{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T08:46:53Z","timestamp":1770713213384,"version":"3.49.0"},"reference-count":54,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T00:00:00Z","timestamp":1738281600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science, Technological Development and Innovation of the Republic of Serbia","award":["451-03-66\/2024-03\/200019"],"award-info":[{"award-number":["451-03-66\/2024-03\/200019"]}]},{"name":"Ministry of Science, Technological Development and Innovation of the Republic of Serbia","award":["200110"],"award-info":[{"award-number":["200110"]}]},{"DOI":"10.13039\/501100016047","name":"Science Fund of the Republic of Serbia","doi-asserted-by":"publisher","award":["451-03-66\/2024-03\/200019"],"award-info":[{"award-number":["451-03-66\/2024-03\/200019"]}],"id":[{"id":"10.13039\/501100016047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016047","name":"Science Fund of the Republic of Serbia","doi-asserted-by":"publisher","award":["200110"],"award-info":[{"award-number":["200110"]}],"id":[{"id":"10.13039\/501100016047","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The expressions of ETS1, miR-203a-3p, and miR-204-3p in papillary thyroid carcinoma (PTC) are poorly described, and their clinical significance is unclear. To determine the prognostic value of ETS1 (E26 transformation-specific), its levels in divergent cell compartments were paired with miR-203a-3p\/-204-3p levels and linked to the presence of unfavorable clinical characteristics of PTC patients. Immunohistochemistry and Western blot were performed to evaluate ETS1 protein expression in PTC and matched nonmalignant thyroid tissue (NMT). qPCR was utilized to quantify ETS1 mRNA, miR-203a-3p, and miR-204-3p expressions. Bioinformatic analysis was applied to predict biological interactions. Although there was a significant increase in ETS1 protein expression (p &lt; 0.05), no difference was observed in ETS1 mRNA levels between PTC and matched NMT (p &gt; 0.05). 98.7% of PTC samples exhibited positive staining for the ETS1 protein, detected in the nucleus, the cytoplasm, or both. In contrast, the ETS1 protein had positive staining in 70.9% of NMT samples, primarily localized in the nucleus. ETS1 cytoplasmic levels correlated with the pT status of PTC patients (p = 0.020, r = \u22120.267), while nuclear levels correlated with the occurrence of lymph node metastasis (p = 0.020, r = \u22120.271). According to the bioinformatic analysis, the 3\u2032-untranslated region of ETS1 mRNA shares a seed sequence with miR-203a-3p\/-204-3p. The mutual distribution of ETS1 and miR-203a-3p levels differs between aggressive and non-aggressive PTCs. ETS1 could be used in the identification of high-risk PTC patients; however, its subcellular localization should be considered. PTC aggression could be influenced by increased cytoplasmic ETS1 protein levels, which may be affected by reduced levels of miR-203a-3p or miR-204-3p.<\/jats:p>","DOI":"10.3390\/ijms26031253","type":"journal-article","created":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T09:16:26Z","timestamp":1738314986000},"page":"1253","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["ETS1 Protein Expression May Be Altered by the Complementarity of ETS1 mRNA Sequences with miR-203a-3p and miR-204-3p in Papillary Thyroid Carcinoma"],"prefix":"10.3390","volume":"26","author":[{"given":"Stefana Stojanovi\u0107","family":"Novkovi\u0107","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Radioimmunology, Institute for the Application of Nuclear Energy\u2014INEP, University of Belgrade, Banatska 31b, Zemun, 11080 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2898-6671","authenticated-orcid":false,"given":"Sonja","family":"\u0160elemetjev","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Radioimmunology, Institute for the Application of Nuclear Energy\u2014INEP, University of Belgrade, Banatska 31b, Zemun, 11080 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jelena Jankovi\u0107","family":"Milju\u0161","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Radioimmunology, Institute for the Application of Nuclear Energy\u2014INEP, University of Belgrade, Banatska 31b, Zemun, 11080 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladan","family":"\u017divaljevi\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Belgrade, Doctor Suboti\u0107 8, 11000 Belgrade, Serbia"},{"name":"Clinic for Endocrine Surgery, University Clinical Center of Serbia, Pasterova 2, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9708-2089","authenticated-orcid":false,"given":"Du\u0161ko","family":"Dun\u0111erovi\u0107","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Faculty of Medicine, University of Belgrade, Doctor Suboti\u0107 1, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marija","family":"Milinkovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Pathology, Clinical Center of Serbia, Pasterova 2, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8475-2266","authenticated-orcid":false,"given":"Tijana I\u0161i\u0107","family":"Den\u010di\u0107","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Radioimmunology, Institute for the Application of Nuclear Energy\u2014INEP, University of Belgrade, Banatska 31b, Zemun, 11080 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21442","article-title":"Cancer statistics, 2018","volume":"68","author":"Siegel","year":"2018","journal-title":"CA Cancer J. Clin."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s00268-018-4479-z","article-title":"Overall Survival of Papillary Thyroid Carcinoma Patients: A Single-Institution Long-Term Follow-Up of 5897 Patients","volume":"42","author":"Ito","year":"2018","journal-title":"World J. Surg."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1097\/RLU.0b013e31805375ca","article-title":"Papillary Thyroid Carcinoma: 35-Year Outcome and Prognostic Factors in 1858 Patients","volume":"32","author":"Pelizzo","year":"2007","journal-title":"Clin. Nucl. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1476-4598-2-29","article-title":"The Biology of the Ets1 Proto-Oncogene","volume":"2","author":"Dittmer","year":"2003","journal-title":"Mol. Cancer"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Wang, Y., Huang, Z., Sun, M., Huang, W., and Xia, L. (2023). ETS transcription factors: Multifaceted players from cancer progression to tumor immunity. Biochim. et Biophys. Acta (BBA)-Rev. Cancer, 1878.","DOI":"10.1016\/j.bbcan.2023.188872"},{"key":"ref_6","first-page":"1931","article-title":"Expression of the Ets-1 proto-oncogene in human gastric carcinoma: Correlation with tumor invasion","volume":"149","author":"Nakayama","year":"1996","journal-title":"Am. J. Pathol."},{"key":"ref_7","first-page":"209","article-title":"Expression of the ets-1 proto-oncogene in human pancreatic carcinoma","volume":"11","author":"Ito","year":"1998","journal-title":"Mod. Pathol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"522","DOI":"10.3109\/10409238.2013.838202","article-title":"Molecular mechanisms of ETS transcription factor-mediated tumorigenesis","volume":"48","author":"Kar","year":"2013","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/modpathol.3880328","article-title":"Expression of the ets-1 Proto-Oncogene in Human Colorectal Carcinoma","volume":"14","author":"Nakayama","year":"2001","journal-title":"Mod. Pathol."},{"key":"ref_10","first-page":"1581","article-title":"Expression of ets-1 and ets-2 in colonic neoplasms","volume":"22","author":"Ito","year":"2002","journal-title":"Anticancer Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"506","DOI":"10.2741\/1546","article-title":"The transcription factor Ets-1 in breast cancer","volume":"10","author":"Lincoln","year":"2005","journal-title":"Front. Biosci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1111\/j.1365-2559.2005.02059.x","article-title":"Overexpression of Ets-1 proto-oncogene in latent and clinical prostatic carcinomas","volume":"46","author":"Alipov","year":"2005","journal-title":"Histopathology"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1530\/eje.1.01912","article-title":"Evaluation of insulin-like growth factor II, cyclooxygenase-2, ets-1 and thyroid-specific thyroglobulin mRNA expression in benign and malignant thyroid tumours","volume":"152","author":"Fuhrer","year":"2005","journal-title":"Eur. J. Endocrinol."},{"key":"ref_14","first-page":"61","article-title":"Expression of the ets-1 proto-oncogene in human thyroid tumor","volume":"12","author":"Nakayama","year":"1999","journal-title":"Mod. Pathol."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Xu, Y., Gao, J., Wang, N., Zedenius, J., Nilsson, I.-L., Lui, W.-O., Xu, D., Juhlin, C.C., Larsson, C., and Mu, N. (2024). BRAF-induced EHF Expression Affects TERT in Aggressive Papillary Thyroid Cancer. J. Clin. Endocrinol. Metab.","DOI":"10.1210\/clinem\/dgae589"},{"key":"ref_16","first-page":"2267","article-title":"Induction of ETS-1 and ETS-2 transcription factors is required for thyroid cell transformation","volume":"61","author":"Mega","year":"2001","journal-title":"Cancer Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1158\/1541-7786.MCR-17-0433","article-title":"Functional Toll-like Receptor 4 Overexpression in Papillary Thyroid Cancer by MAPK\/ERK\u2013Induced ETS1 Transcriptional Activity","volume":"16","author":"Peyret","year":"2018","journal-title":"Mol. Cancer Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1016\/j.neo.2014.10.005","article-title":"TSH Signaling Overcomes B-RafV600E\u2013Induced Senescence in Papillary Thyroid Carcinogenesis through Regulation of DUSP6","volume":"16","author":"Kim","year":"2014","journal-title":"Neoplasia"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1530\/ERC-17-0562","article-title":"Interaction of BRAF-induced ETS factors with mutant TERT promoter in papillary thyroid cancer","volume":"26","author":"Song","year":"2019","journal-title":"Endocr. Relat. Cancer"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"11928","DOI":"10.1093\/nar\/gku929","article-title":"ETS1 is a genome-wide effector of RAS\/ERK signaling in epithelial cells","volume":"42","author":"Plotnik","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"8148","DOI":"10.1111\/jcmm.16545","article-title":"Overexpression of lncRNA SLC26A4-AS1 inhibits papillary thyroid carcinoma progression through recruiting ETS1 to promote ITPR1-mediated autophagy","volume":"25","author":"Peng","year":"2021","journal-title":"J. Cell. Mol. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2750","DOI":"10.1111\/jcmm.17293","article-title":"Overexpression of lncRNA SLC26A4-AS1 inhibits papillary thyroid carcinoma progression through recruiting ETS1 to promote ITPR1-mediated autophagy","volume":"26","author":"Liu","year":"2022","journal-title":"J. Cell. Mol. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.devcel.2006.09.009","article-title":"The Diverse Functions of MicroRNAs in Animal Development and Disease","volume":"11","author":"Kloosterman","year":"2006","journal-title":"Dev. Cell"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-94-007-5590-1_1","article-title":"MicroRNAs in human cancer","volume":"774","author":"Farazi","year":"2013","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Ali Syeda, Z., Langden, S.S.S., Munkhzul, C., Lee, M., and Song, S.J. (2020). Regulatory Mechanism of MicroRNA Expression in Cancer. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21051723"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"535","DOI":"10.3233\/CBM-150492","article-title":"MiR-204 regulates HMGA2 expression and inhibits cell proliferation in human thyroid cancer","volume":"15","author":"Wu","year":"2015","journal-title":"Cancer Biomarkers"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.bbrc.2015.01.037","article-title":"miR-204-5p suppresses cell proliferation by inhibiting IGFBP5 in papillary thyroid carcinoma","volume":"457","author":"Liu","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_28","first-page":"1","article-title":"MiR-203a-3p, miR-204-3p, miR-222-3p as useful diagnostic and prognostic tool for thyroid neoplasia spectrum","volume":"79","year":"2022","journal-title":"Endocrine"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Stojanovi\u0107, S., \u0160elemetjev, S., \u0110ori\u0107, I., Milju\u0161, J.J., Tati\u0107, S., \u017divaljevi\u0107, V., and Den\u010di\u0107, T.I. (2023). BRAFV600E, BANCR, miR-203a-3p and miR-204-3p in Risk Stratification of PTC Patients. Biomedicines, 11.","DOI":"10.3390\/biomedicines11123338"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"3657","DOI":"10.1002\/jcb.29498","article-title":"Diagnostic and mechanistic values of microRNA-130a and microRNA-203 in patients with papillary thyroid carcinoma","volume":"121","author":"Zhu","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"443","DOI":"10.2147\/CMAR.S232294","article-title":"LncRNA WT1-AS Downregulates Survivin by Upregulating miR-203 in Papillary Thyroid Carcinoma","volume":"12","author":"Le","year":"2020","journal-title":"Cancer Manag. Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s11658-019-0192-7","article-title":"The long noncoding RNA LINC00483 promotes lung adenocarcinoma progression by sponging miR-204-3p","volume":"24","author":"Yang","year":"2019","journal-title":"Cell. Mol. Biol. Lett."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1159\/000486422","article-title":"Heterogeneity of Thyroid Cancer","volume":"85","author":"Chmielik","year":"2018","journal-title":"Pathobiology"},{"key":"ref_34","first-page":"570","article-title":"E26 transformation (ETS)-specific related transcription factor-3 (ELF3) orchestrates a positive feedback loop that constitutively activates the MAPK\/Erk pathway to drive thyroid cancer","volume":"41","author":"Chen","year":"2018","journal-title":"Oncol. Rep."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/377635a0","article-title":"Increased T-cell apoptosis and terminal B-cell differentiation induced by inactivation of the Ets-1 proto-oncogene","volume":"377","author":"Bories","year":"1995","journal-title":"Nature"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1038\/sj.onc.1201408","article-title":"A variant form of ETS1 induces apoptosis in human colon cancer cells","volume":"15","author":"Huang","year":"1997","journal-title":"Oncogene"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"3876","DOI":"10.1073\/pnas.96.7.3876","article-title":"The p42 variant of ETS1 protein rescues defective Fas-induced apoptosis in colon carcinoma cells","volume":"96","author":"Li","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1002\/path.844","article-title":"The Ets-1 transcription factor is up-regulated together with MMP 1 and MMP 9 in the stroma of pre-invasive breast cancer","volume":"194","author":"Behrens","year":"2001","journal-title":"J. Pathol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1002\/1097-0142(20001201)89:11<2292::AID-CNCR18>3.0.CO;2-0","article-title":"Immunohistochemical expression of Ets-1 transcription factor and the urokinase-type plasminogen activator is correlated with the malignant and invasive potential in meningiomas","volume":"89","author":"Kitange","year":"2000","journal-title":"Cancer"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1097\/00005072-199904000-00003","article-title":"Ets-1 Positively Regulates Expression of Urokinase-type Plasminogen Activator (uPA) and Invasiveness of Astrocytic Tumors","volume":"58","author":"Nakada","year":"1999","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0344-0338(00)80041-2","article-title":"Overexpression of Ets-1 Transcription Factor in Angiosarcoma of the Skin","volume":"196","author":"Naito","year":"2000","journal-title":"Pathol.-Res. Pr."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1002\/(SICI)1097-4652(199612)169:3<522::AID-JCP12>3.0.CO;2-7","article-title":"Ets-1 regulates angiogenesis by inducing the expression of urokinase-type plas-minogen activator and matrix metalloproteinase-1 and the migration of vascular endothelial cells","volume":"169","author":"Iwasaka","year":"1996","journal-title":"J. Cell Physiol."},{"key":"ref_43","first-page":"149","article-title":"Invasive properties of serous human epithelial ovarian tumors are related to Ets-1, MMP-1 and MMP-9 expression","volume":"8","author":"Behrens","year":"2001","journal-title":"Int. J. Mol. Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.1749-6632.2001.tb03934.x","article-title":"Role of transcription factors in angiogenesis: Ets-1 promotes angiogenesis as well as endothelial apoptosis","volume":"947","author":"Sato","year":"2001","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1006\/bbrc.2002.6418","article-title":"Ets-1 Upregulates Matrix Metalloproteinase-1 Expression through Extracellular Matrix Adhesion in Vascular Endothelial Cells","volume":"291","author":"Naito","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_46","first-page":"2013","article-title":"Inhibition of vascular endothelial growth factor-induced endothelial cell migration by ETS1 antisense oligonucleotides","volume":"57","author":"Chen","year":"1997","journal-title":"Cancer Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1023\/A:1022904624054","article-title":"Estrogen-Induced Ets-1 Promotes Capillary Formation in an in vitro Tumor Angiogenesis Model","volume":"78","author":"Lincoln","year":"2003","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2020\/2052396","article-title":"Differential MicroRNA-Signatures in Thyroid Cancer Subtypes","volume":"2020","author":"Santiago","year":"2020","journal-title":"J. Oncol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2017\/6496570","article-title":"MicroRNAs as Biomarkers in Thyroid Carcinoma","volume":"2017","author":"Celano","year":"2017","journal-title":"Int. J. Genom."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s13238-016-0259-4","article-title":"MiRNA-203 suppresses tumor cell proliferation, migration and invasion by targeting Slug in gastric cancer","volume":"7","author":"Yang","year":"2016","journal-title":"Protein Cell"},{"key":"ref_51","first-page":"61","article-title":"Overexpression of microRNA-203 can downregulate survivin and function as a potential therapeutic target in papillary thyroid cancer","volume":"19","author":"Wu","year":"2019","journal-title":"Oncol. Lett."},{"key":"ref_52","unstructured":"DeLellis, R.A., Lloyd, R., Heitz, P.U., and Eng, C. (2004). Papillary carcinoma Pathology and Genetics of Tumors of Endocrine Organs. World Health Organization Classification of Tumors, IARC Press."},{"key":"ref_53","unstructured":"Edge, S.B., Byrd, D.R., Compton, C.C., Fritz, A.G., Greene, F.L., and Trotti, A. (2010). AJCC Cancer Staging Manual, Springer. [7th ed.]."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"4197","DOI":"10.1210\/jc.2010-0337","article-title":"Correlation between the BRAF V600E Mutation and Tumor Invasiveness in Papillary Thyroid Carcinomas Smaller than 20 Millimeters: Analysis of 1060 Cases","volume":"95","author":"Basolo","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/3\/1253\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:25:00Z","timestamp":1760027100000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/3\/1253"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,31]]},"references-count":54,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,2]]}},"alternative-id":["ijms26031253"],"URL":"https:\/\/doi.org\/10.3390\/ijms26031253","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,31]]}}}