{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:42:23Z","timestamp":1759970543969,"version":"build-2065373602"},"reference-count":71,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T00:00:00Z","timestamp":1737676800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"German Reseearch Foundation","award":["BU 2487\/6-2","EXC 2167-390884018"],"award-info":[{"award-number":["BU 2487\/6-2","EXC 2167-390884018"]}]},{"name":"Germany\u2019s Excellence Strategy","award":["BU 2487\/6-2","EXC 2167-390884018"],"award-info":[{"award-number":["BU 2487\/6-2","EXC 2167-390884018"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Parkinson\u2019s disease (PD) is a neurodegenerative disorder with a high variability of age at onset, disease severity, and progression. This suggests that other factors, including genetic, environmental, or biological factors, are at play in PD. The loss of PINK1 causes a recessive form of PD and is typically fully penetrant; however, it features a wide range in disease onset, further supporting the existence of protective factors, endogenous or exogenous, to play a role. The loss of Pink1 in Drosophila melanogaster results in locomotion deficits, also observed in PINK1-related PD in humans. In flies, Pink1 deficiency induces defects in the ability to fly; nonetheless, around ten percent of the mutant flies are still capable of flying, indicating that advantageous factors affecting penetrance also exist in flies. Here, we aimed to identify the mechanisms underlying this reduced penetrance in Pink1-deficient flies. We performed genetic screening in pink1-mutant flies to identify RNA expression alterations affecting the flying ability. The most important biological processes involved were transcriptional and translational activities, endoplasmic reticulum (ER) regulation, and flagellated movement and microtubule organization. We validated two ER-related proteins, zonda and windbeutel, to positively affect the flying ability of Pink1-deficient flies. Thus, our data suggest that these processes are involved in the reduced penetrance and that influencing them may be beneficial for Pink1 deficiency.<\/jats:p>","DOI":"10.3390\/ijms26030979","type":"journal-article","created":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T04:32:22Z","timestamp":1737693142000},"page":"979","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Endoplasmic Reticulum Proteins Impact Penetrance in a Pink1-Mutant Drosophila Model"],"prefix":"10.3390","volume":"26","author":[{"given":"Melissa","family":"Vos","sequence":"first","affiliation":[{"name":"Institute of Neurogenetics, University of Luebeck, UKSH (Universit\u00e4tsklinikum Schleswig-Holstein, Campus L\u00fcbeck), Ratzeburger Allee 160, Building 67 (BMF), 23562 Luebeck, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0959-2359","authenticated-orcid":false,"given":"Fabian","family":"Ott","sequence":"additional","affiliation":[{"name":"Medical Systems Biology Division, L\u00fcbeck Institute of Experimental Dermatology, University of Luebeck, 23562 Luebeck, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hawwi","family":"Gillo","sequence":"additional","affiliation":[{"name":"Institute of Neurogenetics, University of Luebeck, UKSH (Universit\u00e4tsklinikum Schleswig-Holstein, Campus L\u00fcbeck), Ratzeburger Allee 160, Building 67 (BMF), 23562 Luebeck, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4550-6242","authenticated-orcid":false,"given":"Giuliana","family":"Cesare","sequence":"additional","affiliation":[{"name":"Institute of Neurogenetics, University of Luebeck, UKSH (Universit\u00e4tsklinikum Schleswig-Holstein, Campus L\u00fcbeck), Ratzeburger Allee 160, Building 67 (BMF), 23562 Luebeck, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Misera","sequence":"additional","affiliation":[{"name":"Institute of Neurogenetics, University of Luebeck, UKSH (Universit\u00e4tsklinikum Schleswig-Holstein, Campus L\u00fcbeck), Ratzeburger Allee 160, Building 67 (BMF), 23562 Luebeck, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4763-4521","authenticated-orcid":false,"given":"Hauke","family":"Busch","sequence":"additional","affiliation":[{"name":"Medical Systems Biology Division, L\u00fcbeck Institute of Experimental Dermatology, University of Luebeck, 23562 Luebeck, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2102-3431","authenticated-orcid":false,"given":"Christine","family":"Klein","sequence":"additional","affiliation":[{"name":"Institute of Neurogenetics, University of Luebeck, UKSH (Universit\u00e4tsklinikum Schleswig-Holstein, Campus L\u00fcbeck), Ratzeburger Allee 160, Building 67 (BMF), 23562 Luebeck, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1016\/S0140-6736(21)00218-X","article-title":"Parkinson\u2019s disease","volume":"397","author":"Bloem","year":"2021","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S1474-4422(23)00404-0","article-title":"A biological classification of Parkinson\u2019s disease: The SynNeurGe research diagnostic criteria","volume":"23","author":"Adler","year":"2024","journal-title":"Lancet Neurol."},{"key":"ref_3","first-page":"117","article-title":"Reduced penetrance of Parkinson\u2019s disease models","volume":"34","author":"Morais","year":"2022","journal-title":"Med. Genet."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S1474-4422(08)70117-0","article-title":"Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson\u2019s disease: A case-control study","volume":"7","author":"Healy","year":"2008","journal-title":"Lancet Neurol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1002\/mds.28189","article-title":"Nonsteroidal Anti-inflammatory Use and LRRK2 Parkinson\u2019s Disease Penetrance","volume":"35","author":"Luciano","year":"2020","journal-title":"Mov. Disord."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1002\/mds.27059","article-title":"Penetrance estimate of LRRK2 p.G2019S mutation in individuals of non-Ashkenazi Jewish ancestry","volume":"32","author":"Lee","year":"2017","journal-title":"Mov. Disord."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Chittoor-Vinod, V.G., Nichols, R.J., and Sch\u00fcle, B. (2021). Genetic and Environmental Factors Influence the Pleomorphy of LRRK2 Parkinsonism. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22031045"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1126\/science.1218632","article-title":"Vitamin K2 is a mitochondrial electron carrier that rescues pink1 deficiency","volume":"336","author":"Vos","year":"2012","journal-title":"Science"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1002\/mds.27352","article-title":"Genotype-Phenotype Relations for the Parkinson\u2019s Disease Genes Parkin, PINK1, DJ1: MDSGene Systematic Review","volume":"33","author":"Kasten","year":"2018","journal-title":"Mov. Disord."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"4195","DOI":"10.1007\/s00415-022-11041-x","article-title":"Coffee, smoking and aspirin are associated with age at onset in idiopathic Parkinson\u2019s disease","volume":"269","author":"Gabbert","year":"2022","journal-title":"J. Neurol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1002\/mds.28238","article-title":"Age at Onset of LRRK2 p.Gly2019Ser Is Related to Environmental and Lifestyle Factors","volume":"35","author":"Kasten","year":"2020","journal-title":"Mov. Disord."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/s41531-022-00418-4","article-title":"A systematic review and meta-analysis on effects of aerobic exercise in people with Parkinson\u2019s disease","volume":"8","author":"Zhen","year":"2022","journal-title":"Npj Park. Dis."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.14336\/AD.2021.0123","article-title":"The Proper Diet and Regular Physical Activity Slow Down the Development of Parkinson Disease","volume":"12","author":"Chromiec","year":"2021","journal-title":"Aging Dis."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1080\/07853890.2021.1890330","article-title":"The gut-brain axis and Parkinson disease: Clinical and pathogenetic relevance","volume":"53","author":"Menozzi","year":"2021","journal-title":"Ann. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/s41531-022-00300-3","article-title":"Multiomics implicate gut microbiota in altered lipid and energy metabolism in Parkinson\u2019s disease","volume":"8","author":"Pereira","year":"2022","journal-title":"Npj Park. Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/s41586-019-1405-y","article-title":"Intestinal infection triggers Parkinson\u2019s disease-like symptoms in Pink1\u2212\/\u2212 mice","volume":"571","author":"Matheoud","year":"2019","journal-title":"Nature"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Barazzuol, L., Giamogante, F., Brini, M., and Cal\u00ec, T. (2020). PINK1\/Parkin Mediated Mitophagy, Ca2+ Signalling, and ER\u2013Mitochondria Contacts in Parkinson\u2019s Disease. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21051772"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Chidambaram, R., Kumar, K., Parashar, S., Ramachandran, G., Chen, S., and Ferro-Novick, S. (2024). PINK1 controls RTN3L-mediated ER autophagy by regulating peripheral tubule junctions. J. Cell Biol., 223.","DOI":"10.1083\/jcb.202407193"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1080\/15548627.2016.1277309","article-title":"PINK1 and BECN1 relocalize at mitochondria-associated membranes during mitophagy and promote ER-mitochondria tethering and autophagosome formation","volume":"13","author":"Gelmetti","year":"2017","journal-title":"Autophagy"},{"key":"ref_20","first-page":"595","article-title":"MAM (mitochondria-associated membranes) in mammalian cells: Lipids and beyond","volume":"1841","author":"Vance","year":"2014","journal-title":"Biochim. Biophys. Acta (BBA)-Mol. Cell Biol. Lipids"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/ncb2012","article-title":"PINK1\/Parkin-mediated mitophagy is dependent on VDAC1 and p62\/SQSTM1","volume":"12","author":"Geisler","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1089\/ars.2010.3799","article-title":"Targeting mitochondrial dysfunction: Role for PINK1 and Parkin in mitochondrial quality control","volume":"14","author":"Narendra","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3306","DOI":"10.1523\/JNEUROSCI.5367-11.2012","article-title":"Endoplasmic reticulum stress is important for the manifestations of \u03b1-synucleinopathy in vivo","volume":"32","author":"Colla","year":"2012","journal-title":"J. Neurosci."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Wang, D., Qu, S., Zhang, Z., Tan, L., Chen, X., Zhong, H.J., and Chong, C.M. (2023). Strategies targeting endoplasmic reticulum stress to improve Parkinson\u2019s disease. Front. Pharmacol., 14.","DOI":"10.3389\/fphar.2023.1288894"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Vos, M., Klein, C., and Hicks, A.A. (2023). Role of Ceramides and Sphingolipids in Parkinson\u2019s Disease. J. Mol. Biol., 435.","DOI":"10.1016\/j.jmb.2023.168000"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Mandik, F., and Vos, M. (2021). Neurodegenerative Disorders: Spotlight on Sphingolipids. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222111998"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e2025347118","DOI":"10.1073\/pnas.2025347118","article-title":"Ceramide accumulation induces mitophagy and impairs \u03b2-oxidation in PINK1 deficiency","volume":"118","author":"Vos","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1002\/ana.25942","article-title":"Discordant Monozygotic Parkinson Disease Twins: Role of Mitochondrial Integrity","volume":"89","author":"Trinh","year":"2021","journal-title":"Ann. Neurol."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Vos, M., and Klein, C. (2021). The Importance of Drosophila melanogaster Research to UnCover Cellular Pathways Underlying Parkinson\u2019s Disease. Cells, 10.","DOI":"10.3390\/cells10030579"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1038\/nature04788","article-title":"Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin","volume":"441","author":"Park","year":"2006","journal-title":"Nature"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1038\/nature04779","article-title":"Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin","volume":"441","author":"Clark","year":"2006","journal-title":"Nature"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"706","DOI":"10.4161\/auto.5.5.8505","article-title":"Parkin-induced mitophagy in the pathogenesis of Parkinson disease","volume":"5","author":"Narendra","year":"2009","journal-title":"Autophagy"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Narendra, D.P., Jin, S.M., Tanaka, A., Suen, D.F., Gautier, C.A., Shen, J., Cookson, M.R., and Youle, R.J. (2010). PINK1 is selectively stabilized on impaired mitochondria to activate Parkin. PLoS Biol., 8.","DOI":"10.1371\/journal.pbio.1000298"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1083\/jcb.201511044","article-title":"Cardiolipin promotes electron transport between ubiquinone and complex I to rescue PINK1 deficiency","volume":"216","author":"Vos","year":"2017","journal-title":"J. Cell Biol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/sj.cdd.4401778","article-title":"ER stress and neurodegenerative diseases","volume":"13","author":"Lindholm","year":"2006","journal-title":"Cell Death Differ."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.nbd.2014.10.003","article-title":"Repression of rRNA transcription by PARIS contributes to Parkinson\u2019s disease","volume":"73","author":"Kang","year":"2015","journal-title":"Neurobiol. Dis."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1089\/ars.2019.7997","article-title":"The Mitochondrial Ribosome: A World of Opportunities for Mitochondrial Dysfunction Toward Parkinson\u2019s Disease","volume":"34","author":"Esteves","year":"2021","journal-title":"Antioxid. Redox Signal."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"3879","DOI":"10.1021\/acsptsci.4c00423","article-title":"Evaluating the Role of Lin-11, Isl-1, and Mec-3 Kinases in Dopaminergic Neurodegeneration in a Subacute 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Model of Parkinson\u2019s Disease","volume":"7","author":"Bhardwaj","year":"2024","journal-title":"ACS Pharmacol. Transl. Sci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.neuroscience.2011.06.008","article-title":"The KDEL receptor induces autophagy to promote the clearance of neurodegenerative disease-related proteins","volume":"190","author":"Wang","year":"2011","journal-title":"Neuroscience"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"34525","DOI":"10.1074\/jbc.M304188200","article-title":"The KDEL receptor modulates the endoplasmic reticulum stress response through mitogen-activated protein kinase signaling cascades","volume":"278","author":"Yamamoto","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Wires, E.S., Trychta, K.A., Kennedy, L.M., and Harvey, B.K. (2021). The Function of KDEL Receptors as UPR Genes in Disease. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22115436"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1080\/15548627.2022.2027193","article-title":"Ceramide-induced mitophagy impairs \u00df-oxidation-linked energy production in PINK1 deficiency","volume":"18","author":"Vos","year":"2022","journal-title":"Autophagy"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1139\/gen-2023-0135","article-title":"Variant functional assessment in Drosophila by overexpression: What can we learn?","volume":"67","author":"Her","year":"2024","journal-title":"Genome"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e05338","DOI":"10.7554\/eLife.05338","article-title":"A library of MiMICs allows tagging of genes and reversible, spatial and temporal knockdown of proteins in Drosophila","volume":"4","author":"Lee","year":"2015","journal-title":"eLife"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"5541","DOI":"10.1242\/dev.127.24.5541","article-title":"Windbeutel is required for function and correct subcellular localization of the Drosophila patterning protein Pipe","volume":"127","author":"Sen","year":"2000","journal-title":"Development"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1101\/gad.12.1.120","article-title":"windbeutel, a gene required for dorsoventral patterning in Drosophila, encodes a protein that has homologies to vertebrate proteins of the endoplasmic reticulum","volume":"12","author":"Konsolaki","year":"1998","journal-title":"Genes Dev."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/0968-0004(90)90303-S","article-title":"The retention signal for soluble proteins of the endoplasmic reticulum","volume":"15","author":"Pelham","year":"1990","journal-title":"Trends Biochem. Sci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"3082","DOI":"10.1093\/emboj\/20.12.3082","article-title":"The KDEL receptor mediates a retrieval mechanism that contributes to quality control at the endoplasmic reticulum","volume":"20","author":"Yamamoto","year":"2001","journal-title":"EMBO J."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Brecker, M., Khakhina, S., Schubert, T.J., Thompson, Z., and Rubenstein, R.C. (2020). The Probable, Possible, and Novel Functions of ERp29. Front. Physiol., 11.","DOI":"10.3389\/fphys.2020.574339"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.biocel.2010.09.019","article-title":"Endoplasmic reticulum protein 29 (ERp29): An emerging role in cancer","volume":"43","author":"Zhang","year":"2011","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/j.1471-4159.2008.05392.x","article-title":"Changes in endoplasmic reticulum stress proteins and aldolase A in cells exposed to dopamine","volume":"106","author":"Dukes","year":"2008","journal-title":"J. Neurochem."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"7568","DOI":"10.1074\/jbc.M704097200","article-title":"The Dystonia-associated Protein TorsinA Modulates Synaptic Vesicle Recycling","volume":"283","author":"Granata","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1002\/syn.21534","article-title":"Synaptic vesicle recycling is enhanced by torsinA that harbors the DYT1 dystonia mutation","volume":"66","author":"Kakazu","year":"2012","journal-title":"Synapse"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.devcel.2016.06.017","article-title":"Torsins Are Essential Regulators of Cellular Lipid Metabolism","volume":"38","author":"Grillet","year":"2016","journal-title":"Dev. Cell"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/(SICI)1098-1004(1999)14:3<269::AID-HUMU12>3.0.CO;2-9","article-title":"A common 3-bp deletion in the DYT1 gene in Russian families with early-onset torsion dystonia","volume":"3","author":"Slominsky","year":"1999","journal-title":"Hum. Mutat."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.neuroscience.2017.12.033","article-title":"Exploring the Interaction Between eIF2\u03b1 Dysregulation, Acute Endoplasmic Reticulum Stress and DYT1 Dystonia in the Mammalian Brain","volume":"371","author":"Beauvais","year":"2018","journal-title":"Neuroscience"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S0006-8993(00)02702-5","article-title":"TorsinA accumulation in Lewy bodies in sporadic Parkinson\u2019s disease","volume":"877","author":"Shashidharan","year":"2000","journal-title":"Brain Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0002-9440(10)61700-2","article-title":"A close association of torsinA and alpha-synuclein in Lewy bodies: A fluorescence resonance energy transfer study","volume":"159","author":"Sharma","year":"2001","journal-title":"Am. J. Pathol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"3801","DOI":"10.1523\/JNEUROSCI.5157-04.2005","article-title":"Torsin-Mediated Protection from Cellular Stress in the Dopaminergic Neurons of Caenorhabditis elegans","volume":"25","author":"Cao","year":"2005","journal-title":"J. Neurosci."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Melani, M., Valko, A., Romero, N.M., Aguilera, M.O., Acevedo, J.M., Bhujabal, Z., Perez-Perri, J., De La Riva-Carrasco, R.V., Katz, M.J., and Sorianello, E. (2017). Zonda is a novel early component of the autophagy pathway in Drosophila. Mol. Biol. Cell, 28.","DOI":"10.1091\/mbc.e16-11-0767"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.yjmcc.2017.11.004","article-title":"FKBP8 protects the heart from hemodynamic stress by preventing the accumulation of misfolded proteins and endoplasmic reticulum-associated apoptosis in mice","volume":"114","author":"Misaka","year":"2018","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1242\/dev.01122","article-title":"FKBP8 is a negative regulator of mouse sonic hedgehog signaling in neural tissues","volume":"131","author":"Bulgakov","year":"2004","journal-title":"Development"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"947","DOI":"10.15252\/embr.201643147","article-title":"FKBP8 recruits LC3A to mediate Parkin-independent mitophagy","volume":"18","author":"Bhujabal","year":"2017","journal-title":"EMBO Rep."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1083\/jcb.200809125","article-title":"Parkin is recruited selectively to impaired mitochondria and promotes their autophagy","volume":"183","author":"Narendra","year":"2008","journal-title":"J. Cell Biol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2944","DOI":"10.1096\/fj.201901735R","article-title":"FKBP8 LIRL-dependent mitochondrial fragmentation facilitates mitophagy under stress conditions","volume":"34","author":"Yoo","year":"2020","journal-title":"FASEB J."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.cell.2017.07.015","article-title":"Golgi-Resident G\u03b1o Promotes Protrusive Membrane Dynamics","volume":"170","author":"Solis","year":"2017","journal-title":"Cell"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"i884","DOI":"10.1093\/bioinformatics\/bty560","article-title":"fastp: An ultra-fast all-in-one FASTQ preprocessor","volume":"34","author":"Chen","year":"2018","journal-title":"Bioinformatics"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/nmeth.4324","article-title":"Differential analysis of RNA-seq incorporating quantification uncertainty","volume":"14","author":"Pimentel","year":"2017","journal-title":"Nat. Methods"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.12688\/f1000research.7563.2","article-title":"Differential analyses for RNA-seq: Transcript-level estimates improve gene-level inferences","volume":"4","author":"Soneson","year":"2016","journal-title":"F1000Research"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Luo, W., Friedman, M.S., Shedden, K., Hankenson, K.D., and Woolf, P.J. (2009). GAGE: Generally applicable gene set enrichment for pathway analysis. BMC Bioinform., 10.","DOI":"10.1186\/1471-2105-10-161"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/3\/979\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T10:35:14Z","timestamp":1759919714000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/3\/979"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,24]]},"references-count":71,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,2]]}},"alternative-id":["ijms26030979"],"URL":"https:\/\/doi.org\/10.3390\/ijms26030979","relation":{},"ISSN":["1422-0067"],"issn-type":[{"type":"electronic","value":"1422-0067"}],"subject":[],"published":{"date-parts":[[2025,1,24]]}}}