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Research on novel therapies has become a hot topic due to the reversibility of HF. Research into the molecular mechanisms of the pathology of HF and potential drug screening relies on reliable and rational biological models, mainly including animals and cells. Hence, a number of modeling approaches have been attempted based on human dietary, pathological, and physiological factors in the development of HF. In this review, classical and novel methods of modeling HF in the last 10 years were collected from electronic databases, including Web of Science, PubMed, ScienceDirect, ResearchGate, Baidu Scholar, and CNKI. Animal models of HF are usually induced by chemical toxicants, special diets, pathogenic microorganisms, surgical operations, and gene editing. The advantages and limitations of hepatic stellate cells (HSCs), organoids, and 3D coculture-based HF modeling methods established in vitro were also proposed and summarized. This information provides a scientific basis for the discovery of the pathological mechanism and treatment of HF.<\/jats:p>","DOI":"10.3390\/ijms26020696","type":"journal-article","created":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T09:01:02Z","timestamp":1736931662000},"page":"696","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["In Vivo and In Vitro Models of Hepatic Fibrosis for Pharmacodynamic Evaluation and Pathology Exploration"],"prefix":"10.3390","volume":"26","author":[{"given":"Yanting","family":"Hu","sequence":"first","affiliation":[{"name":"College of Pharmacy and Food, Southwest Minzu University, Chengdu 610093, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongrui","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Food, Southwest Minzu University, Chengdu 610093, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akida","family":"Adiham","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Food, Southwest Minzu University, Chengdu 610093, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Li","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Food, Southwest Minzu University, Chengdu 610093, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Gu","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Food, Southwest Minzu University, Chengdu 610093, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puyang","family":"Gong","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Food, Southwest Minzu University, Chengdu 610093, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"11808","DOI":"10.3389\/jpps.2023.11808","article-title":"Current investigations for liver fibrosis treatment: Between repurposing the FDA-approved drugs and the other emerging approaches","volume":"26","author":"Mohammed","year":"2023","journal-title":"J. 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