiliation":[{"name":"Cell Engineering Laboratory, La Paz University Hospital Health Research Institute, IdiPAZ, 28046 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana I.","family":"Martin-Gonzalez","sequence":"additional","affiliation":[{"name":"Cell Engineering Laboratory, La Paz University Hospital Health Research Institute, IdiPAZ, 28046 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e130","DOI":"10.1016\/S2214-109X(20)30425-3","article-title":"Trends in Prevalence of Blindness and Distance and near Vision Impairment over 30 Years: An Analysis for the Global Burden of Disease Study","volume":"9","author":"Bourne","year":"2021","journal-title":"Lancet Glob. 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