{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:47:03Z","timestamp":1790704023186,"version":"4.1.0"},"reference-count":64,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T00:00:00Z","timestamp":1738195200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The COVID-19 pandemic has raised significant concerns regarding its potential impact on maternal and neonatal health. This study aimed to investigate the immunologic and hemostatic profiles of neonates exposed to SARS-CoV-2 during the peripartum period (0\u201314 days prior to delivery). This retrospective study included 28 neonates born to COVID-19-positive mothers during the peripartum period and a control group of 54 neonates born to mothers who never tested positive for SARS-CoV-2 during pregnancy. Arterial blood samples were collected from all neonates on the second day of life for the simultaneous assessment of full blood count, C-reactive protein (CRP), serum interleukin-6 (IL-6), and Interferon gamma-induced protein 10 (IP-10) levels, as well as Rotational Thromboelastometry (ROTEM) tests (EXTEM, INTEM, and NATEM). Neonates born to COVID-19-positive mothers and those born to COVID-19-negative mothers exhibited similar coagulation profiles based on ROTEM analysis. Multiple linear regression analysis revealed that peripartum COVID-19 infection was associated with higher IP-10 levels in neonates (coefficient: +16.8, 95% CI: +9.0 to +24.6, p &lt; 0.0001). Our study findings suggest that the presence of immunologic disturbance in neonates is related to recent peripartum exposure to maternal SARS-CoV-2 infection, as evidenced by increased IP-10 levels in blood samples obtained from neonates born to SARS-CoV-2-positive mothers. However, peripartum exposure to maternal SARS-CoV-2 did not appear to disrupt the hemostatic profile of the exposed newborns based on ROTEM test results.<\/jats:p>","DOI":"10.3390\/ijms26031201","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T05:40:46Z","timestamp":1738215646000},"page":"1201","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Hemostatic Profile and Serum Levels of Interferon Gamma-Induced Protein 10 (IP-10) in Neonates Born to Mothers with COVID-19 During the Peripartum Period"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9972-8901","authenticated-orcid":false,"given":"Rozeta","family":"Sokou","sequence":"first","affiliation":[{"name":"Neonatal Department, Aretaieio Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece"},{"name":"Neonatal Intensive Care Unit, \u201cAgios Panteleimon\u201d General Hospital of Nikea, 18454 Piraeus, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6129-7616","authenticated-orcid":false,"given":"Efstathia-Danai","family":"Bikouli","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, \u201cAgios Panteleimon\u201d General Hospital of Nikea, 18454 Piraeus, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3695-0759","authenticated-orcid":false,"given":"Andreas G.","family":"Tsantes","sequence":"additional","affiliation":[{"name":"Microbiology Department, \u201cSaint Savvas\u201d Oncology Hospital, 11522 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8559-8977","authenticated-orcid":false,"given":"Panagiotis","family":"Halvatsiotis","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine, Attikon University Hospital, School of Medicine, National and Kapodistrian University of Athens, 12462 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4692-2081","authenticated-orcid":false,"given":"Dimitra","family":"Houhoula","sequence":"additional","affiliation":[{"name":"Department of Food Science and Technology, University of West Attica, 12243 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4978-2539","authenticated-orcid":false,"given":"Paschalia","family":"Taliaka Kopanou","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, \u201cAgios Panteleimon\u201d General Hospital of Nikea, 18454 Piraeus, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0739-1484","authenticated-orcid":false,"given":"Paraskevi","family":"Liakou","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, \u201cAgios Panteleimon\u201d General Hospital of Nikea, 18454 Piraeus, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelia-Filothei","family":"Tavoulari","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, \u201cAgios Panteleimon\u201d General Hospital of Nikea, 18454 Piraeus, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1414-6639","authenticated-orcid":false,"given":"Daniele","family":"Piovani","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, 20090 Milan, Italy"},{"name":"IRCCS Humanitas Research Hospital, 20089 Rozzano, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6102-6579","authenticated-orcid":false,"given":"Stefanos","family":"Bonovas","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, 20090 Milan, Italy"},{"name":"IRCCS Humanitas Research Hospital, 20089 Rozzano, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4316-7305","authenticated-orcid":false,"given":"Zoi","family":"Iliodromiti","sequence":"additional","affiliation":[{"name":"Neonatal Department, Aretaieio Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodora","family":"Boutsikou","sequence":"additional","affiliation":[{"name":"Neonatal Department, Aretaieio Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8021-6191","authenticated-orcid":false,"given":"Nicoletta","family":"Iacovidou","sequence":"additional","affiliation":[{"name":"Neonatal Department, Aretaieio Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha","family":"Theodoraki","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, \u201cAgios Panteleimon\u201d General Hospital of Nikea, 18454 Piraeus, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Argirios E.","family":"Tsantes","sequence":"additional","affiliation":[{"name":"Blood Bank Unit, Laboratory of Haematology, \u201cAttiko\u201d Hospital, School of Medicine, National and Kapodistrian University of Athens, 12462 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Coperchini, F., Chiovato, L., and Rotondi, M. (2021). Interleukin-6, CXCL10 and infiltrating macrophages in COVID-19-related cytokine storm: Not one for all but all for one!. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.668507"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Gudowska-Sawczuk, M., and Mroczko, B. (2022). What is currently known about the role of CXCL10 in SARS-CoV-2 infection?. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23073673"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Elemam, N.M., Talaat, I.M., and Maghazachi, A.A. (2022). CXCL10 chemokine: A critical player in RNA and DNA viral infections. Viruses, 14.","DOI":"10.3390\/v14112445"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Madhurantakam, S., Lee, Z.J., Naqvi, A., and Prasad, S. (2023). Importance of IP-10 as a biomarker of host immune response: Critical perspective as a target for biosensing. Curr. Res. Biotechnol., 5.","DOI":"10.1016\/j.crbiot.2023.100130"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.jpeds.2021.04.069","article-title":"Association of Maternal Immune Activation during Pregnancy and Neurologic Outcomes in Offspring","volume":"238","author":"Jain","year":"2021","journal-title":"J. Pediatr."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Ayed, M., Embaireeg, A., Kartam, M., More, K., Alqallaf, M., AlNafisi, A., Alsaffar, Z., Bahzad, Z., Buhamad, Y., and Alsayegh, H. (2022). Neurodevelopmental outcomes of infants born to mothers with SARS-CoV-2 infections during pregnancy: A national prospective study in Kuwait. BMC Pediatr., 22.","DOI":"10.1186\/s12887-022-03359-2"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.placenta.2023.05.009","article-title":"The effects of COVID-19 on placental morphology","volume":"138","author":"Heeralall","year":"2023","journal-title":"Placenta"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S2352-4642(20)30342-4","article-title":"Characteristics and outcomes of neonatal SARS-CoV-2 infection in the UK: A prospective national cohort study using active surveillance","volume":"5","author":"Gale","year":"2021","journal-title":"Lancet. Child Adolesc. Health"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"211","DOI":"10.2217\/fvl-2021-0213","article-title":"Research progress in vertical transmission of SARS-CoV-2 among infants born to mothers with COVID-19","volume":"17","author":"Peng","year":"2022","journal-title":"Future Virol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1002\/jmv.26622","article-title":"Possible vertical transmission and antibodies against SARS-CoV-2 among infants born to mothers with COVID-19: A living systematic review","volume":"93","author":"Bwire","year":"2021","journal-title":"J. Med. Virol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2162867","DOI":"10.1080\/01443615.2022.2162867","article-title":"Evaluation of pregnancy outcomes in mothers with COVID-19 infection: A systematic review and meta-analysis","volume":"43","author":"Simbar","year":"2023","journal-title":"J. Obstet. Gynaecol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ijid.2023.12.011","article-title":"SARS-CoV-2 perinatal transmission and neonatal outcomes across four different waves of COVID-19 pandemic: A nationwide prospective cohort study from the Italian Society of Neonatology","volume":"140","author":"Pugni","year":"2024","journal-title":"Int. J. Infect. Dis."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"101135","DOI":"10.1016\/j.nmni.2023.101135","article-title":"Maternal COVID-19 infection and the fetus: Immunological and neurological perspectives","volume":"53","author":"Falahi","year":"2023","journal-title":"New Microbes New Infect."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1111\/aogs.14721","article-title":"SARS-CoV-2 infection during pregnancy and perinatal outcomes in Estonia in 2020 and 2021: A register-based study","volume":"103","author":"Veerus","year":"2024","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1002\/uog.23619","article-title":"Pregnancy and neonatal outcomes of COVID-19: Coreporting of common outcomes from PAN-COVID and AAP-SONPM registries","volume":"57","author":"Mullins","year":"2021","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Papapanou, M., Papaioannou, M., Petta, A., Routsi, E., Farmaki, M., Vlahos, N., and Siristatidis, C. (2021). Maternal and Neonatal Characteristics and Outcomes of COVID-19 in Pregnancy: An Overview of Systematic Reviews. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph18020596"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/s41467-023-44549-5","article-title":"Respiratory distress in SARS-CoV-2 exposed uninfected neonates followed in the COVID Outcomes in Mother-Infant Pairs (COMP) Study","volume":"15","author":"Man","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.ejogrb.2021.09.019","article-title":"Haematological parameters and coagulation in umbilical cord blood following COVID-19 infection in pregnancy","volume":"266","author":"Murphy","year":"2021","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_19","unstructured":"WHO (2021). COVID-19 Clinical Management: Living Guidance, WHO. Available online: https:\/\/iris.who.int\/bitstream\/handle\/10665\/349321\/WHO-2019-nCoV-clinical-2021.2-eng.pdf."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Popescu, D.E., Cerbu, S., Rosca, I., Lungu, N., Tru\u0219culescu, A.A., Belengeanu, V., Manea, A.M., Dima, M.A., Gorun, F., and Popa, Z.L. (2023). Comparative Analysis of Hematological and Biochemical Changes in Neonates among Women with and without COVID-19 Infection during Pregnancy. Children, 10.","DOI":"10.3390\/children10081370"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"102","DOI":"10.3892\/etm.2021.11025","article-title":"Diagnostic challenges, management, and outcome of infants born to mothers with COVID 19 during the first wave of the pandemic","volume":"23","author":"Zaharie","year":"2022","journal-title":"Exp. Ther. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.earlhumdev.2005.06.009","article-title":"Sustained hematological consequences in the first week of neonatal life secondary to placental dysfunction","volume":"82","author":"Kush","year":"2006","journal-title":"Early Hum. Dev."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1002\/ajh.25829","article-title":"Hematological findings and complications of COVID-19","volume":"95","author":"Terpos","year":"2020","journal-title":"Am. J. Hematol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1055\/s-0043-1762893","article-title":"Assessment of Hemostatic Profile in Neonates with Intrauterine Growth Restriction: A Systematic Review of Literature","volume":"50","author":"Karapati","year":"2024","journal-title":"Semin. Thromb. Hemost."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s00281-020-00803-2","article-title":"Preterm birth and sustained inflammation: Consequences for the neonate","volume":"42","author":"Humberg","year":"2020","journal-title":"Semin. Immunopathol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/s41467-021-27745-z","article-title":"Maternal-Fetal Immune Responses in Pregnant Women Infected with SARS-CoV-2","volume":"13","author":"Romero","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Wang, X., Tang, G., Liu, Y., Zhang, L., Chen, B., Han, Y., Fu, Z., Wang, L., Hu, G., and Ma, Q. (2022). The role of IL-6 in coronavirus, especially in COVID-19. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.1033674"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1038\/s41590-021-01049-2","article-title":"The legacy of maternal SARS-CoV-2 infection on the immunology of the neonate","volume":"22","author":"Gee","year":"2021","journal-title":"Nat. Immunol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1038\/s41372-022-01391-9","article-title":"Evaluation of maternal-infant dyad inflammatory cytokines in pregnancies affected by maternal SARS-CoV-2 infection in early and late gestation","volume":"42","author":"Taglauer","year":"2022","journal-title":"J. Perinatol."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Kosi\u0144ska-Kaczy\u0144ska, K., Rebizant, B., Czeszko-Paprocka, H., Bojdo, A., Przybylski, M., Chaberek, K., Lewandowska, A., Szymusik, I., and Brawura-Biskupski-Samaha, R. (2023). Maternal SARS-CoV-2 Infection at Delivery Increases IL-6 Concentration in Umbilical Cord Blood. J. Clin. Med., 12.","DOI":"10.3390\/jcm12175672"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Moreira, A.L.E., Silva, P., Gomes, R.S., Santos, M.O., Ito, C.R.M., Barbosa, L.C.G., Souza, P.P., Peixoto, F.A.O., Wastowski, I.J., and Carneiro, L.C. (2023). Characterization of T Helper 1 and 2 Cytokine Profiles in Newborns of Mothers with COVID-19. Biomedicines, 11.","DOI":"10.3390\/biomedicines11030910"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"100453","DOI":"10.1016\/j.xcrm.2021.100453","article-title":"The systemic inflammatory landscape of COVID-19 in pregnancy: Extensive serum proteomic profiling of mother-infant dyads with in utero SARS-CoV-2","volume":"2","author":"Foo","year":"2021","journal-title":"Cell Rep. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"407","DOI":"10.2223\/1226","article-title":"The role of sample collection timing on interleukin-6 levels in early-onset neonatal sepsis","volume":"80","author":"Procianoy","year":"2004","journal-title":"J. Pediatr."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1038\/s41591-020-1038-6","article-title":"A dynamic COVID-19 immune signature includes associations with poor prognosis","volume":"26","author":"Laing","year":"2020","journal-title":"Nat. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.molimm.2021.09.013","article-title":"The role of IP-10 and its receptor CXCR3 in early pregnancy","volume":"140","author":"Jiang","year":"2021","journal-title":"Mol. Immunol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1080\/14767050701483298","article-title":"CXCL10\/IP-10: A missing link between inflammation and anti-angiogenesis in preeclampsia?","volume":"20","author":"Gotsch","year":"2007","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1164\/rccm.2203030","article-title":"Increased IP-10 and MIG expression after intra-amniotic endotoxin in preterm lamb lung","volume":"167","author":"Kallapur","year":"2003","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1007\/s00431-023-04910-8","article-title":"Effects of intrauterine exposure to SARS-CoV-2 on infants\u2019 development: A rapid review and meta-analysis","volume":"182","author":"Pinheiro","year":"2023","journal-title":"Eur. J. Pediatr."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Ayesa-Arriola, R., Castro Quintas, \u00c1., Ortiz-Garc\u00eda de la Foz, V., Miguel Corredera, M., San Mart\u00edn Gonz\u00e1lez, N., Murillo-Garc\u00eda, N., Neergaard, K., Fa\u00f1an\u00e1s Saura, L., and de las Cuevas-Ter\u00e1n, I. (2023). Exploring the impact of COVID-19 on newborn neurodevelopment: A pilot study. Sci. Rep., 13.","DOI":"10.1038\/s41598-023-29680-z"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"e2215787","DOI":"10.1001\/jamanetworkopen.2022.15787","article-title":"Neurodevelopmental Outcomes at 1 Year in Infants of Mothers Who Tested Positive for SARS-CoV-2 During Pregnancy","volume":"5","author":"Edlow","year":"2022","journal-title":"JAMA Netw. Open"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/nri.2017.64","article-title":"The unique immunological and microbial aspects of pregnancy","volume":"17","author":"Mor","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"62","DOI":"10.4103\/jrms.JRMS_1088_15","article-title":"Cytokine profiles at birth and the risk of developing severe respiratory distress and chronic lung disease","volume":"22","author":"Hammoud","year":"2017","journal-title":"J. Res. Med. Sci."},{"key":"ref_43","first-page":"967","article-title":"Cytokines and hemostasis","volume":"85","author":"Grignani","year":"2000","journal-title":"Haematologica"},{"key":"ref_44","first-page":"134","article-title":"Release of thrombomodulin from endothelial cells by concerted action of TNF-alpha and neutrophils: In vivo and in vitro studies","volume":"87","author":"Boehme","year":"1996","journal-title":"Immunology"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1161\/CIRCRESAHA.116.306853","article-title":"Cross Talk Pathways Between Coagulation and Inflammation","volume":"118","author":"Foley","year":"2016","journal-title":"Circ. Res."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Bester, J., and Pretorius, E. (2016). Effects of IL-1\u03b2, IL-6 and IL-8 on erythrocytes, platelets and clot viscoelasticity. Sci. Rep., 6.","DOI":"10.1038\/srep32188"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1046\/j.1538-7836.2003.00261.x","article-title":"Inflammation and thrombosis","volume":"1","author":"Esmon","year":"2003","journal-title":"J. Thromb. Haemost."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1080\/09537104.2021.1881949","article-title":"Rotational thromboelastometry (ROTEM) profiling of COVID-19 patients","volume":"32","author":"Mitrovic","year":"2021","journal-title":"Platelets"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.thromres.2020.06.029","article-title":"The hypercoagulable state in COVID-19: Incidence, pathophysiology, and management","volume":"194","author":"Diamond","year":"2020","journal-title":"Thromb. Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1093\/ajcp\/aqaa089","article-title":"Placental Pathology in COVID-19","volume":"154","author":"Shanes","year":"2020","journal-title":"Am. J. Clin. Pathol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"e24941","DOI":"10.1002\/jcla.24941","article-title":"Coagulopathy and thromboembolic events a pathogenic mechanism of COVID-19 associated with mortality: An updated review","volume":"37","author":"Yousefi","year":"2023","journal-title":"J. Clin. Lab. Anal."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"e24796","DOI":"10.1002\/jcla.24796","article-title":"Investigation of differences in coagulation characteristics between hospitalized patients with SARS-CoV-2 Alpha, Delta, and Omicron variant infection using rotational thromboelastometry (ROTEM): A single-center, retrospective, observational study","volume":"36","author":"Matsuoka","year":"2022","journal-title":"J. Clin. Lab. Anal."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1055\/s-0042-1756306","article-title":"Relative Hypercoagulopathy of the SARS-CoV-2 Beta and Delta Variants when Compared to the Less Severe Omicron Variants Is Related to TEG Parameters, the Extent of Fibrin Amyloid Microclots, and the Severity of Clinical Illness","volume":"48","author":"Grobbelaar","year":"2022","journal-title":"Semin. Thromb. Hemost."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"100951","DOI":"10.1016\/j.blre.2022.100951","article-title":"Fresh frozen plasma transfusion in the neonatal population: A systematic review","volume":"55","author":"Sokou","year":"2022","journal-title":"Blood Rev."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"101157","DOI":"10.1016\/j.blre.2023.101157","article-title":"Contemporary tools for evaluation of hemostasis in neonates. Where are we and where are we headed?","volume":"64","author":"Sokou","year":"2023","journal-title":"Blood Rev."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Tsantes, A.G., Parastatidou, S., Tsantes, E.A., Bonova, E., Tsante, K.A., Mantzios, P.G., Vaiopoulos, A.G., Tsalas, S., Konstantinidi, A., and Houhoula, D. (2023). Sepsis-Induced Coagulopathy: An Update on Pathophysiology, Biomarkers, and Current Guidelines. Life, 13.","DOI":"10.3390\/life13020350"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1055\/s-0042-1753513","article-title":"The Utility of NATEM Assay in Predicting Bleeding Risk in Critically Ill Neonates","volume":"49","author":"Sokou","year":"2023","journal-title":"Semin. Thromb. Hemost."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s00431-017-3072-z","article-title":"Thromboelastometry for diagnosis of neonatal sepsis-associated coagulopathy: An observational study","volume":"177","author":"Sokou","year":"2018","journal-title":"Eur. J. Pediatr."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Sokou, R., Ioakeimidis, G., Piovani, D., Parastatidou, S., Konstantinidi, A., Tsantes, A.G., Lampridou, M., Houhoula, D., Iacovidou, N., and Kokoris, S. (2022). Development and validation of a sepsis diagnostic scoring model for neonates with suspected sepsis. Front. Pediatr., 10.","DOI":"10.3389\/fped.2022.1004727"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1055\/a-1343-3342","article-title":"Prospective Temporal Validation of the Neonatal Bleeding Risk (NeoBRis) Index","volume":"121","author":"Sokou","year":"2021","journal-title":"Thromb. Haemost."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1055\/s-0040-1715832","article-title":"A Risk Score for Predicting the Incidence of Hemorrhage in Critically Ill Neonates: Development and Validation Study","volume":"121","author":"Sokou","year":"2021","journal-title":"Thromb. Haemost."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1055\/s-0041-1729964","article-title":"Rotational Thromboelastometry in Neonates Admitted to a Neonatal Intensive Care Unit: A Large Cross-sectional Study","volume":"47","author":"Sokou","year":"2021","journal-title":"Semin. Thromb. Hemost."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/ijlh.14165","article-title":"Thromboelastometry and prediction of in-hospital mortality in neonates with sepsis","volume":"46","author":"Sokou","year":"2023","journal-title":"Int. J. Lab. Hematol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"67","DOI":"10.4137\/CMPed.S40070","article-title":"Intrauterine Growth Restriction: Antenatal and Postnatal Aspects","volume":"10","author":"Sharma","year":"2016","journal-title":"Clin. Med. Insights Pediatr."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/3\/1201\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T10:38:49Z","timestamp":1759919929000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/3\/1201"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,30]]},"references-count":64,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,2]]}},"alternative-id":["ijms26031201"],"URL":"https:\/\/doi.org\/10.3390\/ijms26031201","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,30]]}}}