{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T23:19:08Z","timestamp":1789773548074,"version":"4.0.1"},"reference-count":30,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,1,25]],"date-time":"2025-01-25T00:00:00Z","timestamp":1737763200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Italian Ministry of University and Research","award":["2022ZRNTHW"],"award-info":[{"award-number":["2022ZRNTHW"]}]},{"name":"Italian Ministry of University and Research","award":["PE00000007"],"award-info":[{"award-number":["PE00000007"]}]},{"name":"Italian Ministry of University and Research","award":["896932"],"award-info":[{"award-number":["896932"]}]},{"name":"EU funding within the MUR PNRR Extended Partnership initiative on Emerging Infectious Diseases","award":["2022ZRNTHW"],"award-info":[{"award-number":["2022ZRNTHW"]}]},{"name":"EU funding within the MUR PNRR Extended Partnership initiative on Emerging Infectious Diseases","award":["PE00000007"],"award-info":[{"award-number":["PE00000007"]}]},{"name":"EU funding within the MUR PNRR Extended Partnership initiative on Emerging Infectious Diseases","award":["896932"],"award-info":[{"award-number":["896932"]}]},{"name":"Italian Ministry of Health \u201cRicerca Corrente\u2014Linea 1\u2014INMI L. Spallanzani I.R.C.C.S\u201d. funding and by the European Union\u2019s Horizon 2020 research and innovation program","award":["2022ZRNTHW"],"award-info":[{"award-number":["2022ZRNTHW"]}]},{"name":"Italian Ministry of Health \u201cRicerca Corrente\u2014Linea 1\u2014INMI L. Spallanzani I.R.C.C.S\u201d. funding and by the European Union\u2019s Horizon 2020 research and innovation program","award":["PE00000007"],"award-info":[{"award-number":["PE00000007"]}]},{"name":"Italian Ministry of Health \u201cRicerca Corrente\u2014Linea 1\u2014INMI L. Spallanzani I.R.C.C.S\u201d. funding and by the European Union\u2019s Horizon 2020 research and innovation program","award":["896932"],"award-info":[{"award-number":["896932"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Recent studies have identified Torquetenovirus (TTV) as a promising biomarker of immune competence, particularly in assessing the vaccine response of solid organ transplant (SOT) recipients. However, given the individual variability of viral load, it is not yet possible to define \"normal levels\u201d. Nevertheless, TTV is just one component of the broader Anelloviridae family, which also includes Torquetenominivirus (TTMV) and Torquetenomidivirus (TTMDV). This study explores whether the viremia of TTMV and TTMDV offers a stronger predictive marker for vaccine efficacy in SOT recipients. A cohort of 168 SOT patients (142 kidney and 26 lung transplant recipients) who received the BNT162B2 mRNA vaccine was examined, with viral loads quantified through virus-specific real-time PCR. While TTV remains a potentially useful biomarker for evaluating immune response, the combined analysis of all anelloviruses viremia provides deeper insights, particularly in cases where TTV is undetectable. Notably, only TTMV exhibited a pattern similar to TTV, suggesting its potential as an alternative biomarker when TTV is absent from the patient\u2019s virome.<\/jats:p>","DOI":"10.3390\/ijms26031022","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T03:54:27Z","timestamp":1737950067000},"page":"1022","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Assessment of Torquetenominivirus (TTMV) and Torquetenomidivirus (TTMDV) as Complementary Biomarkers to Torquetenovirus (TTV)"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2814-5553","authenticated-orcid":false,"given":"Lilia","family":"Cinti","sequence":"first","affiliation":[{"name":"Laboratory of Microbiology and Virology, Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena, 324, 00161 Roma, Italy"},{"name":"PhD National Interest in Innovation in the Diagnosis, Prevention and Treatment of Infections at Epidemic-Pandemic Risk, Department of Medical Biotechnologies, University of Siena, 53100 Siena, Italy"},{"name":"University Hospital \u201cPoliclinico Umberto I\u201d, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6743-014X","authenticated-orcid":false,"given":"Pietro Giorgio","family":"Spezia","sequence":"additional","affiliation":[{"name":"Laboratory of Virology, National Institute for Infectious Diseases Lazzaro Spallanzani-IRCCS, 00149 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9170-3654","authenticated-orcid":false,"given":"Piergiorgio","family":"Roberto","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology and Virology, Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena, 324, 00161 Roma, Italy"},{"name":"University Hospital \u201cPoliclinico Umberto I\u201d, 00161 Rome, Italy"},{"name":"PhD National Programme in One Health Approaches to Infectious Diseases and Life Science Research, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8764-7389","authenticated-orcid":false,"given":"Gianluca","family":"Russo","sequence":"additional","affiliation":[{"name":"University Hospital \u201cPoliclinico Umberto I\u201d, 00161 Rome, Italy"},{"name":"Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quirino","family":"Lai","sequence":"additional","affiliation":[{"name":"University Hospital \u201cPoliclinico Umberto I\u201d, 00161 Rome, Italy"},{"name":"Department of General and Specialistic Surgery, Sapienza University of Rome, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Carillo","sequence":"additional","affiliation":[{"name":"University Hospital \u201cPoliclinico Umberto I\u201d, 00161 Rome, Italy"},{"name":"Department of General and Specialistic Surgery \u201cParide Stefanini\u201d, Sapienza University of Rome, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Frasca","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology and Virology, Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena, 324, 00161 Roma, Italy"},{"name":"Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2533-2939","authenticated-orcid":false,"given":"Guido","family":"Antonelli","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology and Virology, Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena, 324, 00161 Roma, Italy"},{"name":"University Hospital \u201cPoliclinico Umberto I\u201d, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7489-5271","authenticated-orcid":false,"given":"Fabrizio","family":"Maggi","sequence":"additional","affiliation":[{"name":"Laboratory of Virology, National Institute for Infectious Diseases Lazzaro Spallanzani-IRCCS, 00149 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Sakuraba, A., Luna, A., and Micic, D. 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