{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T10:29:01Z","timestamp":1784543341811,"version":"3.55.0"},"reference-count":54,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T00:00:00Z","timestamp":1737417600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"SEPAR-2020-820","award":["PI11\/00495"],"award-info":[{"award-number":["PI11\/00495"]}]},{"name":"SEPAR-2020-820","award":["PI19\/00875"],"award-info":[{"award-number":["PI19\/00875"]}]},{"name":"Ministerio de Economia y Competitividad","award":["PI11\/00495"],"award-info":[{"award-number":["PI11\/00495"]}]},{"name":"Ministerio de Economia y Competitividad","award":["PI19\/00875"],"award-info":[{"award-number":["PI19\/00875"]}]},{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","award":["PI11\/00495"],"award-info":[{"award-number":["PI11\/00495"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","award":["PI19\/00875"],"award-info":[{"award-number":["PI19\/00875"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Programa \u201cRamon Llull,\u201d contractes per a la Intensificaci\u00f3 del\u2019Activitat Investigadora a l\u2019IdISBa 2020","award":["PI11\/00495"],"award-info":[{"award-number":["PI11\/00495"]}]},{"name":"Programa \u201cRamon Llull,\u201d contractes per a la Intensificaci\u00f3 del\u2019Activitat Investigadora a l\u2019IdISBa 2020","award":["PI19\/00875"],"award-info":[{"award-number":["PI19\/00875"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Obstructive sleep apnea (OSA) is common during pregnancy and linked to adverse outcomes. While oxidative stress is a proposed pathogenic mechanism, evidence in pregnant populations remains limited. This multicenter, prospective study evaluated oxidative stress through protein carbonyl levels in 171 pregnant women and 86 cord blood samples. Polysomnography (PSG) performed during pregnancy categorized participants with the apnea\u2013hypopnea index (AHI) in OSA, rapid eye movement (REM) OSA, and supine OSA. Protein carbonyl levels were measured by the dinitrophenyl hydrazine (DNPH) method. No significant differences were found in maternal or cord blood protein carbonyl levels between OSA and non-OSA groups, or between REM and supine OSA subgroups. Interestingly, women with shorter apnea\u2013hypopnea (AH) length showed both higher maternal and cord blood protein carbonyl levels and lower nocturnal oxygen saturation. Overall, OSA in pregnancy was not associated with increased oxidative stress as measured by protein carbonyl levels. However, apnea\u2013hypopnea duration and nocturnal hypoxia may influence oxidative stress, pointing to a complex relationship between OSA and oxidative stress during pregnancy, beyond traditional metrics like AHI. Future studies should explore additional biomarkers and diverse molecular pathways that could play a role, with special attention to emerging factors such as apnea\u2013hypopnea length and hypoxic burden to elucidate the interrelationships between OSA and pregnancy more comprehensively.<\/jats:p>","DOI":"10.3390\/ijms26030886","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T11:47:32Z","timestamp":1737460052000},"page":"886","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Influence of Obstructive Sleep Apnea on Oxidative Stress in Pregnancy"],"prefix":"10.3390","volume":"26","author":[{"given":"Laura","family":"C\u00e0naves-G\u00f3mez","sequence":"first","affiliation":[{"name":"Institut d\u2019Investigaci\u00f3 Sanit\u00e0ria Illes Balears (IdISBa), 07120 Palma de Mallorca, 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