{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:43:22Z","timestamp":1793040202417,"version":"4.5.0"},"reference-count":152,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T00:00:00Z","timestamp":1738022400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fondos Estatales Gen\u00e9ricos de la Universidad Aut\u00f3noma del Estado de Hidalgo","award":["19398\/2022"],"award-info":[{"award-number":["19398\/2022"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Endothelial dysfunction and chronic inflammation are determining factors in the development and progression of chronic degenerative diseases, such as hypertension and atherosclerosis. Among the shared pathophysiological characteristics of these two diseases is a metabolic disorder of lipids and lipoproteins. Therefore, the contents and quality of the lipids and proteins of lipoproteins become the targets of therapeutic objective. One of the stages of lipoprotein formation occurs through the incorporation of dietary lipids by enterocytes into the chylomicrons. Consequently, the composition, structure, and especially the properties of lipoproteins could be modified through the intake of bioactive compounds. The objective of this review is to describe the roles of the different lipid and protein components of lipoproteins and their receptors in endothelial dysfunction and the development of hypertension. In addition, we review the use of some non-pharmacological treatments that could improve endothelial function and\/or prevent endothelial damage. The reviewed information contributes to the understanding of lipoproteins as vehicles of regulatory factors involved in the modulation of inflammatory and hemostatic processes, the attenuation of oxidative stress, and the neutralization of toxins, rather than only cholesterol and phospholipid transporters. For this review, a bibliographic search was carried out in different online metabases.<\/jats:p>","DOI":"10.3390\/ijms26031125","type":"journal-article","created":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T06:47:29Z","timestamp":1738046849000},"page":"1125","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Relevance of Lipoprotein Composition in Endothelial Dysfunction and the Development of Hypertension"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2188-4146","authenticated-orcid":false,"given":"Lisette Monsibaez","family":"Ram\u00edrez-Melo","sequence":"first","affiliation":[{"name":"Nutrition Academic Area Instituto de Ciencias de la Salud, Universidad Aut\u00f3noma del Estado de Hidalgo, Circuito Ex Hacienda La Concepci\u00f3n S\/N, Carretera Pachuca-Actopan, San Agust\u00edn Tlaxiaca 42160, Hidalgo, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Estrada-Luna","sequence":"additional","affiliation":[{"name":"Nursing Academic Area, Instituto de Ciencias de la Salud, Universidad Aut\u00f3noma del Estado de Hidalgo, Circuito Ex Hacienda La Concepci\u00f3n S\/N, Carretera Pachuca-Actopan, San Agust\u00edn Tlaxiaca 42160, Hidalgo, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8844-2078","authenticated-orcid":false,"given":"Mar\u00eda Esther","family":"Rubio-Ruiz","sequence":"additional","affiliation":[{"name":"Department of Physiology, Instituto Nacional de Cardiolog\u00eda Ignacio Ch\u00e1vez, Juan Badiano 1, Tlalpan, Mexico City 14080, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0759-3198","authenticated-orcid":false,"given":"Araceli","family":"Casta\u00f1eda-Ovando","sequence":"additional","affiliation":[{"name":"Chemistry Academic Area, Instituto de Ciencias B\u00e1sicas e Ingenier\u00eda, Universidad Aut\u00f3noma del Estado de Hidalgo, Pachuca 42039, Hidalgo, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3280-1323","authenticated-orcid":false,"given":"Eduardo","family":"Fern\u00e1ndez-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Medicine Academic Area, Instituto de Ciencias de la Salud, Universidad Aut\u00f3noma del Estado de Hidalgo, Pachuca 42039, Hidalgo, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5108-0205","authenticated-orcid":false,"given":"Ang\u00e9lica Sara\u00ed","family":"Jim\u00e9nez-Osorio","sequence":"additional","affiliation":[{"name":"Nursing Academic Area, Instituto de Ciencias de la Salud, Universidad Aut\u00f3noma del Estado de Hidalgo, Circuito Ex Hacienda La Concepci\u00f3n S\/N, Carretera Pachuca-Actopan, San Agust\u00edn Tlaxiaca 42160, Hidalgo, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6977-1829","authenticated-orcid":false,"given":"\u00d3scar","family":"P\u00e9rez-M\u00e9ndez","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Instituto Nacional de Cardiolog\u00eda Ignacio Ch\u00e1vez, Juan Badiano 1, Mexico City 14080, Mexico"},{"name":"Tecnol\u00f3gico de Monterrey, Campus Ciudad de M\u00e9xico, Mexico City 14380, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3600-249X","authenticated-orcid":false,"given":"Elizabeth","family":"Carre\u00f3n-Torres","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Instituto Nacional de Cardiolog\u00eda Ignacio Ch\u00e1vez, Juan Badiano 1, Mexico City 14080, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2982","DOI":"10.1016\/j.jacc.2020.11.010","article-title":"Global Burden of Cardiovascular Diseases and Risk Factors, 1990\u20132019: Update From the GBD 2019 Study","volume":"76","author":"Roth","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_2","unstructured":"(2024, May 13). World Health Organization. Available online: https:\/\/www.who.int\/health-topics\/cardiovascular-diseases#tab=tab_1."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"75","DOI":"10.5334\/gh.1154","article-title":"World Heart Federation Cholesterol Roadmap 2022","volume":"17","author":"Ray","year":"2022","journal-title":"Glob. Heart"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1097\/00004872-200103000-00009","article-title":"Correlation of endothelial function in large and small arteries in human essential hypertension","volume":"19","author":"Park","year":"2001","journal-title":"J. Hypertens."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1038\/s41419-023-06206-z","article-title":"Macrophage polarization and metabolism in atherosclerosis","volume":"14","author":"Hou","year":"2023","journal-title":"Cell Death Dis."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Casas, R., Estruch, R., and Sacanella, E. (2018). Influence of bioactive nutrients on the atherosclerotic process: A review. Nutrients, 10.","DOI":"10.3390\/nu10111630"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1042\/BCJ20200894","article-title":"Role of macrophage autophagy in atherosclerosis: Modulation by bioactive compounds","volume":"478","author":"Zahid","year":"2021","journal-title":"Biochem. J."},{"key":"ref_8","unstructured":"Kotowska, D.E. (2013). Health Promoting Effects of Bioactive Compounds in Plants. [Ph.D. Thesis, University of Copenhagen]."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"407","DOI":"10.4141\/cjps2011-090","article-title":"Anti-atherosclerotic effects of fruit bioactive compounds: A review of current scientific evidence","volume":"92","author":"Thilakarathna","year":"2012","journal-title":"Can. J. Plant Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1080\/10408398.2016.1235546","article-title":"Bioactive compounds as an alternative for drug co-therapy: Overcoming challenges in cardiovascular disease prevention","volume":"58","author":"Scolaro","year":"2018","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Dorantes-Morales, A., Estrada-Luna, D., Bautista-P\u00e9rez, R., Betanzos-Cabrera, G., Luna-Luna, M., Flores-Castillo, C., Vargas-Alarc\u00f3n, G., Fragoso, J.M., P\u00e9rez-M\u00e9ndez, O., and Carre\u00f3n-Torres, E. (2020). Microencapsulated Pomegranate Modifies the Composition and Function of High-Density Lipoproteins (HDL) in New Zealand Rabbits. Molecules, 25.","DOI":"10.3390\/molecules25143297"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Pe\u00f1a-De-La-Sancha, P., Mu\u00f1oz-Garc\u00eda, A., Esp\u00ednola-Zavaleta, N., Bautista-P\u00e9rez, R., Mej\u00eda, A.M., Luna-Luna, M., L\u00f3pez-Olmos, V., Rodr\u00edguez-P\u00e9rez, J.M., Fragoso, J.M., and Carre\u00f3n-Torres, E. (2023). Eicosapentaenoic and docosahexaenoic acid supplementation increases HDL content in n-3 fatty acids and improves endothelial function in hypertriglyceridemic patients. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24065390"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1515\/bc.2010.129","article-title":"Lipoprotein receptors--an evolutionarily ancient multifunctional receptor family","volume":"391","author":"Dieckmann","year":"2010","journal-title":"Biol. Chem."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1161\/ATVBAHA.111.226159","article-title":"Serum amyloid A facilitates the binding of high-density lipoprotein from mice injected with lipopolysaccharide to vascular proteoglycans","volume":"31","author":"Chiba","year":"2011","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s12944-023-01817-z","article-title":"HDL and LDL have distinct, opposing effects on LPS-induced brain inflammation","volume":"22","author":"Yates","year":"2023","journal-title":"Lipids Health Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1194\/jlr.R300019-JLR200","article-title":"Effects of infection and inflammation on lipid and lipoprotein metabolism: Mechanisms and consequences to the host","volume":"45","author":"Khovidhunkit","year":"2004","journal-title":"J. Lipid Res."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Netea, M.G., Joosten, L.A., Keuter, M., Wagener, F., Stalenhoef, A.F.H., van der Meer, J.W.M., and Kullberg, B.J. (2009). Circulating lipoproteins are a crucial component of host defense against invasive Salmonella typhimurium infection. PLoS ONE, 4.","DOI":"10.1371\/journal.pone.0004237"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Estrada-Luna, D., Ortiz-Rodriguez, M.A., Medina-Brise\u00f1o, L., Carre\u00f3n-Torres, E., Izquierdo-Vega, J.A., Sharma, A., Cancino-D\u00edaz, J.C., P\u00e9rez-M\u00e9ndez, O., Belefant-Miller, H., and Betanzos-Cabrera, G. (2018). Current therapies focused on high-density lipoproteins associated with cardiovascular disease. Molecules, 23.","DOI":"10.3390\/molecules23112730"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Kuklenyik, Z., Jones, J.I., Gardner, M.S., Schieltz, D.M., Parks, B.A., Toth, C.A., Rees, J.C., Andrews, M.L., Carter, K., and Lehtikoski, A.K. (2018). Core lipid, surface lipid and apolipoprotein composition analysis of lipoprotein particles as a function of particle size in one workflow integrating asymmetric flow field-flow fractionation and liquid chromatography-tandem mass spectrometry. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0194797"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/1476-9255-7-54","article-title":"Hypercholesterolemia and microvascular dysfunction: Interventional strategies","volume":"7","author":"Stapleton","year":"2010","journal-title":"J. Inflamm."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"748","DOI":"10.14336\/AD.2017.1003","article-title":"Removal of Chylomicron Remnants from the Bloodstream is Delayed in Aged Subjects","volume":"9","author":"Vinagre","year":"2018","journal-title":"Aging Dis."},{"key":"ref_22","first-page":"3","article-title":"Lipid metabolism and classification of hyperlipaemias. Metabolismo lip\u00eddico y clasificaci\u00f3n de las hiperlipemias","volume":"33","author":"Real","year":"2021","journal-title":"Clin. Investig. Arterioscler."},{"key":"ref_23","first-page":"98","article-title":"Mecanismos b\u00e1sicos: Estructura, funci\u00f3n y metabolismo de las lipoprote\u00ednas plasm. [Basic mechanisms: Structure, function and metabolism of plasma lipoproteins]","volume":"25","author":"Errico","year":"2013","journal-title":"Clin. Investig. Arterioscler."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"25650","DOI":"10.1074\/jbc.M801027200","article-title":"Lipolysis stimulated lipoprotein receptor: A novel molecular link between hyperlipidemia, weight gain, and atherosclerosis in mice","volume":"283","author":"Yen","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s13613-021-00800-0","article-title":"Relationship between lipoprotein concentrations and short-term and 1-year mortality in intensive care unit septic patients: Results from the HIGHSEPS study","volume":"11","author":"Tanaka","year":"2021","journal-title":"Ann. Intensive Care"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.5551\/jat.64704","article-title":"Low-Density Lipoprotein Cholesterol to Triglyceride Ratio and Clinical Outcomes after Acute Ischaemic Stroke or Transient Ischaemic Attack","volume":"31","author":"Xu","year":"2024","journal-title":"J. Atheroscler. Thromb."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Barker, G., Leeuwenburgh, C., Brusko, T., Moldawer, L., Reddy, S.T., and Guirgis, F.W. (2021). Lipid and lipoprotein dysregulation in sepsis: Clinical and mechanistic insights into chronic critical illness. J. Clin. Med., 10.","DOI":"10.3390\/jcm10081693"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Mu\u00f1oz-Vega, M., Mass\u00f3, F., P\u00e1ez, A., Vargas-Alarc\u00f3n, G., Coral-V\u00e1zquez, R., and Mas-Olivia, J. (2018). Carre\u00f3n-Torres, E.; P\u00e9rez-M\u00e9ndez, O. HDL-Mediated Lipid Influx to Endothelial Cells Contributes to Regulating Intercellular Adhesion Molecule (ICAM)-1 Expression and eNOS Phosphorylation. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19113394"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.mam.2012.07.010","article-title":"SLC27 fatty acid transport proteins","volume":"34","author":"Anderson","year":"2013","journal-title":"Mol. Asp. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.plipres.2015.04.003","article-title":"Membrane lipid therapy: Modulation of the cell membrane composition and structure as a molecular base for drug discovery and new disease treatment","volume":"59","author":"Busquets","year":"2015","journal-title":"Prog. Lipid Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.tem.2011.04.007","article-title":"Increased very low density lipoprotein (VLDL) secretion, hepatic steatosis, and insulin resistance","volume":"22","author":"Choi","year":"2011","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Hesse, D., Jaschke, A., Chung, B., and Sch\u00fcrmann, A. (2013). Trans-Golgi proteins participate in the control of lipid droplet and chylomicron formation. Biosci. Rep., 33.","DOI":"10.1042\/BSR20120082"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1093\/ajcn\/86.5.1286","article-title":"A high-fat meal induces low-grade endotoxemia: Evidence of a novel mechanism of postprandial inflammation","volume":"86","author":"Erridge","year":"2007","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Medina-Leyte, D.J., Zepeda-Garc\u00eda, O., Dom\u00ednguez-P\u00e9rez, M., Gonz\u00e1lez-Garrido, A., Villarreal-Molina, T., and Jacobo-Albavera, L. (2021). Endothelial dysfunction, inflammation and coronary artery disease: Potential biomarkers and promising therapeutical approaches. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22083850"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1016\/S0140-6736(00)02225-X","article-title":"Blood coagulation","volume":"355","year":"2000","journal-title":"Lancet"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.carpath.2012.06.006","article-title":"Vascular endothelium, hemodynamics, and the pathobiology of atherosclerosis","volume":"22","year":"2013","journal-title":"Cardiovasc. Pathol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/apha.12646","article-title":"Endothelial dysfunction and vascular disease\u2014A 30th anniversary update","volume":"219","author":"Vanhoutte","year":"2017","journal-title":"Acta Physiol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1136\/hrt.2003.032847","article-title":"Evaluating endothelial function in humans: A guide to invasive and non-invasive techniques","volume":"91","author":"Tousoulis","year":"2005","journal-title":"Heart"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"3781","DOI":"10.1002\/cphy.c210029","article-title":"Endothelial glycocalyx","volume":"12","author":"Foote","year":"2022","journal-title":"Compr. Physiol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1097\/00005344-200109011-00004","article-title":"Vascular protective effects of angiotensin converting enzyme inhibitors and their relation to clinical events","volume":"37","author":"Enseleit","year":"2001","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1161\/CIRCRESAHA.116.302855","article-title":"Endothelial cell metabolism in normal and diseased vasculature","volume":"116","author":"Eelen","year":"2015","journal-title":"Circ. Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/S0735-1097(03)00630-2","article-title":"Low body mass index is a risk factor for impaired endothelium-dependent vasodilation in humans: Role of nitric oxide and oxidative stress","volume":"42","author":"Higashi","year":"2003","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1080\/10408363.2017.1394267","article-title":"The vascular endothelium: A regulator of arterial tone and interface for the immune system","volume":"54","author":"Kendrick","year":"2017","journal-title":"Crit. Rev. Clin. Lab. Sci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"302","DOI":"10.2174\/1874192401004010302","article-title":"The endothelium and its role in regulating vascular tone","volume":"4","author":"Sandoo","year":"2010","journal-title":"Open Cardiovasc. Med. J."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1007\/s11906-010-0103-9","article-title":"Oxidative stress and vascular function: Implications for pharmacologic treatments","volume":"12","author":"Weseler","year":"2010","journal-title":"Curr. Hypertens. Rep."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1161\/CIRCULATIONAHA.106.652859","article-title":"Endothelial function and dysfunction: Testing and clinical relevance","volume":"115","author":"Deanfield","year":"2007","journal-title":"Circulation"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"105843","DOI":"10.1016\/j.tvjl.2022.105843","article-title":"The microvascular endothelial glycocalyx: An additional piece of the puzzle in veterinary medicine","volume":"285","author":"Hughes","year":"2022","journal-title":"Vet. J."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Rinaldi, C., Donato, L., Alibrandi, S., Scimone, C., D\u2019Angelo, R., and Sidoti, A. (2021). Oxidative stress and the neurovascular unit. Life, 11.","DOI":"10.3390\/life11080767"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"12633","DOI":"10.1074\/jbc.275.17.12633","article-title":"Oxidized low density lipoprotein (ox-LDL) binding to ox-LDL receptor-1 in endothelial cells induces the activation of NF-\u03baB through an increased production of intracellular reactive oxygen species","volume":"275","author":"Cominacini","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s11883-017-0691-9","article-title":"Glycocalyx in Atherosclerosis-Relevant Endothelium Function and as a Therapeutic Target","volume":"19","author":"Mitra","year":"2017","journal-title":"Curr. Atheroscler. Rep."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Rajendran, P., Rengarajan, T., Thangavel, J., Nishigaki, Y., Sakthisekaran, D., Sethi, G., and Nishigaki, I. (2013). The vascular endothelium and human diseases. Int. J. Biol. Sci., 9.","DOI":"10.7150\/ijbs.7502"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Brosolo, G., Da Porto, A., Marcante, S., Picci, A., Capilupi, F., Capilupi, P., Bulfone, L., Vacca, A., Bertin, N., and Vivarelli, C. (2023). Lipoprotein (a): Just an innocent bystander in arterial hypertension?. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241713363"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1007\/s00134-009-1609-y","article-title":"Changes in HDL-associated apolipoproteins relate to mortality in human sepsis and correlate to monocyte and platelet activation","volume":"35","author":"Barlage","year":"2009","journal-title":"Intensive Care Med."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Munno, M., Mallia, A., Greco, A., Modafferi, G., Banfi, C., and Eligini, S. (2024). Radical Oxygen Species, Oxidized Low-Density Lipoproteins, and Lectin-like Oxidized Low-Density Lipoprotein Receptor 1: A Vicious Circle in Atherosclerotic Process. Antioxidants, 13.","DOI":"10.3390\/antiox13050583"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"e173160","DOI":"10.1172\/JCI173160","article-title":"Endothelial lipid droplets suppress eNOS to link high fat consumption to blood pressure elevation","volume":"133","author":"Kim","year":"2023","journal-title":"J. Clin. Investig."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1042\/BST0350466","article-title":"Postprandial inflammation and endothelial dysfuction","volume":"35","author":"Alipour","year":"2007","journal-title":"Biochem. Soc. Trans."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s11883-003-0036-8","article-title":"The concept of apolipoprotein-defined lipoprotein families and its clinical significance","volume":"5","author":"Alaupovic","year":"2003","journal-title":"Curr. Atheroscler. Rep."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1194\/jlr.P023028","article-title":"Plasma apolipoprotein O level increased in the patients with acute coronary syndrome","volume":"53","author":"Yu","year":"2012","journal-title":"J. Lipid Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1016\/S0022-2275(20)30267-4","article-title":"Structure of apolipoprotein B-100 in low density lipoproteins","volume":"42","author":"Segrest","year":"2001","journal-title":"J. Lipid Res."},{"key":"ref_60","unstructured":"van der Vorst, E.P. (2020). Vertebrate and Invertebrate Respiratory Proteins, Lipoproteins and Other Body Fluid Proteins, Springer International Publishing."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"4165","DOI":"10.1172\/JCI127308","article-title":"Increased apolipoprotein C3 drives cardiovascular risk in type 1 diabetes","volume":"129","author":"Kanter","year":"2019","journal-title":"J. Clin. Investig."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1093\/qjmed\/hcl027","article-title":"Apolipoproteins as markers and managers of coronary risk","volume":"99","author":"Chan","year":"2006","journal-title":"QJM Int. J. Med."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"3002","DOI":"10.1161\/CIRCULATIONAHA.107.713438","article-title":"Lipids, apolipoproteins, and their ratios in relation to cardiovascular events with statin treatment","volume":"117","author":"Kastelein","year":"2008","journal-title":"Circulation"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"7032","DOI":"10.1002\/cam4.2587","article-title":"Apolipoproteins and cancer","volume":"8","author":"Ren","year":"2019","journal-title":"Cancer Med."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1194\/jlr.R900015-JLR200","article-title":"Lipoproteomics: Using mass spectrometry-based proteomics to explore the assembly, structure, and function of lipoproteins: Thematic Review Series: Proteomics","volume":"50","author":"Hoofnagle","year":"2009","journal-title":"J. Lipid Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1161\/01.RES.0000170946.56981.5c","article-title":"New insights into the regulation of HDL metabolism and reverse cholesterol transport","volume":"96","author":"Lewis","year":"2005","journal-title":"Circ. Res."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.gene.2016.07.070","article-title":"Apolipoprotein A5 fifteen years anniversary: Lessons from genetic epidemiology","volume":"592","author":"Hubacek","year":"2016","journal-title":"Gene"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1194\/jlr.R052753","article-title":"Apolipoprotein A-IV: A protein intimately involved in metabolism","volume":"56","author":"Wang","year":"2015","journal-title":"J. Lipid Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/j.1365-2796.2005.01556.x","article-title":"Apolipoprotein B: A clinically important apolipoprotein which assembles atherogenic lipoproteins and promotes the development of atherosclerosis","volume":"258","author":"Olofsson","year":"2005","journal-title":"J. Intern. Med."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1373\/clinchem.2004.038026","article-title":"Lipid disorders and mutations in the APOB gene","volume":"50","author":"Whitfield","year":"2004","journal-title":"Clin. Chem."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1161\/CIRCULATIONAHA.109.875807","article-title":"Apolipoprotein C-III and the metabolic basis for hypertriglyceridemia and the dense low-density lipoprotein phenotype","volume":"121","author":"Zheng","year":"2010","journal-title":"Circulation"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"e98045","DOI":"10.1172\/jci.insight.98045","article-title":"Apolipoproteins E and CIII interact to regulate HDL metabolism and coronary heart disease risk","volume":"3","author":"Morton","year":"2018","journal-title":"JCI Insight"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1161\/CIRCULATIONAHA.105.591743","article-title":"Apolipoprotein CIII in apolipoprotein B lipoproteins enhances the adhesion of human monocytic cells to endothelial cells","volume":"113","author":"Kawakami","year":"2006","journal-title":"Circulation"},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Mart\u00ednez-Pinilla, E., Rubio-Sard\u00f3n, N., Pel\u00e1ez, R., Garc\u00eda-\u00c1lvarez, E., Del Valle, E., Tolivia, J., Larr\u00e1yoz, I.M., and Navarro, A. (2021). Neuroprotective effect of apolipoprotein D in cuprizone-induced cell line models: A potential therapeutic approach for multiple sclerosis and demyelinating diseases. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22031260"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1007\/s11357-011-9286-5","article-title":"Age-related changes of apolipoprotein D expression in female rat central nervous system with chronic estradiol treatment","volume":"34","author":"Navarro","year":"2012","journal-title":"Age"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Do Carmo, S., Forest, J.C., Gigu\u00e8re, Y., Masse, A., Lafond, J., and Rassart, E. (2009). Modulation of Apolipoprotein D levels in human pregnancy and association with gestational weight gain. Reprod. Biol. Endocrinol., 7.","DOI":"10.1186\/1477-7827-7-92"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"S183","DOI":"10.1194\/jlr.R800069-JLR200","article-title":"Apolipoprotein E: Structure determines function, from atherosclerosis to Alzheimer\u2019s disease to AIDS","volume":"50","author":"Mahley","year":"2009","journal-title":"J. Lipid Res."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Seeberg, J.C., Loibl, M., Moser, F., Schwegler, M., B\u00fcttner-Herold, M., Daniel, C., Engel, F.B., Hartmann, A., Schl\u00f6tzer-Schrehardt, U., and Goppelt-Struebe, M. (2019). Non-professional phagocytosis: A general feature of normal tissue cells. Sci. Rep., 9.","DOI":"10.1038\/s41598-019-48370-3"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1146\/annurev.biochem.71.110601.135342","article-title":"Lipoprotein receptors in the nervous system","volume":"71","author":"Herz","year":"2022","journal-title":"Annu. Rev. Biochem."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"7412","DOI":"10.1158\/0008-5472.CAN-04-2077","article-title":"Clusterin-mediated apoptosis is regulated by adenomatous polyposis coli and is p21 dependent but p53 independent","volume":"64","author":"Chen","year":"2004","journal-title":"Cancer Res."},{"key":"ref_81","first-page":"68","article-title":"Dihydrotestosterone regulating apolipoprotein M expression mediates via protein kinase C in HepG2 cells","volume":"11","author":"Bing","year":"2012","journal-title":"Lipids Health Dis."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1074\/jbc.M704576200","article-title":"Effect of apolipoprotein M on high density lipoprotein metabolism and atherosclerosis in low density lipoprotein receptor knock-out mice","volume":"283","author":"Christoffersen","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.3892\/mmr.2015.3658","article-title":"Apolipoprotein M: Research progress, regulation and metabolic functions","volume":"12","author":"Huang","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.atherosclerosis.2021.08.039","article-title":"Apolipoprotein M and its impact on endothelial dysfunction and inflammation in the cardiovascular system","volume":"334","author":"Mattisson","year":"2021","journal-title":"Atherosclerosis"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"e034774","DOI":"10.1161\/JAHA.124.034774","article-title":"Lipoprotein(a), Oxidized Phospholipids, and Progression to Symptomatic Heart Failure: The CASABLANCA Study","volume":"13","author":"Januzzi","year":"2024","journal-title":"J. Am. Heart Assoc."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/s41569-023-00937-4","article-title":"Oxidized phospholipids in cardiovascular disease","volume":"21","author":"Tsimikas","year":"2024","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1194\/jlr.R067314","article-title":"Structure, function, and genetics of lipoprotein (a)","volume":"57","author":"Schmidt","year":"2016","journal-title":"J. Lipid Res."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jacl.2022.10.004","article-title":"Lipoprotein (a) and inflammation-pathophysiological links and clinical implications for cardiovascular disease","volume":"17","author":"Simantiris","year":"2023","journal-title":"J. Clin. Lipidol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1016\/j.jacc.2023.02.050","article-title":"Lipoprotein(a), Oxidized Phospholipids, and Coronary Artery Disease Severity and Outcomes","volume":"81","author":"Gilliland","year":"2023","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/S0092-8674(01)00238-0","article-title":"Atherosclerosis: The Road Ahead","volume":"104","author":"Glass","year":"2001","journal-title":"Cell"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"486","DOI":"10.2741\/3700","article-title":"RAGE and cardiovascular disease","volume":"16","author":"Park","year":"2011","journal-title":"Front. Biosci."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/labinvest.3700366","article-title":"Lipopolysaccharide signaling in endothelial cells","volume":"86","author":"Dauphinee","year":"2006","journal-title":"Lab. Investig."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"100708","DOI":"10.1016\/j.xkme.2023.100708","article-title":"High-Density Lipoprotein Lipidomics and Mortality in CKD","volume":"5","author":"Lidgard","year":"2023","journal-title":"Kidney Med."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"823071","DOI":"10.1155\/2014\/823071","article-title":"Endogenous ceramide contributes to the transcytosis of oxLDL across endothelial cells and promotes its subendothelial retention in vascular wall","volume":"2014","author":"Li","year":"2014","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Peters, L., Kuebler, W.M., and Simmons, S. (2022). Sphingolipids in Atherosclerosis: Chimeras in Structure and Function. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms231911948"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1161\/01.ATV.0000229218.97976.43","article-title":"Scavenger receptors in atherosclerosis: Beyond lipid uptake","volume":"26","author":"Moore","year":"2006","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1097\/MOL.0b013e328306a057","article-title":"Glycation as an atherogenic modification of LDL","volume":"19","author":"Younis","year":"2008","journal-title":"Curr. Opin. Lipidol."},{"key":"ref_98","first-page":"297","article-title":"Apoptosis and proliferation of endothelial cells in early atherosclerotic lesions: Possible role of oxidised LDL","volume":"12","author":"Norata","year":"2002","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1002\/biof.2057","article-title":"Cholesterol transport and beyond: Illuminating the versatile functions of HDL apolipoproteins through structural insights and functional implications","volume":"50","author":"Bhale","year":"2024","journal-title":"BioFactors"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1097\/MED.0b013e32832922fc","article-title":"Dysfunctional high-density lipoprotein","volume":"16","author":"Feng","year":"2009","journal-title":"Curr. Opin. Endocrinol. Diabetes Obes."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1161\/HYPERTENSIONAHA.114.03697","article-title":"Association of longitudinal changes in left ventricular structure and function with myocardial fibrosis: The Multi-Ethnic Study of Atherosclerosis study","volume":"64","author":"Ambale","year":"2014","journal-title":"Hypertension"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"2862","DOI":"10.1016\/j.tjnut.2024.07.015","article-title":"How membrane phospholipids containing long chain polyunsaturated fatty acids and their oxidation products orchestrate lipid raft dynamics to control inflammation","volume":"154","author":"Virk","year":"2024","journal-title":"J. Nutr."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/j.1475-097X.2008.00825.x","article-title":"Relationship of asymmetric dimethylarginine with flow-mediated dilatation in subjects with newly detected severe hypercholesterolemia","volume":"28","author":"Deneva","year":"2008","journal-title":"Clin. Physiol. Funct. Imaging"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s00441-012-1437-1","article-title":"Dual role of lipoproteins in endothelial cell dysfunction in atherosclerosis","volume":"349","author":"Stancu","year":"2012","journal-title":"Cell Tissue Res."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1253\/circj.CJ-09-0274","article-title":"Rheumatoid arthritis a model of systemic inflammation driving atherosclerosis","volume":"73","author":"Ku","year":"2009","journal-title":"Circ. J."},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Kattoor, A.J., Goel, A., and Mehta, J.L. (2019). LOX-1: Regulation, Signaling and Its Role in Atherosclerosis. Antioxidants, 8.","DOI":"10.3390\/antiox8070218"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.1172\/JCI42946","article-title":"Mechanisms underlying adverse effects of HDL on eNOS-activating pathways in patients with coronary artery disease","volume":"121","author":"Besler","year":"2011","journal-title":"J. Clin. Investig."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.immuni.2013.02.009","article-title":"Abnormal high-density lipoprotein induces endothelial dysfunction via activation of Toll-like receptor-2","volume":"38","author":"Speer","year":"2013","journal-title":"Immunity"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.cardiores.2005.09.006","article-title":"Lectin-like, oxidized low-density lipoprotein receptor-1 (LOX-1): A critical player in the development of atherosclerosis and related disorders","volume":"69","author":"Mehta","year":"2006","journal-title":"Cardiovasc. Res."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"42817","DOI":"10.18632\/oncotarget.17069","article-title":"Paraoxonase-1 (PON1) induces metastatic potential and apoptosis escape via its antioxidative function in lung cancer cells","volume":"8","author":"Aldonza","year":"2017","journal-title":"Oncotarget"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"3815","DOI":"10.1172\/JCI67478","article-title":"Myeloperoxidase, paraoxonase-1, and HDL form a functional ternary complex","volume":"123","author":"Huang","year":"2013","journal-title":"J. Clin. Investig."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Aggarwal, G., May-Zhang, L.S., Yermalitsky, V., Dikalov, S., Voynov, M.A., Amarnath, V., Kon, V., Linton, M.F., Vickers, K.C., and Davies, S.S. (2021). Myeloperoxidase-induced modification of HDL by isolevuglandins inhibits paraoxonase-1 activity. J. Biol. Chem., 297.","DOI":"10.1016\/j.jbc.2021.101019"},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Sirca, T.B., Mure\u0219an, M.E., Pallag, A., Marian, E., Jurca, T., Vica\u0219, L.G., Tunduc, I.P., Manole, F., and Stefan, L. (2024). The Role of Polyphenols in Modulating PON1 Activity Regarding Endothelial Dysfunction and Atherosclerosis. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25052962"},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Estrada-Luna, D., Carre\u00f3n-Torres, E., Bautista-P\u00e9rez, R., Betanzos-Cabrera, G., Dorantes-Morales, A., Luna-Luna, M., Vargas-Barr\u00f3n, J., Mej\u00eda, A.M., Fragoso, J.M., and Carvajal-Aguilera, K. (2019). Microencapsulated Pomegranate Reverts High-Density Lipoprotein (HDL)-Induced Endothelial Dysfunction and Reduces Postprandial Triglyceridemia in Women with Acute Coronary Syndrome. Nutrients, 11.","DOI":"10.3390\/nu11081710"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"715","DOI":"10.3892\/ijmm.2015.2072","article-title":"Rosiglitazone attenuates atherosclerosis and increases high-density lipoprotein function in atherosclerotic rabbits","volume":"35","author":"Li","year":"2015","journal-title":"Int. J. Mol. Med."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/978-3-031-63657-8_17","article-title":"Endothelial Dysfunction in Obesity and Therapeutic Targets","volume":"1460","author":"Engin","year":"2024","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.jacl.2023.05.099","article-title":"Nutrition interventions for adults with dyslipidemia: A Clinical Perspective from the National Lipid Association","volume":"17","author":"Kirkpatrick","year":"2023","journal-title":"J. Clin. Lipidol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1097\/HJH.0000000000003563","article-title":"Lifestyle management of hypertension: International Society of Hypertension position paper endorsed by the World Hypertension League and European Society of Hypertension","volume":"42","author":"Charchar","year":"2024","journal-title":"J. Hypertens."},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Imran, T.F., Khan, A.A., Has, P., Jacobson, A., Bogin, S., Khalid, M., Khan, A., Kim, S., Erqou, S., and Choudhary, G. (2023). Proprotein convertase subtilisn\/kexin type 9 inhibitors and small interfering RNA therapy for cardiovascular risk reduction: A systematic review and meta-analysis. PLoS ONE, 18.","DOI":"10.1371\/journal.pone.0295359"},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Giglio, R.V., Pantea Stoian, A., Al-Rasadi, K., Banach, M., Patti, A.M., Ciaccio, M., Rizvi, A.A., and Rizzo, M. (2021). Novel Therapeutical Approaches to Managing Atherosclerotic Risk. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22094633"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1253\/circj.CJ-17-1445","article-title":"Best Treatment Strategies With Statins to Maximize the Cardiometabolic Benefits","volume":"82","author":"Cho","year":"2018","journal-title":"Circ. J."},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Jiang, J., Gan, Z., Li, Y., Zhao, W., Li, H., Zheng, J.-P., and Ke, Y. (2017). REM sleep deprivation induces endothelial dysfunction and hypertension in middle-aged rats: Roles of the eNOS\/NO\/cGMP pathway and supplementation with L-arginine. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0182746"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1097\/MCA.0000000000000178","article-title":"Endothelial dysfunction and coronary artery disease: Assessment, prognosis and treatment","volume":"25","author":"Matsuzawa","year":"2014","journal-title":"Coron. Artery Dis."},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Li, B., Zhang, Q., Zhang, H., Wang, C., and Xiu, R. (2020). Effects of nebivolol versus other antihypertensive drugs on the endothelial dysfunction in patients with essential hypertension. Biosci. Rep., 40.","DOI":"10.1042\/BSR20200436"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"n1537","DOI":"10.1136\/bmj.n1537","article-title":"Associations between statins and adverse events in primary prevention of cardiovascular disease: Systematic review with pairwise, network, and dose-response meta-analyses","volume":"374","author":"Cai","year":"2021","journal-title":"Bmj"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s12020-023-03401-y","article-title":"Benefits and harms of fibrate therapy in patients with type 2 diabetes: A systematic review and meta-analysis","volume":"81","year":"2023","journal-title":"Endocrine"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"3125","DOI":"10.1016\/j.cgh.2023.04.031","article-title":"Bile acid sequestrants in microscopic colitis: Clinical outcomes and utility of bile acid testing","volume":"21","author":"Tome","year":"2023","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Richter, C.K., Skulas-Ray, A.C., Gaugler, T.L., Meily, S., Petersen, K.S., and Kris-Etherton, P.M. (2021). Effects of Cranberry Juice Supplementation on Cardiovascular Disease Risk Factors in Adults with Elevated Blood Pressure: A Randomized Controlled Trial. Nutrients, 13.","DOI":"10.3390\/nu13082618"},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Cho, K.H., Yadav, D., Kim, S.J., and Kim, J.R. (2018). Blood Pressure Lowering Effect of Cuban Policosanol is Accompanied by Improvement of Hepatic Inflammation, Lipoprotein Profile, and HDL Quality in Spontaneously Hypertensive Rats. Molecules, 23.","DOI":"10.3390\/molecules23051080"},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Al-Jarallah, A., and Babiker, F. (2022). High Density Lipoprotein Reduces Blood Pressure and Protects Spontaneously Hypertensive Rats Against Myocardial Ischemia-Reperfusion Injury in an SR-BI Dependent Manner. Front. Cardiovasc. Med., 9.","DOI":"10.3389\/fcvm.2022.825310"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1111\/jdi.14088","article-title":"Fermented soybean foods and diabetes","volume":"14","author":"Hashimoto","year":"2023","journal-title":"J. Diabetes Investig."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1111\/1750-3841.15679","article-title":"Mulberry leaf phenolics and fiber exert anti-obesity through the gut microbiota-host metabolism pathway","volume":"86","author":"Liao","year":"2021","journal-title":"J. Food Sci."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"122","DOI":"10.5455\/jice.20160321115402","article-title":"Guava leaves polyphenolics-rich extract inhibits vital enzymes implicated in gout and hypertension in vitro","volume":"5","author":"Irondi","year":"2016","journal-title":"J. Intercult. Ethnopharmacol."},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Esterbauer, H., Puhl, H., Waeg, G., Krebs, A., and Dieber-Rotheneder, M. (2023). The role of vitamin E in lipoprotein oxidation. Vitamin E in Health and Disease, CRC Press.","DOI":"10.1201\/9781003418160-58"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1096\/fj.13-239384","article-title":"Dark chocolate consumption improves leukocyte adhesion factors and vascular function in overweight men","volume":"28","author":"Esser","year":"2014","journal-title":"FASEB J."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s00394-011-0297-x","article-title":"The effect of plant sterols on serum triglyceride concentrations is dependent on baseline concentrations: A pooled analysis of 12 randomised controlled trials","volume":"52","author":"Demonty","year":"2013","journal-title":"Eur. J. Nutr."},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Tan, B.L., Norhaizan, M.E., Liew, W.-P.-P., and Sulaiman Rahman, H. (2018). Antioxidant and oxidative stress: A mutual interplay in age-related diseases. Front. Pharmacol., 9.","DOI":"10.3389\/fphar.2018.01162"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"105371","DOI":"10.1016\/j.jff.2022.105371","article-title":"Oxyresveratrol from mulberry branch extract protects HUVECs against oxidized Low-density Lipoprotein-induced oxidative injury via activation of the Nrf-2\/HO-1 pathway","volume":"100","author":"Shi","year":"2022","journal-title":"J. Funct. Foods"},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Basu, A. (2019). Role of Berry Bioactive Compounds on Lipids and Lipoproteins in Diabetes and Metabolic Syndrome. Nutrients, 11.","DOI":"10.3390\/nu11091983"},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Tsiantas, K., Konteles, S.J., Kritsi, E., Sinanoglou, V.J., Tsiaka, T., and Zoumpoulakis, P. (2022). Effects of Non-Polar Dietary and Endogenous Lipids on Gut Microbiota Alterations: The Role of Lipidomics. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23084070"},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Luqman, A., Hassan, A., Ullah, M., Naseem, S., Ullah, M., Zhang, L., Din, A.D., Ullah, K., Ahmad, W., and Wang, G. (2024). Role of the intestinal microbiome and its therapeutic intervention in cardiovascular disorder. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1321395"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s11745-013-3780-8","article-title":"Egg consumption modulates HDL lipid composition and increases the cholesterol-accepting capacity of serum in metabolic syndrome","volume":"48","author":"Andersen","year":"2013","journal-title":"Lipids"},{"key":"ref_143","doi-asserted-by":"crossref","unstructured":"Martin-Ventura, J.L., Rodrigues-Diez, R., Martinez-Lopez, D., Salaices, M., Blanco-Colio, L.M., and Briones, A.M. (2017). Oxidative stress in human atherothrombosis: Sources, markers and therapeutic targets. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18112315"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.diabet.2014.11.006","article-title":"Effect of phytosterols\/stanols on LDL concentration and other surrogate markers of cardiovascular risk","volume":"41","author":"Bard","year":"2015","journal-title":"Diabetes Metab."},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Machado, V.A., Santisteban, A.R.N., Martins, C.M., Damasceno, N.R.T., Fonseca, F.A., Neto, A.M.F., and Izar, M.C. (2024). Effects of phytosterol supplementation on lipoprotein subfractions and LDL particle quality. Sci. Rep., 14.","DOI":"10.1038\/s41598-024-61897-4"},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Oliveira Godoy Ilha, A., Sutti Nunes, V., Silva Afonso, M., Regina Nakandakare, E., da Silva Ferreira, G., de Paula Assis Bombo, R., Rodrigues Giorgi, R., Marcondes Machado, R., Rocha Quint\u00e3o, E.C., and Lottenberg, A.M. (2020). Phytosterols supplementation reduces endothelin-1 plasma concentration in moderately hypercholesterolemic individuals independently of their cholesterol-lowering properties. Nutrients, 12.","DOI":"10.3390\/nu12051507"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"10514","DOI":"10.53730\/ijhs.v6nS5.11275","article-title":"Effect of terpenes fraction of Iraqi cicer arietinum in experimentally induced hyperlipidemic mice","volume":"6","author":"Hwerif","year":"2022","journal-title":"Int. J. Health Sci."},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Ayala-Ruiz, L.A., Ortega-P\u00e9rez, L.G., Pi\u00f1\u00f3n-Simental, J.S., Magana-Rodriguez, O.R., Mel\u00e9ndez-Herrera, E., and Rios-Chavez, P. (2022). Role of the major terpenes of Callistemon citrinus against the oxidative stress during a hypercaloric diet in rats. Biomed. Pharmacother., 153.","DOI":"10.1016\/j.biopha.2022.113505"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"5647","DOI":"10.1111\/bph.12986","article-title":"Aspirin enhances protective effect of fish oil against thrombosis and injury-induced vascular remodelling","volume":"172","author":"Gong","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"025","DOI":"10.1055\/s-0032-1333309","article-title":"Effects of omega-3 polyunsaturated fatty acids on platelet function in healthy subjects and subjects with cardiovascular disease","volume":"39","author":"McEwen","year":"2013","journal-title":"Semin. Thromb. Hemost."},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"Yang, Z.H., Amar, M., Sampson, M., Courville, A.B., Sorokin, A.V., Gordon, S.M., Aponte, A.M., Stagliano, M., Playford, M.P., and Fu, Y. (2020). Comparison of omega-3 eicosapentaenoic acid versus docosahexaenoic acid-rich fish oil supplementation on plasma lipids and lipoproteins in normolipidemic adults. Nutrients, 12.","DOI":"10.3390\/nu12030749"},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"Cartolano, F.D.C., Dias, G.D., Miyamoto, S., and Damasceno, N.R.T. (2022). Omega-3 fatty acids improve functionality of high-density lipoprotein in individuals with high cardiovascular risk: A randomized, parallel, controlled and double-blind clinical trial. Front. 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