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SDU","award":["SKLMTFCP-2023-05"],"award-info":[{"award-number":["SKLMTFCP-2023-05"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>African swine fever (ASF) is a highly lethal, infectious, hemorrhagic fever disease, characterized by an acute mortality rate approaching 100%. It is highly contagious, and results in significant losses to the global hog industry as it spreads. Despite incremental progress in research on the African swine fever virus (ASFV), a safe and effective commercial vaccine has yet to be developed. Vector vaccines, a promising type of vaccine, offer unique advantages, and are a primary focus in ASFV vaccine research. This paper focuses on the characteristics of viral, bacterial, and yeast vector vaccines; elucidates the immunological mechanisms associated with antigens; lists the types of antigens that have significant potential; discusses the feasibility of using exogenously expressed cytokines to enhance the protective power of vector vaccines; and, finally, discusses the types of vectors that are commonly used and the latest advances in this field.<\/jats:p>","DOI":"10.3390\/ijms26030921","type":"journal-article","created":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T09:52:20Z","timestamp":1737539540000},"page":"921","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Progress in African Swine Fever Vector Vaccine Development"],"prefix":"10.3390","volume":"26","author":[{"given":"Yue","family":"Yang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Microbial Technology, Institute of Microbial Technology, Helmholtz International Lab for Anti-Infectives, Shandong University\u2013Helmholtz Institute of Biotechnology, Shandong University, Qingdao 266237, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengxing","family":"Yuan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Microbial Technology, Institute of Microbial Technology, Helmholtz International Lab for Anti-Infectives, Shandong University\u2013Helmholtz Institute of Biotechnology, Shandong University, Qingdao 266237, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulu","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Microbial Technology, Institute of Microbial Technology, Helmholtz International Lab for Anti-Infectives, Shandong University\u2013Helmholtz Institute of Biotechnology, Shandong University, Qingdao 266237, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Luan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Microbial Technology, Institute of Microbial Technology, Helmholtz International Lab for Anti-Infectives, Shandong University\u2013Helmholtz Institute of Biotechnology, Shandong University, Qingdao 266237, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9874-5892","authenticated-orcid":false,"given":"Hailong","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Microbial Technology, Institute of Microbial Technology, Helmholtz International Lab for Anti-Infectives, Shandong University\u2013Helmholtz Institute of Biotechnology, Shandong University, Qingdao 266237, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"199434","DOI":"10.1016\/j.virusres.2024.199434","article-title":"Epidemiology and ecology of the sylvatic cycle of African Swine Fever Virus in Kenya","volume":"348","author":"Obanda","year":"2024","journal-title":"Virus Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s40813-015-0013-y","article-title":"African swine fever: A global view of the current challenge","volume":"1","author":"Gallardo","year":"2015","journal-title":"Porc. Health Manag."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1111\/tbed.13538","article-title":"Potential routes for indirect transmission of African swine fever virus into domestic pig herds","volume":"67","author":"Olesen","year":"2020","journal-title":"Transbound. Emerg. Dis."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Wu, K., Liu, J., Wang, L., Fan, S., Li, Z., Li, Y., Yi, L., Ding, H., Zhao, M., and Chen, J. (2020). Current State of Global African Swine Fever Vaccine Development under the Prevalence and Transmission of ASF in China. Vaccines, 8.","DOI":"10.3390\/vaccines8030531"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Diep, N.V., Duc, N.V., Ngoc, N.T., Dang, V.X., Tiep, T.N., Nguyen, V.D., Than, T.T., Maydaniuk, D., Goonewardene, K., and Ambagala, A. (2024). Genotype II Live-Attenuated ASFV Vaccine Strains Unable to Completely Protect Pigs against the Emerging Recombinant ASFV Genotype I\/II Strain in Vietnam. Vaccines, 12.","DOI":"10.20944\/preprints202408.1438.v1"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Chathuranga, K., and Lee, J.S. (2023). African Swine Fever Virus (ASFV): Immunity and Vaccine Development. Vaccines, 11.","DOI":"10.3390\/vaccines11020199"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s40813-020-00154-2","article-title":"African swine fever vaccines: A promising work still in progress","volume":"6","author":"Rodriguez","year":"2020","journal-title":"Porc. Health Manag."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1080\/14760584.2018.1541407","article-title":"Basics of CD8 T-cell immune responses after influenza infection and vaccination with inactivated or live attenuated influenza vaccine","volume":"17","author":"Korenkov","year":"2018","journal-title":"Expert. Rev. Vaccines"},{"key":"ref_9","first-page":"1931","article-title":"Prevention, control and vaccine development of African swine fever: Challenges and countermeasures","volume":"34","author":"Wang","year":"2018","journal-title":"Sheng Wu Gong Cheng Xue Bao"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1099\/jgv.0.000490","article-title":"African swine fever virus serotype-specific proteins are significant protective antigens for African swine fever","volume":"97","author":"Burmakina","year":"2016","journal-title":"J. Gen. Virol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Arias, M., de la Torre, A., Dixon, L., Gallardo, C., Jori, F., Laddomada, A., Martins, C., Parkhouse, R.M., Revilla, Y., and Rodriguez, F.A.J. (2017). Approaches and Perspectives for Development of African Swine Fever Virus Vaccines. Vaccines, 5.","DOI":"10.3390\/vaccines5040035"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Gaudreault, N.N., and Richt, J.A. (2019). Subunit Vaccine Approaches for African Swine Fever Virus. Vaccines, 7.","DOI":"10.3390\/vaccines7020056"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1099\/jgv.0.001049","article-title":"ICTV Virus Taxonomy Profile: Asfarviridae","volume":"99","author":"Alonso","year":"2018","journal-title":"J. Gen. Virol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.virusres.2012.10.020","article-title":"African swine fever virus replication and genomics","volume":"173","author":"Dixon","year":"2013","journal-title":"Virus Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.chom.2019.11.004","article-title":"Cryo-EM Structure of the African Swine Fever Virus","volume":"26","author":"Liu","year":"2019","journal-title":"Cell Host Microbe"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.3201\/eid2411.181274","article-title":"Molecular Characterization of African Swine Fever Virus, China, 2018","volume":"24","author":"Ge","year":"2018","journal-title":"Emerg. Infect. Dis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"197673","DOI":"10.1016\/j.virusres.2019.197673","article-title":"Genetic and antigenic diversity of African swine fever virus","volume":"271","author":"Malogolovkin","year":"2019","journal-title":"Virus Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2300464","DOI":"10.1080\/22221751.2023.2300464","article-title":"The attenuated African swine fever vaccine HLJ\/18-7GD provides protection against emerging prevalent genotype II variants in China","volume":"13","author":"Wang","year":"2024","journal-title":"Emerg. Microbes Infect."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"312","DOI":"10.3201\/eid2102.140649","article-title":"Comparative analysis of African swine fever virus genotypes and serogroups","volume":"21","author":"Malogolovkin","year":"2015","journal-title":"Emerg. Infect. Dis."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Ravilov, R.K., Rizvanov, A.A., Mingaleev, D.N., Galeeva, A.G., Zakirova, E.Y., Shuralev, E.A., Rutland, C.S., Khammadov, N.I., and Efimova, M.A. (2022). Viral Vector Vaccines Against ASF: Problems and Prospectives. Front. Vet. Sci., 9.","DOI":"10.3389\/fvets.2022.830244"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.vetmic.2019.06.006","article-title":"Adenovirus-vectored African Swine Fever Virus antigen cocktails are immunogenic but not protective against intranasal challenge with Georgia 2007\/1 isolate","volume":"235","author":"Lokhandwala","year":"2019","journal-title":"Vet. Microbiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1126\/science.abg9857","article-title":"Scent of a vaccine","volume":"373","author":"Lund","year":"2021","journal-title":"Science"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"eabo2523","DOI":"10.1126\/science.abo2523","article-title":"Unadjuvanted intranasal spike vaccine elicits protective mucosal immunity against sarbecoviruses","volume":"378","author":"Mao","year":"2022","journal-title":"Science"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nature11522","article-title":"A vaccine strategy that protects against genital herpes by establishing local memory T cells","volume":"491","author":"Shin","year":"2012","journal-title":"Nature"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1128\/CVI.00395-16","article-title":"Induction of Robust Immune Responses in Swine by Using a Cocktail of Adenovirus-Vectored African Swine Fever Virus Antigens","volume":"23","author":"Lokhandwala","year":"2016","journal-title":"Clin. Vaccine Immunol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.virusres.2012.11.009","article-title":"Cellular immunity in ASFV responses","volume":"173","author":"Takamatsu","year":"2013","journal-title":"Virus Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1006\/viro.1993.1515","article-title":"Virulent African swine fever virus isolates are neutralized by swine immune serum and by monoclonal antibodies recognizing a 72-kDa viral protein","volume":"196","author":"Zsak","year":"1993","journal-title":"Virology"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"5689","DOI":"10.1128\/jvi.70.8.5689-5694.1996","article-title":"Neutralizing antibodies to different proteins of African swine fever virus inhibit both virus attachment and internalization","volume":"70","author":"Oviedo","year":"1996","journal-title":"J. Virol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.vaccine.2017.12.030","article-title":"Evaluation of protection induced by immunisation of domestic pigs with deletion mutant African swine fever virus Benin\u0394MGF by different doses and routes","volume":"36","author":"Jabbar","year":"2018","journal-title":"Vaccine"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.virusres.2016.05.014","article-title":"African swine fever virus Georgia isolate harboring deletions of 9GL and MGF360\/505 genes is highly attenuated in swine but does not confer protection against parental virus challenge","volume":"221","author":"Holinka","year":"2016","journal-title":"Virus Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1099\/0022-1317-83-6-1331","article-title":"Identification of the principal serological immunodeterminants of African swine fever virus by screening a virus cDNA library with antibody","volume":"83","author":"Kollnberger","year":"2002","journal-title":"J. Gen. Virol."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Sunwoo, S.Y., P\u00e9rez-N\u00fa\u00f1ez, D., Morozov, I., S\u00e1nchez, E.G., Gaudreault, N.N., Trujillo, J.D., Mur, L., Nogal, M., Madden, D., and Urbaniak, K. (2019). DNA-Protein Vaccination Strategy Does Not Protect from Challenge with African Swine Fever Virus Armenia 2007 Strain. Vaccines, 7.","DOI":"10.3390\/vaccines7010012"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"e02219-17","DOI":"10.1128\/JVI.02219-17","article-title":"Immunization of Pigs by DNA Prime and Recombinant Vaccinia Virus Boost To Identify and Rank African Swine Fever Virus Immunogenic and Protective Proteins","volume":"92","author":"Jancovich","year":"2018","journal-title":"J. Virol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s00705-010-0846-2","article-title":"The African swine fever virus lectin EP153R modulates the surface membrane expression of MHC class I antigens","volume":"156","author":"Hurtado","year":"2011","journal-title":"Arch. Virol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.virol.2004.05.019","article-title":"The C-type lectin homologue gene (EP153R) of African swine fever virus inhibits apoptosis both in virus infection and in heterologous expression","volume":"326","author":"Hurtado","year":"2004","journal-title":"Virology"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1006\/viro.1999.0080","article-title":"African swine fever virus EP153R open reading frame encodes a glycoprotein involved in the hemadsorption of infected cells","volume":"266","author":"Galindo","year":"2000","journal-title":"Virology"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1111\/tbed.12504","article-title":"Improved Strategy for Molecular Characterization of African Swine Fever Viruses from Sardinia, Based on Analysis of p30, CD2V and I73R\/I329L Variable Regions","volume":"64","author":"Sanna","year":"2017","journal-title":"Transbound. Emerg. Dis."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"103","DOI":"10.36233\/0507-4088-2020-65-2-103-112","article-title":"[In silico prediction of B- and T-cell epitopes in the CD2v protein of african swine fever virus (African swine fever virus, Asfivirus, Asfarviridae).]","volume":"65","author":"Mima","year":"2020","journal-title":"Vopr. Virusol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"193","DOI":"10.36233\/0507-4088-2019-64-4-193-200","article-title":"[ASF virus replication features in the presence of recombinant proteins CD2v, pX69R and pE248R.]","volume":"64","author":"Mazloum","year":"2019","journal-title":"Vopr. Virusol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1006\/viro.1993.1534","article-title":"Characterization of a soluble hemagglutinin induced in African swine fever virus-infected cells","volume":"196","author":"Coll","year":"1993","journal-title":"Virology"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.vetimm.2018.11.018","article-title":"Evaluation of a viral DNA-protein immunization strategy against African swine fever in domestic pigs","volume":"208","author":"Sunwoo","year":"2019","journal-title":"Vet. Immunol. Immunopathol."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Argilaguet, J.M., P\u00e9rez-Mart\u00edn, E., Nofrar\u00edas, M., Gallardo, C., Accensi, F., Lacasta, A., Mora, M., Ballester, M., Galindo-Cardiel, I., and L\u00f3pez-Soria, S. (2012). DNA vaccination partially protects against African swine fever virus lethal challenge in the absence of antibodies. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0040942"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Lokhandwala, S., Waghela, S.D., Bray, J., Sangewar, N., Charendoff, C., Martin, C.L., Hassan, W.S., Koynarski, T., Gabbert, L., and Burrage, T.G. (2017). Adenovirus-vectored novel African Swine Fever Virus antigens elicit robust immune responses in swine. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0177007"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/s00705-023-05935-y","article-title":"Construction of and evaluation of the immune response to two recombinant pseudorabies viruses expressing the B119L and EP364R proteins of African swine fever virus","volume":"169","author":"Geng","year":"2024","journal-title":"Arch. Virol."},{"key":"ref_45","first-page":"395","article-title":"Vaccination with viral protein-mimicking peptides postpones mortality in domestic pigs infected by African swine fever virus","volume":"4","author":"Ivanov","year":"2011","journal-title":"Mol. Med. Rep."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1007\/s00705-008-0246-z","article-title":"Expression, cellular localization and antibody responses of the African swine fever virus genes B602L and K205R","volume":"153","author":"Reis","year":"2008","journal-title":"Arch. Virol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"358","DOI":"10.5455\/OVJ.2023.v13.i3.13","article-title":"Expression of a recombinant ASFV P30 protein and production of monoclonal antibodies","volume":"13","author":"Liberti","year":"2023","journal-title":"Open Vet. J."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Zajac, M.D., Sangewar, N., Lokhandwala, S., Bray, J., Sang, H., McCall, J., Bishop, R.P., Waghela, S.D., Kumar, R., and Kim, T. (2022). Adenovirus-Vectored African Swine Fever Virus pp220 Induces Robust Antibody, IFN-\u03b3, and CTL Responses in Pigs. Front. Vet. Sci., 9.","DOI":"10.3389\/fvets.2022.921481"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.rvsc.2021.10.003","article-title":"Recent advances in cell homeostasis by African swine fever virus-host interactions","volume":"141","author":"Guo","year":"2021","journal-title":"Res. Vet. Sci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.virol.2017.02.002","article-title":"Identification of residues within the African swine fever virus DP71L protein required for dephosphorylation of translation initiation factor eIF2\u03b1 and inhibiting activation of pro-apoptotic CHOP","volume":"504","author":"Barber","year":"2017","journal-title":"Virology"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Netherton, C.L., Goatley, L.C., Reis, A.L., Portugal, R., Nash, R.H., Morgan, S.B., Gault, L., Nieto, R., Norlin, V., and Gallardo, C. (2019). Identification and Immunogenicity of African Swine Fever Virus Antigens. Front. Immunol., 10.","DOI":"10.3389\/fimmu.2019.01318"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1128\/JCM.44.3.950-956.2006","article-title":"Antigenic properties and diagnostic potential of African swine fever virus protein pp62 expressed in insect cells","volume":"44","author":"Gallardo","year":"2006","journal-title":"J. Clin. Microbiol."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Xu, L., Hao, F., Jeong, D.G., Chen, R., Gan, Y., Zhang, L., Yeom, M., Lim, J.W., Yu, Y., and Bai, Y. (2023). Mucosal and cellular immune responses elicited by nasal and intramuscular inoculation with ASFV candidate immunogens. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1200297"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"e0102222","DOI":"10.1128\/jvi.01022-22","article-title":"African Swine Fever Virus EP364R and C129R Target Cyclic GMP-AMP To Inhibit the cGAS-STING Signaling Pathway","volume":"96","author":"Dodantenna","year":"2022","journal-title":"J. Virol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1099\/0022-1317-77-5-941","article-title":"Characterization of the African swine fever virion protein j18L","volume":"77","author":"Sun","year":"1996","journal-title":"J. Gen. Virol."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Shen, Z., Qiu, W., Luan, H., Sun, C., Cao, X., Wang, G., and Peng, J. (2023). I329L protein-based indirect ELISA for detecting antibodies specific to African swine fever virus. Front. Cell. Infect. Microbiol., 13.","DOI":"10.3389\/fcimb.2023.1150042"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.virusres.2012.10.012","article-title":"Antibody-mediated neutralization of African swine fever virus: Myths and facts","volume":"173","author":"Escribano","year":"2013","journal-title":"Virus Res."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Silva, E.B., Krug, P.W., Ramirez-Medina, E., Valladares, A., Rai, A., Espinoza, N., Gladue, D.P., and Borca, M.V. (2022). The Presence of Virus Neutralizing Antibodies Is Highly Associated with Protection against Virulent Challenge in Domestic Pigs Immunized with ASFV live Attenuated Vaccine Candidates. Pathogens, 11.","DOI":"10.3390\/pathogens11111311"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Goatley, L.C., Nash, R.H., Andrews, C., Hargreaves, Z., Tng, P., Reis, A.L., Graham, S.P., and Netherton, C.L. (2022). Cellular and Humoral Immune Responses after Immunisation with Low Virulent African Swine Fever Virus in the Large White Inbred Babraham Line and Outbred Domestic Pigs. Viruses, 14.","DOI":"10.3390\/v14071487"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/jlb.49.3.227","article-title":"Sources of antibody-dependent cellular cytotoxicity deficiency in young pig leukocytes","volume":"49","author":"Hahn","year":"1991","journal-title":"J. Leukoc. Biol."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Paudyal, B., Mwangi, W., Rijal, P., Schwartz, J.C., Noble, A., Shaw, A., Sealy, J.E., Bonnet-Di Placido, M., Graham, S.P., and Townsend, A. (2022). Fc-Mediated Functions of Porcine IgG Subclasses. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.903755"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1099\/0022-1317-82-3-513","article-title":"The non-haemadsorbing African swine fever virus isolate ASFV\/NH\/P68 provides a model for defining the protective anti-virus immune response","volume":"82","author":"Cartaxeiro","year":"2001","journal-title":"J. Gen. Virol."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Fan, Y., Chen, W., Jiang, C., Zhang, X., Sun, Y., Liu, R., Wang, J., Yang, D., Zhao, D., and Bu, Z. (2022). Host Responses to Live-Attenuated ASFV (HLJ\/18-7GD). Viruses, 14.","DOI":"10.3390\/v14092003"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0165-2427(02)00045-4","article-title":"T-helper cells from naive to committed","volume":"87","author":"Werner","year":"2002","journal-title":"Vet. Immunol. Immunopathol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"110596","DOI":"10.1016\/j.vetimm.2023.110596","article-title":"Immune response following safer administration of recombinant Salmonella typhimurium harboring ASFV antigens in pigs","volume":"259","author":"Bhilare","year":"2023","journal-title":"Vet. Immunol. Immunopathol."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Wieczorek, M., Abualrous, E.T., Sticht, J., \u00c1lvaro-Benito, M., Stolzenberg, S., No\u00e9, F., and Freund, C. (2017). Major Histocompatibility Complex (MHC) Class I and MHC Class II Proteins: Conformational Plasticity in Antigen Presentation. Front. Immunol., 8.","DOI":"10.3389\/fimmu.2017.00292"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Duan, X., Wen, Y., Wu, P., Peng, J., Zhou, Y., Zhu, G., Li, D., Ru, Y., Yang, W., and Zheng, H. (2023). Functional characterization of African swine fever virus I329L gene by transcriptome analysis. Vet. Microbiol., 284.","DOI":"10.1016\/j.vetmic.2023.109836"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/s00705-010-0894-7","article-title":"A novel TLR3 inhibitor encoded by African swine fever virus (ASFV)","volume":"156","author":"Almeida","year":"2011","journal-title":"Arch. Virol."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Correia, S., Moura, P.L., Ventura, S., Leit\u00e3o, A., and Parkhouse, R.M.E. (2023). I329L: A Dual Action Viral Antagonist of TLR Activation Encoded by the African Swine Fever Virus (ASFV). Viruses, 15.","DOI":"10.3390\/v15020445"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"5312","DOI":"10.1128\/jvi.67.9.5312-5320.1993","article-title":"African swine fever virus encodes a CD2 homolog responsible for the adhesion of erythrocytes to infected cells","volume":"67","author":"Rodriguez","year":"1993","journal-title":"J. Virol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"e01293-18","DOI":"10.1128\/JVI.01293-18","article-title":"A Proteomic Atlas of the African Swine Fever Virus Particle","volume":"92","author":"Alejo","year":"2018","journal-title":"J. Virol."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Lu, W., Bai, Y., Zhang, S., Zhao, X., Jin, J., Zhu, X., Wang, R., Wu, Y., Zhang, A., and Zhang, G. (2023). An Intracellular Epitope of ASFV CD2v Protein Elicits Humoral and Cellular Immune Responses. Animals, 13.","DOI":"10.3390\/ani13121967"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1515\/jvetres-2017-0017","article-title":"Roles of African Swine Fever Virus Structural Proteins in Viral Infection","volume":"61","author":"Jia","year":"2017","journal-title":"J. Vet. Res."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1006\/viro.1996.0193","article-title":"Functional and immunological properties of the baculovirus-expressed hemagglutinin of African swine fever virus","volume":"218","author":"Escribano","year":"1996","journal-title":"Virology"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"e01058-17","DOI":"10.1128\/JVI.01058-17","article-title":"BA71\u0394CD2: A New Recombinant Live Attenuated African Swine Fever Virus with Cross-Protective Capabilities","volume":"91","author":"Monteagudo","year":"2017","journal-title":"J. Virol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1126\/science.aaz1439","article-title":"Architecture of African swine fever virus and implications for viral assembly","volume":"366","author":"Wang","year":"2019","journal-title":"Science"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.1007\/s00253-022-11851-z","article-title":"Development of a p72 trimer-based colloidal gold strip for detection of antibodies against African swine fever virus","volume":"106","author":"Geng","year":"2022","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Wei, J., Liu, C., He, X., Abbas, B., Chen, Q., Li, Z., and Feng, Z. (2023). Generation and Characterization of Recombinant Pseudorabies Virus Delivering African Swine Fever Virus CD2v and p54. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25010335"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/s13568-021-01275-9","article-title":"Lactobacillus plantarum surface-displayed ASFV (p54) with porcine IL-21 generally stimulates protective immune responses in mice","volume":"11","author":"Chen","year":"2021","journal-title":"AMB Express"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.ijbiomac.2021.03.059","article-title":"Development and characterization of monoclonal antibodies against the N-terminal domain of African swine fever virus structural protein, p54","volume":"180","author":"Wang","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1002\/j.1460-2075.1993.tb05960.x","article-title":"Polyprotein processing in African swine fever virus: A novel gene expression strategy for a DNA virus","volume":"12","year":"1993","journal-title":"EMBO J."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1128\/JVI.78.5.2445-2453.2004","article-title":"African swine fever virus multigene family 360 genes affect virus replication and generalization of infection in Ornithodoros porcinus ticks","volume":"78","author":"Burrage","year":"2004","journal-title":"J. Virol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.virol.2016.03.019","article-title":"Sensitivity of African swine fever virus to type I interferon is linked to genes within multigene families 360 and 505","volume":"493","author":"Golding","year":"2016","journal-title":"Virology"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"e0189921","DOI":"10.1128\/jvi.01899-21","article-title":"Differential Effect of Deleting Members of African Swine Fever Virus Multigene Families 360 and 505 from the Genotype II Georgia 2007\/1 Isolate on Virus Replication, Virulence, and Induction of Protection","volume":"96","author":"Rathakrishnan","year":"2022","journal-title":"J. Virol."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Dupr\u00e9, J., Le Dimna, M., Hutet, E., Dujardin, P., Fablet, A., Leroy, A., Fleurot, I., Karadjian, G., Roesch, F., and Caballero, I. (2024). Exploring type I interferon pathway: Virulent vs. attenuated strain of African swine fever virus revealing a novel function carried by MGF505-4R. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1358219"},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Goatley, L.C., Reis, A.L., Portugal, R., Goldswain, H., Shimmon, G.L., Hargreaves, Z., Ho, C.S., Montoya, M., S\u00e1nchez-Cord\u00f3n, P.J., and Taylor, G. (2020). A Pool of Eight Virally Vectored African Swine Fever Antigens Protect Pigs Against Fatal Disease. Vaccines, 8.","DOI":"10.3390\/vaccines8020234"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"197871","DOI":"10.1016\/j.virusres.2020.197871","article-title":"Epitope mapping of African swine fever virus (ASFV) structural protein, p54","volume":"279","author":"Petrovan","year":"2020","journal-title":"Virus Res."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.virol.2003.11.011","article-title":"Neutralizing antibodies to African swine fever virus proteins p30, p54, and p72 are not sufficient for antibody-mediated protection","volume":"319","author":"Neilan","year":"2004","journal-title":"Virology"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.antiviral.2013.02.005","article-title":"BacMam immunization partially protects pigs against sublethal challenge with African swine fever virus","volume":"98","author":"Argilaguet","year":"2013","journal-title":"Antiviral Res."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Deng, L., Gu, S., Huang, Y., Wang, Y., Zhao, J., Nie, M., Xu, L., Lai, S., Ai, Y., and Xu, Z. (2023). Immunogenic response of recombinant pseudorabies virus carrying B646L and B602L genes of African swine fever virus in mice. Vet. Microbiol., 284.","DOI":"10.1016\/j.vetmic.2023.109815"},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Zhang, H., Zhao, S., Zhang, H., Shen, Y., Zhang, P., Shan, H., and Cai, X. (2022). Orally administered recombinant Lactobacillus expressing African swine fever virus antigens that induced immunity responses. Front. Microbiol., 13.","DOI":"10.3389\/fmicb.2022.1103327"},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Huang, Q., Niu, T., Zou, B., Wang, J., Xin, J., Niu, H., Li, N., Jiang, Y., Bao, J., and Zhang, D. (2022). Lactobacillus plantarum Surface-Displayed ASFV (p14.5) Can Stimulate Immune Responses in Mice. Vaccines, 10.","DOI":"10.3390\/vaccines10030355"},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Gao, S., Zuo, W., Kang, C., Zou, Z., Zhang, K., Qiu, J., Shang, X., Li, J., Zhang, Y., and Zuo, Q. (2024). Saccharomyces cerevisiae oral immunization in mice using multi-antigen of the African swine fever virus elicits a robust immune response. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1373656"},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Franzoni, G., Pedrera, M., and S\u00e1nchez-Cord\u00f3n, P.J. (2023). African Swine Fever Virus Infection and Cytokine Response In Vivo: An Update. Viruses, 15.","DOI":"10.3390\/v15010233"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/978-1-0716-1892-9_8","article-title":"Developments in Vaccine Adjuvants","volume":"2412","author":"Firdaus","year":"2022","journal-title":"Methods Mol. Biol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1111\/j.1440-1711.2004.01295.x","article-title":"Cytokines as adjuvants for avian vaccines","volume":"82","author":"Asif","year":"2004","journal-title":"Immunol. Cell Biol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.micpath.2018.08.049","article-title":"Kinetics of Interferon gamma and Interleukin-21 response following foot and mouth disease virus infection","volume":"125","author":"Sharma","year":"2018","journal-title":"Microb. Pathog."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"3241","DOI":"10.1128\/iai.63.9.3241-3244.1995","article-title":"Cytokines as adjuvants for vaccines: Antigen-specific responses differ from polyclonal responses","volume":"63","author":"Taylor","year":"1995","journal-title":"Infect. Immun."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"e20191638","DOI":"10.1084\/jem.20191638","article-title":"Regulation of the germinal center and humoral immunity by interleukin-21","volume":"217","author":"Tangye","year":"2020","journal-title":"J. Exp. Med."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"e216","DOI":"10.3324\/haematol.2014.120980","article-title":"Combined immunodeficiency with CD4 lymphopenia and sclerosing cholangitis caused by a novel loss-of-function mutation affecting IL21R","volume":"100","author":"Erman","year":"2015","journal-title":"Haematologica"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.vetmic.2016.12.010","article-title":"Characterization of the interaction of African swine fever virus with monocytes and derived macrophage subsets","volume":"198","author":"Franzoni","year":"2017","journal-title":"Vet. Microbiol."},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Fan, W., Jiao, P., Zhang, H., Chen, T., Zhou, X., Qi, Y., Sun, L., Shang, Y., Zhu, H., and Hu, R. (2020). Inhibition of African Swine Fever Virus Replication by Porcine Type I and Type II Interferons. Front. Microbiol., 11.","DOI":"10.3389\/fmicb.2020.01203"},{"key":"ref_103","first-page":"4784","article-title":"Recombinant porcine interferon-gamma expressed in CHO cells and its antiviral activity","volume":"39","author":"Wang","year":"2023","journal-title":"Sheng Wu Gong Cheng Xue Bao"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/978-1-4939-2205-5_10","article-title":"Insect cells-baculovirus system for the production of difficult to express proteins","volume":"1258","author":"Radu","year":"2015","journal-title":"Methods Mol. Biol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"7119","DOI":"10.1073\/pnas.0902745106","article-title":"IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation","volume":"106","author":"Quiel","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.cyto.2014.03.007","article-title":"How is inflammation initiated? Individual influences of IL-1, IL-18 and HMGB1","volume":"69","author":"Keyel","year":"2014","journal-title":"Cytokine"},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Arango Duque, G., and Descoteaux, A. (2014). Macrophage cytokines: Involvement in immunity and infectious diseases. Front. Immunol., 5.","DOI":"10.3389\/fimmu.2014.00491"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1097\/QAD.0000000000001938","article-title":"Interleukin 21 (IL-21)\/microRNA-29 (miR-29) axis is associated with natural resistance to HIV-1 infection","volume":"32","author":"Ortega","year":"2018","journal-title":"Aids"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s11095-022-03460-2","article-title":"Structure and Function of Cationic and Ionizable Lipids for Nucleic Acid Delivery","volume":"40","author":"Sun","year":"2023","journal-title":"Pharm. Res."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jconrel.2021.01.014","article-title":"Polymeric delivery systems for nucleic acid therapeutics: Approaching the clinic","volume":"331","author":"Yun","year":"2021","journal-title":"J. Control. Release"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.smim.2017.09.011","article-title":"Effects of engineered nanoparticles on the innate immune system","volume":"34","author":"Liu","year":"2017","journal-title":"Semin. Immunol."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Lu, B., Lim, J.M., Yu, B., Song, S., Neeli, P., Sobhani, N., K, P., Bonam, S.R., Kurapati, R., and Zheng, J. (2024). The next-generation DNA vaccine platforms and delivery systems: Advances, challenges and prospects. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1332939"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1038\/nri3084","article-title":"Towards a systems understanding of MHC class I and MHC class II antigen presentation","volume":"11","author":"Neefjes","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"ref_114","first-page":"w14465","article-title":"Virally vectored vaccine delivery: Medical needs, mechanisms, advantages and challenges","volume":"147","author":"Pinschewer","year":"2017","journal-title":"Swiss Med. Wkly."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"100432","DOI":"10.1016\/j.dmpk.2021.100432","article-title":"Adenovirus vector-based vaccine for infectious diseases","volume":"42","author":"Sakurai","year":"2022","journal-title":"Drug Metab. Pharmacokinet."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1126\/science.275.5304.1320","article-title":"Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5","volume":"275","author":"Bergelson","year":"1997","journal-title":"Science"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"3352","DOI":"10.1073\/pnas.94.7.3352","article-title":"HCAR and MCAR: The human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses","volume":"94","author":"Tomko","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"7227","DOI":"10.1128\/JVI.78.13.7227-7247.2004","article-title":"Gene transduction and cell entry pathway of fiber-modified adenovirus type 5 vectors carrying novel endocytic peptide ligands selected on human tracheal glandular cells","volume":"78","author":"Gaden","year":"2004","journal-title":"J. Virol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1128\/JVI.79.4.1992-2000.2005","article-title":"Adenovirus protein VI mediates membrane disruption following capsid disassembly","volume":"79","author":"Wiethoff","year":"2005","journal-title":"J. Virol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.chom.2009.11.006","article-title":"Adenovirus transport via direct interaction of cytoplasmic dynein with the viral capsid hexon subunit","volume":"6","author":"Bremner","year":"2009","journal-title":"Cell Host Microbe"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"3531","DOI":"10.1002\/1873-3468.13695","article-title":"Viral and cellular interactions during adenovirus DNA replication","volume":"593","author":"Charman","year":"2019","journal-title":"FEBS Lett."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1158\/1078-0432.CCR-03-0275","article-title":"A definitive role of RhoC in metastasis of orthotopic lung cancer in mice","volume":"10","author":"Ikoma","year":"2004","journal-title":"Clin. Cancer Res."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1089\/hum.1998.9.9-1293","article-title":"Retrovirus-mediated in vivo gene transfer in the replicating liver using recombinant hepatocyte growth factor without liver injury or partial hepatectomy","volume":"9","author":"Kosai","year":"1998","journal-title":"Hum. Gene Ther."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"2233643","DOI":"10.1080\/22221751.2023.2233643","article-title":"A new vaccination regimen using adenovirus-vectored vaccine confers effective protection against African swine fever virus in swine","volume":"12","author":"Liu","year":"2023","journal-title":"Emerg. Microbes Infect."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.virol.2015.04.013","article-title":"Genomic characterization of emergent pseudorabies virus in China reveals marked sequence divergence: Evidence for the existence of two major genotypes","volume":"483","author":"Ye","year":"2015","journal-title":"Virology"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.bbrc.2006.05.091","article-title":"C3d enhanced DNA vaccination induced humoral immune response to glycoprotein C of pseudorabies virus","volume":"347","author":"Tong","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_127","first-page":"987","article-title":"[C3d-M28 enhanced DNA vaccination induced humoral immune response to glycoprotein C of pseudorabies virus]","volume":"25","author":"Fan","year":"2009","journal-title":"Sheng Wu Gong Cheng Xue Bao"},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Zhang, C., Liu, Y., Chen, S., Qiao, Y., Guo, M., Zheng, Y., Xu, M., Wang, Z., Hou, J., and Wang, J. (2019). A gD&gC-substituted pseudorabies virus vaccine strain provides complete clinical protection and is helpful to prevent virus shedding against challenge by a Chinese pseudorabies variant. BMC Vet. Res., 15.","DOI":"10.1186\/s12917-018-1766-8"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"6153","DOI":"10.1016\/j.vaccine.2020.07.025","article-title":"A single dose glycoprotein D-based subunit vaccine against pseudorabies virus infection","volume":"38","author":"Zhang","year":"2020","journal-title":"Vaccine"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1128\/JVI.78.1.424-440.2004","article-title":"Complete, annotated sequence of the pseudorabies virus genome","volume":"78","author":"Klupp","year":"2004","journal-title":"J. Virol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.virusres.2016.09.004","article-title":"Live attenuated pseudorabies virus developed using the CRISPR\/Cas9 system","volume":"225","author":"Tang","year":"2016","journal-title":"Virus Res."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1186\/1743-422X-8-272","article-title":"Growth, physicochemical properties, and morphogenesis of Chinese wild-type PRV Fa and its gene-deleted mutant strain PRV SA215","volume":"8","author":"Zhu","year":"2011","journal-title":"Virol. J."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1186\/s12985-020-01450-7","article-title":"The recombinant pseudorabies virus expressing African swine fever virus CD2v protein is safe and effective in mice","volume":"17","author":"Feng","year":"2020","journal-title":"Virol. J."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.virusres.2010.07.027","article-title":"Alphavirus vectors for cancer therapy","volume":"153","author":"Quetglas","year":"2010","journal-title":"Virus Res."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s00705-018-4071-8","article-title":"Evaluation of an African swine fever (ASF) vaccine strategy incorporating priming with an alphavirus-expressed antigen followed by boosting with attenuated ASF virus","volume":"164","author":"Murgia","year":"2019","journal-title":"Arch. Virol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"104","DOI":"10.2144\/04371RR02","article-title":"Construction of recombinant fowlpox viruses carrying multiple vaccine antigens and immunomodulatory molecules","volume":"37","author":"Boyle","year":"2004","journal-title":"Biotechniques"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/bs.aivir.2016.07.001","article-title":"Modified Vaccinia Virus Ankara: History, Value in Basic Research, and Current Perspectives for Vaccine Development","volume":"97","author":"Volz","year":"2017","journal-title":"Adv. Virus Res."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.vetimm.2017.01.004","article-title":"Safety and immunogenicity of mammalian cell derived and Modified Vaccinia Ankara vectored African swine fever subunit antigens in swine","volume":"185","author":"Osorio","year":"2017","journal-title":"Vet. Immunol. Immunopathol."},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Lopera-Madrid, J., Medina-Mag\u00fces, L.G., Gladue, D.P., Borca, M.V., and Osorio, J.E. (2021). Optimization in the expression of ASFV proteins for the development of subunit vaccines using poxviruses as delivery vectors. Sci. Rep., 11.","DOI":"10.1038\/s41598-021-02949-x"},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Zhang, D., Ding, Z., and Xu, X. (2023). Pathologic Mechanisms of the Newcastle Disease Virus. Viruses, 15.","DOI":"10.3390\/v15040864"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.virusres.2014.02.016","article-title":"Newcastle disease virus: Current status and our understanding","volume":"184","author":"Ganar","year":"2014","journal-title":"Virus Res."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"101348","DOI":"10.1016\/j.coviro.2023.101348","article-title":"Advantages and challenges of Newcastle disease virus as a vector for respiratory mucosal vaccines","volume":"62","author":"Belov","year":"2023","journal-title":"Curr. Opin. Virol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1128\/JVI.80.3.1130-1139.2006","article-title":"Protection against respiratory syncytial virus by a recombinant Newcastle disease virus vector","volume":"80","author":"Gitiban","year":"2006","journal-title":"J. Virol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"9366","DOI":"10.1128\/JVI.78.17.9366-9375.2004","article-title":"Induction of cellular immune responses to simian immunodeficiency virus gag by two recombinant negative-strand RNA virus vectors","volume":"78","author":"Nakaya","year":"2004","journal-title":"J. Virol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1084\/jem.191.10.1777","article-title":"Type I interferon as a powerful adjuvant for monocyte-derived dendritic cell development and activity in vitro and in Hu-PBL-SCID mice","volume":"191","author":"Santini","year":"2000","journal-title":"J. Exp. Med."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"10872","DOI":"10.1073\/pnas.1934678100","article-title":"Selective contribution of IFN-alpha\/beta signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection","volume":"100","author":"Honda","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1007\/s12250-015-3692-2","article-title":"Recombinant Newcastle disease virus expressing African swine fever virus protein 72 is safe and immunogenic in mice","volume":"31","author":"Chen","year":"2016","journal-title":"Virol. Sin."},{"key":"ref_148","first-page":"891","article-title":"Lactic acid bacteria as oral delivery systems for biomolecules","volume":"67","author":"Berlec","year":"2012","journal-title":"Pharmazie"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s12033-011-9450-2","article-title":"Development of vaccine delivery vehicles based on lactic acid bacteria","volume":"51","author":"Tarahomjoo","year":"2012","journal-title":"Mol. Biotechnol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1128\/CVI.00050-11","article-title":"Evaluation of oral immunization with recombinant avian influenza virus HA1 displayed on the Lactococcus lactis surface and combined with the mucosal adjuvant cholera toxin subunit B","volume":"18","author":"Lei","year":"2011","journal-title":"Clin. Vaccine Immunol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jviromet.2008.02.014","article-title":"Expression of the capsid protein of porcine circovirus type 2 in Lactococcus lactis for oral vaccination","volume":"150","author":"Wang","year":"2008","journal-title":"J. Virol. Methods"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.jmii.2014.11.009","article-title":"Heterologous expression of carcinoembryonic antigen in Lactococcus lactis via LcsB-mediated surface displaying system for oral vaccine development","volume":"49","author":"Zhang","year":"2016","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"8475","DOI":"10.1007\/s00253-017-8600-2","article-title":"Recombinant Lactobacillus plantarum expressing HA2 antigen elicits protective immunity against H9N2 avian influenza virus in chickens","volume":"101","author":"Yang","year":"2017","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"2696","DOI":"10.1098\/rsif.2012.0163","article-title":"Dynamics of Salmonella infection of macrophages at the single cell level","volume":"9","author":"Gog","year":"2012","journal-title":"J. R. Soc. Interface"},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Senevirathne, A., Park, J.Y., Hewawaduge, C., Perumalraja, K., and Lee, J.H. (2021). Eukaryotic expression system complemented with expressivity of Semliki Forest Virus\u2019s RdRp and invasiveness of engineered Salmonella demonstrate promising potential for bacteria mediated gene therapy. Biomaterials, 279.","DOI":"10.1016\/j.biomaterials.2021.121226"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.vaccine.2007.11.033","article-title":"Recombinant Saccharomyces cerevisiae (yeast-CEA) as a potent activator of murine dendritic cells","volume":"26","author":"Bernstein","year":"2008","journal-title":"Vaccine"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1146\/annurev.immunol.20.103001.114744","article-title":"Phagocytosis of microbes: Complexity in action","volume":"20","author":"Underhill","year":"2002","journal-title":"Annu. Rev. Immunol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1517\/14712598.5.4.565","article-title":"Yeasts encoding tumour antigens in cancer immunotherapy","volume":"5","author":"Franzusoff","year":"2005","journal-title":"Expert. Opin. Biol. Ther."},{"key":"ref_159","first-page":"101","article-title":"Vectors for cloning in yeast","volume":"96","author":"Hinnen","year":"1982","journal-title":"Curr. Top. Microbiol. Immunol."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/3\/921\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T10:33:52Z","timestamp":1759919632000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/3\/921"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,22]]},"references-count":159,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,2]]}},"alternative-id":["ijms26030921"],"URL":"https:\/\/doi.org\/10.3390\/ijms26030921","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,22]]}}}