{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T05:44:55Z","timestamp":1789191895320,"version":"build-2803163510"},"reference-count":64,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T00:00:00Z","timestamp":1738108800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Colombian Ministry of Science Technology and Innovation-Minciencias","award":["832"],"award-info":[{"award-number":["832"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Up to 30% of individuals with obesity may exhibit normal insulin sensitivity, a favorable lipid profile, and no signs of hypertension. This prompts the exploration of factors distinguishing cardiometabolically healthy individuals from those developing complications. This cross-sectional study included 116 individuals categorized into four groups by combining abdominal obesity and cardiometabolic health statuses. We compared circulating adipokines and gut microbiota composition between these groups. Individuals with abdominal obesity had higher levels of hs-CRP, TNF-\u03b1, MCP-1, IL-18, chemerin, and leptin, and a less favorable gut microbiota composition, including higher levels of potentially harmful bacteria (CAG-Pathogen) and lower levels of beneficial bacteria (CAG-Ruminococcaceae and CAG-Akkermansia), compared to those with adequate waist circumference. Those with obesity but cardiometabolically healthy displayed similar adipokine levels and microbiota composition to those with adequate waist. In contrast, individuals with abdominal obesity cardiometabolically abnormal exhibited significantly higher levels of hs-CRP, IL-18, chemerin, and leptin, and lower levels of adiponectin and CAG-Ruminococcaceae compared to those with abdominal obesity cardiometabolically healthy and adequate waist. Additionally, they differed in hs-CRP and adiponectin\/leptin ratio from individuals with obesity cardiometabolically healthy. These findings suggest that altered adipokine profiles and gut microbiota may contribute to the development or persistence of cardiometabolic complications in obesity.<\/jats:p>","DOI":"10.3390\/ijms26031176","type":"journal-article","created":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T11:10:39Z","timestamp":1738149039000},"page":"1176","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Circulating hs-CRP, IL-18, Chemerin, Leptin, and Adiponectin Levels Reflect Cardiometabolic Dysfunction in Adults with Excess Weight"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2434-6228","authenticated-orcid":false,"given":"\u00d3scar Javier","family":"Lara-Guzm\u00e1n","sequence":"first","affiliation":[{"name":"Vidarium\u2013Nutrition, Health, and Wellness Research Center, Grupo Empresarial Nutresa, Carrera 52 #2-38, Medellin 050023, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngela Mar\u00eda","family":"Arango-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Vidarium\u2013Nutrition, Health, and Wellness Research Center, Grupo Empresarial Nutresa, Carrera 52 #2-38, Medellin 050023, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0937-8259","authenticated-orcid":false,"given":"Rafael","family":"\u00c1lvarez-Quintero","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n en Ciencias Farmac\u00e9uticas-ICIF-CES, Facultad de Ciencias y Biotecnolog\u00eda, Universidad CES, Calle 10A #22-04, Medellin 050021, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7304-917X","authenticated-orcid":false,"given":"Juan S.","family":"Escobar","sequence":"additional","affiliation":[{"name":"Vidarium\u2013Nutrition, Health, and Wellness Research Center, Grupo Empresarial Nutresa, Carrera 52 #2-38, Medellin 050023, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7905-1243","authenticated-orcid":false,"given":"Katalina","family":"Mu\u00f1oz-Durango","sequence":"additional","affiliation":[{"name":"Vidarium\u2013Nutrition, Health, and Wellness Research Center, Grupo Empresarial Nutresa, Carrera 52 #2-38, Medellin 050023, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8541-1535","authenticated-orcid":false,"given":"Jelver Alexander","family":"Sierra","sequence":"additional","affiliation":[{"name":"Vidarium\u2013Nutrition, Health, and Wellness Research Center, Grupo Empresarial Nutresa, Carrera 52 #2-38, Medellin 050023, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.1016\/j.jacc.2022.11.001","article-title":"Global Burden of Cardiovascular Diseases and Risks Collaboration, 1990\u20132021","volume":"80","author":"Lindstrom","year":"2022","journal-title":"J. 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