{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:40:41Z","timestamp":1759970441583,"version":"build-2065373602"},"reference-count":36,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T00:00:00Z","timestamp":1737158400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["U22A20525","2023BCF01038","2021BEF02028","2017BN04","2022AAC03077"],"award-info":[{"award-number":["U22A20525","2023BCF01038","2021BEF02028","2017BN04","2022AAC03077"]}]},{"name":"Key Research and Development Program of Ningxia Hui Autonomous Region","award":["U22A20525","2023BCF01038","2021BEF02028","2017BN04","2022AAC03077"],"award-info":[{"award-number":["U22A20525","2023BCF01038","2021BEF02028","2017BN04","2022AAC03077"]}]},{"name":"Key Research and Development Program of Ningxia Hui Autonomous Region","award":["U22A20525","2023BCF01038","2021BEF02028","2017BN04","2022AAC03077"],"award-info":[{"award-number":["U22A20525","2023BCF01038","2021BEF02028","2017BN04","2022AAC03077"]}]},{"name":"Nanjing University-Ningxia University Collaborative Project","award":["U22A20525","2023BCF01038","2021BEF02028","2017BN04","2022AAC03077"],"award-info":[{"award-number":["U22A20525","2023BCF01038","2021BEF02028","2017BN04","2022AAC03077"]}]},{"DOI":"10.13039\/501100004772","name":"Ningxia Natural Science Foundation","doi-asserted-by":"publisher","award":["U22A20525","2023BCF01038","2021BEF02028","2017BN04","2022AAC03077"],"award-info":[{"award-number":["U22A20525","2023BCF01038","2021BEF02028","2017BN04","2022AAC03077"]}],"id":[{"id":"10.13039\/501100004772","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Tuberculosis (TB), a human and animal disease caused by Mycobacterium tuberculosis (M.tb), has the highest global mortality rate after coronavirus disease 2019 (COVID-19) and poses a major public health threat globally. Since 1890, vaccine candidates for various forms of TB have been developed for different age groups, but these vaccine candidates have not provided intended protection in adolescents and adults in clinical trials. To help prevent and control the spread of TB, the development of a safe and effective TB vaccine is imperative. The MTB39A protein and the molecular adjuvant MTB32C protein were expressed by an insect-baculovirus expression system, and the recombinant baculovirus surface-displayed particles were evaluated for their immunogenicity in BALB\/c mice and calves. The results showed that the rvAc-71CA\/rvAc-MTB39A recombinant baculovirus surface-displayed particles exhibited good immunogenicity in mice and calves and could be further developed as potential candidates.<\/jats:p>","DOI":"10.3390\/ijms26020797","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T06:53:32Z","timestamp":1737442412000},"page":"797","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Development of a Vaccine Candidate Based on Surface-Displayed Particles of Mycobacterium tuberculosis from the MTB39A Protein"],"prefix":"10.3390","volume":"26","author":[{"given":"Pu","family":"Wang","sequence":"first","affiliation":[{"name":"Key Laboratory of Ministry of Education for Protection and Utilization of Special Biological Resources in Western China, School of Life Sciences, Ningxia University, Yinchuan 750021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Ministry of Education for Protection and Utilization of Special Biological Resources in Western China, School of Life Sciences, Ningxia University, Yinchuan 750021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingling","family":"Jiang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Ministry of Education for Protection and Utilization of Special Biological Resources in Western China, School of Life Sciences, Ningxia University, Yinchuan 750021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sinong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Ministry of Education for Protection and Utilization of Special Biological Resources in Western China, School of Life Sciences, Ningxia University, Yinchuan 750021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weifeng","family":"Gao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Ministry of Education for Protection and Utilization of Special Biological Resources in Western China, School of Life Sciences, Ningxia University, Yinchuan 750021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0672-948X","authenticated-orcid":false,"given":"Zhiwei","family":"Wu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Ministry of Education for Protection and Utilization of Special Biological Resources in Western China, School of Life Sciences, Ningxia University, Yinchuan 750021, China"},{"name":"Center for Public Health Research, Medical School, Nanjing University, Nanjing 210023, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2036-9166","authenticated-orcid":false,"given":"Yong","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Ministry of Education for Protection and Utilization of Special Biological Resources in Western China, School of Life Sciences, Ningxia University, Yinchuan 750021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"170077","DOI":"10.1183\/16000617.0077-2017","article-title":"Tuberculosis and lung damage: From epidemiology to pathophysiology","volume":"27","author":"Ravimohan","year":"2018","journal-title":"Eur. 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