{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T21:02:48Z","timestamp":1779310968218,"version":"3.51.4"},"reference-count":231,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T00:00:00Z","timestamp":1737331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Fund for Science, Technology, and Innovation (FONACIT)","award":["LX22NPO5103"],"award-info":[{"award-number":["LX22NPO5103"]}]},{"name":"National Fund for Science, Technology, and Innovation (FONACIT)","award":["CZ.02.1.01\/0.0\/0.0\/16_019\/0000868"],"award-info":[{"award-number":["CZ.02.1.01\/0.0\/0.0\/16_019\/0000868"]}]},{"name":"National Institute of Virology and Bacteriology","award":["LX22NPO5103"],"award-info":[{"award-number":["LX22NPO5103"]}]},{"name":"National Institute of Virology and Bacteriology","award":["CZ.02.1.01\/0.0\/0.0\/16_019\/0000868"],"award-info":[{"award-number":["CZ.02.1.01\/0.0\/0.0\/16_019\/0000868"]}]},{"name":"Ministry of Education, Youth, and Sport, Czech Republic: Molecular and Cellular Clinical Approach to Healthy Ageing, ENOCH","award":["LX22NPO5103"],"award-info":[{"award-number":["LX22NPO5103"]}]},{"name":"Ministry of Education, Youth, and Sport, Czech Republic: Molecular and Cellular Clinical Approach to Healthy Ageing, ENOCH","award":["CZ.02.1.01\/0.0\/0.0\/16_019\/0000868"],"award-info":[{"award-number":["CZ.02.1.01\/0.0\/0.0\/16_019\/0000868"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Vaccines represent an essential tool for the prevention of infectious diseases. Upon administration, a complex interaction occurs between the vaccine formulation and the recipient\u2019s immune system, ultimately resulting in protection against disease. Significant variability exists in individual and population responses to vaccination, and these differences remain the focus of the ongoing research. Notably, well-documented factors, such as age, gender, and genetic predisposition, influence immune responses. In contrast, the effects of overweight and obesity have not been as thoroughly investigated. The evidence indicates that a high body mass index (BMI) constitutes a significant risk factor for infections in general, with adipose tissue playing a crucial role in modulating the immune response. Furthermore, suboptimal levels of vaccine seroconversion have been observed among individuals with obesity. This review provides a plausible examination of the immunity and protection conferred by various vaccines in individuals with an overweight status, offering a comprehensive analysis of the mechanisms to enhance vaccination efficiency.<\/jats:p>","DOI":"10.3390\/ijms26020862","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T06:53:32Z","timestamp":1737442412000},"page":"862","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Exploring How Adipose Tissue, Obesity, and Gender Influence the Immune Response to Vaccines: A Comprehensive Narrative Review"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5480-4608","authenticated-orcid":false,"given":"Juan Bautista","family":"De Sanctis","sequence":"first","affiliation":[{"name":"Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, Hn\u011bvot\u00ednsk\u00e1 1333\/5, 77900 Olomouc, Czech Republic"},{"name":"Czech Advanced Technology and Research Institute, Palacky University, 77900 Olomouc, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3250-6902","authenticated-orcid":false,"given":"Germ\u00e1n","family":"Balda Noria","sequence":"additional","affiliation":[{"name":"Institute of Immunology Nicol\u00e1s Enrique Bianco, Faculty of Medicine, Universidad Central de Venezuela Los Chaguaramos, Caracas 1040, Venezuela"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2354-0160","authenticated-orcid":false,"given":"Alexis Hip\u00f3lito","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Institute of Immunology Nicol\u00e1s Enrique Bianco, Faculty of Medicine, Universidad Central de Venezuela Los Chaguaramos, Caracas 1040, Venezuela"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,20]]},"reference":[{"key":"ref_1","unstructured":"(2024, December 08). 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