{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T19:18:32Z","timestamp":1787858312860,"version":"build-2784847793"},"reference-count":55,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T00:00:00Z","timestamp":1736985600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Research, Development, and Innovation Fund","award":["EK\u00d6P-24-3-I"],"award-info":[{"award-number":["EK\u00d6P-24-3-I"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>C-reactive protein (CRP) and estimated glomerular filtration rate (eGFR) are key biomarkers reflecting systemic inflammation and metabolic dysfunction. This study explored systemic and oral health indicators, including CRP and eGFR, as potential factors associated with periodontitis, using a longitudinal clinical dataset comprising 23,742 records from patients identified by ICD-10 codes between 2015 and 2022. Univariate Cox analysis and Gompertz models, selected based on AIC and BIC after evaluating alternative models, were employed to assess the predictive roles of CRP and eGFR in periodontitis incidence, adjusting for oral and systemic health factors. Elevated CRP (&gt;15 mg\/L) and reduced eGFR (&lt;60 mL\/min\/1.73 m2) were significant predictors of periodontitis, with hazard ratios (HR) of 1.36 [1.05\u20131.77] and 1.39 [1.08\u20131.78], respectively. Atherosclerosis (HR: 2.12 [1.11\u20134.06]), diseases of the hard tissues of the teeth (HR: 7.30 [5.45\u20139.78]), and disorders of the teeth and supporting structures (HR: 3.02 [2.05\u20134.43]) also demonstrated strong predictive associations. CRP and eGFR emerged as potential biomarkers for predicting periodontitis, enabling early interventions to prevent tooth loss and systemic complications. Patients with chronic kidney disease, atherosclerotic heart disease, and lipid metabolism disorders are at higher risk, emphasizing the need for integrated care addressing both systemic and oral health factors.<\/jats:p>","DOI":"10.3390\/ijms26020741","type":"journal-article","created":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T09:58:36Z","timestamp":1737021516000},"page":"741","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The Role of Systemic Health Indicators, Including C-Reactive Protein and eGFR, in Predicting Periodontal Disease: A Longitudinal Study"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0593-0188","authenticated-orcid":false,"given":"Amr Sayed","family":"Ghanem","sequence":"first","affiliation":[{"name":"Department of Health Informatics, Faculty of Health Sciences, University of Debrecen, 4032 Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,16]]},"reference":[{"key":"ref_1","unstructured":"(2024, December 02). The Global Status Report on Oral Health. Available online: https:\/\/www.who.int\/team\/noncommunicable-diseases\/global-status-report-on-oral-health-2022."},{"key":"ref_2","unstructured":"(2024, December 02). Oral Health. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/oral-health."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"GBD 2017 Oral Disorders Collaborators, Bernabe, E., Marcenes, W., Hernandez, C.R., Bailey, J., Abreu, L.G., Alipour, V., Amini, S., Arabloo, J., and Arefi, Z. (2020). Global, Regional, and National Levels and Trends in Burden of Oral Conditions from 1990 to 2017: A Systematic Analysis for the Global Burden of Disease 2017 Study. J. Dent. Res., 99, 362\u2013373.","DOI":"10.1177\/0022034520908533"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"S140","DOI":"10.1002\/JPER.17-0670","article-title":"Dye, Age-dependent distribution of periodontitis in two countries: Findings from NHANES 2009 to 2014 and SHIP-TREND 2008 to 2012","volume":"89","author":"Billings","year":"2018","journal-title":"J. Periodontol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1002\/JPER.21-0458","article-title":"Prevalence, extent, and severity of periodontitis among Australian older adults: Comparison of two generations","volume":"93","author":"Ju","year":"2022","journal-title":"J. Periodontol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Burton-Jeangros, C., Cullati, S., Sacker, A., and Blane, D. (2015). Oral Health Over the Life Course. A Life Course Perspective on Health Trajectories and Transitions, Springer.","DOI":"10.1007\/978-3-319-20484-0"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1177\/0022034516634663","article-title":"Oral Health\u2013related Beliefs, Behaviors, and Outcomes through the Life Course","volume":"95","author":"Broadbent","year":"2016","journal-title":"J. Dent. Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"E132","DOI":"10.5888\/pcd16.180641","article-title":"Current Knowledge on Correlations Between Highly Prevalent Dental Conditions and Chronic Diseases: An Umbrella Review","volume":"16","author":"Seitz","year":"2019","journal-title":"Prev. Chronic Dis."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"318","DOI":"10.4239\/wjd.v15.i3.318","article-title":"Periodontitis: An often-neglected complication of diabetes","volume":"15","author":"Kudiyirickal","year":"2024","journal-title":"World J. Diabetes"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Ghanem, A.S., N\u00e9meth, O., M\u00f3r\u00e9, M., and Nagy, A.C. (2024). Role of oral health in heart and vascular health: A population-based study. PLoS ONE, 19.","DOI":"10.1371\/journal.pone.0301466"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Ghanem, A.S., and Nagy, A.C. (2024). Oral healths role in diabetes risk: A cross-sectional study with sociodemographic and lifestyle insights. Front. Endocrinol., 15.","DOI":"10.3389\/fendo.2024.1342783"},{"key":"ref_12","first-page":"211","article-title":"Bidirectional Relationship between Chronic Kidney Disease & Periodontal Disease","volume":"29","author":"Wahid","year":"2013","journal-title":"Pak. J. Med. Sci."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s10096-010-1101-1","article-title":"C-reactive protein as a systemic marker of inflammation in periodontitis","volume":"30","author":"Pejcic","year":"2011","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Machado, V., Botelho, J., Escalda, C., Hussain, S.B., Luthra, S., Mascarenhas, P., Orlandi, M., Mendes, J.J., and D\u2019aiuto, F. (2021). Serum C-Reactive Protein and Periodontitis: A Systematic Review and Meta-Analysis. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.706432"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e16495","DOI":"10.7717\/peerj.16495","article-title":"Estimation of serum C-reactive protein activity in periodontal health and disease and response to treatment: A clinico-biochemical study","volume":"11","author":"Abullais","year":"2023","journal-title":"PeerJ"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Sun, J., Wang, W., Li, D., Song, J., Chen, Z., Chen, L., Smeets, R., Beikler, T., Strenge, J., and Yang, Z. (2023). Association between C-Reactive protein and periodontitis in an obese population from the NHANES 2009\u20132010. BMC Oral Health, 23.","DOI":"10.1186\/s12903-023-03189-3"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Kuppa, A., Tripathi, H., Al-Darraji, A., Tarhuni, W.M., and Abdel-Latif, A. (2023). C-Reactive Protein Levels and Risk of Cardiovascular Diseases: A Two-Sample Bidirectional Mendelian Randomization Study. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24119129"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/prd.12431","article-title":"Association between periodontitis and chronic kidney disease","volume":"89","author":"Parsegian","year":"2022","journal-title":"Periodontology 2000"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1111\/jcpe.12067","article-title":"Periodontitis and chronic kidney disease: A systematic review of the association of diseases and the effect of periodontal treatment on estimated glomerular filtration rate","volume":"40","author":"Chambrone","year":"2013","journal-title":"J. Clin. Periodontol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e011836","DOI":"10.1136\/bmjopen-2016-011836","article-title":"Association of dental and periodontal disease with chronic kidney disease in patients of a single, tertiary care centre in Thailand","volume":"6","author":"Ausavarungnirun","year":"2016","journal-title":"BMJ Open"},{"key":"ref_21","first-page":"e41618","article-title":"Periodontitis Severity Grading Scale and C-Reactive Protein: A Possible Relation","volume":"15","author":"Rai","year":"2023","journal-title":"Cureus"},{"key":"ref_22","first-page":"ZE21","article-title":"C-Reactive Protein (CRP) and its Association with Periodontal Disease: A Brief Review","volume":"8","author":"Bansal","year":"2014","journal-title":"J. Clin. Diagn. Res."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Tan, K.H., Seers, C.A., Dashper, S.G., Mitchell, H.L., Pyke, J.S., Meuric, V., Slakeski, N., Cleal, S.M., Chambers, J.L., and McConville, M.J. (2014). Porphyromonas gingivalis and Treponema denticola Exhibit Metabolic Symbioses. PLoS Pathog., 10.","DOI":"10.1371\/journal.ppat.1003955"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1053\/j.ajkd.2018.10.013","article-title":"Long-term Association of Periodontitis with Decreased Kidney Function","volume":"73","author":"Wangerin","year":"2019","journal-title":"Am. J. Kidney Dis."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1002\/JPER.18-0464","article-title":"Effect of chronic kidney disease on progression of clinical attachment loss in older adults: A 4-year cohort study","volume":"90","author":"Iwasaki","year":"2019","journal-title":"J. Periodontol."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Rapa, S.F., Di Iorio, B.R., Campiglia, P., Heidland, A., and Marzocco, S. (2019). Inflammation and Oxidative Stress in Chronic Kidney Disease\u2014Potential Therapeutic Role of Minerals, Vitamins and Plant-Derived Metabolites. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21010263"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Lee, B.T., Ahmed, F.A., Hamm, L.L., Teran, F.J., Chen, C.-S., Liu, Y., Shah, K., Rifai, N., Batuman, V., and Simon, E.E. (2015). Association of C-reactive protein, tumor necrosis factor-alpha, and interleukin-6 with chronic kidney disease. BMC Nephrol., 16.","DOI":"10.1186\/s12882-015-0068-7"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1053\/j.ackd.2019.01.004","article-title":"Immune Dysfunction and Risk of Infection in Chronic Kidney Disease","volume":"26","author":"Narayanan","year":"2019","journal-title":"Adv. Chronic Kidney Dis."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1136\/jech-2015-206745","article-title":"Periodontitis is an independent risk indicator for atherosclerotic cardiovascular diseases among 60,174 participants in a large dental school in the Netherlands","volume":"71","author":"Beukers","year":"2017","journal-title":"J. Epidemiol. Community Health"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1161\/CIR.0b013e31825719f3","article-title":"Periodontal Disease and Atherosclerotic Vascular Disease: Does the Evidence Support an Independent Association?","volume":"125","author":"Lockhart","year":"2012","journal-title":"Circulation"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Huang, X., Xie, M., Lu, X., Mei, F., Song, W., Liu, Y., and Chen, L. (2023). The Roles of Periodontal Bacteria in Atherosclerosis. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241612861"},{"key":"ref_32","unstructured":"Dyslipidemia\u2014An Overview (2024, December 02). ScienceDirect Topics. Available online: https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/dyslipidemia."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Batty, M., Bennett, M.R., and Yu, E. (2022). The Role of Oxidative Stress in Atherosclerosis. Cells, 11.","DOI":"10.3390\/cells11233843"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.redox.2017.01.007","article-title":"Angiogenesis in the atherosclerotic plaque","volume":"12","author":"Pucelle","year":"2017","journal-title":"Redox Biol."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Bitencourt, F.V., Nascimento, G.G., Costa, S.A., Orrico, S.R.P., Ribeiro, C.C.C., and Leite, F.R.M. (2023). The Role of Dyslipidemia in Periodontitis. Nutrients, 15.","DOI":"10.3390\/nu15020300"},{"key":"ref_36","first-page":"5","article-title":"Dental attrition and periodontal disease","volume":"6","author":"Chen","year":"2022","journal-title":"Dent. Case Rep."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e9","DOI":"10.4317\/jced.60039","article-title":"Correlations between different plaque indexes and bleeding on probing: A concurrent validity study","volume":"15","author":"Carvalho","year":"2023","journal-title":"J. Clin. Exp. Dent."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1002\/JPER.20-0598","article-title":"Occlusal trauma is associated with periodontitis: A retrospective case-control study","volume":"92","author":"Botero","year":"2021","journal-title":"J. Periodontol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"627","DOI":"10.14219\/jada.archive.1979.0364","article-title":"Developmental variations of tooth morphology and periodontal disease","volume":"99","author":"Shiloah","year":"1979","journal-title":"J. Am. Dent. Assoc."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"S237","DOI":"10.1002\/JPER.17-0733","article-title":"Periodontal manifestations of systemic diseases and developmental and acquired conditions: Consensus report of workgroup 3 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions","volume":"89","author":"Jepsen","year":"2018","journal-title":"J. Periodontol."},{"key":"ref_41","unstructured":"WHO (2004). ICD-10: International Statistical Classification of Diseases and Related Health Problems: Tenth Revision, World Health Organization. Available online: https:\/\/iris.who.int\/handle\/10665\/42980."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1053\/j.ajkd.2005.04.037","article-title":"C-Reactive Protein: \u201cCutoff\u201d Point and Clinical Applicability","volume":"46","author":"Sirpanlis","year":"2005","journal-title":"Am. J. Kidney Dis."},{"key":"ref_43","first-page":"29","article-title":"Estimated Glomerular Filtration Rate Explained","volume":"108","author":"Tarwater","year":"2011","journal-title":"Mo. Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","article-title":"Regression Models and Life-Tables","volume":"34","author":"Cox","year":"1972","journal-title":"J. R. Stat. Soc. Ser. B Methodol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/01621459.1958.10501452","article-title":"Nonparametric Estimation from Incomplete Observations","volume":"53","author":"Kaplan","year":"1958","journal-title":"J. Am. Stat. Assoc."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1093\/biomet\/69.1.239","article-title":"Partial Residuals for The Proportional Hazards Regression Model","volume":"69","author":"Schoenfeld","year":"1982","journal-title":"Biometrika"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1080\/00401706.2000.10485975","article-title":"Theory and Applications of Hazard Plotting for Censored Failure Data","volume":"42","author":"Nelson","year":"2000","journal-title":"Technometrics"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1214\/aos\/1176344247","article-title":"Nonparametric Inference for a Family of Counting Processes","volume":"6","author":"Aalen","year":"1978","journal-title":"Ann. Stat."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1214\/aos\/1176345976","article-title":"Coxs Regression Model for Counting Processes: A Large Sample Study","volume":"10","author":"Andersen","year":"1982","journal-title":"Ann. Stat."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1109\/TAC.1974.1100705","article-title":"A new look at the statistical model identification","volume":"19","author":"Akaike","year":"1974","journal-title":"IEEE Trans. Autom. Control"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1214\/aos\/1176344136","article-title":"Estimating the Dimension of a Model","volume":"6","author":"Schwarz","year":"1978","journal-title":"Ann. Stat."},{"key":"ref_52","unstructured":"Burnham, K.P., and Anderson, D.R. (2002). Formal Inference From More Than One Model: Multimodel Inference (MMI). Model Selection and Multimodel Inference: A Practical Information\u2014Theoretic Approach, Springer."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Lee, E.T., and Wang, J.W. (2003). Statistical Methods for Survival Data Analysis. Wiley Series in Probability and Statistics, Wiley. [1st ed.].","DOI":"10.1002\/0471458546"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Klein, J.P., and Moeschberger, M.L. (2003). Multivariate Survival Analysis. Survival Analysis: Techniques for Censored and Truncated Data, Springer.","DOI":"10.1007\/b97377"},{"key":"ref_55","unstructured":"StataCorp (Stata, 2021). Stata, Version 17; Statistical Software."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/2\/741\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T10:30:10Z","timestamp":1759919410000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/2\/741"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,16]]},"references-count":55,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,1]]}},"alternative-id":["ijms26020741"],"URL":"https:\/\/doi.org\/10.3390\/ijms26020741","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,16]]}}}