{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T15:58:23Z","timestamp":1792166303078,"version":"4.4.0"},"reference-count":83,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T00:00:00Z","timestamp":1737331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Endometriosis is a widely spread disease that affects about 8% of the world\u2019s female population. This condition may be described as a spread of endometrial tissue apart from the uterine cavity, but this process\u2019s pathomechanism is still unsure. Apart from classic endometriosis symptoms, which are pelvic pain, infertility, and bleeding problems, there are neuropsychiatric comorbidities that are usually difficult to diagnose. In our review, we attempted to summarize some of them. Conditions like migraine, anxiety, and depression occur more often in women with endometriosis and have a significant impact on life quality and pain perception. Interestingly, 77% of endometriosis patients with depression also have anxiety. Neuroimaging gives an image of the so-called endometriosis brain, which means alternations in pain processing and cognition, self-regulation, and reward. Genetic factors, including mutations in KRAS, PTEN, and ARID1A, influence cellular proliferation, differentiation, and chromatin remodeling, potentially exacerbating lesion severity and complicating treatment. In this review, we focused on the aspects of sciatic and obturator nerve endometriosis, the emotional well-being of endometriosis-affected patients, and the potential influence of endometriosis on dementia, also focusing on prolonged diagnosis. Addressing endometriosis requires a multidisciplinary approach, encompassing molecular insights, innovative therapies, and attention to its psychological and systemic effects.<\/jats:p>","DOI":"10.3390\/ijms26020839","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T06:53:32Z","timestamp":1737442412000},"page":"839","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Understanding Deep Endometriosis: From Molecular to Neuropsychiatry Dimension"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4068-4772","authenticated-orcid":false,"given":"Magdalena","family":"Pszczo\u0142owska","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Wroc\u0142aw Medical University, 50-367 Wroc\u0142aw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamil","family":"Walczak","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Wroc\u0142aw Medical University, 50-367 Wroc\u0142aw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2648-7214","authenticated-orcid":false,"given":"Weronika","family":"Ko\u0142odziejczyk","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Wroc\u0142aw Medical University, 50-367 Wroc\u0142aw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6928-866X","authenticated-orcid":false,"given":"Magdalena","family":"Koz\u0142owska","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Wroc\u0142aw Medical University, 50-367 Wroc\u0142aw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gracjan","family":"Koz\u0142owski","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Wroc\u0142aw Medical University, 50-367 Wroc\u0142aw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0749-2098","authenticated-orcid":false,"given":"Martyna","family":"Gachowska","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Wroc\u0142aw Medical University, 50-367 Wroc\u0142aw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerzy","family":"Leszek","sequence":"additional","affiliation":[{"name":"Clinic of Psychiatry, Department of Psychiatry, Medical Department, Wroc\u0142aw Medical University, 50-367 Wroc\u0142aw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/S0140-6736(04)17403-5","article-title":"Endometriosis","volume":"364","author":"Giudice","year":"2004","journal-title":"Lancet"},{"key":"ref_2","first-page":"e21329","article-title":"A 10-Year Journey to Diagnosis With Endometriosis: An Autobiographical Case Report","volume":"14","author":"Frankel","year":"2022","journal-title":"Cureus"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"529","DOI":"10.12688\/f1000research.14817.1","article-title":"Endometriosis: Advances and controversies in classification, pathogenesis, diagnosis, and treatment","volume":"8","author":"Rolla","year":"2019","journal-title":"F1000Research"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ejogrb.2016.04.021","article-title":"Epidemiology of endometriosis and its comorbidities","volume":"209","author":"Parazzini","year":"2017","journal-title":"Eur. 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